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Topic: Thrombophilia

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Factor V Leiden

Factor V

Factor XI

Antiphospholipid antibody syndrome

Thrombus

Autoimmune disease

Autoimmune disorder

Hereditary

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	HEREDITARY THROMBOPHILIA: Contact a Family - for families with disabled children: information on rare syndromes and ...
		Hereditary Thrombophilia is the increased tendency to develop blood clots in veins and arteries.
		Thrombophilia may occur in association with abnormalities in either coagulation or anticoagulation proteins.
		The most common form of inherited thrombophilia is associated with a change in the factor V gene, otherwise known as factor V Leiden mutation.
	www.cafamily.org.uk /Direct/h41.html (1496 words)

	Disorders IHTC
		Answer: Thrombophilia is not a new disease, but it has become a more recognized and discussed topic due to an increased ability to test for and identify some of the underlying contributing abnormalities.
		Acquired thrombophilia refers to a group of disorders that an individual is not born with, but may develop throughout his or her life due to another illness or situation.
		Thrombophilia is also related to hemophilia in that the providers that staff hemophilia treatment centers (HTCs) may be well suited to provide specialized services to this population, as well.
	www.ihtc.org /Disorders/clotting.html (1481 words)

	Thrombophilia: Another Factor to Considerin Cases of Recurrent Pregnancy Loss
		Thrombophilia can be an inherited disorder, but can also be caused by external events such as surgery, obesity, pregnancy, use of oral contraceptives, antiphospholipid syndrome, or long periods of immobility.
		Physicians may suspect thrombophilia when patients have a blocked blood vessel at a young age or have a strong family history of clotting disorders (such as stroke, pulmonary embolism, or deep vein thrombosis).
		Because inherited thrombophilia has been shown to be a major cause of recurrent miscarriage, patients with recurrent fetal loss should be evaluated for clotting disorders, even in the absence of clinical signs.
	www.ivf.com /thrombophilia.html (750 words)

	Thrombophilia
		Thrombophilias are a group of disorders that cause blood to clot too easily.
		Thrombophilias, and the increased risk of clots that result, can also lead to problems during pregnancy (Read about "Healthy Pregnancy"), including poor fetal growth, separation of the placenta from the uterine wall, and stillbirth.
		According to MOD, thrombophilias can also cause a severe form of preeclampsia, a condition characterized by high blood pressure, protein in the urine, and swelling of the hands and feet, which is very dangerous.
	www.stayinginshape.com /3osfcorp/libv/h26.shtml (458 words)

	National Hemophilia Foundation for All Bleeding Disorders \| Hemophilia, von Willebrand Disease, Thrombophilia
		A: Thrombophilia is a term used to describe a group of conditions in which there is an increased tendency, often repeated and often over an extended period of time, for excessive clotting.
		A: Thrombophilia is not a new disease, but it has become a more recognized and discussed topic due to an increased ability to test for and identify some of the underlying contributing abnormalities.
		Both children and adults may have thrombophilia, but it is more commonly diagnosed during the tendency to show symptoms due to the contributing adolescent and adult years due to normal changes in the hemostatic balance that occurs with growth and aging.
	www.hemophilia.org /bleeding_disorders/thrombophilia.htm (1511 words)

	Thrombophilia and Leiden Factor V : Public Health Genetics Unit 2006
		Thrombophilia is the term used to refer to an inherited or acquired disorder of the haemostatic (blood clotting) system that causes an increased risk of venous thrombosis (blood clots in the veins).
		Inherited thrombophilia is a genetically determined predisposition to venous thromboembolism, and may be caused by a number of known mutations.
		Joffe H.V. and Goldhaber S.Z. Laboratory thrombophilias and venous thromboembolism.
	www.phgu.org.uk /pages/info/diseases/thrombophilia.htm (2780 words)

	Thrombophilia: Bleeding and Clotting Disorders: Merck Manual Home Edition
		Thrombophilia is a disorder in which the blood clots easily or excessively.
		Most disorders that cause thrombophilia increase the risk of blood clot formation in veins; a few increase the risk of clot formation in both arteries and veins.
		The inherited disorders that cause thrombophilia are incurable.
	www.merck.com /mmhe/sec14/ch173/ch173g.html (616 words)

	Factor V Leiden Thrombophilia
		Factor V Leiden thrombophilia is characterized by a poor anticoagulant response to activated protein C (APC) and an increased risk of venous thromboembolism.
		The diagnosis of factor V Leiden thrombophilia is suspected in individuals with a history of venous thrombosis or in families with a high incidence of venous thrombosis.
		In the Leiden Thrombophilia study, the risk of venous thrombosis was increased fourfold in oral contraceptive users, and sevenfold in women with a heterozygous factor V Leiden mutation.
	www.geneclinics.org /profiles/factor-v-leiden/details.html (7823 words)

	The Warde Report Archives: Thrombophilia (Hypercoagulable States) (Site not responding. Last check: 2007-11-03)
		Thrombophilia may be defined as hereditary or aquired conditions which predispose individuals to thromboembolic events.
		Thrombophilia may be defined as hereditary or acquired conditions which predispose individuals to thromboembolic events.
		Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci USA 90:1004-1008, 1993.
	wardelab.com /arc_2.html (2194 words)

	Prevalence and Significance of Thrombophilia in Peripheral Arterial Disease
		Prevalence and Significance of Thrombophilia in Peripheral Arterial Disease
		Thrombophilia may be defined as a propensity to thrombosis secondary to abnormalities in haemostasis.(1) Thrombophilia has long been recognised as contributing to venous thrombosis, but is increasingly associated with arterial disease.
		The presence of thrombophilia was particularly significant in early graft failures, where 11 of the 12 occlusions within one month had a pre-operative hypercoagulable abnormality.
	www.vascular.co.nz /Thrombophilia.htm (4885 words)

	Thrombophilia
		Thrombophilia is the potential to develop dangerous blood clotting in the veins or arteries.
		The presence of these genetic predispositions in certain families has been termed thrombophilia to emphasize their special risk for thromboembolism or clotting.
		No. It is likely that intensive research efforts in families with a history of thrombophilia will lead to the identification of additional genetic risk factors.
	www.med.umich.edu /1libr/aha/umthrombo.htm (814 words)

	Finger Lakes Triathlon
		Thrombophilia is the tendency for people to develop blood clots unexpectedly.
		Patients with thrombophilia often develop blood clots in a vein in the leg.
		Patients who have thrombophilia and develop clots are treated with blood-thinning medicines called anticoagulants.
	www.fingerlakestriathlon.com /about_us_thrombophilia.htm (193 words)

	genome.gov \| Learning about Factor V Leiden Thrombophilia
		Factor V Leiden thrombophilia is an inherited disorder of blood clotting.
		Factor V Leiden is the name of a specific mutation (genetic alteration) that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels.
		People who have the factor V Leiden mutation are at somewhat higher than average risk for a type of clot that forms in large veins in the legs (deep venous thrombosis, or DVT) or a clot that travels through the bloodstream and lodges in the lungs (pulmonary embolism, or PE).
	www.genome.gov /15015167 (1285 words)

	Thrombophilia: Excessive Blood Clotting
		Thrombophilia is a term that describes a group of conditions in which dangerous clots form in the veins and arteries.
		Thrombophilia is often hereditary, but the disorder may also be acquired through pregnancy or hormone replacement therapy.
		Thrombophilia is a general term that denotes a propensity for excessive blood clotting.
	about-blood-disorders.com /blood-clotting-disorders/thrombophilia.php (519 words)

	Quick Reference: The Thrombophilias and Pregnancy
		However, the thrombophilias contribute to a number of pregnancy complications, including fetal losses that occur in late in the first trimester or in the second or third trimesters (i.e., stillbirths), placental abruption (when the placenta separates from the uterine wall, partially or completely, before delivery) and poor fetal growth.
		The thrombophilias also may cause a severe form of preeclampsia, a pregnancy-related disorder that can pose serious risks for mother and baby, that is characterized by high blood pressure and protein in the urine.
		Women with a thrombophilia who have a past history of blood clots are usually treated with heparin during pregnancy and the postpartum period.
	www.marchofdimes.com /professionals/14332_9264.asp (1567 words)

	About Thrombophilia - Thrombophilia - Clinical Services - Children's Hospital Boston (Site not responding. Last check: 2007-11-03)
		Thrombophilia is a condition that increases the tendency to develop excessive and dangerous blood clots that can lead to loss of blood supply and severe tissue damage.
		The name "thrombophilia" was coined as an "opposite" of hemophilia, a disorder that prevents the blood from clotting.
		Thrombophilia may be inherited or acquired due to lifestyle or medical conditions.
	www.childrenshospital.org /clinicalservices/Site1975/mainpageS1975P4.html (143 words)

	Thrombophilia: Inherited and Acquired -- Alan E. Beer Center for Reproductive Immunology and Genetics
		Once diagnosed as acquired or inherited, thrombophilia can be treated and healthy, normally grown babies can be born.
		Since patients with inherited thrombophilia suffer clotting complications throughout life with a higher frequency than those without, monitoring for this complication is essential.
		Thrombophilia is much more common in women than in men.
	repro-med.net /papers/thromb.php (1082 words)

	What Is Thrombophilia? (Site not responding. Last check: 2007-11-03)
		Thrombophilia is a blood clotting disorder in which the blood has a tendency to clot more than normal.
		Thrombophilia leads to an increased risk of developing potentially dangerous blood clots in the veins (venous thrombosis).
		The two most common forms of inherited thrombophilia are factor V Leiden and the prothrombin mutation.
	www.dnadirect.com /resource/conditions/thrombophilia/GH_Thr_What_Is_Throm.jsp (461 words)

	Hereditary Thrombophilia and Venous Thromboembolism -- MURIN et al. 158 (5): 1369 -- American Journal of Respiratory ...
		The hereditary thrombophilias are a group of inherited conditions that predispose to thrombosis.
		Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: predication of a cofactor to activated protein C. Proc.
		A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.
	ajrccm.atsjournals.org /cgi/content/full/158/5/1369 (3631 words)

	Factor V Leiden thrombophilia - Genetics Home Reference
		Factor V Leiden is the name of a specific mutation that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood vessels.
		People who have the factor V Leiden mutation are at somewhat higher than average risk for a type of clot that forms in veins, such as the deep veins of the legs (deep venous thrombosis), or a clot that travels through the bloodstream and lodges in the lungs (pulmonary embolism).
		Mutations in the F5 gene cause factor V Leiden thrombophilia.
	ghr.nlm.nih.gov /condition=factorvleidenthrombophilia (764 words)

	Thrombophilia, Recurrent Pregnancy Losses and Reproductive Disorders -- Alan E. Beer Center for Reproductive Immunology ...
		This contribution will help the patient and the clinician to understand the diagnosis of thrombophilia, the preconception, pregnancy and post partum anticoagulant therapy, as well as pathological conditions of pregnancy that are greatly increased when thrombophilia is present.
		In contrast, to other varieties of thrombophilia, homozygous mutation of factor V may be associated with a minor clinical severity suggesting the role of environmental factors and/or still unknown molecular alterations.
		Although there are numerous risk factors for venous thromboembolic disease, the term thrombophilia refers only to those familial or acquired disorders of the haemostatic system that result in an increased risk of thrombosis.
	repro-med.net /info/thromb.php (1572 words)

	Summary: Screening for thrombophilia in high-risk situations: systematic review and cost-effectiveness analysis. The ...
		A decision analytical model was developed to simulate the clinical consequences of four thrombophilia screening scenarios: screening women prior to prescribing combined oral contraceptives, screening women prior to prescribing hormone replacement therapy, screening women at the onset of pregnancy (week six of gestation) and screening patients prior to major orthopaedic surgery.
		Thrombophilia is associated with increased risks of VTE in women taking oral oestrogen preparations and patients undergoing major elective orthopaedic surgery, and VTE and adverse pregnancy outcomes in pregnancy.
		Universal thrombophilia screening in women prior to prescribing oral oestrogen preparations, in women during pregnancy and in patients undergoing major orthopaedic surgery is not supported by the evidence.
	www.ncchta.org /execsumm/summ1011.htm (2235 words)

	The National Alliance for Thrombosis & Thrombophilia
		The National Alliance for Thrombosis and Thrombophilia (NATT) is a nationwide, community-based, volunteer health organization formed in August 2003.
		With the goal to ensure that people suffering from thrombosis and thrombophilia get early diagnosis, optimal treatment, and quality support, NATT members are committed to fostering research, education, support, and advocacy on behalf of those at risk of, or affected by, blood clots.
		NATT is quickly being recognized as the premier community-based organization dedicated to thrombosis and thrombophilia issues in the United States.
	www.nattinfo.org (295 words)

	Thrombophilia in pregnancy -- Walker 53 (8): 573 -- Journal of Clinical Pathology (Site not responding. Last check: 2007-11-03)
		Familial thrombophilia due to a previously unrecognised mechanism characterised by poor anticoagulant response to activated protein C. Prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A 1993;90:1004–8.
		Hellgren M, Svensson P, Dahlback B. Resistance to activated protein C is a basis for venous thromboembolism associated with pregnancy and oral contraceptives.
		Increased frequency of genetic thrombophilias in women with complications of pregnancy.
	jcp.bmjjournals.com /cgi/content/full/53/8/573 (5373 words)

	Thrombophilia testing: what do we think the tests mean and what should we do with the results? -- Baglin 53 (3): 167 -- ... (Site not responding. Last check: 2007-11-03)
		Thrombophilia testing: what do we think the tests mean and what should we do with the results?
		"Thrombophilia screening" of the general population is not justified.
		Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: a study of 150 families.
	jcp.bmjjournals.com /cgi/content/full/53/3/167 (2501 words)

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