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| | HHMI Bulletin May 2007: Hints from Wnts |
 | | Zebrafish, for example, have no problem regenerating perfect tailfins after being nipped by an aquarium mate—or snipped by an inquisitive doctoral student, like the University of Washington's Cristi Stoick-Cooper. |
 | | In particular, Stoick-Cooper, University of Washington postdoc Gilbert Weidinger (now at the Technical University of Dresden), and colleagues found that Wnt/ß-catenin activity rises in zebrafish undergoing tailfin regeneration, but the fish were unable to regrow snipped tailfins when researchers disabled the Wnt/ß-catenin pathway. |
 | | Surprisingly, zebrafish that overproduced a different Wnt—Wnt5b—failed to regenerate tailfins altogether, but mutant fish lacking a functional Wnt5b gene replaced their tailfins at an accelerated pace, indicating that this Wnt protein normally inhibits regeneration. |
| www.hhmi.org /bulletin/may2007/chronicle/hints.html (383 words) |
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