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Topic: Telithromycin

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	Telithromycin - Wikipedia, the free encyclopedia
		Telithromycin is the first ketolide antibiotic to enter clinical use.
		Telithromycin was approved by the European Commission in July 2001 and subsequently came on sale in October 2001.
		Telithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides.
	en.wikipedia.org /wiki/Telithromycin (447 words)

	TELITHROMYCIN
		Telithromycin is metabolized in the liver, with about 15% of a dose being excreted unchanged in the urine; 7% appears unchanged in the feces.
		Oral telithromycin is indicated in the treatment acute bacterial exacerbation of chronic bronchitis, acute bacterial sinusitis, and community- acquired pneumonia caused by susceptible organisms.
		Telithromycin 800 milligrams (mg) once daily is as effective as clarithromycin 500 mg twice daily in the treatment of community- acquired pneumonia in adults.
	www.micromedex.com /products/updates/drugdex_updates/de/telithromycinfull.html (6829 words)

	ICC: Telithromycin Effective For Treating Pneumococcal Pneumonia (Site not responding. Last check: 2007-10-08)
		Telithromycin is the first ketolide to reach the market and is available as an oral preparation.
		The overall clinical success rate at the end of treatment was 92.4 percent (1046/1132) for telithromycin, 90.1 percent (137/152) for amoxicillin, 88.5 percent (138/156) for clarithromycin and 94.2 percent (81/86) for trovafloxacin.
		The authors conclude that telithromycin was equal in efficacy to high-dose amoxicillin and other comparators for the treatment of CAP and for patients with pneumococcal pneumonia.
	www.pslgroup.com /dg/1FFEB2.htm (485 words)

	Annals - ARTICLE
		Derived from the macrolide class of antibacterial agents, telithromycin is approved for use in respiratory tract infections, including pneumonia, sinusitis, and bacterial exacerbations of chronic bronchitis (1).
		However, total adverse event rates were statistically significantly higher in the telithromycin arms of 2 trials in which trovafloxacin (13) and clarithromycin (14) were used as comparators and were statistically significantly lower in the telithromycin arm in 1 trial (16) in which amoxicillin–clavulanate was used as the comparator.
		Data from telithromycin’s prescribing information (1) state that abnormal results on liver function tests (alanine aminotransferase levels >3 times the upper limit of normal) occurred in 1.6% of patients receiving telithromycin and 1.7% of those receiving the comparator drug and that reversible hepatitis, with or without jaundice, occurred in 0.07% of patients receiving telithromycin.
	www.acponline.org /journals/annals/hepatotoxicity.htm (3033 words)

	Telithromycin for respiratory tract infections American Family Physician - Find Articles
		Telithromycin is the first member of the ketolides, a new subclass of the macrolide class of antibiotics.
		Telithromycin is labeled for treatment of community-acquired pneumonia (CAP), acute exacerbations of chronic bronchitis (AECB), and acute sinusitis (AS) in adults.
		Telithromycin is primarily metabolized by the hepatic CYP450 3A4 enzymes, although it has not been shown to be affected by grapefruit juice (which is known to affect drug metabolism in this group of hepatic enzymes).
	www.findarticles.com /p/articles/mi_m3225/is_6_70/ai_n6210751 (314 words)

	Telithromycin (marketed as Ketek) Questions and Answers
		Telithromycin is an FDA approved antibiotic drug, which belongs to the ketolide class, marketed in the U.S. by Aventis under the brand name Ketek.
		Telithromycin was approved in the U.S. in April 2004.
		As with all antibiotics, telithromycin should only be used for infections by a susceptible microorganism; telithromycin is not effective on viral infections, so a patient with a viral infection who took telithromycin would be taking a risk without any benefit.
	www.fda.gov /cder/drug/infopage/telithromycin/qa.htm (587 words)

	Telithromycin Shown Active In Combating Treatment-Resistant Respiratory Infections (Site not responding. Last check: 2007-10-08)
		Telithromycin is the first in a new family of antibiotics called ketolides, which are a novel addition to the macrolide-lincosamide-streptogramin (MLSb) group.
		Telithromycin administered for five days was as effective (75.8 percent clinical cure rate) as a 10-day course of the comparator (74.6 percent); and as effective as a 10-day course of telithromycin (74.1 percent clinical cure rate).
		In a second study, conducted in North America, telithromycin taken for only five days demonstrated equivalence in clinical and bacteriological cure to clarithromycin (91.3 percent vs. clarithromycin 88.1 percent clinical cure rate), which was taken over the course of 10 days in the treatment of pharyngitis or tonsillitis caused by group A Beta-hemolytic streptococci.
	www.pslgroup.com /dg/1ECCEE.htm (1309 words)

	Mayo Clinic Proceedings
		The pharmacokinetics of telithromycin and its in vitro activity against typical and atypical respiratory pathogens are summarized in Table 4.
		Telithromycin was equally effective in a 7-day dosing regimen, and results were similar for telithromycin in the comparator and open-label trials.
		Telithromycin was tolerated equally well among various high-risk patient groups including elderly patients, severely ill patients, and patients with concomitant illness such as renal or hepatic insufficiency, diabetes mellitus, and cardiovascular disease.
	www.mayoclinicproceedings.com /inside.asp?AID=415&UID= (6610 words)

	PTCommunity.com - Daily News Briefing
		Patients who have been prescribed telithromycin and are not experiencing side effects such as jaundice should continue taking their medicine as prescribed unless otherwise directed by their healthcare provider.
		Telithromycin is not effective in treating viral infections, so a patient with a viral infection should not receive telithromycin since they would be exposed to the risk of side effects without any benefit.
		Telithromycin is an antibiotic of the ketolide class.
	www.ptcommunity.com /Daily/DailyDetail.cfm?chosen=64476 (510 words)

	Experimental estimation of the role of P-glycoprotein in the pharmacokinetic behaviour of telithromycin, a novel ...
		The aim of this study was to examine the transport mechanism of telithromycin in comparison with erythromycin, azithromycin, clarithromycin and roxithromycin.
		Telithromycin efflux increased as the concentration of the compound increased until a plateau was reached at 2.10
		Telithromycin is administered to humans daily at a dose of 800g and the aqueous solubility of telithromycin in buffer at pH 2.2 and 7 are 0.24 M and 3.2x10
	www.ualberta.ca /~csps/JPPS6(1)/J.Pachot/p-gp.htm (6243 words)

	U.S. Pharmacist
		Telithromycin concentration in white blood cells is also greater than the concentration in plasma, and the drug is eliminated more slowly from white blood cells than from plasma.
		Approximately 7% of the oral dose of telithromycin is excreted unchanged in feces by biliary and/or intestinal secretion, and 13% is excreted unchanged in urine by renal excretion.
		Telithromycin is shown to increase the Cmax and AUC of warfarin and theophylline when these drugs are used concurrently; thus, these drugs should be used with caution.
	www.uspharmacist.com /index.asp?show=article&page=8_1442.htm (2732 words)

	Telithromycin Drug Information Medicine Online
		Telithromycin is used to treat certain infections caused by bacteria, such as bronchitis (infection of the airways that lead to the lungs), pneumonia (infection of the lungs), and sinus infections.
		Telithromycin is in a class of medications called ketolide antibiotics.
		If you stop taking telithromycin too soon, your infection may not be cured and bacteria may become resistant to antibiotics.
	www.medicineonline.com /druginfo/info1/Telithromycin/Telithromycin (748 words)

	Telithromycin
		Telithromycin works by preventing bacteria from producing proteins that are essential to them.
		By controlling bacterial numbers, telithromycin stops the spread of infection and the remaining bacteria eventually die or are killed by the body's immune system.
		Telithromycin is used to treat bacterial infections involving the respiratory tract, such as pneumonia, sinusitis and bronchitis.
	www.as9105.co.uk /lifestyle/healthfitness/health_advice/netdoctor/archive/100004751.html (695 words)

	ASHP News: Rare But Serious Liver Disease Reported by Telithromycin Users (Site not responding. Last check: 2007-10-08)
		BETHESDA, MD, 23 January 2006 â” Recent reports of a possible link between telithromycin use and severe liver disease have prompted the Food and Drug Administration (FDA) to issue a public health advisory that warns clinicians and patients to be alert for signs of liver toxicity in those who use the drug.
		The FDA-approved labeling for telithromycin states that liver disease, including increased levels of liver enzymes and the occurrence of hepatitis with and without jaundice, has been reported among patients who received the drug.
		The agency advised patients who are prescribed telithromycin and have no problems tolerating the drug to continue their recommended course of therapy.
	www.ashp.org /news/ShowArticle.cfm?cfid=15296718&CFToken=15936773&id=13938 (487 words)

	Pharmacokinetics of the New Ketolide Telithromycin (HMR 3647) Administered in Ascending Single and Multiple Doses -- ...
		of pharmacokinetic parameters for telithromycin and RU 76363,
		The pharmacokinetics of telithromycin and RU 76363 deviated
		Telithromycin was generally well tolerated at all doses, though the incidence of adverse events tended to be higher at the
	aac.asm.org /cgi/content/full/45/1/170 (3784 words)

	MedlinePlus Drug Information: Telithromycin (Systemic) (Site not responding. Last check: 2007-10-08)
		Telithromycin (tel-ith-roe-MYE-sin) belongs to the family of medicines called antibiotics.
		Telithromycin may be taken with or without food.
		Telithromycin should not be taken with cisapride or pimozide.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/500531.html (1109 words)

	Baylor Health Care System: Telithromycin: a novel agent for the treatment of community-acquired upper respiratory ...
		The ketolides are a new subclass of macrolides, and telithromycin is the first of these agents to be approved.
		It is therefore an option in the treatment of mild to moderate community-acquired respiratory infections, such as pneumonia, acute exacerbations of chronic bronchitis, pharyngitis/tonsillitis, and sinusitis.
		Telithromycin also offers the advantages of once-daily dosing and a shorter course of therapy in certain infections.
	www.baylorhealth.edu /proceedings/17_4/17_4_Tran.htm (155 words)

	Telithromycin Linked To Two Cases Of Liver Failure And Implicated In A Third Case Of Hepatitis (Site not responding. Last check: 2007-10-08)
		Researchers at Carolinas Medical Center in Charlotte, N. C., say that one of the patients died; one required and received a liver transplant; and the third recovered from drug-induced hepatitis after the antibiotic was stopped.
		Telithromycin was approved by the U.S. Food and Drug Administration in 2004 to treat acute bacterial infections from chronic bronchitis, acute bacterial sinusitis and community-acquired pneumonia.
		Telithromycin, an antibiotic derived from the macrolide class of antibacterial agents, appears effective against some pneumonia strains resistant to other older antibacterials such as penicillin.
	www.medicalnewstoday.com /medicalnews.php?newsid=36447 (466 words)

	Mechanisms of resistance to telithromycin in Streptococcus pneumoniae -- Hisanaga et al. 56 (3): 447 -- Journal of ...
		Mechanisms of resistance to telithromycin in Streptococcus pneumoniae -- Hisanaga et al.
		Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniae.
		Telithromycin activity is reduced by efflux in Streptococcus pyogenes.
	jac.oxfordjournals.org /cgi/content/full/56/3/447 (1906 words)

	Macrolide- and Telithromycin-Resistant S. pyogenes \| CDC EID
		In Belgium, the first ketolide to be used clinically, telithromycin, was approved in October 2002 to treat community-acquired respiratory infections in patients >12 years of age.
		Telithromycin resistance was distributed among 7 cMLS serotypes (emm22, emm28, emm11, emm12, emm77, emm6, and, emm2).
		Clearly, other factors like natural fluctuations in prevalence of clones (18), patient compliance with antimicrobial drug regimens, fitness costs of drug resistance, or even tetracycline consumption (tetracycline and macrolide-resistance genes cosegregate) (19) might be important determinants for the development and spread of macrolide-resistant S.
	www.cdc.gov /ncidod/EID/vol11no06/04-1247.htm (2464 words)

	Activities of Telithromycin against 13,874 Streptococcus pneumoniae Isolates Collected between 1999 and 2003 -- Farrell ...
		Antipneumococcal activity of telithromycin by agar dilution, microdilution, E test, and disk diffusion methodologies.
		Community-acquired respiratory tract infections caused by resistant pneumococci: clinical and bacteriological efficacy of the ketolide telithromycin.
		Telithromycin- and fluoroquinolone-resistant Streptococcus pneumoniae in Taiwan with high prevalence of resistance to macrolides and ß-lactams: SMART program 2001 data.
	aac.asm.org /cgi/content/full/48/5/1882 (1485 words)

	Tissue kinetics of telithromycin, the first ketolide antibacterial -- Muller-Serieys et al. 53 (2): 149 -- Journal of ...
		Briefly, the pharmacokinetics of telithromycin in WBCs and
		Mean telithromycin concentrations (mg/L) in white blood cells (WBC; diamonds) and plasma (squares) after (a) a single 600 mg oral dose and (b) 10 days once-daily dosing in healthy volunteers.
		Broncho-pulmonary disposition of the ketolide antimicrobial, telithromycin (HMR 3647).
	jac.oxfordjournals.org /cgi/content/full/53/2/149 (4436 words)

	Ketolides for pneumonia (Site not responding. Last check: 2007-10-08)
		Telithromycin can be used for mild-to-moderate pneumonia that you get in your daily life, such as at school or work (community-based pneumonia).
		The most common side effects of telithromycin are nausea, headache, dizziness, vomiting, and diarrhea.
		You have ever had a severe allergic reaction to telithromycin or to any of the group of antibiotics known as macrolides.
	www.webmd.com /hw/pneumonia/ug2984.asp (372 words)

	Telithromycin - Drugs & Vitamins - Drug Library - DrugDigest
		Telithromycin kills certain bacteria or stops their growth.
		Telithromycin will not work for colds, flu, or other viral infections.
		Telithromycin may be affecting the way your heart beats.
	www.drugdigest.org /DD/DVH/Uses/0,3915,553033\|Telithromycin,00.html (746 words)

	Facts & Comparisons: FDA Issues Public Health Advisory for Telithromycin
		Hepatoxicity in association with telithromycin use is being evaluated by the FDA to determine if labeling changes or other actions are necessary.
		The FDA is also recommending that health care providers monitor patients taking telithromycin for signs or symptoms of liver problems.
		Patients who develop signs of symptoms of liver problems should discontinue telithromycin use, but those not experiencing side effects such as jaundice should continue taking it as prescribed unless otherwise directed by their health care provider.
	www.factsandcomparisons.com /News/ArticlePage.aspx?id=7059 (166 words)

	Telithromycin: The first ketolide for the treatment of respiratory infections -- Kasbekar and Acharya 62 (9): 905 -- ...
		Telithromycin: The first ketolide for the treatment of respiratory infections -- Kasbekar and Acharya 62 (9): 905 -- American Journal of Health-System Pharmacy
		Telithromycin: The first ketolide for the treatment of respiratory infections
		Telithromycin is the first ketolide to be approved
	www.ajhp.org /cgi/content/abstract/62/9/905 (344 words)

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