Where results make sense

About us   |   Why use us?   |   Reviews   |   PR   |   Contact us

Topic: TNF-alpha

    Note: these results are not from the primary (high quality) database.

Tumor necrosis factor -- Facts, Info, and Encyclopedia article TNFα is a member of a group of other (Any of various proteins secreted by cells of the immune system that serve to regulate the immune system) cytokines that all stimulate the (Click link for more info and facts about acute phase reaction) acute phase reaction. It is a 185 (Organic compounds containing an amino group and a carboxylic acid group) amino acid (A conjugated protein having a carbohydrate component) glycoprotein (Click link for more info and facts about peptide hormone) peptide hormone, cleaved from a 212 amino acid-long propeptide. www.absoluteastronomy.com /encyclopedia/t/tu/tumor_necrosis_factor.htm   (403 words)

THE ROLE OF TNF ALPHA AND BETA CYTOKINES IN SCAR HYPERTROPHY IN BURN PATIENTS: AN IMMUNOHISTOCHEMICAL STUDY The percentage of cells positive for TNF alpha and beta was calculated as the ratio between cells marked positively with TNF alpha and beta respectively and the total number of infiltrating cells, calculated in corresponding fields in the first section of the series. This implies that a mechanism regulating TNF alpha synthesis is involved in the process of scarring, not the presence of tissue inhibitors that neutralize in situ the TNF alpha molecules, as might also have been hypothesized. TNF beta was produced by 37% of cells infiltrating hypertrophic scars, 30% in normal scars and 15% in healthy skin. www.medbc.com /annals/review/vol_8/num_1/text/vol8n1p23.htm   (2249 words)

TNF-alpha ELISA (human, mouse & rat) > TNF alpha Assay Kit > Assay Designs TNF alpha is the primary mediator of immune regulation. TNF alpha has been suggested to play a pro-inflammatory role and has been detected in synovial fluid of patients with rheumatoid arthritis. The biosynthesis of TNF alpha is tightly controlled being produced in extremely small quantities in quiescent cells, but is a major secreted factor in activated cells. www.assaydesigns.com /products/catalog/immuno_assay/product_TNF-a.htm   (214 words)

Horst Ibelgaufts'COPE: Cytokines Online Pathfinder Encyclopaedia The release of TNF-alpha from isolated rat macrophages in culture is stimulated by Histogranin. IL6 suppresses the synthesis of IL1 induced by bacterial endotoxins and TNF, and the synthesis of TNF induced by endotoxins. TNF promotes the proliferation of astroglia and microglia and therefore may be involved in pathological processes such as astrogliosis and demyelinisation. www.copewithcytokines.de /cope.cgi?9404   (5517 words)

TNF alpha antibody [P/T2] (ab9579) datasheet TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. TNF alpha is believed to mediate pathogenic shock and tissue injury associated with endotoxemia. TNF alpha is closely related to the 25 kDa protein Tumor Necrosis Factor beta (lymphotoxin), sharing the same receptors and cellular actions. www.abcam.com /?datasheet=9579   (640 words)

Peptide T immunomodulation: inhibition of TNF alpha. TNF alpha activity was confirmed by inhibition with anti-TNF alpha. Cytotoxicity of 3H-thymidine labelled K562 cells, detected by release of radiolabel into culture supernatants, was used as a measure of macrophage and TNF alpha activity. CONCLUSIONS: Inhibition of TNF alpha appears to be a result of physiological effects on target cells rather than competitive inhibition. www.aegis.com /aidsline/1993/nov/M93B5427.html   (408 words)

etanercept (Enbrel) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com TNF alpha is a protein that the body produces during the inflammatory response, the body's reaction to injury. TNF alpha promotes the inflammation and its associated fever and signs (pain, tenderness, and swelling) in several inflammatory conditions including rheumatoid arthritis and ankylosing spondylitis. This prevents TNF alpha from promoting inflammation and the fever, pain, tenderness and swelling of joints in patients with rheumatoid or psoriatic arthritis and ankylosing spondylitis. www.medicinenet.com /etanercept/article.htm   (889 words)

TNF-alpha TNF-A is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. Prolonged overproduction of TNF-A also results in a condition known as cachexia, which is characterized by anorexia, net catabolism, weight loss and anemia and which occurs in illnesses such as cancer and AIDS. Additionally, a mutant form of TNF-A which exists only in the transmembrane form acts only by cell-to-cell contact and may result only in cytotoxicity (Perez et al.,1990), suggesting that mutant forms of TNF-A might effectively be used therapeutically as against specific types of cancers. www.bio.davidson.edu /courses/Immunology/Students/spring2000/wolf/tnfalpha.html   (1751 words)

LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-alpha and the TNF-p55 receptor -- Nowak et al. 278 (5): 1202 -- AJP - Regulatory, Integrative and Comparative Physiology Revisiting the role of tumor necrosis factor alpha and the response to surgical injury and inflammation. TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. TNF receptors (p55 and p75) to the lethality and apoptotic hepatic ajpregu.physiology.org /cgi/content/full/278/5/R1202   (3633 words)

Obesity and Diabetes in TNF-alpha Receptor- deficient Mice -- Schreyer et al. 102 (2): 402 -- Journal of Clinical Investigation Female C57BL/6 (wild-type) and TNF receptor-deficient mice were fed rodent chow (top) or a high-fat diet (bottom) for 16 wk and fasted for 4 h before intraperitoneal insulin injection at a dose of 1 U/kg body weight (n = 5). In summary, this is the first report to evaluate the role of individual TNF receptors in glucose homeostasis. Wild-type mice express circulating TNF and leptin (Lp), as well as receptors for TNF (p55 and p75) and leptin (LR). www.jci.org /cgi/content/full/102/2/402   (6157 words)

Cytokine Panel - Il1B, Il6,Il8, Tnf Alpha In the absence of IL-2, TNF- induces the proliferation and differentiation of beta cells. TNF- levels may be elevated in sepsis, cachexia, AIDS, Hepatitis C, transplant rejection, various infectious and autoimmune diseases. A variety of cells are shown to produce TNF-.TNF- is a growth factor for fibroblasts and stimulates the synthesis of collagenase and prostaglandin E2. www.lef.org /newshop/items/itemLCCYT.html   (454 words)

Hybrid Publishing -- TNF-Alpha Antagonism and Rheumatoid Arthritis In response to stresses, both physical and infectious, TNF is the most rapidly released of a series of cytokines that includes other proinflammatory mediators, such as interleukin (IL)-1, IL-6, and various chemokines, including IL-8, macrophage inflammatory proteins, and monocyte chemoattractant proteins. TNF belongs to one of the largest cytokine families. The trial provided firm evidence of the important role of TNF in rheumatoid inflammation and paved the way for further trials examining the long-term use of infliximab for the treatment of RA. hybridpub.com /eldercare/Maini.html   (2533 words)

2005.09.22 -- Scientists Spot Treatment Target for Severe Asthma TNF alpha is also found in a number of chronic inflammatory conditions such as rheumatoid arthritis, psoriasis and Crohn's disease. Bronchial fluid and lung tissue samples showed that TNF alpha levels were much higher in the people with severe asthma and that the TNF was concentrated in mast cells, which are immune cells that play a role in the asthmatic inflammatory reaction. About one in 10 people with asthma has a severe form of the disease, which correlates with relatively large amounts of circulating TNF alpha. www.4women.gov /news/english/527977.htm   (316 words)

Arch Surg -- Abstract: Revisiting the Role of Tumor Necrosis Factor {alpha} and the Response to Surgical Injury and Inflammation, May 1998, Ksontini et al. 133 (5): 558 Leaks in the epithelial barrier caused by spontaneous and TNF-{alpha}-induced single-cell apoptosis Identification of Tumor Necrosis Factor (TNF) Amino Acids Crucial for Binding to the Murine p75 TNF Receptor and Construction of Receptor-selective Mutants Arch Surg -- Abstract: Revisiting the Role of Tumor Necrosis Factor {alpha} and the Response to Surgical Injury and Inflammation, May 1998, Ksontini et al. archsurg.ama-assn.org /cgi/content/abstract/133/5/558   (348 words)

High Beryllium-stimulated TNF-alpha Is Associated with the -308 TNF-alpha Promoter Polymorphism and with Clinical Severity in Chronic Beryllium Disease -- MAIER et al. 164 (7): 1192 -- American Journal of Respiratory and Critical Care Medicine Secretion of tumour necrosis factor alpha and lymphotoxin alpha in relation to polymorphisms in the TNF genes and HLA-DR alleles: relevance for inflammatory bowel disease. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Kappa B-type enhancers are involved in lipopolysaccharide-mediated transcriptional activation of the tumor necrosis factor alpha gene in primary macrophages. ajrccm.atsjournals.org /cgi/content/full/164/7/1192   (4725 words)

TNF{alpha} inhibits skeletal myogenesis through a PW1-dependent pathway by recruitment of caspase pathways -- Coletti et al. 21 (4): 631 -- The EMBO Journal Szalay,K., Razga,Z. and Duda,E. (1997) TNF inhibits myogenesis and downregulates the expression of myogenic regulatory factors myoD and myogenin. Darnay,B.G. and Aggarwal,B.B. (1997) Early events in TNF signaling: a story of associations and dissociations. pathway is not activated by cytokines such as TNF embojournal.npgjournals.com /cgi/content/full/21/4/631   (5557 words)

Roles of tumor necrosis factor p55 and p75 receptors in TNF-alpha -induced vascular permeability -- Ferrero et al. 281 (4): C1173 -- AJP - Cell Physiology It is generally believed that TNFR1 mediates most of the TNF effects on different cell targets (9, 10, 20, 28, 35). Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. The effect of mouse and human TNF on the leakage of trypan blue-albumin complex from liver vessels was evaluated in anesthetized ajpcell.physiology.org /cgi/content/full/281/4/C1173   (4259 words)

Indian Journal of Medical Research: Circulating tumour necrosis factor alpha & soluble TNF receptors in patients with Guillain-Barre syndrome This present study was undertaken to find out the role of TNF-[alpha] and soluble TNF receptors in the pathogenesis of GBS; and to study the effect of intravenous immunoglobulin (ivIg) therapy on the serum TNF-[alpha] and soluble TNF receptors in patients with GBS. The serum TNF-[alpha] and soluble TNF receptors (TNF-RI, TNF-RII) were measured in the serum samples of these patients before and after ivIg therapy by a sandwich ELISA. Disturbances in the TNF receptor shedding might be linked with TNF-[alpha] mediated demyelinating autoimmune diseases of the central nervous system including GBS. www.findarticles.com /p/articles/mi_qa3867/is_200305/ai_n9242895   (1402 words)

Intravenous Liposomal Prednisolone Downregulates In Situ TNF-{alpha} Production by T-cells in Experimental Autoimmune Encephalomyelitis -- Schmidt et al. 51 (9): 1241 -- Journal of Histochemistry and Cytochemistry Kassiotis G, Kollias G (2001) Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination. TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. (1998) TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. www.jhc.org /cgi/content/full/51/9/1241   (1948 words)

Recombinant Human Tumor Necrosis Factor-alpha (TNF-a) - CYT- 223 The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1. Inhibition of TNF-alpha improves indomethacin-induced enteropathy in rats by modulating iNOS expression. Recombinant Human Tumor Necrosis Factor-alpha (TNF-a) - CYT- 223 www.prospec.co.il /~prospec/cart/catalog/rHuTNFa.html   (451 words)

IL-4-Stat6 Signaling Induces Tristetraprolin Expression and Inhibits TNF-{alpha} Production in Mast Cells -- Suzuki et al. 198 (11): 1717 -- The Journal of Experimental Medicine Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies. CFTL-15 cells were transfected with pRL-TK and either pGL3 TNF ARE(+) or pGL3 TNF ARE(-) in the presence of pcDNA3 Stat6, pcDNA3 Stat6VT, or pcDNA3 (as a control). for IgE (2, 3), and the mast cell–derived TNF- www.jem.org /cgi/content/full/198/11/1717   (5466 words)

ARS Publication request: Tnf-Alpha Induction of Lipolysis Is Mediated Through Activation of the Extracellular Signal Related Kinase Pathway in 3t3-L1 Adipocytes To determine if the MAP kinases have a role in TNF-alpha-induced lipolysis, 3T3-L1 adipocytes were treated with it, in the presence or absence of PD98059 or U0126, specific inhibitors of ERK activity. TNF-a is a molecule that activates enzymes called mitogen-activated protein (MAP) kinases including extracellular signal-related kinase (ERK) and n-terminal-c-Jun-kinase (JNK) in different cell types. www.ars.usda.gov /research/publications/Publications.htm?seq_no_115=164184   (511 words)

Cardiomyocytes overexpressing TNF-{alpha} attract migration of embryonic stem cells via activation of p38 and c-Jun amino-terminal kinase -- CHEN et al. 17 (15): 2231 -- The FASEB Journal Li, D., Zhao, L., Liu, M., Du, X., Ding, W., Zhang, J., Mehta, J. (1999) Kinetics of tumor necrosis factor alpha in plasma and the cardioprotective effect of a monoclonal antibody to tumor necrosis factor alpha in acute myocardial infarction. ; 5, 10, 30, 60, and 180 min, durations of ESCs incubated with 20 ng/mL TNF- rat cardiomyocytes with or without transfection of the TNF- www.fasebj.org /cgi/content/full/17/15/2231   (4399 words)

T Cell-Specific Expression of the Human TNF-{alpha} Gene Involves a Functional and Highly Conserved Chromatin Signature in Intron 3 -- Barthel and Goldfeld 171 (7): 3612 -- The Journal of Immunology Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Approximately 2.6 kb of the genomic sequence of the TNF- Jurkat cells were left untreated or were stimulated with PMA (50 ng/ml) or P+I (50 ng/ml; 1 µM) for times ranging from 4–24 h, following which the supernatants were harvested and processed as described above. www.jimmunol.org /cgi/content/full/171/7/3612   (4225 words)

Expression of TNF receptors by T cells and membrane TNF-alpha by alveolar macrophages suggests a role for TNF-alpha in the regulation of the local immune responses in the lung of HIV-1-infected patients. Expression of TNF receptors by T cells and membrane TNF-alpha by alveolar macrophages suggests a role for TNF-alpha in the regulation of the local immune responses in the lung of HIV-1-infected patients. The state of the art may have changed since the publication date. www.aegis.com /aidsline/1995/jun/M9560851.html   (564 words)

IL-1 and TNF Receptor-Deficient Mice Show Decreased Inflammation in an Immune Complex Model of Uveitis -- Brito et al. 40 (11): 2583 -- Investigative Ophthalmology & Visual Science IL-1 and TNF appear to have critical roles in RPAR uveitis. IL-1 and TNF Receptor-Deficient Mice Show Decreased Inflammation in an Immune Complex Model of Uveitis -- Brito et al. IL-1 and TNF Receptor–Deficient Mice Show Decreased Inflammation in an Immune Complex Model of Uveitis www.iovs.org /cgi/content/abstract/40/11/2583   (499 words)

Tumor Necrosis Factor (TNF)-{alpha} and TNF Receptors in Viral Pathogenesis -- Herbein and O'brien 223 (3): 241 -- Experimental Biology and Medicine of the receptors, the TNFR1 and the TNFR2 for TNF and LT, and TNFs are present as trimers, and the trimeric structure of TNF TNF modulates the viral cycle of HIV-1 in both T cells and macrophages. www.ebmonline.org /cgi/content/full/223/3/241   (8362 words)

Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-alpha -stimulated neutrophils -- Liu et al. 101 (1): 295 -- Blood Dotted contours indicate resting neutrophils; bolded contours, neutrophils stimulated with TNF alone; filled-in contours, neutrophils stimulated with TNF in the presence of zVAD. Dusi S, Della Bianca V, Donini M, Nadalini KA, Rossi F. Mechanisms of stimulation of the respiratory burst by TNF in nonadherent neutrophils: its independence of lipidic transmembrane signaling and dependence on protein tyrosine phosphorylation and cytoskeleton. In each panel, the percentages of cells in the left lower (live), the right lower (early apoptotic), and the right upper (primary necrotic and late apoptotic/secondary necrotic) quadrants are indicated. www.bloodjournal.org /cgi/content/full/101/1/295   (6743 words)

Developing a New Generation of TNF{alpha} Antagonists for the Treatment of Rheumatoid Arthritis -- Fleischmann and Shealy 3 (6): 310 -- Molecular Interventions Scallon, B.J., Moore, M.A., Trinh, H., Knight, D.M., and Ghrayeb, J. Chimeric anti-TNF alpha monoclonal antibody cA2 binds recombinant transmembrane TNF alpha and activates immune effector functions. Sequences coding for the p75 TNF receptor extracellular domain, cloned from a human cDNA library, are inserted into a plasmid vector containing the CH2 and CH3 heavy chain constant domain sequences and subsequently transfected into Chinese hamster ovary cells. Piguet, P. Evolution of collagen arthritis in mice is arrested by treatment with anti-tumor necrosis factor (TNF) antibody or recombinant soluble TNF receptor. molinterv.aspetjournals.org /cgi/content/full/3/6/310   (3113 words)

Try your search on: Qwika (all wikis)

About us   |   Why use us?   |   Reviews   |   Press   |   Contact us   Copyright © 2005-2007 www.factbites.com Usage implies agreement with terms.