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Topic: Thrombolytic

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	Thrombolytic drug - Wikipedia, the free encyclopedia
		Thrombolytic drugs are used in medicine to dissolve blood clots in a procedure termed thrombolysis.
		A less frequent use is to clear blocked catheters that are used in long-term medical therapy.
		It should be noted that thrombolytic therapy in hemorrhagic strokes is contraindicated, as its use in that situation would prolong bleeding and hasten the demise of the patient.
	en.wikipedia.org /wiki/Thrombolytic_drug (238 words)

	Special Procedures, Thrombolytic Therapy
		At the time of the consensus conference, thrombolytic therapy meant administration of large systemic intravenous doses of thrombolytic enzyme, and it was associated with a four-fold increase in major and minor bleeding (39%) compared with heparin alone (10%).
		It is probably that because of these two factors, not enough patients have received thrombolytic therapy to be able to answer the question of whether rapid restoration of venous function with thrombolytic therapy prevents the long-term complications associated with anticoagulant therapy.
		This protocol is similar to thrombolytic regimens provided by university centers in that it involves catheterization of the thrombosed vein in order to inject the thrombolytic enzyme directly into the thrombus.
	www.cc.nih.gov /drd/sp/t-therapy.html (1156 words)

	Thrombolytic Therapy Underused In Elderly Patients With Heart Attack
		Past clinical trials among nearly 60,000 patients have shown that thrombolytic therapy is associated with an 18 percent reduction in the odds of dying among those with suspected heart attack.
		In addition: "Physicians are less likely to use thrombolytic therapy in eligible patients with characteristics associated with an increased risk of bleeding, lower-risk infarction, less certain diagnosis, less certain efficacy, or altered mental state," the researchers write.
		Thrombolytic therapy is most effective when fewer than six hours has elapsed from the onset of symptoms.
	www.docguide.com /dg.nsf/PrintPrint/7218DF31B85E9F11852564AB006D4F81 (771 words)

	s000417b - Angioplasty vs. Thrombolytic Therapy - Trials
		Thrombolytic therapy was not an independent predictor of short-term: mortality (odds ratio 0.67, 95% CI 0.37-1.20).
		The success of thrombolytic therapy for acute myocardial infarction is limited by bleeding: complications, the impossibility of reperfusing all occluded coronary arteries, recurrent myocardial ischemia, and the: relatively small number of patients who are appropriate candidates for this therapy.
		Despite the widespread use of intravenous thrombolytic therapy and of immediate percutaneous: transluminal coronary angioplasty for the treatment of acute myocardial infarction, randomized comparisons of the: two approaches to reperfusion are lacking.
	www.emory.edu /WHSCL/grady/amreport/litsrch99/s000417b.html (11153 words)

	PROVET HEALTHCARE INFORMATION - Thrombolytic Drugs (Site not responding. Last check: 2007-10-22)
		You should seek the advice of your veterinarian if your pet is ill as only he or she can correctly advise on the diagnosis and recommend the treatment that is most appropriate for your pet.
		Thrombolytic drugs "dissolve" thrombi that have formed in blood vessels.
		Thrombolytic drugs are not licensed for use in veterinary patients and they have only been used sporadically.
	www.provet.co.uk /health/diseases/thrombolyticdrugs.htm (234 words)

	Thrombolytic Therapy \| AHealthyMe.com
		Thrombolytic therapy is used to dissolve blood clots that could cause serious, and possibly life-threatening, damage if they are not removed.
		Thrombolytic therapy also is used to dissolve blood clots that form in tubes put into people's bodies for medical treatments, such as dialysis or chemotherapy.
		Thrombolytic therapy may be more likely to cause serious bleeding in people who have certain medical conditions or have recently had certain medical procedures.
	www.ahealthyme.com /topic/topic100587562 (1004 words)

	Thrombolytic Therapy for DVT and Pulmonary Embolism, Vol. 2, No. 4, SEMJ (Site not responding. Last check: 2007-10-22)
		Thrombolytic therapy for recent pulmonary embolism is most efficacious in the limited number of patients with ongoing hypoxia, respiratory distress, pulmonary hypertension and right heart failure.
		Thrombolytic therapy should be considered in all patients with massive pulmonary embolism and hypotension associated with deep venous thrombosis in the popliteal area or higher.
		Thrombolytic therapy is the front-line treatment for patients with massive pulmonary embolism and major hemodynamic disturbance (15).
	www.sums.ac.ir /semj/vol2/oct2001/DVTPE.htm (1421 words)

	Thrombolytic Therapy
		Administration of thrombolytics in the emergency department, either by the emergency department physician or by the patient’s private physician, is now the standard of care for acute myocardial infarction.
		Because of this risk, thrombolytics are contraindicated in patients with a history of stroke, brain tumor or AV malformation, or recent CNS surgery.
		Thrombolytics may be used for other situations, such as clotted dialysis fistula, pulmonary embolism, or DVT when appropriate.
	www.madsci.com /manu/ches_thr.htm (3705 words)

	MedlinePlus Drug Information: Thrombolytic Agents (Systemic) (Site not responding. Last check: 2007-10-22)
		Thrombolytic agents are used to dissolve blood clots that have formed in certain blood vessels.
		Thrombolytic agents are also used to dissolve blood clots that form in tubes that are placed into the body.
		There is a slight chance that use of a thrombolytic agent during the first five months of pregnancy may cause a miscarriage.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202565.html (1191 words)

	Fast Thrombolytic Therapy Helps Heart Attack (Site not responding. Last check: 2007-10-22)
		In their study, the researchers tracked time between a call for help and the delivery of thrombolytic drugs in 1,046 Scottish patients with suspected heart attack, of whom 544 lived in rural communities and 502 in urban or suburban areas.
		The researchers report that about a third of patients living in rural areas were given thrombolytic drugs within 45 minutes of calling their GP.
		Jennings said that the failure of urban and suburban GPs to administer thrombolytic drugs was a case of habit.
	www.personalmd.com /news/a1998082809.shtml (416 words)

	THROMBOLYTIC THERAPY IN ACUTE MYOCARDIAL INFARCTION:EXPERIENCE AT A UNIVERSITY HOSPITAL IN KUWAIT (Site not responding. Last check: 2007-10-22)
		Data from the Middle East pertaining to the use of thrombolytic therapy in Arab populations is sparse.
		The observed rate of thrombolytic treatment in the whole study population was 62%, compared to 35% in the European study.
		Data from the fibrinolytic trials have shown that there is no benefit from administering thrombolytic treatment to patients with AMI who present with ST Comparison of observed thrombolysis rate, factors limiting thrombolysis and shortfall between study population and a European study.
	www.kfshrc.edu.sa /annals/184/97-286.html (2098 words)

	Thrombolytic agent definition - Medical Dictionary definitions of popular medical terms
		Thrombolytic agent: A drug that is able to dissolve a clot (thrombus) and reopen an artery or vein.
		Thrombolytic agents may be used to treat a heart attack, stroke, deep vein thrombosis (clot in a deep leg vein), pulmonary embolism, and occlusion of a peripheral artery or indwelling catheter.
		All thrombolytic agents are serine proteases (they digest protein) and convert plasminogen to plasmin which breaks down the fibrinogen and fibrin and dissolves the clot.
	www.medterms.com /script/main/art.asp?articlekey=5770 (223 words)

	CHEST: Thrombolytic Therapy of Pulmonary Embolism (Site not responding. Last check: 2007-10-22)
		Although anticoagulation is the standard treatment for PE, thrombolytic therapy, with its ability to produce rapid clot lysis, has long been considered an attractive alternative.
		Thrombolytic therapy, by actually dissolving thromboemboli, has several potential advantages over anticoagulation in the treatment of patients with PE.
		The terms thrombolytic therapy, thrombolysis, fibrinolysis, urokinase (UK), streptokinase (SK), recombinant tissue-type plasminogen activator (rt-PA), and pulmonary embolism were utilized as Medical Subject Headings terms and text words.
	www.findarticles.com /p/articles/mi_m0984/is_6_115/ai_55051821 (1063 words)

	Postgraduate Medicine: Early intervention in massive pulmonary embolism
		Thrombolytic agents may be lifesaving by quickly reducing pulmonary vascular resistance and right ventricular overload.
		Thrombolytic therapy should be initiated in either an ICU or a step-down unit.
		The treatment plan should carefully consider severity of pulmonary vascular obstruction, risk of dying of the current pulmonary embolism, ability to tolerate a recurrent pulmonary embolism, risk of bleeding from heparin therapy or thrombolysis, and the ability of local surgeons or invasive radiologists, or both, to rapidly perform embolectomy.
	www.postgradmed.com /issues/2002/03_02/gossage1.htm (4218 words)

	Influence of thrombolytic therapy on the patterns of ventricular septal rupture after acute myocardial infarction -- ...
		Influence of thrombolytic therapy on the patterns of ventricular septal rupture after acute myocardial infarction -- Rhydwen et al.
		Thrombolytic therapy is known to reduce the overall incidence
		Fatal cardiac rupture among patients treated with thrombolytic agents and adjunctive thrombin antagonists: observations from the Thrombolysis and Thrombin Inhibition in Myocardial Infarction 9 Study.
	pmj.bmjjournals.com /cgi/content/full/78/921/408 (2761 words)

	THROMBOLYTIC THERAPY VS. ANGIOPLASTY FOR ACUTE MI - Journal Watch (General)
		Randomized trials comparing thrombolytic therapy with primary coronary angioplasty for acute myocardial infarction have been relatively small.
		Three years after the initial hospitalization, the thrombolytic group was significantly less likely to have undergone cardiac catheterization than the primary-angioplasty group.
		Comment: Proponents of thrombolytic therapy will use this study to bolster their position, since thrombolytic therapy appeared equivalent to angioplasty and is more widely available and easier to administer.
	general-medicine.jwatch.org /cgi/content/full/1996/1105/1 (226 words)

	Thrombolytic Therapy Primer - CareInternet.net
		Thrombolytic agents are proteins that activate a plasma proenzyme, plasminogen, to the active enzyme plasmin.
		Bleeding is the major complication of thrombolytic therapy.
		Thrombolytic agents seem to offer less benefits in patients over 75 although age is not a contraindication.
	www.careinternet.com /caregiver/thrombolytictherapy.php (639 words)

	Recent Age-Related Trends in the Use of Thrombolytic Therapy in Patients Who Have Had Acute Myocardial Infarction -- ...
		thrombolytic therapy were examined according to age and sex.
		Patient delay and receipt of thrombolytic therapy among patients with acute myocardial infarction from a community-wide perspective.
		Effect of age on use of thrombolytic therapy and mortality in acute myocardial infarction.
	www.annals.org /cgi/content/full/124/3/283 (5577 words)

	Embolic Stroke Following Thrombolytic Therapy for Myocardial Infarction in a Patient With Preexisting Ventricular ... (Site not responding. Last check: 2007-10-22)
		Ischemic stroke and intracranial hemorrhage following thrombolytic therapy for acute myocardial infarction: a risk-benefit analysis.
		Stroke and acute myocardial infarction in the thrombolytic era: clinical correlates and long term prognosis.
		Thrombolytic therapy in acute ischemic stroke patients with cardiac thrombus
	stroke.ahajournals.org /cgi/content/full/26/2/324 (994 words)

	Thrombolytic Therapy of Pulmonary Embolism: A Comprehensive Review of Current Evidence -- Arcasoy and Kreit 115 (6): ...
		thrombolytic therapy and 550 were treated with heparin alone.
		Thrombolytic therapy is accompanied by a significantly greater risk
		Thrombolytic therapy in thrombosis: a National Institutes of Health consensus development conference.
	www.chestjournal.org /cgi/content/full/115/6/1695 (6508 words)

	NGC - NGC Summary
		Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thromboly
		Antithrombotic and thrombolytic therapy for ischemic stroke: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
		Antithrombotic and thrombolytic therapy: from evidence to application: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.
	www.guideline.gov /summary/summary.aspx?view_id=1&doc_id=5896 (1963 words)

	MAMC: Thrombolytic Therapy Core Document (Site not responding. Last check: 2007-10-22)
		Clinical Standard for the Use of Thrombolytic Therapy for the Treatment of Acute Ischemic Stroke
		Thrombolytic therapy with streptokinase and acute ischemic stroke, Mulitcenter Acute Stroke Trial- Europe Study Group.
		Guidelines for thrombolytic therapy for acute stroke: a supplement to the Guidelines for the management of patients with acute ischemic stroke.
	mamc.amedd.army.mil /Clinical/standards/thrombolytic_therapy_cor.htm (963 words)

	Interaction between arrival time and thrombolytic treatment in determining early outcome of acute myocardial infarction ...
		Prospective evaluation of eligibility for thrombolytic therapy in acute myocardial infarction.
		Consequences of overutilization and underutilization of thrombolytic therapy in clinical practice.
		Efficacy and safety of thrombolytic therapy after initially unsuccessful cardiopulmonary resuscitation: a prospective clinical trial.
	heart.bmjjournals.com /cgi/content/full/88/6/583 (2200 words)

	Initial Experience with the Combination of Reteplase and Abciximab for Thrombolytic Therapy in Peripheral Arterial ...
		U/h and was continued until the end of the thrombolytic infusion.
		A comparison of thrombolytic therapy with operative revascularization in the initial treatment of acute peripheral arterial ischemia.
		Thrombolytic therapy with use of alteplase (t-PA) in peripheral arterial occlusive disease: review of the clinical literature.
	www.jvir.org /cgi/content/full/13/1/37 (3934 words)

	NEJM -- An International Randomized Trial Comparing Four Thrombolytic Strategies for Acute Myocardial Infarction
		thrombolytic regimens in the treatment of acute myocardial infarction.
		Kennedy, J. Thrombolytic therapy in acute myocardial infarction.
		Are we underestimating the full potential of early thrombolytic treatment in patients with acute myocardial infarction?.
	content.nejm.org /cgi/content/short/329/10/673 (8431 words)

	eMedicine - Thrombolytic Therapy in Stroke : Article by Mary Kalafut, MD (Site not responding. Last check: 2007-10-22)
		Although the risk of hemorrhage is increased with thrombolytic therapy, the risk is outweighed by improved functional outcome at 3 months after stroke onset.
		After thrombolytic therapy is initiated, transfer the patient to an intensive care unit, stroke unit, or other unit capable of close observation.
		Education regarding the availability of thrombolytic therapy for stroke is important for patients with risk factors for stroke and those who have experienced a transient ischemic attack or prior stroke.
	www.emedicine.com /neuro/topic370.htm (4457 words)

	eMedicine - Thrombolytic Therapy : Article by Craig Feied, MD, FACEP, FAAEM, FACPh (Site not responding. Last check: 2007-10-22)
		It is the physiologic thrombolytic agent responsible for most of the body's natural efforts to prevent excessive thrombus propagation.
		Urokinase is a physiologic thrombolytic agent that is produced in renal parenchymal cells.
		When the decision is made to use thrombolysis, the fastest-acting available thrombolytic agent with an acceptable safety and efficacy profile should be chosen.
	www.emedicine.com /emerg/topic831.htm (3544 words)

	Age-related differences in in-hospital mortality and the use of thrombolytic therapy for acute myocardial infarction -- ...
		Age-related differences in in-hospital mortality and the use of thrombolytic therapy for acute myocardial infarction -- Boucher et al.
		Age-related trends (1986–1993) in the use of thrombolytic agents in patients with acute myocardial infarction.
		Thrombolytic therapy for eligible elderly patients with acute myocardial infarction.
	www.cmaj.ca /cgi/content/full/164/9/1285 (3318 words)

	Delays In Administration of Thrombolytic Drugs More Likely In Elderly Patients (Site not responding. Last check: 2007-10-22)
		As expected, the later time period (1995-1996) was associated with earlier administration of thrombolytic treatment, perhaps indicating a trend toward speedier use of thrombolytic agents.
		Use of emergency transport was strongly associated with receipt of thrombolytic treatment in less than an hour (OR 0.46), as was chest pain (OR 0.40).
		Further delay in use of thrombolytic agents for older, more impaired patients may be due to the complex clinical decisionmaking concerning these patients.
	www.pslgroup.com /dg/164cb2.htm (466 words)

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