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Topic: Thelarche

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	Thelarche
		Thelarche is usually noticed as a firm, tender lump directly under the center of the nipple (papilla and areola).
		Thelarche is also referred to as a "breast bud", or more formally as Tanner stage 2 breast development (Tanner stage 1 being the entirely undeveloped prepubertal state).
		Thelarche is usually the first physical change of puberty in girls, and is a result of rising levels of estradiol.
	www.mrsci.com /Gynecology/Thelarche.php (123 words)

	Thelarche Gynecology
		Thelarche is usually noticed as a firm, tender lump directly under the center of the nipple(papillaand areola).
		Thelarche is also referred to as a "breast bud", or more formally as Tanner stage2 breast development (Tanner stage 1 being the entirely undeveloped prepubertal state).
		When thelarche occurs at an unusually early age, it may be the first manifestation of precocious puberty.
	www.lumrix.com /medical/gynecology/thelarche.html (191 words)

	Premature Thelarche and Adrenarche (Site not responding. Last check: 2007-11-04)
		Treatment is reassurance and careful observation to make sure that the thelarche is not the first manifestation of precocious puberty.
		In one study, 6% of premature thelarche represented the earliest sign of true precocious puberty.
		Adrenarche is the presence of pubic hair before 8 years of age in girls and 9 years of age in boys.
	pedclerk.bsd.uchicago.edu /thelarchePubarche.html (274 words)

	Thelarche - Pediatric Oncall (Site not responding. Last check: 2007-11-04)
		I have an 8 year old daughter and i have noticed that one breast has started to develop before the other one and she complains at times about it being sore.
		What she has is a condition called as thelarche.
		However, if it starts earlier than that, then it is premature thelarche and one may need to find out the cause for the same and treat the same.
	www.pediatriconcall.com /forpatients/querylook/queryans/parans777.asp (148 words)

	Research Summaries - Arbuckle et al.
		Females with thelarche often have one or both breasts enlarged without any other physical signs of the onset of puberty.
		Cases were girls between the ages of 6 months and 8 years of age with a diagnosis of premature thelarche between 1994 and 1998 (n=41).
		Colón et al found that phthalate esters were significantly higher in girls with thelarche than in the control group with high levels of phthalate esters being found in 68% of the cases.
	www.emcom.ca /summaries/colon.shtml (631 words)

	Child Health Resources \| Children's Hospital & Regional Medical Center
		Thelarche means "the beginning of breast development." Therefore, if a girl begins to show breast enlargement at an early age (anywhere from birth to six years), it is called "premature thelarche."
		Premature thelarche is not a disease; instead, it is a normal finding in some young girls or female infants.
		Most commonly, premature thelarche is diagnosed in a female infant or a girl up to three years of age.
	www.pediatricweb.com /seattle/article.asp?ArticleID=837&ArticleType=9 (652 words)

	Outcome of premature thelarche: relation to puberty and final height -- Salardi et al. 79 (2): 173 -- Archives of ... (Site not responding. Last check: 2007-11-04)
		Outcome of premature thelarche: relation to puberty and final height
		Isolated premature thelarche with onset before 3 years of age progresses towards precocious puberty, although this was consistent
		Garibaldi L. Progression of premature thelarche to precocious puberty.
	adc.bmjjournals.com /cgi/content/full/79/2/173 (1275 words)

	"Thelarche pathway" linked to obesity, possibly breast cancer - News
		Girls who begin puberty with breast development before pubic hair growth are at increased risk for obesity and possibly also breast cancer, according to a report published in the June issue of the Journal of Pediatrics.
		Therefore, in the current study, girls in the thelarche pathway had a number of factors that could increase their risk of breast cancer--earlier age of menarche, greater BMI, and increased body fat.
		As the study included only white girls, "it is unclear whether the impact of asynchronous maturation is the same in fl females as it is in white female," the authors note.
	www.virtualcancercentre.com /news.asp?artid=3515 (364 words)

	Premature Thelarche -- eCureMe.com
		In premature thelarche, there are no other signs of early puberty, except the breast development.
		Close medical followup of the girls with this condition is needed, every 6 months, because a small percentage of these girls will additionally have precocious puberty (early puberty) before the age of 8 years, and precocious puberty is abnormal.
		No laboratory test is available to predict which girls with premature thelarche will go on to have precocious puberty.
	www.ecureme.com /emyhealth/Pediatrics/Premature_Thelarche.asp (525 words)

	Premature Thelarche; Environmental Connections Bibliography
		Devriendt, K., Lemli, L., Craen, M., and de Zegher, F. Growth hormone deficiency and premature thelarche in a female infant with Kabuki makeup syndrome.
		Stanhope, R., and Brook, C. Thelarche variant: a new syndrome of precocious sexual maturation.
		Bongiovanni, A. An epidemic of premature thelarche in Puerto Rico.
	envirocancer.cornell.edu /Bibliography/General/bib.thelarche.cfm (901 words)

	The Hindu : `Premature thelarche major cause of secondary sexual character'
		The child is psychologically unable to cope with its physical change and the family members who abuse the child for its altered features instead of seeking medical help, cause harm.
		Two years ago, a survey by the Institute of Child Health, Egmore of the 100 reported cases of premature sexual development, revealed that the majority were due to premature thelarche upto the age of two and a half.
		In the past five years, the ICH has treated 50 cases of premature thelarche, a harmless, little understood condition that affects girl children.
	www.hindu.com /thehindu/2003/07/09/stories/2003070908730300.htm (578 words)

	Identification of Phthalate Esters in the Serum of Young Puerto Rican Girls with Premature Breast Development
		Premature breast development (thelarche) is the growth of mammary tissue in girls younger than 8 years of age without other manifestations of puberty.
		We focused specifically on girls with premature thelarche because this condition represents the majority (71%) of the total cases of premature sexual development reported on the island.
		An epidemic of premature thelarche in Puerto Rico.
	www.ehponline.org /members/2000/108p895-900colon/colon-full.html (5036 words)

	The Ultimate Menarche Dog Breeds Information Guide and Reference (Site not responding. Last check: 2007-11-04)
		When menarche occurs, it confirms that the female has had a gradual estrogen-induced growth of the uterus, especially the endometrium, and that the "outflow tract" from the uterus, through the cervix to the vagina, is open.
		When menarche has failed to occur for more than 3 years after thelarche, or past 14.5 years of age, the delay is referred to as primary amenorrhea.
		See also puberty, delayed puberty, precocious puberty, thelarche, adrenarche, pubarche, gonadarche, menstrual cycle.
	www.dogluvers.com /dog_breeds/Menarche (235 words)

	Apr/May 2001 Sentient Times
		Since 1970, there have been 4674 cases of precocious thelarche recorded in Puerto Rico, where the condition is now occurring in 8 out of every 1000 baby girls, or just under 1%.
		Phthalates were present in the blood of 68% of the precocious thelarche group and 14% of the control group.
		The average levels of DEHP in the control group were 70 ppb and in the precious thelarche group 450 ppb—more than six times as great.
	www.sentienttimes.com /01/apr_may/print_PlasticSofteners.html (1355 words)

	Thelarche - GlWiki (Site not responding. Last check: 2007-11-04)
		Thelarche is now a normal event at an earlier age (e.g., age 8).
		The term thelarche comes from two Greek words: "thele" = nipple + "arche" = beginning.
		This is where the breasts begin to form much earlier than normal, say at 1 - 2 years of age.
	www.childlover.org /index.php/Thelarche (123 words)

	premature developement (Site not responding. Last check: 2007-11-04)
		Often in such cases, the breast tissue diminishes in size before true puberty, although it may not.
		In most cases, premature thelarche reflects an increased internal sensitivity of receptors in breast tissue to normal levels of estrogens circulating in the child.
		I presume your daughter is not receiving treatment with topical estrogen cream.
	www.medhelp.org /perl6/Maternal/archive/1636.html (290 words)

	Thelarche - Talk Medical
		Thelarche is now a normal event at an earlier age (e.g., age 8) than in the past.
		The term thelarche comes from two Greek words: "thele," nipple + "arche," beginning.
		Thelarche is frequently (and incorrectly) written without the "h" as telarche.
	www.talkmedical.com /medical-dictionary/14223/Thelarche (72 words)

	Breast Swelling in Children - Keep Kids Healthy (Site not responding. Last check: 2007-11-04)
		Children who are going through early puberty need a thorough evaluation by their doctor to try and find the cause.
		premature thelarche: this is the early appearance of breast development without any of the other signs of puberty (growth spurt, pubic hair, axillary hair, etc.).
		Children with premature thelarche need to be seen by their Pediatrician for an evaluation and careful monitoring.
	www.keepkidshealthy.com /symptoms/breastswelling.html (685 words)

	[Differential diagnosis of Poland-syndrome versus unilateral accentuated thelarche]
		METHOD: The three girls, all born in 1990, were independently introduced to our unit of children and adolescent gynaecology because of unilateral "developmental defects" of the breasts at the beginning of puberty.
		To discriminate a Poland-Syndrome from unilateral accentuation of thelarche standardized clinical and sonographical examinations were performed.
		RESULTS: In 2 cases we found unilateral aplasia of the glandular tissue of the breast with different distinction of mamilla and pectoralis muscle.
	www.findyourhope.com /Article/67190/Page_Article.aspx (202 words)

	Phthalates Information Center -- Media Center -- PEP Statements
		Without a strong indication that phthalates could induce an estrogenic response in laboratory animals, it is unscientific speculation to suggest that estrogen-induced effects, such as thelarche, could be produced by phthalates.
		The authors observe the possibility for multiple causes of thelarche: "It may well be that the etiology of the various manifestations of premature sexual development (including thelarche) on this island is multifactorial."
		The apparent high incidence of thelarche in this population seems unusual and warrants continued investigation.
	www.phthalates.org /mediacenter/panelstatement.asp?ID=33 (599 words)

	Thelarche - IKE (Site not responding. Last check: 2007-11-04)
		Thelarche is the beginning of development of the breasts in the reproductive female (1).
		Thelarche indicates that there is estrogen production by the ovaries.
		This page was last modified 13:35, 3 May 2004.
	tarek.2y.net /wiki/Thelarche (33 words)

	Here We Go Again: Phthalates Rachel's Environment & Health n.708 14sep00
		Blood samples from two groups of girls in Puerto Rico -- 41 baby girls with precocious thelarche and 35 with normal development -- were examined for pesticides and phthalates.
		One particular phthalate -- di-(2-ethylhexyl) phthalate, or DEHP -- accounted for 88% of the total phthalates measured in the precocious thelarche group and 80% of the total phthalates in the control group.
		The average levels of DEHP in the control group were 70 ppb and in the precious thelarche group 450 ppb -- more than six times as great.
	www.mindfully.org /Plastic/Phthalates-Rachels-708-14sep00.htm (1749 words)

	Author's Response: Children Referred for Signs of Early Puberty Warrant Endocrine Evaluation and Follow-Up -- Kaplowitz ...
		age of 5.1 yr at the time of thelarche.
		Kaplowitz P 2004 Clinical characteristics of 104 children referred for evaluation of precocious puberty.
		Pasquino AM, Pucarelli I, Passeri F, Segni M, Mancini MA, Municchi G 1995 Progression of premature thelarche to central precocious puberty.
	jcem.endojournals.org /cgi/content/full/90/1/593-a (675 words)

	Ovarian and Uterine Sonography in Healthy Girls Between 1 and 13 Years Old: Correlation of Findings with Age and ...
		of 117 girls without thelarche and in four of 22 with thelarche.
		Studies of gonadotrophin pulsatility and pelvic ultrasound examinations distinguish between isolated premature thelarche and central precocious puberty.
		Pelvic ultrasonography: early differentiation between isolated premature thelarche and central precocious puberty.
	www.ajronline.org /cgi/content/full/178/6/1531 (2967 words)

	Breast US in Children and Adolescents -- García et al. 20 (6): 1605 -- RadioGraphics
		(thelarche) but may be pubic hair development (pubarche).
		In a 7-year-old girl with unilateral thelarche, US scans show Tanner stage II development (arrows) in the right breast (a) and a small hyperechoic retroareolar area (arrows) in the left breast region (Tanner stage I) (b).
		Pelvic ultrasonography: early differentiation between isolated premature thelarche and central precocious thelarche.
	radiographics.rsnajnls.org /cgi/content/full/20/6/1605 (2527 words)

	Cecil Textbook of Medicine : />
		If breast budding occurs before the age of 8 years in the absence of any other development, the diagnosis may be premature thelarche.
		Premature thelarche is believed due to transient increases in estrogen secretion or increased breast sensitivity to the small quantities of circulating estrogens present before puberty.
		Simple ovarian cysts may be present in some girls with this disorder.
	www.merckmedicus.com /ppdocs/us/common/cecils/chapters/249_006.htm (831 words)

	Precocious Puberty in Children: Keep Kids Healthy Conditions
		Children with central precocious puberty will have a MRI of their head and girls may have a pelvic ultrasound.
		It is also possible to have incomplete precocious puberty, with either early breast development (premature thelarche) or early growth of pubic hair (premature pubarche/adrenarche) and no other signs of puberty or advanced growth.
		These children should have a normal bone age, and if they do, your Pediatrician may just observe their growth and watch for the development of other signs of puberty before doing a further workup.
	www.keepkidshealthy.com /welcome/conditions/precocious_puberty.html (837 words)

	Arch Pediatr Adolesc Med -- Abstract: Premature thelarche. Natural history and etiologic investigation, August 1981, ... (Site not responding. Last check: 2007-11-04)
		Arch Pediatr Adolesc Med -- Abstract: Premature thelarche.
		The natural history of premature thelarche was investigated by contacting
		Girls with premature thelarche were no more likely
	archpedi.ama-assn.org /cgi/content/abstract/135/8/743 (106 words)

	While giving her a bath, I noticed that one of my daughter’s breasts was enlarged. I called her pediatrician (she is ...
		Premature thelarche (thele=nipple, arche=beginning) is a condition is which the breasts of little girls start to develop without any other signs of sexual development.
		We do not know what causes some girls to develop premature thelarche.
		Perhaps it is caused by a small amount of estrogen hormone secreted by her ovary or that her breast tissue is over sensitive to estrogen hormone found in some foods.
	www.kidsgrowth.com /resources/advicedetail.cfm?id=1765 (326 words)

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