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	Thiol - Wikipedia, the free encyclopedia
		The thiol group is the sulfur analog of the hydroxyl group (-OH) found in alcohols.
		Thiols bind strongly to skin proteins, and are responsible for the intolerable, persistent odor produced by feces, rotting flesh and the spraying of skunks.
		Thiols are also responsible for a class of wine faults caused by an unintended reaction between sulfur and yeast.
	en.wikipedia.org /wiki/Thiol (810 words)

	Thiol - Biocrawler (Site not responding. Last check: 2007-10-11)
		In chemistry, thiols (formerly known as mercaptans) are those compounds which contain the sulfhydryl group -SH attached to a carbon atom.
		Thiols are similar to alcohols, with the oxygen of the hydroxyl group -OH being replaced by a sulfur atom.
		Thiols bind strongly to skin proteins, and are responsible for the intolerable, persistent odor produced by the spraying of skunks.
	www.biocrawler.com /encyclopedia/Thiol (317 words)

	Thiol Functional Group \| World of Chemistry
		Thiols tend to be a clear liquid or white crystalline form.
		Biologically, thiols are found in the human body in protein linkages.
		Thiols are also found naturally in garlic, onions, coffee, and skunk secretions.
	www.bookrags.com /research/thiol-functional-group-woc (217 words)

	Polymer having thiol end group - Patent 4565854
		A polymer having a thiol group at one end obtained by polymerizing at least one monomer capable of radical polymerization in contact with a thiolcarboxylic acid represented by the formula R--COSH wherein R is a C.sub.1 -C.sub.18 aliphatic or aromatic hydrocarbon group; and then treating the resulting polymer wtih an alkali or acid.
		The polymer having a thiol group at one end as set forth in claim 1, wherein said monomer capable of radical polymerization is selected from the group consisting of a vinyl ester, a vinyl halide, an aromatic vinyl compound, an.alpha.-olefin, acrylic acid, methacrylic acid, acrylic ester, methacrylic ester, acrylamide, methacrylamide, acrylonitrile and methacrylonitrile.
		The special polymer composition of vinyl ester polymer having a thiol group at only one end thereof is utilized for polymerizing monomers capable of radical polymerization in the presence of the vinyl ester polymer to form a block copolymer in which the vinyl ester polymer constitutes one component.
	www.freepatentsonline.com /4565854.html (10174 words)

	Cys Thiol AA (Site not responding. Last check: 2007-10-11)
		Thiols ionize at about pH 8 and so usually they are protonated at biological pH.
		In the presence of oxygen or oxidizing conditions, the 2 thiols react to form a disulfide bond between them.
		Since this is a redox reaction, the hydride ion released by each thiol is usually coupled to an electron acceptor reaction or in simple oxidiation with oxygen, hydrogen peroxide is usually formed with further reduction to water.
	www.bio.mtu.edu /campbell/cysthiol.htm (285 words)

	Reference Library/Applications:Industrial Wastewater - Organic Pollutant / Hydrogen Peroxide for Thiol Control in ...
		Thiols are found in many industrial wastes, both liquid and gaseous.
		Thiols find application in ore flotation and are used or formed as byproducts in many chemical manufacturing processes, i.e., pharmaceuticals, insecticides, wetting agents, plastics, rubber additives.
		Thiols are formed also by bacterial decomposition of organic materials typically found in the rendering industry and at sewage treatment plants.
	www.h2o2.com /applications/industrialwastewater/thiol.html (651 words)

	Glutaredoxin 2 Catalyzes the Reversible Oxidation and Glutathionylation of Mitochondrial Membrane Thiol Proteins: ...
		MBTA for 30 min, and the exposed thiols quantitated by the DTNB assay.
		Assaying the oxidation of exposed thiols by papain
		GSH ± Grx2, and the exposed thiols quantitated by the DTNB assay.
	www.jbc.org /cgi/content/full/279/46/47939 (7679 words)

	The Platelet Integrin alpha IIbbeta 3 Has an Endogenous Thiol Isomerase Activity -- O'Neill et al. 275 (47): 36984 -- ...
		The presumed thiol bonds are indicated by the arrows, taken from Calvete et al.
		b, endogenous thiol isomerase activity of this purified preparation was determined according to the procedures of Pigiet (21).
		The function of the endogenous integrin thiol isomerase activity remains unknown and was not the focus of this study.
	www.jbc.org /cgi/content/full/275/47/36984 (4526 words)

	Using Thiol-Modified Oligos
		Two types of reagents can be used to introduce a thiol group at the 5' end of an oligonucleotide: the 5'-Thiol-Modifier-C6 and the 5'-Thiol Modifier C6 S-S (Disulfide).
		Modified oligos terminated with the 5'-Thiol-Modifier C6 are shipped with the trityl protecting group still attached to the sulfur.
		In order to free the thiol group for use, remove the trityl group and reduce the sulfur.
	www.oligos.com /thiolModified.htm (347 words)

	Control of Cell Cycle Progression in Human Natural Killer Cells Through Redox Regulation of Expression and ...
		Using thiol deprivation, we have previously shown that the response of natural killer (NK) cells to interleukin-2 (IL-2) is subject to redox regulation downstream of IL-2 binding and internalization.
		The data suggest the possibility that the premature and prolonged enhancement of CDK activity in thiol-deprived NK cells is associated with, and therefore may contribute to, the reduced expression and phosphorylation of RB, and the associated cell cycle arrest.
		Thiol depletion of NK3.3 cells reduced RB expression and greatly reduced or abrogated phosphorylation of RB in response to IL-2.
	www.bloodjournal.org /cgi/content/full/89/11/4092 (5184 words)

	Tellurite-mediated thiol oxidation in Escherichia coli -- Turner et al. 145 (9): 2549 -- Microbiology
		Tellurite-mediated thiol oxidation in Escherichia coli -- Turner et al.
		Thiol oxidation, as observed as a decrease in the amount of
		thiol oxidation or the oxidation generated by paraquat.
	mic.sgmjournals.org /cgi/content/full/145/9/2549 (3819 words)

	Contrasting effects of thiol-modulating agents on endothelial NO bioactivity -- Huang et al. 281 (2): C719 -- AJP - ...
		Intracellular thiol was estimated from the acid-soluble supernatant of PAECs lysed with 5% metaphosphoric acid-0.1 mmol/l
		NEM or oxidizing intracellular thiols with DTDP (8).
		Role of intracellular thiols in release of EDRF from cultured endothelial cells.
	ajpcell.physiology.org /cgi/content/full/281/2/C719 (4017 words)

	thiol - HighBeam Encyclopedia (Site not responding. Last check: 2007-10-11)
		Potentiation of limulin-mediated cytolysis by thiol ester-reacted forms of limulus alpha2-macroglobulin: identification of functionally important domains.
		The plasma-based cytolytic system of the American horseshoe crab, Limulus polyphemus: cooperative interaction of the sialic acid-binding lectin limulin and thiol ester-reacted alpha2-macroglobulin.
		Sulfur assimilation in soybean: molecular cloning and characterization of O-acetylserine (thiol) lyase (cysteine synthase).(Genomics, Molecular Genetics & Biotechnology)
	www.encyclopedia.com /doc/1E1-x-thiol.html (199 words)

	Low Ubiquinone Content in Escherichia coli Causes Thiol Hypersensitivity -- Zeng et al. 180 (14): 3681 -- The Journal ...
		Thiol hypersensitivity in a mutant of Escherichia coli (IS16) was reversed by complementation with a plasmid that carried
		The neutral water-soluble thiols 2-mercaptoethanol, 1-thioglycerol, and dithiothreitol inhibit gram-positive and gram-negative
		The thiol hypersensitivity of dsb mutants could be the result of accumulation of reduced periplasmic and outer membrane proteins.
	jb.asm.org /cgi/content/full/180/14/3681 (2799 words)

	Thiol Antioxidants Inhibit the Adjuvant Effects of Aerosolized Diesel Exhaust Particles in a Murine Model for Ovalbumin ...
		Thiol Antioxidants Inhibit the Adjuvant Effects of Aerosolized Diesel Exhaust Particles in a Murine Model for Ovalbumin Sensitization -- Whitekus et al.
		Thiol antioxidants interfere in the adjuvant effect of inhaled DEP in an OVA sensitization model.
		The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols.
	www.jimmunol.org /cgi/content/full/168/5/2560 (6431 words)

	InterPro: IPR000866 Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen
		Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant enzymes that also control cytokine-induced peroxide levels which mediate signal transduction in mammalian cells.
		The recycling of the sulphenic acid back to a thiol is what distinguishes the three enzyme classes.
		Thiol specific antioxidant (TSA) is a physiologically important antioxidant which constitutes an enzymatic defense against sulphur-containing radicals.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000866 (3405 words)

	Thiol Oxidation Activates a Novel Redox-Regulated Coronary Vasodilator Mechanism Involving Inhibition of Ca2+ Influx -- ...
		Evidence for reversibility and role of thiol redox in relaxation of BCAs to diamide.
		Shown is relaxation of BCAs precontracted with U46619 to similar levels of force in absence or presence of 1 µmol/L nifedipine and 10 µmol/L diltiazem to increasing cumulative concentrations of diamide (n=7 to 8, A) and SNAP (n=5 to 7, B).
		an inhibitor of GSH reductase, and it was reversed by the thiol
	atvb.ahajournals.org /cgi/content/full/20/11/2359 (4113 words)

	Thiol -- from Eric Weisstein's World of Chemistry
		Select the longest chain containing the thiol group.
		Number the carbon atoms so that the number for the thiol group is as low as possible.
		Name the compound as a hydrocarbon, changing the -e ending to -thiol and including a number indicating the position of the thiol group (ethanethiol).
	scienceworld.wolfram.com /chemistry/Thiol.html (65 words)

	Antioxidant and Antiprotease Status in Peripheral Blood and BAL Fluid After Cardiopulmonary Bypass -- Frass et al. 120 ...
		Free thiol moieties are ubiquitous in eucaryotic cells.
		The intracellular thiol content of cells (left, A) in peripheral blood and (right, B) in BALF recovered preoperatively (light columns) and postoperatively (dark columns), respectively.
		thiol depletion correlated with the extent of airway obstruction.
	www.chestjournal.org /cgi/content/full/120/5/1599 (4479 words)

	Thiol Protein Defect in Sodium-Lithium Countertransport in Subset of Essential Hypertension -- Mead et al. 34 (6): 1275 ...
		Thiol Protein Defect in Sodium-Lithium Countertransport in Subset of Essential Hypertension -- Mead et al.
		Thus, a thiol protein is strongly implicated in the abnormality,
		to the thiol alkylation with NEM in the presence of sodium or
	hyper.ahajournals.org /cgi/content/full/34/6/1275 (3550 words)

	Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the ...
		Thiol Regulation of Pro-Inflammatory Cytokines Reveals a Novel Immunopharmacological Potential of Glutathione in the Alveolar Epithelium -- Haddad et al.
		as a neurotransmitter and an immunopharmacological thiol; and
		of thiol regulation mediated by glutathione in the alveolar epithelium.
	jpet.aspetjournals.org /cgi/content/full/296/3/996 (5244 words)

	Tyrosine Phosphorylation, Thiol Status, and Protein Tyrosine Phosphatase in Rat Epididymal Spermatozoa -- Seligman et ...
		with thiol oxidation of capacitated spermatozoa [11, 15].
		Dynamics of the thiol status of rat spermatozoa during maturation: analysis with the fluorescent labeling agent monobromobimane.
		Seligman J, Shalgi R. Protein thiols in spermatozoa and epididymal fluid of rats.
	www.biolreprod.org /cgi/content/full/71/3/1009 (4161 words)

	Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells -- Jonas ...
		thiol pools was enhanced by Gln (-56 mV) and KGF (-76 mV) (Fig.
		Growth-associated modifications of low-molecular-weight thiols and protein sulfhydryls in human bronchial fibroblasts.
		Characterization of the membrane-associated thiol oxidase activity of rat small-intestinal epithelium.
	ajpregu.physiology.org /cgi/content/full/285/6/R1421 (5790 words)

	Free thiol groups are essential for infectivity of human cytomegalovirus -- Mirazimi et al. 80 (11): 2861 -- Journal of ...
		Free thiol groups are essential for infectivity of human cytomegalovirus -- Mirazimi et al.
		Free thiol groups are essential for infectivity of human cytomegalovirus
		groups protrude and react with thiol groups on the virus.
	vir.sgmjournals.org /cgi/content/full/80/11/2861 (2474 words)

	Kinetics of Cisplatin Binding to Cellular DNA and Modulations by Thiol-Blocking Agents and Thiol Drugs -- Sadowitz et ...
		Cellular thiols that were not modified by NEM were alkylated with the fluorescent probe mBBr.
		At the end of the incubation period, cisplatin was added to a final concentration of 7 µM, and the reactions were continued at 37°C for the indicated time.
		Effect of drug thiol concentration on the amount of Pt bound to DNA, according to the kinetic model described in text.
	dmd.aspetjournals.org /cgi/content/full/30/2/183 (6636 words)

	Thiol-Reactive Agents Biphasically Regulate Inositol 1,4,5-Trisphosphate Binding and Ca2+ Release Activities in Bovine ...
		thiol groups, microsomes were pretreated for 15 min with 500
		Bootman MD, Taylor CW, Berridge MJ 1992 The thiol reagent, thimerosal, evokes Ca spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor.
		Bird GS, Burgess GM, Putney Jr JW 1993 Sulfhydryl reagents and cAMP-dependent kinase increase the sensitivity of the inositol 1,4,5-trisphosphate receptor in hepatocytes.
	endo.endojournals.org /cgi/content/full/142/6/2614 (4039 words)

	Transformed and Tumor-derived Human Cells Exhibit Preferential Sensitivity to the Thiol Antioxidants, N-Acetyl Cysteine ...
		Thiol antioxidants, typified by N-acetyl cysteine, are known
		Immortalized human fibroblasts are sensitive to thiol antioxidants.
		LG1, MSU 1.0, and PH2MT cells were treated with thiol compounds for the indicated times, harvested, and lysed; 50 µg of protein were run on 10% SDS-polyacrylamide gels.
	cancerres.aacrjournals.org /cgi/content/full/62/5/1443 (4499 words)

	Redox regulation of ubiquitin-conjugating enzymes: mechanistic insights using the thiol-specific oxidant diamide -- ...
		conjugates and E1~Ub and E2s~Ub thiol esters; or 3) ice-cold
		E1A and E1A~Ub thiol ester were identified on immunoblots by using rabbit anti-serum specific for the E1A isoform (E1A) and its Ub thiol ester (E1A-Ub).
		Liu, H., Lightfoot, R., and Stevens, J. (1996) Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols.
	www.fasebj.org /cgi/content/full/12/7/561 (5005 words)

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