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Topic: Thromboxane A2

    Note: these results are not from the primary (high quality) database.

Abstract Thromboxane A2 generation by platelets interacting with immobilized fibrinogen was blocked by wortmannin and LY294002, inhibitors of PI-3 kinase. Thromboxane A2 generation was also inhibited by piceatannol, a Syk-selective inhibitor. ADP did not potentiate thromboxane A2 generation under these conditions, and the ADP receptor antagonists, MRS-2179 or AR-C69931MX, also did not have any effect on thromboxane generation on fibrinogen-coated plates. www.blackwellpublishing.com /isth2003/abstract.asp?id=8890   (326 words)

Assessment of Thromboxane B2, Prostaglandin I2 (6 Ketoprosta-glandin), and cyclic AMP in patitMnts with ischemic heart disease Thromboxane A2 may play a role in coronary arterial spasm, unstable angina, myocardial infarction, cardiac arrhythmias, and sudden death. Previous studies have demonstrated increases in transcardiac thromboxane B2 (a stable thromboxane A2 metabolite) in patients with unstable angina and recent chest pain, but not in those with stable ischemic heart disease or non-ischemic chest pain syndromes (4). Thromboxane A2 exerts powerful effects on vascular smooth muscle tone and platelet aggregability. www.egyptheart.org /EHJ1/EHJ1/ehj5001p083.htm   (3378 words)

Researchers work to block blood vessel growth in tumors Blockers of the thromboxane A2 receptor might be effective in situations when COX-2 inhibitors are not,” Daniel said. Combinations of drugs attacking different parts of the angiogenesis process, such as thromboxane A2 receptor antagonists and COX-2 inhibitors, may have fewer side effects and be more effective than standard chemotherapy. Thromboxane A2 receptor-directed drugs may offer advantages over COX-2 inhibitors alone in blocking tumor angiogenesis. www.vanderbilt.edu /News/register/Sept27_99/story10.html   (593 words)

16334.050224&ELEMENT_SET=DECL Thromboxane A2 receptor antagonists that may be used in the compositions include 7-oxabicycloheptane substituted prostaglandin analogs such as those described in U. 5,100, 889, benzenealkonic acids and benzenesulfonamide derivatives, typically at 1-1000 mg per unit dose and 1-5000 mg per day. The method of claim 36, wherein said thromboxane A2 receptor antagonist is a 7- oxabicycloheptane substituted prostaglandin analog; a benzenealkonic acid; or a benzenesulfonamide derivative. The method of claim 30, wherein said thromboxane A2 receptor antagonist is a 7- oxabicycloheptane substituted prostaglandin analog; a benzenealkonic acid; or a benzenesulfonamide derivative. www.wipo.int /cgi-pct/guest/getbykey5?KEY=05/16334.050224&ELEMENT_SET=DECL   (3921 words)

Effects of antiplatelet agents on pulmonary haemodynamic response to fMLP in endotoxin primed rats -- Song et al. 59 (1): 39 -- Thorax Thromboxane A2 receptor activation elicits organ-specific increases in microvascular permeability in the rat. Thromboxane A2 mediates increased pulmonary microvascular permeability after intestinal reperfusion. Thromboxane A2 stimulated signal transduction in vascular smooth muscle. thorax.bmjjournals.com /cgi/content/full/59/1/39   (3655 words)

BioCarta - Charting Pathways of Life (2002) Role of prostacyclin in the cardiovascular response to thromboxane A2. Intracellular calcium increases induced by thrombin activates phospholipase A2, liberating arachidonic acid, the first step in prostaglandin and thromboxane biosynthesis. Thromboxane is a potent vasoconstrictor and platelet activator, so inhibition of Cox-1 in platelets by aspirin may explain some of the cardioprotective actions of aspirin. www.biocarta.com /pathfiles/h_sppaPathway.asp   (295 words)

Thromboxane synthase immunohistochemistry in inflammatory bowel disease -- Carty et al. 55 (5): 367 -- Journal of Clinical Pathology Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis. Thromboxane A2 biosynthesis in human lung fibroblasts WI-38. Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease. jcp.bmjjournals.com /cgi/content/full/55/5/367   (2204 words)

NEJM -- Effect of cholesterol on production of thromboxane b2 by platelets in vitro These platelets were then used to study the influence of cholesterol content on the metabolism of arachidonic acid, a fatty acid that serves as the critical precursor in the platelet for formation of the potent aggregating agent thromboxane A2. Conversion of released arachidonic acid to platelet thromboxane B2 (the stable end product of thromboxane A2) was also higher in cholesterol-rich platelets (22.6 +/- 3.9 per cent) than in cholesterol-depleted platelets (13.8 +/- 2.7 per cent). These studies show that changes in the cholesterol content of human platelets in vitro have a significant effect on platelt metabolism of arachidonic acid. content.nejm.org /cgi/content/short/302/1/6   (408 words)

Encyclopedia: Thromboxane Low-dose long-term aspirin irreversibly blocks formation of thromboxane A2 in platelets, producing an inhibitory affect on platelet aggregation, and this blood thinning property makes it useful for reducing the incidence of heart attacks. Thromboxane is a member of the family of lipids known as eicosanoids. The cyclooxygenase pathway produces thromboxane, prostacyclin and prostaglandin D, E and F. The lipoxygenase pathway is active in leukocytes and in macrophages and synthesises leukotrienes. www.nationmaster.com /encyclopedia/Thromboxane   (536 words)

Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study -- Neri Serneri et al. 25 (20): 1845 -- European Heart Journal Thromboxane (Tx) A2 receptor blockade and TxA2 synthase inhibitor alone and in combination: comparison of antiaggregatory efficacy in human platelets Br. Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study -- Neri Serneri et al. synthase and of platelet thromboxane and endoperoxide receptors, eurheartj.oxfordjournals.org /cgi/content/full/25/20/1845   (4559 words)

STORY OF LOW-DOSE ASPIRIN: ITS POTENTIAL USE IN OBSTETRICS BY WAY OF INFLUENCING THROMBOXANE AND PROSTACYCLIN:15(2):Editorial Modulation of human platelet adenyl cyclase by prostacyclin and thromboxane A2. Thromboxane, however, is synthesized in the platelets and the enzyme responsible for their synthesis is cyclooxygenase. This tilt of the balance toward thromboxane is attributable to the vascular occlusions associated with reduced uteroplacental perfusion, abnormal platelet characteristics and uteroplacental arterial thrombosis resulting in placental infarctions. www.kfshrc.edu.sa /annals/152/ed9433ar.html   (2322 words)

Thromboxane A2 modulates the fibrinolytic system in glomerular mesangial cells -- Coffman et al. 275 (2): 262 -- AJP - Renal Physiology Thromboxane stimulation of mesangial fibronectin synthesis is signalled by protein kinase C and modulated by cGMP. The role of thromboxane in the pathogenesis of acute renal failure. Glomerular prostaglandin and thromboxane synthesis in rat nephrotoxic serum nephritis. ajprenal.physiology.org /cgi/content/full/275/2/F262   (3884 words)

NEJM -- Thromboxane biosynthesis and platelet function in type II diabetes mellitus Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID study. The fractional conversion of exogenous thromboxane B2 (infused at a rate of 4.5, 45.3, or 226.4 fmol per kilogram of body weight per second) to urinary 11-dehydro-thromboxane B2 was assessed in four patients, in whom it averaged 5.4 +/- 0.1 percent; this value did not differ from that measured in healthy subjects. We therefore compared the excretion of a thromboxane metabolite and platelet function in 50 patients with Type II diabetes mellitus who had normal renal function and clinical evidence of macrovascular disease and in 32 healthy controls. content.nejm.org /cgi/content/abstract/322/25/1769   (1773 words)

Adenosine diphosphate (ADP)-induced thromboxane A2 generation in human platelets requires coordinated signaling through integrin alpha IIbbeta 3 and ADP receptors -- Jin et al. 99 (1): 193 -- Blood The aggregation tracings are representative of the data from 3 independent experiments, and the corresponding thromboxane B During the preparation of washed platelets, ADP is released from damaged cells and activated platelets. The data are derived from at least 3 independent experiments in triplicate and analyzed as in Figure 1. www.bloodjournal.org /cgi/content/full/99/1/193   (4075 words)

Thromboxane definition - Medical Dictionary definitions of popular medical terms Thromboxane A2 (TXA2) is active but is very unstable and has a half-life of only 30 seconds before it undergoes hydrolysis to form thromboxane B2 (TXB2) which is inactive. The thromboxanes are derived from arachidonic acid and are related to prostaglandin. Thromboxane: A substance made by platelets that causes blood clotting and constriction of blood vessels. www.medterms.com /script/main/art.asp?articlekey=32482   (254 words)

OriGene - Antibodies - Thromboxane A2 Receptor (TBXA2R) The thromboxane A2 receptor (TBXA2R) is a member of the Prostanoid Receptor subfamily. Thromboxane A2 has been implicated in myocardial infarct, stroke, and asthma. TBXA2R performs an essential role in hemostasis by interacting with thromboxane A2 to induce platelet aggregation. www.origene.com /antibody/TA200126.aspx   (173 words)

Journal of Cerebral Blood Flow & Metabolism - Involvement of Thromboxane A2 in the Mediation of the Contractile Effect Induced by Inhibition of Nitric Oxide Synthesis in Isolated Rat Middle Cerebral Arteries Previous studies have shown constitutive thromboxane release from cerebrovascular endothelial cells (Spatz et al., 1997). Maintenance of a resting vasodilatory tone, however, may not be the only physiologic function of NO mediated by suppression of thromboxane release. Nevertheless, the contractile effect of L-NA was recently found to be more than two times stronger in lamb coronary arteries than that of ODQ, indicating the presence of a cyclic GMP-independent component in the effect of endogenous NO (Simonsen et al., 1997). www.nature.com /jcbfm/journal/v18/n6/full/9590399a.html   (1868 words)

Necessity of Thromboxane A2 for Initiation of Platelet-Mediated Contact Sensitivity: Dual Activation of Platelets and Vascular Endothelial Cells -- Mitsuhashi et al. 166 (1): 617 -- The Journal of Immunology Necessity of Thromboxane A2 for Initiation of Platelet-Mediated Contact Sensitivity: Dual Activation of Platelets and Vascular Endothelial Cells -- Mitsuhashi et al. Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. The source of thromboxane and prostaglandin in experimental inflammation. www.jimmunol.org /cgi/content/full/166/1/617   (4658 words)

Adenosine diphosphate (ADP) does not induce thromboxane A2 generation in human platelets -- Cattaneo et al. 99 (10): 3868 -- Blood Adenosine diphosphate (ADP) does not induce thromboxane A2 generation in human platelets-- Cattaneo et al. The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionized calcium. thromboxane generation is greatly enhanced and can be seen in www.bloodjournal.org /cgi/content/full/99/10/3868   (1260 words)

Involvement of thromboxane A2 in airway mucous cells in asthma-related cough -- Xiang et al. 92 (2): 763 -- Journal of Applied Physiology Involvement of thromboxane A2 in airway mucous cells in asthma-related cough -- Xiang et al. The protein was loaded on SDS-polyacrylamide gel, transferred onto a polyvinylidene difluoride membrane, and immunoblotted with anti-human thromboxane synthetase (TxS) antibodies at a dilution of 1:20. The aim of this study was to elucidate the role of thromboxane A jap.physiology.org /cgi/content/full/92/2/763   (3976 words)

Role of serotonin in thromboxane A2-induced coronary chemoreflex -- Wacker et al. 284 (3): 867 -- AJP - Heart and Circulatory Physiology Cardiopulmonary responses to HCl infusion are mediated by thromboxane A2 but not by serotonin. Release of prostaglandins and thromboxanes into the coronary circulation in patients with ischemic heart disease. Likewise, thromboxane may also be important in stimulating nerves during ischemia. ajpheart.physiology.org /cgi/content/full/284/3/H867   (5593 words)

Gene Transfer of Thromboxane A2 Synthase and Prostaglandin I2 Synthase Antithetically Altered Tumor Angiogenesis and Tumor Growth -- Pradono et al. 62 (1): 63 -- Cancer Research Gene Transfer of Thromboxane A2 Synthase and Prostaglandin I2 Synthase Antithetically Altered Tumor Angiogenesis and Tumor Growth -- Pradono et al. Thromboxane A2 Receptor Agonists Antagonize the Proangiogenic Effects of Fibroblast Growth Factor-2: Role of Receptor Internalization, Thrombospondin-1, and {alpha}v{beta}3 Thromboxane A2 Receptor Signaling Inhibits Vascular Endothelial Growth Factor-Induced Endothelial Cell Differentiation and Migration cancerres.aacrjournals.org /cgi/content/full/62/1/63   (2505 words)

Thromboxane A2 Limits Differentiation and Enhances Apoptosis of Cultured Human Trophoblasts -- YUSUF et al. 50 (2): 203 -- Pediatric Research Thromboxane A2 Limits Differentiation and Enhances Apoptosis of Cultured Human Trophoblasts -- YUSUF et al. Ogletree ML, Allen GT 1992 Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. Nicolaou KC, Magolda RL 1982 Synthesis of stable thromboxane A www.pedresearch.org /cgi/content/full/50/2/203   (3330 words)

Effect of a Thromboxane A2 Antagonist on Sputum Production and Its Physicochemical Properties in Patients With Mild to Moderate Asthma -- Tamaoki et al. 118 (1): 73 -- Chest Involvement of thromboxane A2 in airway mucous cells in asthma-related cough Effect of a Thromboxane A2 Antagonist on Sputum Production and Its Physicochemical Properties in Patients With Mild to Moderate Asthma -- Tamaoki et al. Study objective: To determine the effects of a specific thromboxane www.chestjournal.org /cgi/content/full/118/1/73   (3066 words)

Castration reduces platelet thromboxane A2 receptor density and aggregability -- Ajayi and Halushka 98 (5): 349 -- QJM Castration reduces platelet thromboxane A2 receptor density and aggregability -- Ajayi and Halushka 98 (5): 349 -- QJM response to thromboxane mimetics in healthy male volunteers. Address correspondence to Professor A.A.L. Ajayi, Department of Medicine, Baylor College of Medicine, 6565 Fannin Street, Houston, Texas 77060, USA. qjmed.oxfordjournals.org /cgi/content/abstract/98/5/349   (268 words)

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