
	Where results make sense

Topic: Thalidomide

In the News (Thu 10 Dec 09)

Northern Trust

Marvin Harrison

Peter Chernin

Gary Locke

Match Play

Penelope Cruz

Mickey Rourke

AR Rahman

Danny Boyle

Hugh Jackman

	Home
		Thalidomide was invented in 1954 at the Grünenthal Labs in Germany by the inventors Dr. W.
		Thalidomide UK would like to the drug banned for the treatment of leprosy and in countries were the drug cannot be controlled or monitored.
		Thalidomide UK believes that we should work towards licensing the drug, which would prevent it being easily available over the internet and would stop pharmaceutical companies supplying the drug with the side effect warnings being displayed on a little piece of paper which includes small print.
	www.thalidomideuk.com (1090 words)

	Thalidomide - Wikipedia, the free encyclopedia
		Thalidomide is a drug that was originally sold during the late 1950s and 1960s as a sleeping aid and to pregnant women as an antiemetic to combat morning sickness and other symptoms.
		Thalidomide received federal approval on May 25, 2006 for treatment of multiple myeloma, a form of bone marrow cancer, bringing its total number of approvals for multiple myeloma to five.
		Thalidomide also shows anti-angiogenic activity and has been shown to have activity in Kaposi's sarcoma, although it is not approved by the FDA or generally used for this condition because of the availability of better and safer drugs.
	en.wikipedia.org /wiki/Thalidomide (2115 words)

	Thalidomide - Important Patient Information
		Thalidomide is not approved for general sale in the United States.
		While you are taking thalidomide, you will be told by your doctor of any new information that might cause you to change your mind about taking thalidomide.
		Tragically, when thalidomide was used by pregnant women, it resulted in the birth of thousands of deformed babies.
	www.fda.gov /cder/news/thalidomide.htm (795 words)

	Thalidomide (Site not responding. Last check: 2007-11-02)
		Thalidomide is a derivative of glutamic acid and glutethimide but has a different activity profile.
		Thalidomide inhibited viral activation in the peripheral blood mononuclear calls In 16/17 patients with advanced HIV infection In 23 patients with systemic lupus erythematosus and cutaneous lesions unresponsive to standard therapies, 90% had complete remission and a significant reduction in average prednisone dose (from 40.5 to 17.4 mg/day) while receiving thalidomide 300 mg/day.
		The FDA issued an approvable letter on September 19, 1997 to Celegene for thalidomide as treatment for ENL, a serious complication Of leprosy indicating the benefits are viewed to outweigh the risks in this patient population.
	www.alpenmic.com /pharmacy/thalidomide.htm (701 words)

	Thalidomide: An Old Drug with New Tricks - Lupus Foundation of America, Inc.
		As a result, thalidomide is now a very useful drug in the treatment of a large number of disorders from cutaneous (skin) lupus to multiple myeloma (a type of blood cancer).
		Thalidomide has been used in a fairly large number of people with the type of lupus that affects their skin (discoid lupus, subacute cutaneous lupus, lupus profundus, tumid lupus).
		Thalidomide, developed as a sleep aid in the 1950s, is effective in treating a large number of inflammatory and autoimmune disorders.
	www.lupus.org /education/articles/thalidomide.html (1174 words)

	Thalidomide For Brain Tumors
		Thalidomide was used widely outside of the United States as a hypnotic/sedative agent in the late 1950s and the early 1960s, but was withdrawn from the market because of the high incidence of severe birth defects attributed to this drug.
		Thalidomide was never approved in the US until recently, when it was approved for use in the treatment of leprosy-related conditions.
		Thalidomide is currently being tested in combination with a chemotheraputic agent active in malignant gliomas (carboplatin), and single-agent clinical trials are being initiated in the treatment of recurrent brain metastases and in the treatment of recurrent atypical or malignant meningiomas.
	www.virtualtrials.com /thalidomide.cfm (409 words)

	Thalidomide (Site not responding. Last check: 2007-11-02)
		Pharmacokinetics: Thalidomide is administered orally and is slowly absorbed from the GI tract.
		Thalidomide appears to undergo non-enzymatic hydrolysis in the plasma and is not hepatically metabolized.
		Thalidomide is contraindicated in pregnancy and in women of childbearing potential (Pregnancy category X) unless other treatment options are not appropriate and the woman complies with all requirements to ensure she can not become pregnant while taking thalidomide.
	www.behcetsuk.org /medications/thalidomide.html (4264 words)

	Thalomid (thalidomide)
		Thalidomide was approved by the Food and Drug Administration (FDA) in May of 2006 for use in combination with dexamethasone for the treatment of newly diagnosed multiple myeloma.
		Thalidomide appears to have multiple actions, including the ability to inhibit the growth and survival of myeloma cells in various ways and to inhibit the growth of new blood vessels (angiogenesis).
		Thalidomide has been investigated in numerous trials as a single-agent or as part of combination therapy with chemotherapy and/or dexamethasone in patients with relapsed and refractory myeloma as well as in newly diagnosed patients.
	www.multiplemyeloma.org /treatments/3.04.html (2315 words)

	Thalidomide
		Thalidomide stands out as it is the only anti-cancer agent that is available which maintains the same high response rate noted in newly diagnosed as well as in the relapsed refractory multiple myeloma patients 1;2.
		Thalidomide and its class appear to have a broad spectrum of activities and may act as an anti-myeloma agent thorough several mechanisms 8.
		Thalidomide may have a direct effect on the multiple myeloma cell and/or BM stromal cell through free radical–mediated oxidative DNA damage may play a role in the teratogenicity of thalidomide 9.
	www.clevelandclinic.org /myeloma/thalidomide.htm (2638 words)

	Redeeming thalidomide
		Thalidomide’s soiled reputation presents challenges to clinical development, the most pressing of which is to ensure that no woman taking the drug is or becomes pregnant.
		Thalidomide’s wide range of activities lends hope to researchers that they can tease apart its effects and develop the next generation of drugs with more specific activity and, one hopes, none of thalidomide’s disturbing side effects.
		Thalidomide is also the first real therapy available for multiple myeloma in almost 20 years, says Stirling, and the FDA has approved it for that indication.
	pubs.acs.org /hotartcl/mdd/00/jun/mddkling.html (1730 words)

	NTP-CERHR: Common Concerns - Thalidomide
		Thalidomide was recognized as a powerful human teratogen (a drug or other agent that causes abnormal development in the embryo or fetus).
		Thalidomide may be dispensed only by licensed pharmacists who are registered in the S.T.E.P.S. program and have been educated to understand the risk of severe birth defects if thalidomide is used during pregnancy.
		It is vital that each patient understands that thalidomide is prescribed for him or her alone and must not be shared with, or given to, others.
	cerhr.niehs.nih.gov /common/thalidomide.html (1149 words)

	THE THALIDOMIDE TRAGEDY:
		Thalidomide, the nightmare drug responsible for over 10,000 human birth deformities, has again reared its ugly head with the appearance of its dreadful effects being passed on to the children of victims.
		In fact, thalidomide apologists still adhere to the defence that the thalidomide tragedy could not have been predicted, mainly because the drug had not been tested specifically for birth defects before being marketed, as at the time it wasn't required by law.
		Thalidomide campaigners argue that the thalidomide tragedy is not an example of an animal-tested drug that proved disastrous for humans, but of the dishonesty and sharp practices of the pharmaceutical industry.
	www.pnc.com.au /~cafmr/online/research/thalid2.html (1453 words)

	BBC - Radio 4 - The Archive Hour
		When in the late 1950s and early 1960s pregnant women across the globe reached for a recommended remedy for bouts of morning sickness, they had no idea how this, "chemical shrapnel", as it has since been called, would affect the lives of their unborn children.
		Thalidomide: 40 Years On draws on archive from the UK, Germany (where the majority of Thalidomide survivors reside), Australia, and Canada.
		The presenter, Geoff Adams-Spink — himself affected by thalidomide — looks at how the drug was developed as a ‘totally harmless’ sedative, the shock of the birth defects that it brought about, and the lives of those affected.
	www.bbc.co.uk /radio4/factual/thalidomide.shtml (482 words)

	Thalidomide : Cancerbackup
		Thalidomide tablets or capsules are swallowed whole with plenty of water an hour after food, preferably in the late evening.
		Thalidomide may be given in combination with chemotherapy drugs.
		This is due to the effect of thalidomide on the nerves and is known as peripheral neuropathy.
	www.cancerbackup.org.uk /Treatments/Biologicaltherapies/Angiogenesisinhibitors/Thalidomide (1777 words)

	Thalidomide Victims Association of Canada
		Thalidomide is a drug that was introduced on to the market on October 1, 1957 in West Germany.
		Thalidomide soon became a drug prescribed to pregnant women to combat symptoms associated with morning sickness.
		The Thalidomide Victims Association of Canada (TVAC) is an organization representing approximately 125 Canadians born disabled as a consequence of the drug Thalidomide.
	www.thalidomide.ca /en/index.html (273 words)

	ACS :: Cancer Drug Guide: thalidomide
		Thalidomide appears to interfere with the growth of blood vessels.
		Thalidomide interferes with the growth of these new blood vessels, and theoretically stops the cancer from growing larger than the size of a pencil tip.
		Thalidomide is taken as a capsule with water, at least 1 hour after a meal.
	www.cancer.org /docroot/CDG/content/CDG_thalidomide.asp (815 words)

	Giving Thalidomide a Second Chance
		In the early 1960s the very mention of the word "thalidomide" was enough to conjure up the vision of a parent's worst nightmare: the birth of a deformed child.
		The thalidomide story began when a marked increase in the number of infants born with a severe deformity of the limbs called phocomelia was noted in a number of European countries.
		Thalidomide is not approved for use in the United States; however, in appropriate circumstances FDA allows restricted investigational use of the drug to treat the diseases now under clinical trials.
	www.webmd.com /cancer/giving-thalidomide-second-chance (1704 words)

	Thalidomide (Site not responding. Last check: 2007-11-02)
		Thalidomide affected more than 10,000 babies, mainly in Europe and Canada, while in the United States, just a few women gave birth to "thalidomide babies." These were women who had obtained the drug while living abroad, or who had participated in investigational studies.
		Today this function of thalidomide may be useful in the treatment of macular degeneration, which results from an overgrowth of new blood vessels in the central portion of the retina.
		Thalidomide has also been shown to be useful in combating aphthous lesions in the mouth and esophagus which are often found in AIDS patients, and which are deep and painful and may lead to malnutrition because they prevent the patient from eating
	www.nyu.edu /classes/jaeger/thalidomide.htm (3105 words)

	BBC - Health - Ask the doctor - Thalidomide
		The very name thalidomide is enough to send chills through most people old enough to be aware of the terrible damage it caused pregnant women who took the drug between 1959 and 61.
		Thalidomide has a range of effects on the body, and researchers are looking at its potential in treating several different medical problems.
		Another potentially important effect of thalidomide is the way it can interfere with how white blood cells move around the body.
	www.bbc.co.uk /health/ask_the_doctor/thalidomide.shtml (506 words)

	The Michigan Daily Online
		Thalidomide may soon be sold in U.S. WASHINGTON - Thalidomide, which became the world's most infamous drug after causing thousands of horrific birth defects more than 30 years ago, may soon be sold in the United States - perhaps as early as next year.
		Thalidomide, once sold in 48 countries as a sleeping pill and morning sickness cure, was banned worldwide in 1962 after some 12,000 babies were born with missing or malformed limbs, serious facial deformities and defective organs.
		Thalidomide also stops blood vessel growth-one reason for the birth defects-making it a possible future treatment for cancer and the incurable macular degeneration that blinds the elderly.
	www.pub.umich.edu /daily/1996/nov/11-13-96/news/newsnr.html (951 words)

	Thalidomide: Research advances in cancer and other conditions - MayoClinic.com
		Between 1957 and the early 1960s, thalidomide was used by several thousand pregnant women across the world to ease their morning sickness.
		Thalidomide appears to slow the growth of myeloma cells and prevent them from attaching to bone marrow cells.
		If you and your doctor decide thalidomide is the right treatment for you, you will need to agree to the terms of a restricted distribution program required by the FDA to prevent birth defects.
	www.mayoclinic.com /health/thalidomide/HQ01507 (759 words)

	Thalidomide : BC Cancer Agency
		Thalidomide is relatively contraindicated in the presence of neutropenia or peripheral neuropathy.
		Thalidomide should be discontinued when neuropathy is present in early stages as sensory effects may not be reversible if thalidomide is continued with ongoing symptoms.
		Thalidomide induces amenorrhea in patients with lupus disease.
	www.bccancer.bc.ca /HPI/DrugDatabase/DrugIndexPro/thalidomide.htm (1827 words)

	Thalidomide (Contergan) - Annotated Collection of Links
		Thalidomide (α-phthalimidoglutarimide) has a chiral centre and was dispensed as a racemate (1:1 mixture) of dextrorotatory (R)- and levorotatory (S)-thalidomide.
		The terrible drug thalidomide, once responsible for causing severe birth defects in thousands of unborn children, is experiencing a comeback as a cancer treatment.
		In 1998, thalidomide became FDA approved for the acute treatment and suppression of the cutaneous manifestations of erythema nodosum leprosum (ENL).
	www.k-faktor.com /thalidomide (2674 words)

	Thalidomide
		The actual number of malformations that Thalidomide caused to babies can never be precisely assessed in the official casualty figures as in many of the poorer countries 'monster babies' and 'freaks', as they were deemed, were locked from view or destroyed by distraught parents who accepted the terrible afflictions as 'visitations from the devil'.
		In fact, thalidomide apologists still adhere to the defence that the thalidomide tragedy could not have been predicted, mainly because the drug had not been tested specifically for birth defects before being marketed, as at the time it was not required by law.
		Thalidomide is being used to treat not only the side affects of leprosy drugs, but in Britain it is widely used to treat a condition that results in terrible mouth ulcers in AIDS and non-AIDS patients.
	www.vaccinetruth.org /thalidomide.htm (6925 words)

	Chemical & Engineering News: Top Pharmaceuticals: Thalidomide
		This remarkable transformation of thalidomide from notoriety to respectability testifies to the success of the stronger drug regulations in the U.S. that the tragedy of thalidomide babies engendered.
		Until a restriction-free, nonteratogenic analog comes to light, patients with difficult-to-treat diseases that are treatable by thalidomide have good reason to turn to the old drug: As dangerous as it is, its dangers are well-known and have proven to be manageable.
		Thalidomide's notoriety has been accompanied by a myth that must be dispelled as the drug continues to gain respectability: that the birth defects the drug caused could have been avoided had it been made available as a single enantiomer rather than a racemate.
	pubs.acs.org /cen/coverstory/83/8325/8325thalidomide.html (1876 words)

	Limited Course of Thalidomide Effective in Treating AIDS-Related Mouth Ulcers - The Body
		Thalidomide effectively heals severe mouth and throat ulcers in people with HIV infection, according to a study supported by the National Institute of Allergy and Infectious Diseases (NIAID) and reported in the May 22, 1997, issue of The New England Journal of Medicine.
		A second reason for caution, according to the study results, is that patients taking thalidomide had elevated plasma levels of tumor necrosis factor (TNF)-alpha, a substance released from phagocytes and from some T cells during the immune response and known to provoke HIV replication and expression from infected cells.
		Because of thalidomide’s well-known ability to cause severe birth defects, every precaution was taken to prevent pregnancy, and pregnancy tests were given weekly to women of childbearing age.
	www.thebody.com /niaid/thalidom.html (901 words)

Try your search on: Qwika (all wikis)