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Topic: Thrombotic thrombocytopenic purpura

Related Topics

Microangiopathic hemolytic anemia

Hemolytic uremic syndrome

Idiopathic thrombocytopenic purpura

Von Willebrand factor

Blood film

Disseminated intravascular coagulation

Apheresis

Immune thrombocytopenic purpura

Thrombocytopenia

Systemic Lupus Erythematosus

Hematology

Thrombopenia

Von Willebrand disease

Paroxysmal nocturnal hemoglobinuria

Ticlopidine

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	eMedicine - Thrombocytopenic Purpura : Article by D Symonette, MD, MPH, FACEP (Site not responding. Last check: 2007-10-16)
		Thrombocytopenic purpura is a syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever, and renal dysfunction.
		Thrombotic thrombocytopenic purpura (TTP) is a hematologic emergency.
		Tsai HM, Lian EC: Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura.
	www.emedicine.com /emerg/topic579.htm (3238 words)

	Thrombotic Thromboctyopenic Purpura
		Thrombotic thrombocytopenic purpura (TTP) is a rare blood condition characterized by the formation of small clots (thrombi) within the circulation, which results in the consumption of platelets and thus a low platelet count (thrombocytopenia).
		The first case of TTP was described by Moschcowitz, in 1925, in which a 16 year old female was admitted to the hospital with an acute and fatal illness that included stroke and heart failure.
		Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome were once thought to represent opposite ends of the spectrum of the same disease process and are classified by some as thrombotic microangiopathy (TMA).
	www.about-ttp.com (823 words)

	s030303a - Thrombotic thrombocytopenic purpura (TTP) - HIV Infection
		Thrombotic thrombocytopenic purpura associated with human immunodeficiency virus infection: demonstration of p24 antigen in endothelial cells.
		Abstract: Thrombotic thrombocytopenic purpura (TTP) is a syndrome characterised by the clinical pentad of microangiopathic haemolytic anaemia (MAHA), thrombocytopenia, renal failure, fluctuating neurologic signs, and fever.
		The association of thrombotic thrombocytopenic purpura with HIV infection was judged to be statistically significant on the basis of the proportion of patients with AIDS among the general population of patients admitted to the same institution during the same period.
	www.emory.edu /WHSCL/grady/amreport/litsrch02/s030303a.html (2780 words)

	Purpura, Thrombotic Thrombocytopenic
		TTP is occasionally associated with pregnancy and collagen-vascular diseases (a group of diseases affecting connective tissue).
		Henoch-Shonlein purpura is one of a group of disorders characterized by purplish or brownish-red discolorations of the skin caused by abnormal bleeding into the skin and mucous membranes.
		Thrombotic thrombocytopenic purpura-like syndrome in the absence of schistocytes.
	hw.healthdialog.com /kbase/nord/nord653.htm (1908 words)

	Thrombotic thrombocytopenic purpura (TTP)
		Thrombotic thrombocytopenic purpura (TTP) is a rare blood condition characterised by the formation of small clots (thrombi) within the circulation, which results in the consumption of platelets and thus a low platelet count (thrombocytopenia).
		Most adult-onset TTP appears to be secondary to the development of an antibody that inhibits this enzyme activity, whereas the childhood form is due to a simple reduction in enzyme activity.
		TTP can occur in late pregnancy or even after the birth and as it can also cause high blood pressure TTP can sometimes be hard to distinguish from eclampsia.
	www.netdoctor.co.uk /diseases/facts/ttp.htm (2449 words)

	NIH Guide: THROMBOTIC THROMBOCYTOPENIC PURPURA AND HIV
		This Request for Application (RFA), Thrombotic Thrombocytopenic Purpura and HIV, is related to the priority areas of heart disease and stroke, and HIV infection.
		This has fueled the debate about whether the clinical manifestations of TTP result from a missing plasma factor that inhibits aggregation (which is replaced during plasma infusion) or a platelet aggregatory factor that is not normally present in plasma (which is removed during plasmapheresis).
		A recent controlled trial of plasma exchange versus plasma infusion in patient with TTP of all origins, except HIV infection, demonstrated the superiority of plasma exchange, although proponents of plasma infusion argue that plasma exchange merely allows a greater volume of plasma to be infused.
	grants.nih.gov /grants/guide/rfa-files/RFA-HL-95-007.html (2446 words)

	Thrombotic thrombocytopenic purpura : Epilepsy.com/Professionals
		TTP and hemolytic uremic syndrome (HUS), primarily a pediatric disorder, can be grouped as thrombotic microangiopathies.
		TTP is characterized by the pentad of microangiopathic hemolytic anemia, thrombocytopenia, neurologic symptoms, renal dysfunction, and fever.
		TTP must be included in the differential diagnosis of any patient with intravascular hemolysis caused by red cell fragmentation.
	professionals.epilepsy.com /page/hematologic_ttp.html (1065 words)

	Thrombotic Thrombocytopenic Purpura (Site not responding. Last check: 2007-10-16)
		Then a doctor at the hospital, a nephrologist, diagnosed my case as being TTP and recommended that I be transferred to a hospital in a nearby city (Lewisville, TX) to receive plasmapheresis treatments, the common method of treating TTP.
		Thrombotic Thrombocytopenic Purpura (TTP) is a rare blood disorder that usually develops as a result of a severe bacterial or viral infection elsewhere in the body, often as a result of an E. Coli infection.
		Left to progress unchecked, TTP is often fatal, and it very nearly killed me. Apparently, I was a victim of acute idiopathic (unknown-cause) TTP, although to this day I will swear that it was brought about as a result of a gallbladder inflammation due to cholelithiasis (gallstones) in the common bile duct.
	www.wizardrealm.com /personal/ttp.html (1473 words)

	Hemolytic-Uremic Syndrome (HUS) & Thrombotic Thrombocytopenic Purpura (TTP) - nephrologychannel
		Hemolytic-uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are microangiopathic disorders—that is, they are characterized by abnormalities (chiefly blood clots) that occur within the small blood vessels of the body.
		Although the exact cause(s) of HUS and TTP are unknown, experts believe that an abnormal, inflammatory reaction within the blood stimulates the deposition of platelet-rich thrombi.
		Purpura (bleeding into the tissues) sometimes can be seen in the skin, and patients often complain of tiredness due to anemia.
	www.nephrologychannel.com /hus_ttp (575 words)

	Symptoms of Thrombotic Thrombocytopenic Purpura (TTP)
		In the study published by Silverstein (1968), involving over 300 patients with Thrombotic Thrombocytopenic Purpura, 90% of the patients had neurologic involvement and the illness began as a neurologic one in 60% of the patients.
		In a more recently published study by Bakashi (1999), on 12 patients with Thrombotic Thrombocytopenic Purpura, clinical neuroimaging revealed a variety of brain lesions, which included reversible cerebral edema lesions which resembled RPLS (reversible posterior leukoencephalopathy syndrome) and were seen in patients with hypertension and renal dysfunction.
		Since TTP is a diffuse disease involving virtually every organ in the body, and because some of the patients studied had cardiac rhythm disturbances, as well as sudden cardiac arrest, it was important to investigate the potential effects of this disease on the heart and the conduction system.
	www.about-ttp.com /ttp_symptoms_risks.htm (1232 words)

	eMedicine - Thrombotic Thrombocytopenic Purpura : Article by Theodore Wun, MD
		In its full-blown form, the disease consists of the pentad of microangiopathic hemolytic anemia, thrombocytopenic purpura, neurologic abnormalities, fever, and renal disease.
		Patients with thrombotic thrombocytopenic purpura (TTP) should remain hospitalized until at least a partial response, such as resolution of altered mental status, improved platelet count, and reduced LDH with stable hemoglobin, is achieved.
		Peripheral smear from a patient with thrombotic thrombocytopenic purpura: Red blood cells are fragmented and appear as schistocytes.
	www.emedicine.com /MED/topic2265.htm (3950 words)

	October, 1998 - Thrombotic Thrombocytopenic Purpura Syndrome
		Thrombotic thrombocytopenic purpura (TTP) is a clinical syndrome which consists of microangiopathic hemolytic anemia, thrombocytopenia, and fever, along with a variable degree of renal insufficiency and fluctuating neurologic abnormalities.
		TTP occurs in a heterogeneous group of patients with an increased incidence and association with pregnancy, autoimmune conditions, infections, malignancy and certain medications.
		Clinical response to the management of TTP is dependent upon the etiology, with cancer and chemotherapy-associated TTP being less responsive to conventional therapy.
	www.itxm.org /TMU1998/tmu10-98.htm (985 words)

	Thrombotic Thrombocytopenic Purpura Associated with Bone Marrow Metastasis and Secondary Myelofibrosis in Cancer -- ...
		Thrombotic microangiopathy manifesting as thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in the cancer patient.
		Thrombotic thrombocytopenic purpura subsequent to acute myelogenous leukemia chemotherapy.
		Tsai H-M, Lian EC-Y. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura.
	theoncologist.alphamedpress.org /cgi/content/full/8/4/375 (2747 words)

	Postpartum Thrombotic Thrombocytopenic Purpura (TTP) Complicating Pregnancy-associated Immune Thrombocytopenic Purpura ...
		thrombocytopenic purpura and was successfully treated with plasmapheresis.
		Thrombotic microangiopathy in pregnancy and the postpartum period.
		The obfuscation of eclampsia by thrombotic thrombocytopenic purpura.
	www.annals.org /cgi/content/full/120/10/845 (788 words)

	Platelets: Thrombotic Thrombocytopenic Purpura -- George et al. 2002 (1): 315 -- Hematology
		ADAMTS13 deficiency, as was the thrombotic microangiopathy in
		Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura.
		Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome.
	www.asheducationbook.org /cgi/content/full/2002/1/315 (8579 words)

	Thrombotic Thromboctyopenic Purpura (via CobWeb/3.1 planetlab1.netlab.uky.edu) (Site not responding. Last check: 2007-10-16)
		In 1936, the subsequent report of 4 cases of disseminated arteriolar and capillary platelet thrombosis, by Baehr et al.
		Thereafter, the emphasis of reports on Thrombotic Thrombocytopenic Purpura was almost uniformly on the triad, consisting of thrombocytopenia purpura, hemolytic anemia, and varying neurologic manifestations.
		hereditary and recurrent TTP in children and adults, in which microangiopathy in the kidney is predominantly arterial, and hypertension is often severe;
	www.about-ttp.com.cob-web.org:8888 (823 words)

	Thrombotic Thrombocytopenic Purpura - Page 2
		Thrombotic thrombocytopenic purpura (TTP) is a rare and life-threatening blood disorder in which the blood cells that play a key role in blood clotting (platelets) are rapidly consumed by excessive clotting.
		Thrombocytopenic refers to a reduced number of platelets, otherwise known as thrombocytes.
		Purpura refers to the typical bleeding that occurs with this condition, especially in the mucous membranes or beneath the skin, often producing bruises or a rash-like appearance.
	heart.healthcentersonline.com /blooddisorders/TTP2.cfm (335 words)

	Thrombotic Thrombocytopenic Purpura and Systemic Lupus Erythematosus
		Thrombotic thrombocytopenic purpura (TTP) and systemic lupus erythematosus (SLE) are distinct entities that share many overlapping features.
		Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening syndrome characterized by the classic pentad of clinical features that includes microangiopathic hemolytic anemia, thrombocytopenia, neurologic abnormalities, fever, and renal dysfunction.
		This is the first case of simultaneous presentation of TTP and SLE in a male above 60 years of age.
	www.ispub.com /ostia/index.php?xmlFilePath=journals/ijim/vol5n2/ttp.xml (1381 words)

	Virginia Hospital Center - Thrombotic Thrombocytopenic Purpura
		TTP is a blood disorder characterized by low platelets, low red blood cell count (caused by premature breakdown of the cells), abnormalities in kidney function, and neurological abnormalities.
		Purpura -- purplish discolorations in the skin produced by small bleeding vessels near the surface of the skin
		In thrombotic thrombocytopenic purpura, this treatment is repeated daily until blood tests show improvement.
	www.virginiahospitalcenter.com /content/adam_000552.asp (426 words)

	Thrombotic Thrombocytopenic Purpurs
		Thrombotic thrombocytopenic purpura (TTP) is a condition caused by platelet aggregation in the microcirculation.
		TTP is a rare disorder that occurs in about 1 of 50,000 hospitalizations.
		It is not clear whether TTP is due to the presence of a procoagulant factor or the absence of a antithrombotic factor (Kaplan, 1999).
	learn.sdstate.edu /craigg/Mennenga.html (1936 words)

	Recent Advances in Thrombotic Thrombocytopenic Purpura -- Sadler et al. 2004 (1): 407 -- Hematology
		the diagnosis of recurrent TTP was uncertain because of coexisting
		Furlan M, Lammle B. Aetiology and pathogenesis of thrombotic thrombocytopenic purpura and haemolytic uraemic syndrome: the role of von Willebrand factor-cleaving protease.
		Role of splenectomy in patients with refractory or relapsed thrombotic thrombocytopenic purpura.
	www.asheducationbook.org /cgi/content/full/2004/1/407 (7064 words)

	TTP - Thrombotic Thrombocytopenic Purpura
		Their episodes of thrombotic thrombocytopenic purpura are reversed or prevented by the
		Some patients with acquired acute idiopathic thrombotic thrombocytopenic purpura and high titers of antibodies against ADAMTS 1397 do not respond to plasma exchange alone.
		PURPOSE: Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are uncommon disorders that are generally fatal if left untreated.
	members.tripod.com /enotes/ttp.htm (765 words)

	Thrombotic Thrombocytopenic Purpura: Overview (Site not responding. Last check: 2007-10-16)
		The purpose of this case is to define and summarize thrombotic thrombocytopenic purpura (TTP), emphasizing the importance of early diagnosis, treatment and management of patients with this life-threatening, multisystem disease.
		An additional purpose is to offer greater insight regarding the challenges that face emergency room (ER) clinicians who need to recognize the signs and symptoms of TTP among other symptomalogy of patients that come to the ER.
		This case may also interest patients with TTP who desire a better understanding of this disease.
	www.vhct.org /case2300/index.htm (215 words)

	NEJM -- Thrombotic Thrombocytopenic Purpura Associated with Clopidogrel
		Subacute coronary stent thrombosis in a patient developing clopidogrel associated thrombotic thrombocytopenic purpura.
		Thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome associated with clopidogrel: report of two new cases.
		Schuhlen, H., Kastrati, A., Pache, J.u., Dirschinger, J., Schomig, A. Incidence of thrombotic occlusion and major adverse cardiac events between two and four weeks after coronary stent placement: analysis of 5,678 patients with a four-week ticlopidine regimen.
	content.nejm.org /cgi/content/abstract/342/24/1773 (1265 words)

	purpura thrombocytopenic thrombotic
		purpura thrombocytopenic thrombotic, purpura thrombocytopenic treatment, cure for thrombocytopenic thrombotic, herbal purpura thrombocytopenic thrombotic remedy,
		Thrombotic thrombocytopenic purpura (TTP) is a rare blood condition characterised by the formation of small clots (thrombi) within the circulation, which results in the consumption of platelets and thus a low platelet count
		Most adult-onset TTP appears to be secondary to the development of an antibody that inhibits this
	www.drraomd.com /diseaseindex/b_blood_thrombotic.htm (773 words)

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