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Topic: Thromboxane B2

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NEJM -- Thromboxane biosynthesis and platelet function in type II diabetes mellitus The fractional conversion of exogenous thromboxane B2 (infused at a rate of 4.5, 45.3, or 226.4 fmol per kilogram of body weight per second) to urinary 11-dehydro-thromboxane B2 was assessed in four patients, in whom it averaged 5.4 +/- 0.1 percent; this value did not differ from that measured in healthy subjects. Tight metabolic control achieved with insulin therapy reduced the levels of 11-dehydro-thromboxane B2 by approximately 50 percent. We therefore compared the excretion of a thromboxane metabolite and platelet function in 50 patients with Type II diabetes mellitus who had normal renal function and clinical evidence of macrovascular disease and in 32 healthy controls. content.nejm.org /cgi/content/abstract/322/25/1769   (1773 words)

Assessment of Thromboxane B2, Prostaglandin I2 (6 Ketoprosta-glandin), and cyclic AMP in patitMnts with ischemic heart disease Neither the increase in thromboxane B2 levels nor the decrease in prostaglandin I2 levels correlated with the severity of coronary artery disease. Previous studies have demonstrated increases in transcardiac thromboxane B2 (a stable thromboxane A2 metabolite) in patients with unstable angina and recent chest pain, but not in those with stable ischemic heart disease or non-ischemic chest pain syndromes (4). Prostaglandins and thromboxane proved to be important in ischemic vascular disease, so attention directed at the correction of their pathologic imbalance. www.egyptheart.org /EHJ1/EHJ1/ehj5001p083.htm   (3378 words)

Aspirin resistance increases risk of death The researchers didn't find an association between 11-dehydro thromboxane B2 levels and stroke, but Eikelboom says this is probably due to the small number of stroke cases. When the researchers divided the cases and controls into quartiles based on 11-dehydro thromboxane B2 levels, those in the highest quartile had twice the risk for heart attack as those in the lowest quartile. In the study, patients taking aspirin who had a high level of thromboxane in their urine had a 3.5 times higher risk of cardiovascular death than patients who had the lowest level says Eikelboom, a clinical lecturer at the University of Western Australia, Royal Perth Hospital, Perth, Australia. www.americanheart.org /presenter.jhtml?identifier=3001556   (567 words)

Thromboxane as an Aid in the Diagnosis of Venous Thromboembolic Disease -- Lauder et al. 9 (5): 464 -- Academic Emergency Medicine thromboxane B2 in patients with venous thromboembolic disease. Thromboxane as an Aid in the Diagnosis of Venous Thromboembolic Disease -- Lauder et al. Thromboxane as an Aid in the Diagnosis of Venous Thromboembolic Disease www.aemj.org /cgi/content/abstract/9/5/464-a   (243 words)

Thromboxane synthase immunohistochemistry in inflammatory bowel disease -- Carty et al. 55 (5): 367 -- Journal of Clinical Pathology Picotamide inhibition of excess in vitro thromboxane B2 release by colorectal mucosa in inflammatory bowel disease. Thromboxane A2 receptor is highly expressed in mouse immature thymocytes and mediates DNA fragmentation and apoptosis. Effects of thromboxane synthase inhibition on in vivo release of inflammatory mediators in chronic ulcerative colitis. jcp.bmjjournals.com /cgi/content/full/55/5/367   (2204 words)

Thromboxane definition - Medical Dictionary definitions of popular medical terms Thromboxane A2 (TXA2) is active but is very unstable and has a half-life of only 30 seconds before it undergoes hydrolysis to form thromboxane B2 (TXB2) which is inactive. The thromboxanes are derived from arachidonic acid and are related to prostaglandin. Thromboxane: A substance made by platelets that causes blood clotting and constriction of blood vessels. www.medterms.com /script/main/art.asp?articlekey=32482   (254 words)

The Expression and Activity of Prostaglandin H Synthase-2 Is Enhanced in Trophoblast from Women with Preeclampsia -- Johnson et al. 82 (9): 3059 -- Journal of Clinical Endocrinology & Metabolism and thromboxane B2 by 5.6-fold in media from normal trophoblasts. One source of thromboxane is villous trophoblast (4, 5). the excess thromboxane from trophoblast in preeclampsia is secondary jcem.endojournals.org /cgi/content/full/82/9/3059   (2110 words)

Adenosine diphosphate (ADP) does not induce thromboxane A2 generation in human platelets -- Cattaneo et al. 99 (10): 3868 -- Blood The in vitro production of thromboxane B2 by platelets of diabetic patients is normal at physiological concentrations of ionized calcium. Adenosine diphosphate (ADP) does not induce thromboxane A2 generation in human platelets-- Cattaneo et al. thromboxane generation is greatly enhanced and can be seen in www.bloodjournal.org /cgi/content/full/99/10/3868   (1260 words)

NEJM -- Effect of cholesterol on production of thromboxane b2 by platelets in vitro Conversion of released arachidonic acid to platelet thromboxane B2 (the stable end product of thromboxane A2) was also higher in cholesterol-rich platelets (22.6 +/- 3.9 per cent) than in cholesterol-depleted platelets (13.8 +/- 2.7 per cent). These platelets were then used to study the influence of cholesterol content on the metabolism of arachidonic acid, a fatty acid that serves as the critical precursor in the platelet for formation of the potent aggregating agent thromboxane A2. These studies show that changes in the cholesterol content of human platelets in vitro have a significant effect on platelt metabolism of arachidonic acid. content.nejm.org /cgi/content/short/302/1/6   (408 words)

Thromboxane B2 ELISA > TXB2 ELISA > Assay Kit > Assay Designs Thromboxane B2 ELISA > TXB2 ELISA > Assay Kit > Assay Designs One of the major compounds produced by activated platelets, Thromboxane A in vivo is typically monitored by measurement of the stable non-enzymatic hydration product Thromboxane B www.assaydesigns.com /products/catalog/immuno_assay/product_TXB2.htm   (118 words)

IZOTOP 11-dehydro-Thromboxane B2 radioimmunoassay kit Extrarenal thromboxane biosynthesis can be most reliably monitored by measuring urinary 11-dehydro-TXB , is accepted to be the relevant parameter of systemic thromboxane production. This is clearly assisted by setting up the present RIA system, which combines a high-specific-activity radioiodinated tracer with a sensitive polyclonal rabbit antiplasma. www.izotop.hu /immuno/rk67m_r.htm   (144 words)

Glutathione thromboxane by thromboxane B2, and prostacyclin by 6-keto-prostaglandin thromboxane and oxygen radicals, which increase lipid peroxides. thromboxane were significantly higher in preeclamptic than in normal www.cfsn.com /gsh62.html   (1443 words)

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