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Topic: Thiazolidinedione

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Rosiglitazone

Antidiabetic

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	THIAZOLIDINEDIONE (Site not responding. Last check: 2007-10-21)
		The medication class of thiazolidinedione was introduced in the late 1990s as an adjunctive therapy for diabetes mellitus and related diseases.
		It is being investigated experimentally in polycystic ovary syndrome and non-alcoholic steatohepatitis.
		The main side-effect of all thiazolidinediones is fluid retention, leading to edema and potentially aggravating heart failure.
	www.yotor.org /wiki/en/th/Thiazolidinedione.htm (265 words)

	Australian Prescriber - Clinical indications for thiazolidinediones
		Thiazolidinediones are therefore contraindicated in patients with moderate to severe symptoms or signs of angina or heart failure during daily activities or at rest (NewYork Heart Association (NYHA) class III or IV cardiac functional status).
		The established glycaemic, 'non-hypoglycaemic and emerging indications for the use of thiazolidinediones are summarised in Table 2.
		Thiazolidinediones might be shown to preserve ß-cell function, alleviate many of the components of the metabolic syndrome/insulin resistance states, and offer cardiovascular protection.
	www.australianprescriber.com /index.php?content=/magazines/vol27no3/70_74_clinicalthiaz.htm (2471 words)

	[No title] (Site not responding. Last check: 2007-10-21)
		Thiazolidinediones or thiazolidinedione-like compounds can be used alone, in combination with other thiazolidinediones and/or thiazolidinedione-like compounds, and/or with other compounds such as at least one tocolytic agent.
		A therapeutically effective amount of a thiazolidinedione, such as troglitazone, that may be combined with a second tocolytic agent as treatment varies depending upon the host treated and the particular mode of administration.
		A method of screening for an oxytocin antagonist comprising (a) administering a thiazolidinedione to an oxytocin receptor; (b) administering a composition comprising a candidate oxytocin antagonist; and, (c) determining whether the thiazolidinedione binds to the receptor.
	www.wipo.int /cgi-pct/guest/getbykey5?KEY=00/25781.000511&ELEMENT_SET=DECL (9576 words)

	Thiazolidinedione - Art History Online Reference and Guide
		The medication class of thiazolidinedione was introduced in the late 1990s as an adjunctive therapy for diabetes mellitus (type II) and related diseases.
		It is being investigated experimentally in polycystic ovary syndrome (PCOS) and non-alcoholic steatohepatitis (NASH).
		Therefore, thiazolidinediones cannot be prescribed in patients with decreased ventricular function (NYHA grade III and IV heart failure).
	www.arthistoryclub.com /art_history/TZD (301 words)

	Rosiglitazone & Pioglitazone Treatment for Lipodystrophy, diabetes, effects on lipids
		The differences between the thiazolidinediones in their lipid effects may reflect the fact that different populations have been studied; a randomized comparative trial is needed to determine whether a true difference exists.
		We agree that the long-term cardiovascular effects of thiazolidinediones are not known for this population and warrant further investigation.
		Several recent studies have demonstrated that the thiazolidinedione, troglitazone, decreases visceral fat content in type 2 diabetic patients, but no previous study has examined whether the alterations in abdominal fat distribution after thiazolidinedione treatment are related to the improvement in glycemic control and/or insulin sensitivity.
	www.natap.org /2005/HIV/011005_07.htm (4346 words)

	CE: An overview and comparison of the thiazolidinediones - Drug Topics
		It is worth noting that all of these patients recovered after discontinuation of the thiazolidinediones and that there are other possible explanations for their liver dysfunction.
		Triple-combination therapy (typically involving thiazolidinedione plus metformin plus sulfonylurea) is becoming more common as we strive to achieve good glycemic control and because patients often wish to avoid insulin injections.
		Thiazolidinediones should not be used in patients with NYHA class III or IV heart failure.
	www.drugtopics.com /drugtopics/article/articleDetail.jsp?id=110784 (4269 words)

	Mayo Clinic Proceedings
		Thiazolidinediones are oral hypoglycemic drugs that are increasingly being used to treat type 2 diabetes mellitus.
		Although thiazolidinediones are well known to cause idiosyncratic hepatotoxicity and fluid retention, only a few patients have been reported to have developed congestive heart failure and pulmonary edema.
		The remaining 350 patients (54%) were prescribed a combination of a thiazolidinedione with a sulfonylurea and/or metformin or with metformin alone.
	www.mayoclinicproceedings.com /inside.asp?AID=404&UID= (1818 words)

	Rosiglitazone - Wikipedia, the free encyclopedia
		Rosiglitazone is an anti-diabetic drug from the thiazolidinedione class.
		It is being marketed as Avandia® by the pharmaceutical company GlaxoSmithKline, both as a standalone preparation and in combination with metformin (Avandamet®).
		Like other thiazolidinediones, its mechanism of action is by activation of the intracellular receptor class of the peroxisome proliferator-activated receptors (PPARs), specifically PPARγ.
	en.wikipedia.org /wiki/Rosiglitazone (194 words)

	CHEST: Inhibition of monocyte chemoattractant protein-1 expression in cytokine-treated human lung epithelial cells by ... (Site not responding. Last check: 2007-10-21)
		In the present study, we examined the effects of a thiazolidinedione (TZD), which is used to improve the insulin resistance of individuals with diabetes mellitus, on MCP-1 expression in a human lung epithelial cell line, A549.
		The alveolar macrophage, an important phagocyte of the pulmonary airspace and interstitium, is derived predominantly from peripheral blood monocytes and, to a limited extent, from local macrophage replication.
		Thiazolidinediones (TZDs), which are known to have potent enhancing effects on insulin sensitivity, have been developed for the treatment of non-insulin-dependent diabetes mellitus.
	www.findarticles.com /p/articles/mi_m0984/is_4_120/ai_80157469 (1172 words)

	Discovery Health :: Center Article :: Thiazolidinediones
		Thiazolidinediones work by increasing the sensitivity of the insulin receptor sites in muscle, fat, and liver cells.
		Before you take a thiazolidinedione, tell all your doctors and your pharmacist about all the medicines you take.
		This complete list helps your doctor be better prepared to prescribe a thiazolidinedione that is the least likely to interact with your other treatments.
	health.discovery.com /centers/articles/articles.html?chrome=c10&article=LC_62¢er=p07 (438 words)

	AVANDIA (Site not responding. Last check: 2007-10-21)
		The first medication in the thiazolidinedione class sold in the U.S. was troglitazone (sold as "Rezulin").
		Another drug in this thiazolidinedione class of medications was also recently approved in the U.S.; it is sold as "Actos." Because Avandia was only recently approved in the U.S., information about this medication probably will not be available yet in the PDR or other reference books at your public library.
		Another drug of the thiazolidinedione class, troglitazone, has been associated with idiosyncratic hepatotoxicity, and very rare cases of liver failure, liver transplants, and death have been reported during postmarketing clinical use.
	www.diabetic-help.com /avandia.htm (2978 words)

	Diabetes Scene
		One of the most interesting new drugs being tested for NIDDM is troglitazone, a member of the thiazolidinedione class of anti-diabetic agents.
		The thiazolidinedione, which include ciglitazone and pioglitazone as well as troglitazone, have a beneficial effect on insulin resistance and may actually be useful for preventing NIDDM.
		The thiazolidinedione have been shown to reduce elevated plasma glucose, triglycerides, and insulin concentrations in animals with hyperinsulinemia and to improve both fasting and postprandial hyperglycemia and hyperinsulinemia in patients with NIDDM.
	www.banting.com /rcenter/thiazon.html (430 words)

	Triple therapy fights type 2 diabetes without weight gain
		It's the first study to analyze the safety and effectiveness of triple therapy using insulin, metformin and a drug in the thiazolidinedione family.
		Patients who took the therapy in a particular order, with the thiazolidinedione administered after a period of insulin and metformin use, actually showed a slight decrease in weight, along with lowering blood sugar.
		Drugs like metformin and those in the thiazolidinedione family help the body regulate the amount of glucose (sugar) in the blood and decrease the amount of glucose made by the liver.
	www.medicalnewstoday.com /medicalnews.php?newsid=9974 (610 words)

	Alzforum: News
		Hope that thiazolidinedione agonists of PPARγ; (Peroxisome Proliferator Activated Receptor-γ;) will prove beneficial for Alzheimer's patients (see ARF recent live discussion) may be tempered slightly by a report in this week's Mayo Clinic Proceedings.
		On admission to the center, all of the patients were placed on diuretics to reduce plasma volume and in five cases thiazolidinedione treatment was immediately stopped.
		Because the second generation of thiazolidinediones, including pioglitazone and rosiglitazone, were milder on the liver, it was hoped that they would have fewer, less serious side effects.
	www.alzforum.org /new/detail.asp?id=870 (849 words)

	Abstract: 776 (Site not responding. Last check: 2007-10-21)
		Background and Aims: We already reported thiazolidinedione treatment increases fat deposition in muscle and decreases fat deposition in liver accompanied with body weight gain.
		We evaluated modifying effects of vitamin A in combination with thiazolidinedione treatment on fat deposition in wister rats with high-fat, high-sugar feeding (26% fat, 32% sugar) without food intake restriction.
		This may be a key mechanism of a secondary failure of thiazolidinedione treatment.
	www.easd.org /customfiles/easd/37th/Abs01/776.html (361 words)

	JAMA -- Abstract: Metformin and Thiazolidinedione Use in Medicare Patients With Heart Failure, July 2, 2003, Masoudi et ...
		JAMA -- Abstract: Metformin and Thiazolidinedione Use in Medicare Patients With Heart Failure, July 2, 2003, Masoudi et al.
		Use of Thiazolidinediones and Risk of Heart Failure in People With Type 2 Diabetes: A Retrospective Cohort Study: Response to Karter et al.
		Use of Thiazolidinediones and Risk of Heart Failure in People With Type 2 Diabetes: A Retrospective Cohort Study: Response to Delea et al.
	jama.ama-assn.org /cgi/content/abstract/290/1/81 (441 words)

	Inhibition of Monocyte Chemoattractant Protein-1 Expression in Cytokine-Treated Human Lung Epithelial Cells by ...
		Saltiel, AR, Olefsky, JM (1996) Thiazolidinediones in the treatment of insulin resistance and type II diabetes.
		Peraldi, P, Xu, M, Spiegelman, BM (1997) Thiazolidinediones block tumor necrosis factor-alpha-induced inhibition of insulin signaling.
		Lehmann, JM, Moore, LB, Smith-Oliver, TA, et al (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).
	www.chestjournal.org /cgi/content/full/120/4/1293 (3249 words)

	TPNA - Press Releases
		Furthermore, fasting insulin levels were significantly reduced in the ACTOS/metformin arm (3.5 micro units per ml versus 1.1 micro units per ml), suggesting that the ongoing glycemic control was impacted by reductions in insulin resistance and improved insulin activity.
		ACTOS is an oral treatment for type 2 diabetes belonging to the thiazolidinedione class of drugs.
		It is known as an “insulin sensitizer” because it directly targets insulin resistance, a condition where the body does not produce enough insulin or does not effectively use the insulin it produces.
	www.tpna.com /prdetail.asp?articleid=90 (1133 words)

	Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure: A Consensus Statement From the American Heart ...
		Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure: A Consensus Statement From the American Heart Association and American Diabetes Association -- Nesto et al.
		Thiazolidinedione derivative improves fat distribution and multiple risk factors in subjects with visceral fat accumulation: double-blind placebo-controlled trial.
		Use of thiazolidinediones and risk of heart failure in people with type 2 diabetes: a retrospective cohort study.
	circ.ahajournals.org /cgi/content/full/108/23/2941 (5366 words)

	dlife.com - Thiazolidinedione Drugs for Type 2 Diabetes
		Call your doctor right away if you have any signs of liver disease: nausea, vomiting, stomach pain, lack of appetite, tiredness, yellowing of the skin or whites of the eyes, or dark-colored urine.
		Yes, your health care provider may ask you to take another diabetes medicine along with a thiazolidinedione.
		Or you may take a thiazolidinedione as your only diabetes medicine.
	www.dlife.com /dLife/do/ShowContent/about_diabetes/type_2/treatment/oral_medication/thiazolidinedione (355 words)

	Type 2 diabetes in Alstrom syndrome: Targeting insulin resistance with a thiazolidinedione
		Total cholesterol and serum triglycerides have increased from 6.28mmol/l and 3.71mmol/l to 9.02 mmol/l and 6.94 mmol/l respectively over the same period.
		Thiazolidinediones are highly effective in reducing insulin resistance.
		Rosiglitazone improved glycaemic control in our patient with Alstrom syndrome though this was associated with deterioration in lipid control and progressive weight gain.
	www.endocrine-abstracts.org /ea/0005/ea0005p104.htm (306 words)

	Nursing Spectrum- Career Fitness Online (Site not responding. Last check: 2007-10-21)
		Patients with diabetes and elevated triglycerides who are using repaglinide in combination with gemfibrozil (Lopid) must be cautioned to closely monitor their blood sugar levels and be alert for episodes of hypoglycemia.
		Thiazolidinediones are not recommended for patients with congestive heart failure (CHF) classifications III and IV; however, they may be used for those with classifications I and II.
		Gradually developing edema is a frequent side effect of thiazolidinedione use, and both associations have stressed the importance of careful monitoring when diabetics with CHF take a thiazolidinedione.
	nsweb.nursingspectrum.com /NurseNewsEzine/DrugNews/item.cfm?ID=109 (402 words)

	Diabetes Monitor - rosiglitazone (Avandia)
		Avandia (rosiglitazone) is a thiazolidinedione medication for the therapy of
		When using AVANDIA in combination with other hypoglycemic agents, the risk of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and their family members.
		To read the complete MedWatch 2002 Safety Alert about the cardiovascular risks associated with the use of thiazolidinediones as monotherapy and in combination with other antidiabetic agents, particularly insulin, including links to "dear healthcare professional" letters and the revised labeling, go to: http://www.fda.gov/medwatch/SAFETY/2002/safety02.htm#Thiazo.
	www.diabetesmonitor.com /avandia.htm (705 words)

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