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Topic: Thrombospondin

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	Haematologic Technologies - Thrombospondin (via CobWeb/3.1 planetlab2.cs.unc.edu) (Site not responding. Last check: 2007-10-03)
		Thrombospondin is also an integral component of the basement membrane in a number of different tissues (16).
		Thrombospondin interacts with a variety of extracellular macromolecules including heparin (1,17), collagen (18), fibrinogen and fibronectin (19), plasminogen (20), plasminogen activator (21), and osteonectin (22).
		Human thrombospondin is prepared from the supernatant of activated platelets by heparin-agarose affinity and gel filtration chromatography (25).
	www.haemtech.com.cob-web.org:8888 /Platelet_Proteins/Thrombospondin.htm (395 words)

	BioMed Central \| Full text \| Thrombospondin-1 expression in urothelial carcinoma: prognostic significance and ...
		Thrombospondins (TSPs) are a family of extracellular proteins recognized as an endogenous constituent of the extracellular matrix (ECM) in many human tissues.
		In the study, of Grossfeld et al [14] the antibody used was the mouse anti-TSP monoclonal antibody MA-II that recognizes an epitope in the amino-terminal region of TSP-1, while in the study of Goddard JC et al [17] used monoclonal antibody against TSP-1(Ab-4).
		Lahav J: The functions of thrombospondin and its involvement in physiology and pathophysiology.
	www.biomedcentral.com /1471-2407/6/140 (4970 words)

	Thrombospondin - Wikipedia, the free encyclopedia
		Thrombospondins (TSP) are secreted proteins with the ability to inhibit angiogenesis.
		The thrombospondins (TSP) are a family of multifunctional proteins.
		The family consists of thrombospondins 1-5 and can be divided into 2 subgroups: A, which contains TSP-1 and -2, and B, which contains TSP-3, -4 and -5 (also designated cartilage oligomeric protein or COMP).
	en.wikipedia.org /wiki/Thrombospondin (248 words)

	THBS2 - Thrombospondin 2 - aka: TSP2 - Cancer GeneticsWeb
		Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer Br J Cancer.
		Thrombospondins I and II messenger RNA expression in lung carcinoma: relationship with p53 alterations, angiogenic growth factors, and vascular density Clin Cancer Res.
		Thrombospondin 2 gene expression is correlated with decreased vascularity in non-small cell lung cancer.
	www.cancerindex.org /geneweb/THBS2.htm (237 words)

	Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast -- ... (Site not responding. Last check: 2007-10-03)
		Thrombospondin 1 protein expression relates to good prognostic indices in ductal carcinoma in situ of the breast -- Rice et al.
		Distribution of thrombospondin and integrin alpha V in DCIS, invasive ductal and lobular human breast carcinomas.
		Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis.
	jcp.bmj.com /cgi/content/full/55/12/921 (3236 words)

	Animal Clinical Investigation: Publications
		Thrombospondin-I is a large protein that has a number of biological roles including the inhibition of new blood vessel formation and the enhancement of existing blood vessels death.
		At the onset of this ongoing trial we were hopeful that Thrombospondin-I peptides would control the growth of measurable cancers in pet dogs and result in disease stabilization.
		Treatment with Thrombospondin-I resulted in resolution of nasal bleeding and a complete regression of a portion of the tumor that had invaded the hard palate.
	www.animalci.com /pubs.php (3497 words)

	Vascular smooth muscle cell growth arrest on blockade of thrombospondin-1 requires p21Cip1/WAF1 -- Chen et al. 277 (3): ... (Site not responding. Last check: 2007-10-03)
		A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.
		Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.
		Thrombospondin 3 is a developmentally regulated heparin binding protein.
	ajpheart.physiology.org /cgi/content/full/277/3/H1100 (3848 words)

	The Role of Thrombospondin-1 in Tumor Progression -- Sargiannidou et al. 226 (8): 726 -- Experimental Biology and ... (Site not responding. Last check: 2007-10-03)
		Thrombospondin is synthesized and secreted by human osteoblasts and osteosarcoma cells: A model to study the different effects of thrombospondin in cell adhesion.
		Thrombospondin peptides are potent inhibitors of mesangial and glomerular endothelial cell proliferation in vitro and in vivo.
		Thrombospondin co-localises with TGF beta and IGF-I in the extracellular matrix of human osteoblast-like cells and is modulated by 17 beta estradiol.
	www.ebmonline.org /cgi/content/full/226/8/726 (5287 words)

	Thiol-Disulfide Isomerization in Thrombospondin: Effects of Conformation and Protein Disulfide Isomerase -- Huang et ... (Site not responding. Last check: 2007-10-03)
		Additional evidence for the correlation of EDTA-conformation and thiol-disulfide exchange was the enhanced conversion of thrombospondin to its EDTA-conformation in the presence of protein disulfide isomerase and the inability of thrombospondin pretreated with NEM to attain the EDTA-conformation.
		Flow cytometry with antibody D4.6 revealed platelet-associated thrombospondin in the EDTA-conformation in the presence of calcium, suggesting that the EDTA-conformation is a physiological conformation that does not necessarily require EDTA.
		THROMBOSPONDIN (TSP) is a large multifunctional protein released by activated platelets and by various cells in culture.
	www.bloodjournal.org /cgi/content/full/89/9/3205 (5547 words)

	Immunohistochemical detection of thrombospondin in microglia in the developing rat brain.
		In the present study, the expression of thrombospondin was investigated in tissue sections of the developing rat forebrain in relation to the distribution of microglia.
		Immunocytochemical detection of thrombospondin clearly outlined a cell population displaying the morphologies and distribution of brain macrophages, from the 17th day of embryonic life up to the end of the second postnatal week.
		The localization of thrombospondin in brain macrophages was confirmed by double immunostaining using ED1 monoclonal anti-macrophage antibodies.
	www.arclab.org /medlineupdates/abstract_8637616.html (225 words)

	THBS2 (thrombospondin-2)
		Thrombospondin 2 levels are increased in aged mice: consequences for cutaneous wound healing and angiogenesis.
		Decreased expressions of thrombospondin 2 in cyclosporin A-induced gingival overgrowth.
		Thrombospondin and vascular endothelial growth factor are cyclically expressed in an inverse pattern during bovine ovarian follicle development.
	atlasgeneticsoncology.org /Genes/THBS2ID42549ch6q27.html (2942 words)

	Thrombospondin 1 acts as a strong promoter of transforming growth factor {beta} effects via two distinct mechanisms in ... (Site not responding. Last check: 2007-10-03)
		Thrombospondin 1 acts as a strong promoter of transforming growth factor {beta} effects via two distinct mechanisms in hepatic stellate cells -- Breitkopf et al.
		Thrombospondin 1 acts as a strong promoter of transforming growth factor ß effects via two distinct mechanisms in hepatic stellate cells
		Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen fibrillogenesis, an increased vascular density, and a bleeding diathesis.
	www.gutjnl.com.cob-web.org:8888 /cgi/content/full/54/5/673 (5496 words)

	Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APCMin/+ mouse model -- Gutierrez et ... (Site not responding. Last check: 2007-10-03)
		Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APCMin/+ mouse model -- Gutierrez et al.
		(1998) Thrombospondin 2 gene expression is correlated with decreased vascularity in non-small cell lung cancer.
		(1999) Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer.
	carcin.oxfordjournals.org /cgi/content/full/24/2/199 (4733 words)

	Thrombospondin-1 Is Required for Normal Murine Pulmonary Homeostasis and Its Absence Causes Pneumonia -- Lawler et al. ...
		The thrombospondins are a family of extracellular calcium-binding proteins that modulate cellular phenotype.
		The members of the thrombospondin gene family are expressed widely during murine development (19-22).
		Raugi, G.J., J.E. Olerud, and A.M. Gown (1987) Thrombospondin
	www.jci.org /cgi/content/full/101/5/982 (5342 words)

	In vivo mechanisms by which tumors producing thrombospondin 1 bypass its inhibitory effects -- Filleur et al. 15 (11): ...
		Bornstein, P. Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1.
		Mettouchi, A., Cabon, F., Montreau, N., Vernier, P., Mercier, G., Blangy, D., Tricoire, H., Vigier, P., and Binetruy, B. SPARC and thrombospondin genes are repressed by the c-jun oncogene in rat embryo fibroblasts.
		Sheibani, N. and Frazier, W.A. Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis.
	www.genesdev.org /cgi/content/full/15/11/1373 (5783 words)

	The thrombospondin 1-TGF-{beta} axis in fibrotic renal disease -- Hugo 18 (7): 1241 -- Nephrology Dialysis ...
		The thrombospondin 1-TGF-{beta} axis in fibrotic renal disease -- Hugo 18 (7): 1241 -- Nephrology Dialysis Transplantation
		Thrombospondin causes activation of latent transforming growth factor-ß secreted by endothelial cells by a novel mechanism.
		Thrombospondin peptides are potent inhibitors of mesangial and endothelial cell proliferation in vitro and in vivo.
	ndt.oxfordjournals.org /cgi/content/full/18/7/1241 (2652 words)

	Thrombospondin (TSP-1) can cause kidney failure when normal blood flow is disrupted
		Thrombospondin (TSP-1) can cause kidney failure when normal blood flow is disrupted
		Scientists led by a University of Cincinnati (UC) kidney expert have found that a naturally occurring protein that normally fights cancer cells can also cause severe kidney failure when normal blood flow is disrupted.
		The protein, thrombospondin (TSP-1), is known for its role in fighting cancer.
	www.news-medical.net /?id=14650 (581 words)

	Amazon.com: Thrombospondin: Books: Judith Lahav (Site not responding. Last check: 2007-10-03)
		Thrombospondin represents the most extensive compilation of knowledge on this important protein.
		Information regarding thrombospondin's cell receptor and future directions of research are also considered.
		Thrombospondin will be an important reference for hematologists, cell biologists, developmental biologists, biochemists, artificial organ engineers, and others interested in this vital protein.
	www.amazon.com /Thrombospondin-Judith-Lahav/dp/084934929X (808 words)

	Deane F. Mosher
		We are particularly interested in how integrin cell surface adhesion receptors participate in the assembly of fibronectin, how this participation is related to other functions of integrins, and the role of integrin phosphorylation in integrin function.
		There are five described thrombospondin genes in vertebrates and one in flies.
		We are using recombinant baculoviruses to express multi-modular segments of thrombospondins and carry out pioneering studies that give insight into how the SNPs may cause pathophysiology.
	www.wisc.edu /molpharm/faculty/mosher.html (1324 words)

	Differential Expression of Thrombospondin and Cellular Fibronectin During Remodeling in Proliferative ... (Site not responding. Last check: 2007-10-03)
		Frazier WA (1987) Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cells.
		Hogg PJ, Stenflo J, Mosher DF (1992) Thrombospondin is a slow tight-binding inhibitor of plasmin.
		Lawler J, Weinstein R, Hynes RO (1988) Cell attachment to thrombospondin: the role of arg-gly-asp, calcium, and integrin receptors.
	www.jhc.org /cgi/content/full/47/4/533 (4675 words)

	Thrombospondin Mediates Focal Adhesion Disassembly through Interactions with Cell Surface Calreticulin -- Goicoechea et ... (Site not responding. Last check: 2007-10-03)
		Thrombospondin induces reorganization of the actin cytoskeleton and restructuring of focal adhesions.
		However, the receptor for this thrombospondin sequence is unknown.
		focal adhesions in response to thrombospondin (5, 8).
	www.jbc.org /cgi/content/full/275/46/36358 (7067 words)

	The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice -- Kyriakides et ... (Site not responding. Last check: 2007-10-03)
		The Distribution of the Matricellular Protein Thrombospondin 2 in Tissues of Embryonic and Adult Mice -- Kyriakides et al.
		Bornstein P (1995) Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1.
		Tucker RP (1993) The in situ localization of tenascin splice variants and thrombospondin 2 mRNA in the avian embryo.
	www.jhc.org /cgi/content/full/46/9/1007 (5037 words)

	Antibody Blockade of Thrombospondin Accelerates Reendothelialization and Reduces Neointima Formation in Balloon-Injured ... (Site not responding. Last check: 2007-10-03)
		Expression of thrombospondins by endothelial cells: injury is correlated with TSP-1.
		Thrombospondin mediates migration and potentiates platelet-derived growth factor-dependent migration of calf pulmonary artery smooth muscle cells.
		Transfection of thrombospondin 1 cDNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis.
	circ.ahajournals.org /cgi/content/full/100/8/849 (3712 words)

	CD36 Mediates the In Vitro Inhibitory Effects of Thrombospondin-1 on Endothelial Cells -- Dawson et al. 138 (3): 707 -- ... (Site not responding. Last check: 2007-10-03)
		A radioimmunoassay for thrombospondin, used in a comparative study of thrombospondin, beta-thromboglobulin and platelet factor 4 in healthy volunteers.
		Thrombospondin levels in plasma, platelets and urine in normal subjects, subjects receiving heparin, and patients undergoing cardiopulmonary bypass.
		The functions of thrombospondin and its involvement in physiology and pathology.
	www.jcb.org /cgi/content/full/138/3/707 (7690 words)

	BLAST Search Results
		Homo sapiens thrombospondin 1 (THBS1), mRNA 1432 0.0 refNM_003246.1
		Homo sapiens thrombospondin 1 (THBS1), mRNA 1432 0.0 embX14787.1HSTS Human mRNA for thrombospondin 1432 0.0 embX04665.1HSTHROMR Human mRNA for thrombospondin 1432 0.0 dbjAB005287.2AB005287 Bos taurus mRNA for thrombospondin...
		Mus musculus thrombospondin 4 (Thbs4), mRNA 583 e-164 gbAF102887.1AF102887 Mus musculus thrombospondin-4 mRNA,...
	www.chickest.udel.edu /orthohuman/h60.html (2578 words)

	Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast -- Rice and Quinn 55 (8): 569 -- Journal of ... (Site not responding. Last check: 2007-10-03)
		Thrombospondin binding by human squamous carcinoma and melanoma cells: relationship to biological activity.
		Binding and degradation of platelet thrombospondin by cultured fibroblasts.
		Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis.
	jcp.bmj.com /cgi/content/full/55/8/569 (5035 words)

	Single Nucleotide Polymorphisms in Multiple Novel Thrombospondin Genes May Be Associated With Familial Premature ... (Site not responding. Last check: 2007-10-03)
		A novel enzyme immunoassay for plasma thrombospondin: comparison with beta-thromboglobulin as platelet activation marker in vitro and in-vivo.
		Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development.
		Yang Z, Kyriakides TR, Bornstein P. Matricellular proteins as modulators of cell-matrix interactions: adhesive defect in thrombospondin 2-null fibroblasts is a consequence of increased levels of matrix metalloproteinase-2.
	circ.ahajournals.org /cgi/content/full/104/22/2641 (3448 words)

	InterPro: IPR000884 Thrombospondin, type I (Site not responding. Last check: 2007-10-03)
		The intron-exon organisation of the properdin gene confirms the hypothesis that the repeat might have evolved by a process involving exon shuffling [ 8 ].
		Analysis of the sequences of thrombomodulin, thrombospondin complement components C9, C8 alpha and C8 beta, vitronectin and plasma cell membrane glycoprotein PC-1.
		Guo N. Krutzsch H.C. Inman J.K. Roberts D.D. Thrombospondin 1 and type I repeat peptides of thrombospondin 1 specifically induce apoptosis of endothelial cells.
	www.ebi.ac.uk /interpro/IEntry?ac=IPR000884 (3228 words)

	BestBETs: Thrombospondin as an early marker of acute coronar...
		Thrombospondin as an early marker of acute coronary syndromes
		Knowing that platelet activation is key to the pathogenesis of acute coronary syndromes and, having heard that thrombospondin may be a marker of this, you wonder if measurement of thrombospondin would allow earlier exclusion of acute coronary syndrome.
		Thrombospondin (TSP) is a large matricellular protein with diverse functions.
	www.bestbets.org /cgi-bin/bets.pl?record=01047 (1088 words)

	Physician, heal thyself (Site not responding. Last check: 2007-10-03)
		Thrombospondin-1 is normally present in small amounts at the base of the epidermis, the outer layer of the skin, where it forms part of the natural barrier that prevents the tiny blood capillaries in the deeper dermis growing through into the epidermis.
		To try to resolve a controversy over whether thrombospondin helps or hinders wound healing, Michael Streit and colleagues of Harvard Medical School genetically modified mice to produce more thrombospondin than normal in the epidermis.
		In laboratory cultures of fibroblast cells, thrombospondin impaired the ability of the fibroblasts to migrate towards collagen and fibronectin.
	www.mindswap.org /2002/nature/000720-8.xml (390 words)

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