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MedlinePlus Drug Information: Diuretics, Thiazide (Systemic)   (Site not responding. Last check: 2007-10-22) Thiazide or thiazide-like diuretics are commonly used to treat high blood pressure (hypertension). Thiazide diuretics are also used to help reduce the amount of water in the body by increasing the flow of urine. Thiazide diuretics may cause your skin to be more sensitive to sunlight than it is normally. www.nlm.nih.gov /medlineplus/druginfo/uspdi/202208.html   (2957 words)

Thiazide diuretics and anti-gout therapy Thiazide diuretics double the risk of being put on anti-gout therapy, to the extent of about 1% of persons treated with thiazides. That there is an association between thiazide diuretics and hyperuricaemia and gout is well known, but no previous study has examined the size of the association. There is a substantially increased risk of having anti-gout therapy initiated when thiazide diuretics are used, but the absolute risk is small (about 1%) in a population in which we have no idea about the initial uric acid level. www.jr2.ox.ac.uk /bandolier/booth/gout/thiagout.html   (411 words)

Thiazide -- Facts, Info, and Encyclopedia article   (Site not responding. Last check: 2007-10-22) Thiazides are a class of (A substance that is used as a medicine or narcotic) drug that promote water loss from the body (((Any substance that tends to increase the flow of urine) diuretics)). They inhibit (A silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt)) Na Thiazides are often used to treat (A common disorder in which blood pressure remains abnormally high (a reading of 140/90 mm Hg or greater)) hypertension, although the mechanism is not fully understood. www.absoluteastronomy.com /encyclopedia/t/th/thiazide.htm   (191 words)

Methyldopa and Thiazide Diuretics (Systemic) Combinations of methyldopa and a thiazide diuretic (chlorothiazide or hydrochlorothiazide) are used to treat high blood pressure (hypertension). Thiazide diuretics help reduce the amount of water in the body by increasing the flow of urine. However, when thiazide diuretics are used during pregnancy, they may cause side effects including jaundice, blood problems, and low potassium in the newborn infant. allnutritionals.com /drugs/m/methyldopathiazidediuretics-systemic.shtml   (2278 words)

Thiazide Diuretics, Bendrofluazide, Bendroflumethiazide, Benzthiazide, Chlorothiazide, Chlorthalidone, ... Thiazide diuretics are a family of drugs that remove water from the body. Magnesium supplementation for people taking thiazide diuretics is typically 300–600 mg per day, though higher amounts (over 800 mg per day) have been reported in a controlled study to reduce side effects of thiazides. Thiazide diuretics and digitalis-containing products should be used only under the direct supervision of a doctor trained in their use. www.truestarhealth.com /Notes/1517000.html   (1348 words)

Thiazide Diuretics - Patient UK Thiazide diuretics are mainly used to treat high blood pressure. Thiazide diuretics are a common treatment for high blood pressure. Thiazide diuretics tend to have only a weak action on the kidneys so you dont notice a great increase of urine if you take these (compared to loop diuretics). www.patient.co.uk /showdoc/27000315   (589 words)

Hydrochlorothiazide And Reduction Of Urinary Calcium   (Site not responding. Last check: 2007-10-22) In the present study, the effect of combined thiazide and potassium bicarbonate on urine calcium excretion in otherwise healthy older subjects was studied. Thiazide therapy alone may slow decline or increase bone mineral density and decrease the risk of fractures. V induced by thiazide therapy alone plays an important role in its apparent osteo protective effect, combining thiazide therapy with an alkalinizing salt of potassium alkali might substantially augment that effect. www.indegene.com /Nep/Jour/indJour_KI_Sum_01-08-2000_1.asp   (512 words)

Thiazide References LaCroix, A. Thiazide diuretic agents and the incidence of hip fracture. Cumming, R. Psychotropics, thiazide diuretics and hip fractures in the elderly. Ma, Y. Impact of antihypertensive therapy on the skeleton: effects of moexipril and hydrochlorothiazide on osteopenia in spontaneously hypertensive ovariectomized rats. courses.washington.edu /bonephys/refs/HCTZrefs.html   (1038 words)

AORN Journal: Patients' questions about orthopedic surgery; surgical errors; thiazide diuretics; iodophor-impregnated ... Thiazide diuretics, widely used to treat hypertension, have been associated with a reduction in age-related bone loss. The objectives of this prospective, population-based, cohort study were to examine the association between thiazide diuretic use and the risk for hip fracture and the effect of discontinuing thiazide diuretic use. Current use of thiazides for more than 365 days was significantly associated with a lower risk for hip fracture relative to nonuse (hazard ratio 0.46, 95% confidence interval, 0.21 to 0.96). www.findarticles.com /p/articles/mi_m0FSL/is_2_79/ai_113802534   (1276 words)

A kinetic model of the thiazide-sensitive Na-Cl cotransporter -- Chang and Fujita 276 (6): 952 -- AJP - Renal Physiology and 6) inhibition of sodium influx by extracellular thiazide. Thiazide, when present in the extracellular fluid, inhibits transport by TSC in a dose-dependent manner. Thiazide diuretics (D) are assumed to compete for the same binding site with chloride. ajprenal.physiology.org /cgi/content/full/276/6/F952   (4200 words)

Thiazide Diuretics Thiazide diuretics are commonly used to treat hypertension. However, since greatly increased calcium levels in the body can cause side effects such as calcium deposits, if you are using thiazide diuretics you should consult with your physician on the proper dose of calcium and vitamin D for you. Riis B and Christiansen C. Actions of thiazide on vitamin D metabolism: A controlled therapeutic trial in normal women early in the postmenopause. www.al-hikmah.org /thiazide-diuretics.asp   (538 words)

Arch Intern Med -- Abstract: Thiazide Diuretics and the Risk of Gallbladder Disease Requiring Surgery in Women, March ... Arch Intern Med -- Abstract: Thiazide Diuretics and the Risk of Gallbladder Disease Requiring Surgery in Women, March 14, 2005, Leitzmann et al. thiazide use and cholecystectomy, a surrogate for symptomatic Assessment of thiazide diuretic use was updated in 1982, archinte.ama-assn.org /cgi/content/abstract/165/5/567   (211 words)

NEJM -- Thiazide diuretic agents and the incidence of hip fracture We prospectively studied the effect of thiazide diuretic agents on the incidence of hip fracture among 9518 men and women 65 years of age or older residing in three communities. The protective effect of the use of thiazides was independent of sex, age, impaired mobility, body-mass index, and current and former smoking status; the multivariate adjusted relative risk of hip fracture was 0.68 (95 percent confidence interval, 0.49 to 0.94). These prospective data suggest that in older men and women the use of thiazide diuretic agents is associated with a reduction of approximately one third in the risk of hip fracture. content.nejm.org /cgi/content/short/322/5/286   (685 words)

Thiazide Diuretics May Prevent Hip Fractures Thiazide diuretics are often used to treat high blood pressure, but researchers say they may also protect against age-related bone loss by reducing the amount of calcium expelled in urine. The study showed that people who had used thiazide diuretics for a year or more were about half as likely to suffer a hip fracture than those who had never used them. Thiazide diuretics are inexpensive and have few side effects. my.webmd.com /content/article/73/89023.htm   (423 words)

BETA-ADRENERGIC BLOCKING AGENTS AND THIAZIDE DIURETICS (Systemic)   (Site not responding. Last check: 2007-10-22) However, use of thiazide diuretics during pregnancy may cause side effects such as jaundice, blood problems, and low potassium in the newborn infant. Animal studies have not shown thiazide diuretic medicines to cause birth defects even when used in doses several times the usual human dose. Before taking a beta-blocker and thiazide diuretic combination, make sure your doctor knows if you are pregnant or if you may become pregnant. www.medformation.com /ac/mm_usp.nsf/usp/202088b.htm   (3055 words)

McCormack, JP. ALLHAT - So What? J Inform Pharmacother 2003;12:1.   (Site not responding. Last check: 2007-10-22) Even though thiazide diuretics produce these so-called “metabolic abnormalities”, all trials prior to ALLHAT showed that thiazide diuretics were at least as effective as other agents at reducing clinical endpoints. The only possible exceptions where thiazide diuretics would not be first line would be for those patients with a concurrent symptomatic condition that could be managed (along with their blood pressure) with one drug (e.g. Thiazides may aggravate urinary symptoms and require inconvenient electrolyte monitoring, but they are not alone. www.informedpharmacotherapy.com /Issue12/Editorial/editorial12.htm   (3924 words)

Dietary NaCl and KCl do not regulate renal density of the thiazide diuretic receptor -- Fanestil et al. 273 (4): 1241 ... The DCT is the predominant locus of the thiazide diuretic receptor (TZR) or the Na-Cl cotransporter inhibitable by thiazide-type Thiazide diuretic receptors: autoradiographic localization in rat kidney with [3H]-metolazone. Reversible downregulation of thiazide diuretic receptors by acute renal ischemia. ajpregu.physiology.org /cgi/content/full/273/4/R1241   (3117 words)

Effects of Thiazide Diuretic Therapy on Bone Mass, Fractures, and Falls -- Cauley et al. 118 (9): 666 -- Annals of ... Thiazide diuretics are known to decrease urinary excretion of use of thiazide diuretics and the presence of vertebral deformities. Thiazide diuretic agents and the incidence of hip fracture. www.annals.org /cgi/content/full/118/9/666   (6002 words)

Thiazides first-line for hypertension Contrary to common opinion, in ALLHAT the thiazide was similar to the ACEI and CCB in preventing end-stage renal disease, and in a large subgroup of patients with diabetes (12,063) none of the pre-specified subgroup outcomes favored the ACEI or CCB as compared to the thiazide. If you presently use a thiazide as your first choice in all patients with hypertension, the ALLHAT results confirm your practice, and most of your treated hypertensive patients receive a thiazide alone or as a part of combination therapy. To start a new patient on a thiazide, begin with HCTZ or chlorthalidone 12.5 mg daily, and if there is an inadequate BP response after 1-2 months increase to a maximum dose of 25 mg daily. www.ti.ubc.ca /pages/letter47.htm   (1416 words)

Diuretics, Thiazide (Systemic) Although there is no specific information comparing the use of thiazide diuretics in children with use in other age groups, these medicines are not expected to cause different side effects or problems in children than they do in adults. Dizziness or lightheadedness and signs of too much potassium loss may be more likely to occur in the elderly, who are more sensitive than younger adults to the effects of thiazide diuretics. • Some thiazide diuretics are used in the treatment of diabetes insipidus (water diabetes). allnutritionals.com /drugs/d/diuretics-thiazide-systemic.shtml   (2871 words)

Thiazide - Wikipedia, the free encyclopedia The chemical structure of the original thiazide diuretics contained a thiazide ring system; the term is also used for drugs with a similar action that are not chemically thiazides, such as chlortalidone. Side-effects can include hypokalemia, increased serum cholesterol, and impotence. The side effect of hypokalemia has motivated combining thiazides with ACE inhibitors, which also lower blood pressure but cause hyperkalemia as a side-effect. en.wikipedia.org /wiki/Thiazide   (175 words)

symptom of fluid retention allergy & reactions to foods risk factors cure water retention SWOLLEN ANKLES human growth ... Thiazide (or thiazide-like) diuretics increase the excretion of both sodium and chloride into the urine. We're the BEST resource on Thiazide (or thiazide-like) diuretics increase the excretion of both sodium and chloride into the urine. dandelion herbs; Thiazide (or thiazide-like) diuretics increase the excretion of both sodium and chloride into the urine.; In some cases, the underlying problem (for example congestive heart failure or preeclampsia of pregnancy) must be medically treated in order for the oedema to resolve. digestion.virtualave.net /oedema/diabetes_retention_water_galacimu.html   (1478 words)

Thiazide   (Site not responding. Last check: 2007-10-22) Thiazides are not approved for treatment or prevention of osteoporosis. Thiazide diuretics have been used by millions of people for decades. Whenever a drug has been around for so many years, used by so many people, there will be a long list of very rare side effects, such as liver failure or thrombocytopenia. courses.washington.edu /bonephys/hypercalU/opthiazide.html   (236 words)

MedlinePlus Drug Information: Beta-adrenergic Blocking Agents and Thiazide Diuretics ( Systemic)   (Site not responding. Last check: 2007-10-22) Thiazide diuretics (bendroflumethiazide, chlorthalidone, and hydrochlorothiazide) reduce the amount of fluid pressure in the body by increasing the flow of urine. The dose of beta-blocker and thiazide diuretic combinations will be different for different patients. Since all of the beta-blockers are very similar and the thiazide diuretics are also very similar, any of the above side effects may occur with any of these medicines. www.nlm.nih.gov /medlineplus/druginfo/uspdi/202088.html   (3074 words)

The diabetogenic potential of thiazide diuretics and beta-blocker combinations in the management of hypertension   (Site not responding. Last check: 2007-10-22) Methods: Hypertension treatment trials were included in the analysis that: i) featured an arm beginning with a thiazide diuretic or beta-blocker and subsequently added the other drug when necessary; ii) assessed cardiovascular outcomes; iii) reported new-onset diabetes; and, iv) featured at least one-year duration. Meta-analysis of available trials suggests that patients exposed to treatment regimens combining thiazide (or thiazide-like) diuretics and beta-blockers are at greater risk of developing diabetes than regimens avoiding this combination (risk ratio for alternative therapy: 0.81, 95%CI: 0.77 to 0.86; Q; p=0.17). Conclusions: The balance of benefit and harm suggests that the routine combined use of a thiazide diuretic with a beta-blocker may need to be avoided in the early management of hypertension. www.cochrane.org /colloquia/abstracts/ottawa/P-097.htm   (392 words)

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