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| | Literature Review: Arlin Stoltzfus: On the Possibility of Constructive Neutral Evolution |
 | | In the gene-scrambling and RNA pan-editing cases, and in the fragmentation of introns, the initial state of the system (unscrambled, unedited, unfragmented) is unique or rare with regard to some extensive set of combinatorial possibilities (scrambled, edited, fragmented) that may be reached by mutation and (possibly neutral) fixation. |
 | | In both cases, the biases are systemic and result from a history of selection such that the initial state of the system (genes with highly specific activities, introns with independent splicing ability) is unusual with respect to possible alternative states. |
 | | The more immediately obvious type is a "mutational" bias, an inequality in the rates of mutational change between specific genetic states that arise from specific aspects of the machinery for replication, repair, and transmission of genetic material. |
| www.iscid.org /boards/ubb-get_topic-f-18-t-000012.html (1300 words) |
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