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Topic: Thrombolytic drug

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	Med-Lib - Medical Online Library - English Articles - Oxford Textbook of Surgery - Thrombolytic therapy
		Thrombolytic therapy is indicated for the treatment of venous thrombosis, peripheral arterial occlusion, and myocardial infarction.
		Minimizing the delay between onset of symptoms and administration of the drug increases the likelihood of limiting the infarct: the thrombolytic drugs that hold the greatest appeal for this application are those with clot or fibrin andlsquo;selectivityandrsquo;.
		Although it is clear that thrombolytic drugs are useful and effective for the acute removal of thrombus from veins, no published series has demonstrated a clinical advantage of this therapy to avoid the long-term complications of postphlebitic syndrome years after the illness.
	med-lib.ru /english/oxford/thromb_ther.shtml (3598 words)

	Thrombolytic therapy (tissue plasminogen activator - tPA) Encyclopedia Search - Drug Price Search
		Thrombolytic therapy is a drug that break ups or dissolves blood clots, which are the main cause of both heart attacks and stroke.
		The drug is successful in restoring some blood flow to the heart muscle in approximately 75% of patients, but the resultant blood flow may not be entirely normal.
		The decision to administer the drug is based upon the history, physical exam consistent with a significant stroke, and a brain CT scan to exclude bleeding.
	www.drug-price-search.com /encyclopedia/?encyclopedia_name_url=132&level=2 (885 words)

	Research Findings Register: summary number 992
		Thrombolytic and neuroprotective therapy for acute ischaemic stroke.
		There was heterogeneity between the trials that could have been due to: the thrombolytic drug used, variation in the concomitant use of aspirin and heparin, severity of the stroke, and time to treatment.
		The data for thrombolytic drugs are limited and the estimates of effectiveness and cost-effectiveness are imprecise.
	www.refer.nhs.uk /ViewRecord.asp?ID=992 (900 words)

	MedlinePlus Drug Information: Thrombolytic Agents (Systemic) (Site not responding. Last check: 2007-10-12)
		Thrombolytic agents are used to dissolve blood clots that have formed in certain blood vessels.
		Thrombolytic agents are also used to dissolve blood clots that form in tubes that are placed into the body.
		There is a slight chance that use of a thrombolytic agent during the first five months of pregnancy may cause a miscarriage.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202565.html (1188 words)

	HighBeam Encyclopedia - thrombolytic drug (Site not responding. Last check: 2007-10-12)
		THROMBOLYTIC DRUG [thrombolytic drug] or clot-dissolving drug, substance, such as streptokinase or tissue plasminogen activator (tPA), that causes the breakdown of blood clots (see thrombosis) that obstruct the flow of blood through the vessels.
		Platelet-active drugs: the relationships among dose, effectiveness, and side effects.(The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy)
		Hemorrhagic complications of thrombolytic therapy in the treatment of myocardial infarction and venous thromboembolism.
	www.encyclopedia.com /html/t/thrombol.asp (336 words)

	PROVET HEALTHCARE INFORMATION - Thrombolytic Drugs (Site not responding. Last check: 2007-10-12)
		Thrombolytic drugs "dissolve" thrombi that have formed in blood vessels.
		Anistreplase - anisoylated plasminogen streptokinase activator complex - a synthetic thrombolytic drug that is injected intravenously.
		Thrombolytic drugs are not licensed for use in veterinary patients and they have only been used sporadically.
	www.provet.co.uk /health/diseases/thrombolyticdrugs.htm (234 words)

	Turkish Journal of Haematology (Site not responding. Last check: 2007-10-12)
		Thrombolytic drugs play a crucial role in the management of patients with thrombotic and thromboembolic complications during pre-, peri-, and postinterventional cardiologic procedures and acute thrombotic stroke, most often in combination with anticoagulants, antiplatelet agents or mechanical procedures, in order to achieve vascular reperfusion.
		To maximize the extent of thrombolysis, there is a necessity of the simultaneous administration of antithrombotic drugs with the lytic agent because of an increase in thrombin generation[8,9].
		Thrombolytic therapy for AMI is highly effective when applied early, preferable within 1 hour but not longer than 6 hours after the onset of symptoms.
	tjh.dergisi.org /text.php3?id=192 (9937 words)

	Acute Ischemic Stroke: Stroke Center at University Hospital, Newark, New Jersey
		Thrombolytic drug therapy has helped to change the course of ischemic stroke.
		It involves the use of a thrombolytic drug — also called a fibronolytic or clot-buster — delivered through the blood vessels to break-up the clot that is disrupting the blood flow.
		A new potential companion or alternative to thrombolytic therapy is generating excitement among brain experts for speeding up the process of removing clots involved in ischemic stroke.
	www.theuniversityhospital.com /stroke/ischemic.htm (1253 words)

	American Heart Association Prevention Conference IV: Prevention and Rehabilitation of Stroke
		A review of thrombolytic drugs and updated guidelines for their use in patients with stroke has recently been prepared.
		The insensitivity of functional scales to the presence or absence of a neuroprotective action is due to the natural variability in stroke outcome, which is influenced by factors such as patient age, comorbid illness, size and location of infarct, previous infarct, and vascular pathology.
		The early initiation of neuroprotective drug therapy might be useful in that the time window for effective use of thrombolytic therapy is extended.
	www.americanheart.org /presenter.jhtml?identifier=1844 (2957 words)

	Study Reversal: Direct Angioplasty Isn't Better Than Clot-Busting Drugs For Treating Heart Attacks
		However, intravenous thrombolytic therapy is the standard of care for patients having heart attacks, because of its widespread availability and proven ability to reduce death.
		It looked at the outcomes of 1,138 heart attack patients who were given either the clot-busting drug t-PA or direct angioplasty in 57 hospitals in nine countries as part of a sub-study of the GUSTO IIb (Global Use of Strategies to Open Occluded Coronary Arteries in Acute Coronary Syndromes) clinical trial.
		Although an angioplasty is more expensive than clot-busting drugs, 36 percent of the drug therapy patients needed to have a follow-up angioplasty, they found.
	www.eurekalert.org /pub_releases/1997-11/DUMC-SRDA-101197.php (1016 words)

	eMedicine - Thrombolytic Therapy : Article by José G Cabañas, MD (Site not responding. Last check: 2007-10-12)
		Thrombolytic agents available today are serine proteases that work by converting plasminogen to the natural fibrinolytic agent plasmin.
		During the time this drug was not available, the FDA encouraged the off-label use of reteplase and alteplase for local-regional lysis of venous and arterial thrombus at any location.
		The effectiveness of thrombolytic therapy in stroke is strictly associated to strict patient selection within the inclusion and exclusion criteria.
	www.emedicine.com /emerg/topic831.htm (4884 words)

	[No title]
		Achieving the resolution of a clinical picture of acute cerebral insufficiency by a thrombolytic treatment is a topic of evident scientific value and of undeniable practical and therapeutic meaning.
		The remark which is at the base of the use of the thrombolytic drug in the reminded conditions, is that over 80% of cerebral focal ischemic attacks comes from an athero thrombotic occlusive disease, on which an action of the thrombolytic drug can just be guessed.
		As to possible connections between haemorrhage and thrombolytic use, the possibility of the intervention of some etiologic factors is hypothesised, such as the long time interval between the start of the symptoms and the exposition to thrombolytic drug; arterial hypertension; enhanced drug doses, if compared to a light body mass.
	web.tiscali.it /afunc/isvb/ebt/dissonan/marcia_e.htm (510 words)

	Review: Thrombolysis for acute ischaemic stroke
		Despite this, thrombolytic therapy, administered up to six hours after ischaemic stroke, significantly reduced the proportion of patients who were dead or dependent (modified Rankin 3 to 6) at the end of follow-up (OR 0.83, 95% CI 0.73 to 0.94).
		Overall, thrombolytic therapy was associated with a significant excess of deaths within the first seven to ten days, symptomatic and fatal intracranial haemorrhages and deaths by the end of follow-up.
		However, with tested thrombolytic agents in recent trials there is, overall, proof beyond all reasonable doubt of a substantial excess risk of fatal intracranial haemorrhage and death from all causes with thrombolytic therapy.
	www.dcn.ed.ac.uk /csrg/reviews/thromb.htm (13852 words)

	The University of Melbourne - INTEGRATED PHARMACOLOGY LABORATORY (Site not responding. Last check: 2007-10-12)
		Platelet interactions with injured vessel walls are critical in the development of thrombosis and antiplatelet therapy decreases the incidence of heart attack and stroke.
		Thus, the development of drugs which inhibit thrombosis - but do not inhibit normal wound healing or prolong bleeding - is the goal of this program.
		Cardiovascular and autonomic reflex effects of the drugs are being assessed in conscious rabbits in the Integrated Pharmacology 1 Laboratory.
	www.pharmacology.unimelb.edu.au /research/integrated.html (1258 words)

	News: Barren-Metcalfe EMS gives first thrombolytic in pre-hospital study
		With Bunch's injection of the drug in the ambulance, Wells became the first heart attack victim in Kentucky to receive a thrombolytic drug prior to their arrival at a hospital.
		Retavase is a thrombolytic commonly given to heart attack victims upon their arrival at the hospital.
		The purpose of this national study is to evaluate the significance on patient outcome by the administration of the drug prior to the patient's arrival at the emergency department.
	www.hultgren.org /news/99-4/n9-0381.htm (791 words)

	Encyclopedia :: encyclopedia : Drug trafficking (Site not responding. Last check: 2007-10-12)
		The Royal Commission into Drug Trafficking (2001 - 2003) (1977-1980) investigated drug trafficking in New South Wales, especially links between the Mafia and New South Wales Police and the disappearance of investigative journalist Donald Mackay.
		The Royal Commission of Inquiry into Drug Trafficking (1980-1983) was also known as the "Stewart Royal Commission".
		Royal Commission into Drug Trafficking, ("Woodward Royal Commission"), (1977-1980)
	www.hallencyclopedia.com /Drug_trafficking (131 words)

	A systematic review of the effectiveness, cost-effectiveness and barriers to implementation of thrombolytic and ... (Site not responding. Last check: 2007-10-12)
		Thrombolytic therapy significantly increased the odds of fatal intracranial haemorrhage (OR = 4.15; 95% confidence interval (CI), 2.96 to 5.84).
		Thrombolytic therapy also increased the odds of death at the end of follow-up (OR = 1.31; 95% CI, 1.13 to 1.52).
		However, despite the increase in deaths, (because it markedly reduced the degree of disability in survivors), thrombolytic therapy within 6 hours significantly reduced the proportion of patients who were dead or dependent at the end of follow-up (OR = 0.83; 95% CI, 0.73 to 0.94).
	www.hta.nhsweb.nhs.uk /execsumm/summ626.htm (1448 words)

	Medical Imaging - Keeping Workers Productive: Medical Imaging Reduces Disability From Stroke
		The average length of hospital stays for patients who receive thrombolytic therapy is significantly shorter than for patients who do not (10.9 days versus 12.4 days), according to one study.
		Per 1,000 patients, thrombolytic drug treatment creates overall savings to the health care system by increasing hospital costs $1.7 million, but decreasing rehabilitation costs $1.4 million and nursing home costs $4.8 million.
		Though thrombolytic treatment must be administered within 3 hours after symptoms appear, preliminary studies show that advances in imaging (for example, perfusion computerized tomography) can extend the 3-hour time window even further, thus further extending savings in lives and dollars.
	medicalimaging.org /workerproductivity/stroke.cfm (740 words)

	clot-dissolving drug (Site not responding. Last check: 2007-10-12)
		thrombolytic drug - thrombolytic drug or clot-dissolving drug,substance, such as streptokinase or tissue plasminogen...
		Streptokinase is found to be safest of clot-dissolving drugs.
		Suppliers at work on nearly 100 drugs for heart disease, stroke.
	www.infoplease.com /ce6/sci/A0911961.html (111 words)

	Health Report - 08/11/1999: Angioplasty - Long-Term Benefits
		Instead of the clot buster, thrombolysis, the person with the heart attack is taken to theatre, what they call a cardiac catheter lab, and has a balloon inserted into the coronary artery and inflated at the site of the blockage.
		Norman Swan: Now one criticism of your study is that if the clot busting drug that you used, called streptokinase isn't the most advanced on the market, and that the more advanced, genetically-engineered kind called TPA may well have fewer side effects and be more effective, although that's debated.
		One of the additional advantages in my perspective is that you avoid for instance, the risk of haemorrhagic stroke, that is a risk of about 1%-1-1/2% of the use of thrombolytic drugs which might be quite dramatic: you either die from it or you might end up with severe physical limitations.
	www.abc.net.au /rn/talks/8.30/helthrpt/stories/s65120.htm (1237 words)

	Point-of-care fibrinolytic tests: the other side of blood coagulation -- Oberhardt et al. 43 (9): 1697 -- Clinical ...
		before the administration of a thrombolytic drug (6).
		Exploration of rapid bedside monitoring of coagulation and fibrinolysis parameters during thrombolytic therapy.
		Differences in clot lysis among patients demonstrated in vitro with three thrombolytic agents (tissue-type plasminogen activator, streptokinase and urokinase).
	www.clinchem.org /cgi/content/full/43/9/1697 (2483 words)

	Cerebral Hematoma: Encyclopedia of Neurological Disorders
		Research is under way to develop effective, safer medications and methods to both stop a hemorrhage while it is occurring, and dissolve clots within the brain once they have formed.
		Direct injection of a local-acting clotting agent into an expanding hematoma, or of a thrombolytic drug, such as recombinant tissue plasminogen activator (rt-PA), into the clot are two avenues of research.
		The prognosis after an ICH varies anywhere from excellent to fatal, depending on the size and location of the hematoma.
	health.enotes.com /neurological-disorders-encyclopedia/cerebral-hematoma (1216 words)

	Highbeam Encyclopedia - Search Results for thrombolytic drug (Site not responding. Last check: 2007-10-12)
		thrombolytic drug THROMBOLYTIC DRUG [thrombolytic drug] or clot-dissolving drug, substance, such as streptokinase or tissue plasminogen activator (tPA), that causes the breakdown of blood clots (see thrombosis) that obstruct the flow of blood through the vessels.
		clot-dissolving drug CLOT-DISSOLVING DRUG [clot-dissolving drug] see thrombolytic drug.
		The acute emergency known as myocardial infarction, or heart attack, is usually caused by a
	www.encyclopedia.com /articles/12844.html (423 words)

	SIR Reporting Standards for the Treatment of Acute Limb Ischemia with Use of Transluminal Removal of Arterial Thrombus ...
		role of vasoactive drugs in acute limb ischemia (1).
		the thrombolytic drug needed to dissolve the thrombus (12).
		A comparison of thrombolytic therapy with operative revascularization in the initial treatment of acute peripheral arterial ischemia.
	www.jvir.org /cgi/content/full/14/9/S453 (5747 words)

	Guidelines for Thrombolytic Therapy for Acute Stroke: A Supplement to the Guidelines for the Management of Patients ... (Site not responding. Last check: 2007-10-12)
		"Guidelines for Thrombolytic Therapy for Acute Stroke: A Supplement to the Guidelines for the Management of Patients With Acute Ischemic Stroke" was approved by the American Heart Association Science Advisory and Coordinating Committee on June 20, 1996.
		mm Hg is a contraindication to the use of thrombolytic drugs.
		of the drug and the onset of hemorrhage, and (5) the thrombolytic
	www.circ.ahajournals.org /cgi/content/full/94/5/1167 (5759 words)

	amediplase (K2tu-PA)
		A new thrombolytic drug obtained through recombinant DNA technology.
		In animal models, Amediplase is a more potent and longer-lasting thrombolytic than Alteplase (the standard thrombolytic drug for the treatment of acute myocardial infarction).
		Amediplase is indicated for administration in a bolus injection, which constitutes an advantage over the standard thrombolytic treatments.
	www.menarini.com /english/ricerca_sviluppo/amediplase.htm (116 words)

	Evolving Strategies for Thrombolytic Therapy of Peripheral Vascular Occlusion -- Valji 11 (4): 411 -- Journal of ...
		The drug is derived from kidney cells of Colombian
		Earnshaw JJ, Westby JC, Gregson RHS, et al.Local thrombolytic therapy of acute peripheral arterial ischaemia with tissue plasminogen activator: a dose-ranging study.
		Stability and activity of alteplase with injectable drugs commonly used in cardiac therapy.
	www.jvir.org /cgi/content/full/11/4/411 (5304 words)

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