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Topic: Thromboxane

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  NEJM -- Thromboxane biosynthesis and platelet function in type II diabetes mellitus
We therefore compared the excretion of a thromboxane metabolite and platelet function in 50 patients with Type II diabetes mellitus who had normal renal function and clinical evidence of macrovascular disease and in 32 healthy controls.
The fractional conversion of exogenous thromboxane B2 (infused at a rate of 4.5, 45.3, or 226.4 fmol per kilogram of body weight per second) to urinary 11-dehydro-thromboxane B2 was assessed in four patients, in whom it averaged 5.4 +/- 0.1 percent; this value did not differ from that measured in healthy subjects.
Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study.
content.nejm.org /cgi/content/abstract/322/25/1769   (2086 words)

  Thromboxane definition - Medical Dictionary definitions of popular medical terms
Thromboxane: A substance made by platelets that causes blood clotting and constriction of blood vessels.
Thromboxane A2 (TXA2) is active but is very unstable and has a half-life of only 30 seconds before it undergoes hydrolysis to form thromboxane B2 (TXB2) which is inactive.
The thromboxanes are derived from arachidonic acid and are related to prostaglandin.
www.medterms.com /script/main/art.asp?articlekey=32482   (213 words)

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