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| | MVS Solutions - Method for Preparing Chiral Amines |
 | | A method for preparing chiral amine, comprising: reacting ketoxime represented by formula 1, a palladium catalyst, a lipase, an acyl donor, and a tertiary amine in an organic solvent to prepare an amide of formula IV ; and hydrolyzing the amide. |
 | | In this method, a chiral amine was prepared as optically pure amide by dynamic kinetic resolution from the mixture of racemic 1-phenylethylamine as a substrate, palladium as a racemization catalyst, and lipase as a selective acylation catalyst. |
 | | The final chemical structure of chiral amine derivative was identified by 1H NMR and 13C-NMR, and the optical purity which were determined with a chiral high-performance liquid chromatography (equipped with Whelk-01 or Chiraldex OD-H column), was 95% ee, and the yield was 80%. |
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