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Topic: Threo

	Process for preparing the d-threo isomer of methylphenidate hydrochloride - US Patent 6162919 (Site not responding. Last check: 2007-10-17)
		2,957,880 discloses a rather tedious sequence involving the resolution of the amide derivative of the corresponding erythro isomer, conversion to the threo isomer, followed by the hydrolysis of the amide to the corresponding acid, and esterification of the resulting acid with methanol.
		In WO 97/27176, the d-threo enantiomer is prepared by resolving racemic threo methylphenidate employing a di-aroyltartaric acid, preferably a ditoluoyltartaric acid, whereas in WO 97/32851, the d-threo enantiomer is prepared by resolving racemic threo methylphenidate employing (-)-menthoxyacetic acid.
		A resolution of the free base form of racemic threo methylphenidate with the recovered material yielded the desired phosphate salt enriched with the d-threo isomer of methylphenidate.
	www.patentstorm.us /patents/6162919.html (3651 words)

	Malaria Journal \| Full text \| The relationship of physico-chemical properties and structure to the differential ...
		Differences in the antiplasmodial activity of the erythro and threo cinchona alkaloids may therefore be attributed to the cumulative effects of lipid/aqueous distribution ratio and drug-haematin interaction.
		As a result of these studies a drug receptor was proposed, comprising 2 planar areas accommodating the quinoline rings of Q and QD with, in between, an electropositive area in the plane and a raised electronegative area [2].
		In view of the acidic milieu (pH 5.2) existing in the vacuole within the lysosomal membrane, log D at pH 5.2 was also measured and calculated and the figures are shown in table 1.
	www.malariajournal.com /content/2/1/26 (6692 words)

	Inhibition of the reverse transcriptase from HIV by 3'-azido-3'-deoxythymidine triphosphate and its threo analogue.
		Inhibition of the reverse transcriptase from HIV by 3'-azido-3'-deoxythymidine triphosphate and its threo analogue.
		3'-Azido-3'-deoxythymidine triphosphate (erythro) and its threo isomer were synthesized and investigated for their inhibition of HIV reverse transcriptase from virus isolate U 937/HTLV-III.
		The threo isomer was at least 100-fold less active.
	ww1.aegis.org /aidsline/1987/oct/M87A0141.html (355 words)

	Lib #: 850909 - Enantiomeric resolution of dl - threo - methylphenidate, U.S.P. ( Ritalin ) by HPLC (Site not responding. Last check: 2007-10-17)
		Lib #: 850909 - Enantiomeric resolution of dl - threo - methylphenidate, U.S.P. (Ritalin) by HPLC
		If you are having problems opening the PDF, press and hold the Control Key while you click on the PDF.
		Enantiomeric resolution of dl - threo - methylphenidate, U.S.P. (Ritalin) by HPLC
	www2.waters.com /Watprod.nsf/Newdocs/850909 (74 words)

	Orgo 3D Web : Chapter 7 : threo -3-Phenyl-2-butyl tosylate (Site not responding. Last check: 2007-10-17)
		Orgo 3D Web : Chapter 7 : threo -3-Phenyl-2-butyl tosylate
		Here, look for the 180° angle between the hydrogen to be lost and the tosylate leaving group.
		Remind me again of why tosylate is such a good leaving group?
	www.wwnorton.com /orgo3dweb/ch7/8_threophneylbutyltosylate.htm (49 words)

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