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	Thalassemia - Wikipedia, the free encyclopedia
		Thalassemia (American English) (or thalassaemia in British English), also known as "Cooley's anemia", is an inherited disease of the red blood cells, classified as a hemoglobinopathy.
		Thalassemia Minor, although not life threatening on its own, can affect quality of life due to the effects of a mild to moderate anemia.
		Reports of dominantly inherited α and β thalassemias have been reported the first of which was in an Irish family who had a two deletions of 4 and 11 bp in exon 3 interrupted by an insertion of 5 bp in the β-globin gene.
	en.wikipedia.org /wiki/Thalassemia_minor (2065 words)

	OHSU Health - Beta Thalassemia (Cooley's Anemia) (Site not responding. Last check: 2007-11-01)
		Thalassemia is an inherited disorder that affects the production of normal hemoglobin (a type of protein in red blood cells that carries oxygen to the tissues of the body).
		Beta thalassemia is caused by mutations in the beta chain of the hemoglobin molecule.
		Thalassemia major is inherited by an autosomal recessive gene, which means that two copies of the gene are necessary to produce the condition, one inherited from each of two carrier parents who have thalassemia minor.
	www.ohsuhealth.com /htaz/blood/blooddis/thalassemias/beta_thalassemia_cooleys_anemia.cfm (473 words)

	About Thalassemia
		Since thalassemia is not a single disorder but a group of related disorders that affect the human body in similar ways, it is important to understand the differences between the various types of thalassemia.
		As in mild alpha thalassemia, physicians often mistake the small red blood cells of the person with beta thalassemia minor as a sign of iron-deficiency anemia and incorrectly prescribe iron supplements.
		While thalassemia patients were given infrequent transfusions in the past, clinical research led to a more frequent program of regular blood cell transfusions that has greatly improved the patients' quality of life.
	www.thalassemia.org /sections.php?sec=1 (1438 words)

	Thalassemias
		Thalassemias is the name for the group of genetic blood diseases which vary widely in severity.
		Thalassemia is a genetic disorder that involves the decreased and defective production of hemoglobin, a molecule that's found inside all red blood cells and is necessary to transport oxygen throughout the body.
		Frequently, thalassemia is not diagnosed in a family until a baby is born with the disease.
	www.kidshealth.org /parent/medical/heart/thalassemias.html (1695 words)

	[No title]
		Thalassemia is a group of genetic blood diseases that vary widely in severity involving decreased and defective production of hemoglobin, a molecule that's found inside all red blood cells and is necessary to transport oxygen throughout the body.
		Both forms of thalassemia are genetic disorders and both parents have to pass the thalassemia gene to their child for him or her to have the disease.
		However, genetic counseling is important for families that carry the thalassemia gene because someone with the trait has a 25% (1 in 4) chance of having a child with the disease if his or her partner also carries the trait.
	www.utoronto.ca /kids/Thalassemia.htm (969 words)

	Thalassemia - thalassemia minor
		Thalassemia (American English) (or thalassemia minor Thalassaemia in British English) is an inherited disease of the red blood cells, classified thalassemia + anemia as a hemoglobinopathy.
		The thalassemias thalassemia pictures are classified according to which thalassemia cooley's anemia chain of the globin molecule is affected: in a thalassemia, the production of a globin is deficient, while in ß thalassemia the production of ß globin is defective.
		If thalassemia at mayo clinic all four how to tell alpha thalassemia electrophoresis if you have thalassemia trait or minor loci are affected, the fetus cannot live once outside the thalassemia org uterus: most such infants are dead at birth with hydrops fetalis, and those who are born alive die shortly after birth.
	www.medicalgeo.com /Med-Diseases-T/Thalassemia.html (1137 words)

	What Causes Thalassemia?
		Thalassemia is caused by variant or missing genes that affect how the body makes hemoglobin.
		A person who inherits a thalassemia gene or genes from one parent and normal genes from the other parent is a carrier (thalassemia trait).
		If two people with alpha thalassemia trait (carriers) have a child, the baby could have a mild or severe form of alpha thalassemia or could be healthy.
	www.nhlbi.nih.gov /health/dci/Diseases/Thalassemia/Thalassemia_Causes.html (540 words)

	Beta Thalassemia Information on Healthline
		Beta thalassemia minima and beta thalassemia minor are less severe and usually asymptomatic.
		Individuals with thalassemia minor are carriers for the beta globin gene and therefore possess only one of the genes necessary to express the disorder.
		This is rarely seen in individuals with beta thalassemia minor and may be accompanied by pain in the upper left portion of the abdomen.
	www.healthline.com /galecontent/beta-thalassemia (1139 words)

	MedlinePlus Medical Encyclopedia: Thalassemia
		Beta thalassemias are caused by a mutation in the beta globin chain.
		This is the minor form of the disease.
		With severe thalassemia, regular blood transfusions and folate supplementation are given.
	www.nlm.nih.gov /medlineplus/ency/article/000587.htm (651 words)

	What You Need to Know About Thalassemia - Children's Blood Foundation (Site not responding. Last check: 2007-11-01)
		The alpha thalassemias are concentrated in Southeast Asia, Malaysia and southern China.
		If a person has Thalassemia Minor, the cause of the slight anemia is known and no other blood tests or treatments such as iron are needed.
		More important, since individuals with Thalassemia Minor can pass the Thalassemia gene to their children, most people would like to know if there is a risk that their children could inherit this severe blood disease.
	www.childrensbloodfoundation.org /thalassemia.html (1154 words)

	..:: Thalassemia Foundation of Canada ::.. (Site not responding. Last check: 2007-11-01)
		People with a thalassemia mutation only in one gene are known as carriers or are said to have thalassemia minor.
		Many people from the areas of the world where thalassemia is common carry the gene for it on one chromosome (that is, they have thalassemia minor).
		If both parents carry thalassemia minor, their children may have thalassemia minor, or they may have completely normal blood, or they may have thalassemia major.
	www.thalassemia.ca /viewarticle.asp?aID=31&searchQ=F.A.Q (709 words)

	Thalassemia overview
		Thalassemia is a difficult subject to explain, since the condition is not a single disorder, but a group of defects with similar clinical effects.
		With alpha thalassemia, the "failed" genes are almost invariably lost from the cell due to a genetic accident.
		The patient has thalassemia that is more severe than thalassemia trait, but not so severe as to require chronic transfusion as do the patients with thalassemia major.
	sickle.bwh.harvard.edu /thalover.html (1772 words)

	Pathology
		The thalassemias are a diverse group of inherited disorders in which the rate of production of certain hemoglobins is decreased leading to an imbalance of globin chains available for hemoglobin dimer construction.
		In a thalassemia, it is synthesis of the a chain that is defective.
		In thalassemia minor, the severity of disease expression may only be seen as mild anemia and a microcytic state.
	www.med-ed.virginia.edu /courses/path/innes/rcd/thalassemia.cfm (1401 words)

	Beta Thalassemia (Cooley's Anemia) - Children's Hospital of Philadelphia
		Beta thalassemia is an inherited blood disorder in which there is an absent or decreased production of normal hemoglobin, the protein in red blood cells that carries oxygen to the tissues of the body.
		Persons with thalassemia minor have a 50/50 chance to pass the gene to their offspring, who would also have thalassemia minor if their other beta chain is normal.
		Thalassemia major is inherited as an autosomal recessive disorder, which means that in order to have the condition, a person must inherit the defective gene from both parents, each of whom have thalassemia minor.
	www.chop.edu /consumer/your_child/condition_section_index.jsp?id=-8811 (562 words)

	Thalassemia minor - beta thalassemia minor
		Thalassemia (American English) (or Thalassaemia in British English) is an inherited disease of the red blood cells, classified as a hemoglobinopathy.
		The thalassemias are classified according to which chain of the globin molecule is affected: in a thalassemia, the production of a globin is deficient, while in ß thalassemia the production of ß globin is defective.
		Thalassemia produces a deficiency of a or ß globin, unlike sickle-cell disease which produces a specific mutant form of ß alpha thalassemia minor globin.
	www.medicalgeo.com /Med-Diseases-T/Thalassemia-minor.html (1057 words)

	Beta Thalassemia - Health and Medical Information produced by doctors - MedicineNet.com
		The thalassemias are a group of genetic (inherited) blood disorders that share in common one feature, the defective production of hemoglobin, the protein that enables red blood cells to carry oxygen (and carbon dioxide).
		Thalassemia minor: The individual with thalassemia minor has only one copy of the beta thalassemia gene (together with one perfectly normal beta-chain gene).
		Persons with thalassemia minor have (at most) mild anemia (with slight lowering of the hemoglobin level in the blood).
	www.medicinenet.com /beta_thalassemia/article.htm (592 words)

	Thalassemia
		The first type of alpha thalassemia minor (trait) is a carrier state with no anemia and no symptoms.
		Beta thalassemia minor (thalassemia trait) may cause no symptoms, but can be identified by changes in the blood.
		Children with thalassemia minor (thalassemia trait) are considered carriers and lead completely normal, healthy lives.
	www.comeunity.com /adoption/health/thalessemia.html (1136 words)

	Nikon MicroscopyU: Human Pathology Digital Image Gallery - Thalassemia Minor
		Thalassemias are typically classed as either alpha thalassemias or beta thalassemias depending on whether the hemoglobin abnormality results from aberrant alpha or beta proteins.
		Thalassemia minor is sometimes accompanied by mild anemia and on rare occasions can lead to minor swelling of the spleen.
		Thalassemia Minor at 20x Magnification - Individuals that are diagnosed with thalassemia minor have inherited the disorder from only one parent, making them heterozygous for the condition.
	www.microscopyu.com /galleries/pathology/thalassemiaminor.html (452 words)

	Birth Defects & Genetics: Thalassemia
		Individuals with E-beta thalassemia produce a variant form of hemoglobin called hemoglobin E. Individuals who produce hemoglobin E generally are healthy or have only a mild anemia, unless they also have a form of beta thalassemia.
		Thalassemia is passed on through parents who carry the thalassemia genes in their cells.
		When two individuals with beta thalassemia trait have children together, there is a 25 percent chance (1 in 4) that any child they have will inherit a thalassemia gene from each parent and have a severe form of the disease.
	www.marchofdimes.com /pnhec/4439_1229.asp (2206 words)

	Medical References: Thalassemia (Site not responding. Last check: 2007-11-01)
		Thalassemia major, the most severe form, is also called Cooley's anemia, named after the doctor who first described it in 1925.
		Children with thalassemia intermedia may develop some of the same complications, although in most cases, the course of the disease is mild for the first two decades of life.
		When children with thalassemia major are treated with frequent transfusions (generally every 3 to 4 weeks) aimed at keeping their hemoglobin level near normal, many of the complications of thalassemia can be prevented.
	www.marchofdimes.com /professionals/681_1229.asp (1157 words)

	Iron Disorders Institute - Thalassemia
		E Thalassemia-is not truly thalassemia; it is considered a hemoglobinopathy (disorders characterized by structural alteration of globin chains) and otherwise known as Hemoglobin E which is a mild form of hemolytic anemia.
		Thalassemia on the other hand, is characterized by the inability to produce sufficient number of globin chains.
		Diagnosis of thalassemia intermedia is usually made after a period of observation; the decision to transfuse is often a complex one.
	www.irondisorders.org /Disorders/Thalassemia.asp (651 words)

	Medical Dictionary: Thalassemia minor - WrongDiagnosis.com
		Thalassemia minor is listed as a "rare disease" by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH).
		This means that Thalassemia minor, or a subtype of Thalassemia minor, affects less than 200,000 people in the US population.
		Thalassemia: Thalassemia is an inherited disease of faulty synthesis of hemoglobin.
	www.wrongdiagnosis.com /medical/thalassemia_minor.htm (266 words)

	eMedicine - Thalassemia, Beta : Article by Kenichi Takeshita, MD
		Thalassemia minor (beta thalassemia trait) usually is asymptomatic, and it typically is identified during routine blood count evaluation.
		The diagnosis of beta thalassemia minor usually is suggested by the presence of an isolated, mild microcytic anemia, target cells on the peripheral blood smear, and a normal red blood cell count.
		Educate patients with thalassemia minor about the genetic (hereditary) nature of their disease, and inform them that their immediate family members (ie, parents, siblings, children) may be affected.
	www.emedicine.com /med/topic2260.htm (3252 words)

	Thalassemia
		Thalassemia is a genetically determined defect in hemoglobin synthesis.
		The importance of identifying heterzygous beta thalassemia is to prevent the investigation and expense caused by confusion with iron deficiency.
		Thalassemia is characterized by the inability to produce sufficient numbers of globin chains.
	www.cariboo.bc.ca /schs/medtech/rice/thalassemia.html (1994 words)

	Dr. Koop - Thalassemia
		Thalassemias are hereditary disorders characterized by defective production of hemoglobin.
		In the major form, children are normal at birth, but develop anemia during the first year of life.
		Alpha thalassemias occur most commonly in people from southeast Asia and China, and are caused by deletion of a gene or genes from the alpha globin chain.
	www.drkoop.com /ency/93/000587.html (408 words)

	Beta thalassemia - Genetics Home Reference
		Signs and symptoms of beta thalassemia are severe in the form of the disorder known as thalassemia major and less severe in the form called thalassemia intermedia.
		Mutations in the HBB gene cause beta thalassemia.
		Beta thalassemia major and thalassemia intermedia are inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered.
	ghr.nlm.nih.gov /condition=betathalassemia (699 words)

	..:: Thalassemia Foundation of Canada ::..
		In Thalassemia minor, the hemoglobin genes are inherited during conception, one from the mother (egg) and one from the father (sperm).
		People with a Thalassemia trait in one gene are known as carriers or are said to have Thalassemia minor.
		Possessing the Thalassemia minor trait gives you a 25%, (1 in 4) chance of having a baby with Thalassemia major, providing that both parents of the child are both carriers of the disorder.
	www.thalassemia.ca /viewarticle.asp?aID=14&searchQ=What (238 words)

	Can Beta-Thalassemia Minor have symptoms?
		It's really frusterating to hear that there is no help out there for minor patients yet as we must all be making up the same exact symptoms since the doctors all contest that their are no known symptoms for minor patients.
		Thalassemia is known to cause bone diformity during your youth...
		It wasn't until i was 19 before they confirmed i had thalassemia Minor, mind you i specifically asked to be tested for thalassemia Minor.(because my Dad had it)....All the other blood tests i had prior to that never picked it up....
	www.medhelp.org /forums/Maternal/messages/32854.html (7166 words)

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