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Topic: Tirap

In the News (Thu 10 Dec 09)

Northern Trust

Marvin Harrison

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Penelope Cruz

Mickey Rourke

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Danny Boyle

Hugh Jackman

	Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways
		However, the relative roles of the TLR4 adaptor proteins TIRAP and TRIF and of the MyD88-dependent IL-1 and IL-18 receptor pathways in this response are unclear.
		Absence of LPS-induced bronchoconstriction in mice deficient for TIRAP or MyD88, not TRIF.
		Therefore, both TIRAP and MyD88 adaptors are essential for the synthesis of TNF, IL-12 p40 and of the chemokine KC upon aerogenic endotoxin administration.
	www.nature.com /labinvest/journal/v86/n11/full/3700473a.html (4942 words)

	Polyclonal Antibody, RABBIT ANTI MOUSE TIRAP
		Antisera to mouse TIRAP were raised by repeated immunisation of rabbits with highly purified antigen.
		TIRAP is one of a family of TIR domain-containing proteins which serve as adaptor proteins for the Toll-like receptors during the innate immune response.
		TIRAP is reported to participate in the MyD88-dependent signaling pathways shared by TLR2 and TLR4.
	www.serotec.com /asp/datasheet.asp?code=AHP866 (286 words)

	About District : Tirap (Site not responding. Last check: 2007-10-13)
		Tirap District derives its name from the river Tirap which originates in the district and flows through Changlang District of Arunachal Pradesh.
		The entire area of Tirap District is covered with high hills and deep gorges.
		Tirap District lies between the latitude 26º 38º N and 27º 47º N and the longitude 96º 16º E and 95º 40º E. The total area of the district is situated in a peculiar geographical setting bounded towards south of Myanmar.
	www.indianngos.com /districts/tirap_about.htm (531 words)

	BJP demands early panchayat polls in Tirap (Site not responding. Last check: 2007-10-13)
		The BJP in Arunachal has demanded the state government to hold panchayat polls in Tirap district immediately to enable people enjoy the fruits of development and for exercising their privileges and democratic rights at the grassroots.
		Referring to the rampant misutilisation of fund under Department of Tirap and Changlang (DoTC) meant for development at the grassroots level, Lowangcha called for minimizing the corruption through immediate conduct of Panchayat polls under the three-tier Panchayati Raj system as is being followed in 15 other districts of the state.
		When his attention was drawn to the government's claim in the Assembly recently that the people of the district preferred the existing system of chieftainship rather than panchayati raj and has adopted a wait and watch policy, Mr Lowangcha said the chieftainship was a dictatorial system and was almost abolished.
	news.webindia123.com /news/Articles/India/20060416/307844.html (227 words)

	Toll-like receptors: TIRAP it up - Cell Signaling Update - Signaling Gateway
		TIRAP functions downstream of TLR4 and, since its discovery in 2001, has been thought to be involved in a MyD88-independent signaling pathway.
		B and MAP-kinase, similar to MyD88-deficient mice, confirming that TIRAP is implicated in TLR4 signaling.
		Both papers conclude that TIRAP is not involved in TLR3, TLR5, TLR7, TLR9, IL-1 and IL-18 signaling pathways by showing that TIRAP (-/-) mice exhibit a normal response to activation of these receptors.
	www.signaling-gateway.org /update/updates/200211/su-0211-4.html (357 words)

	Innate immunity: Untangling the TLRs - Cell Signaling Update - Signaling Gateway (Site not responding. Last check: 2007-10-13)
		TIRAP is structurally similar to the adaptor protein MYD88, which links the TLRs and interleukin-1 receptors (IL-1Rs) to downstream signalling pathways.
		So, together, these papers show that TIRAP is dispensable for TLR3, TLR5, TLR7, TLR9 and IL-1R function, but has a specific role in TLR2 and TLR4 signal-transduction pathways.
		Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
	www.signaling-gateway.org /update/updates/200212/nri975.html (439 words)

	[No title]
		We had no fore warning of his arrival and all of us, including himself, are still in question as to his status except that some Chinese will frequent the station in the near future.
		Hkalak Ga was well south of the Ledo-North Tirap area, on the West Axis Trail, and it was the staging and final training area for the 3d Battalion, 112th Infantry, of the 38th Chinese Division.
		The Tirap chicken farm is not doing so well, two more are struggling for their last breath and Russ is tearing his hair out trying to keep the mortality rate down.
	history.amedd.army.mil /booksdocs/wwii/CrisisFleeting/bookone.htm (19895 words)

	Update news (Site not responding. Last check: 2007-10-13)
		The economic/peace package, which the people of Tirap and Changlang, the two insurgency affected districts have always called for, should have been initiated much earlier.
		Are being occupied by Khakhi uniforms in place of school uniform forcing the schools to close down for 2 (two) months, which may even stretch out and for how long.
		The saddest part of the story is that Mithi Government is treating the Tirap and Changlang districts of Arunachal Pradesh as alien.
	www.nscnonline.org /webpage/press_release/tichro_5_july_03.htm (528 words)

	Measles claim 49 lives in Arunachal's Tirap district (Site not responding. Last check: 2007-10-13)
		At least 49 deaths have been reported after a measles epidemic broke out at Pumao and Longkhao villages under Tirap district of Arunachal Pradesh from July 20 to October 3 last.
		Tirap district medical officer Dr N Ninu rushed to Pumao on October five last along with staff and distributed medicines, sources informed adding, most of the victims were reported to be children.
		Local MLA Thangwang Wangham has appealed to the medical department and district administration to initiate remedial measures to arrest the epidemic.
	news.webindia123.com /news/articles/Health/20061010/475149.html (189 words)

	Tirap district - Wikipedia, the free encyclopedia (via CobWeb/3.1 planet2.scs.cs.nyu.edu) (Site not responding. Last check: 2007-10-13)
		Since time in memorial, Tirap has been inhabited by ancestors of the indigenous tribes.
		The vibrant folk-culture of the indigenous tribes has attracted many tourists to visit Tirap.
		However, missionaries in Khonsa poses a major threat to the future of the indigenous tribes as the slow process of Christian proselytisation takes place.
	en.wikipedia.org.cob-web.org:8888 /wiki/Tirap_district (558 words)

	Rediff On The NeT: Tirap aboriginals demand autonomous region
		The long forgotten aboriginals of the Tirap, who occupy a contiguous area in Assam and Arunachal Pradesh which borders Myanmar, are clamouring for an autonomous area following decades of negligence and under development.
		The Tirap Frontier Tract, one of the least populated areas in the tip of north eastern India, is inhabited by a number of small aboriginal groups which are on the verge of extinction over pressure from non-tribals.
		Chao Prasanna Turung, the force behind the political mobilisation of these aboriginals, is apprehensive that at the rate at which their population is dwindling a number of sub clans would become extinct within the next decade.
	www.rediff.com /news/1999/may/24tirap.htm (351 words)

	Polyclonal Antibody to TIRAP/Mal (IN)
		In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling.
		Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-?B and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.
		Western blot analysis of TIRAP in MCF-7 cell lysate using IMG-5625 at 4 µg/ml.
	www.imgenex.com /antibody_details.php?catalog=IMG-5625 (259 words)

	TIRAP antibody (ab17218) datasheet (Site not responding. Last check: 2007-10-13)
		TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4.
		Store at +4°C. At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this TIRAP antibody is on this datasheet.
		TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis in endothelial cells.
	www.abcam.com /index.html?datasheet=17218 (475 words)

	TIRAP (Site not responding. Last check: 2007-10-13)
		Description This record contains information about the TIRAP (TIRAP) component in the context of.Information on the district administration and departments, telephone directory and important links.Two studies published in Nature show that the adaptor molecule TIRAP has a restricted role in a shared TLR2 and TLR4 signal-transduction pathway.net: Tirap.
		Description This record contains information about the TIRAP (TIRAP) component in the context of.TIRAP is a TIR domain containing adaptor involved in signaling downstream of TLR2 and TLR4.
		TIRAP can associate with MyD88.Two studies published in Nature show that the adaptor molecule TIRAP has a restricted role in a shared TLR2 and TLR4 signal-transduction pathway.TIRAP is a TIR domain containing adaptor involved in signaling downstream of TLR2 and TLR4.
	tirap-ugjwjzq.marmarineto.info /index.html (1324 words)

	Threat to Mithi government
		Then, as now, the disaffection against the government was centred in Tirap and Changlang districts, the area inhabited by Naga tribes where the Naga insurgency has substantial support.
		It is widely believed that Mukut Mithi secured the support of the faction of the NSCN headed by S.S. Khaplang to wean away legislators from Tirap and Changlang.
		An answer would be that during this period the issue of a political settlement on what may broadly be said the `Naga National Question' has become alive, with meetings and negotiations with the NSCN (I-M) initiated by the Government of India.
	www.hindu.com /thehindu/fline/fl2016/stories/20030815007213300.htm (519 words)

	New Hot Paper Comment by Masahiro Yamamoto & Shizuo Akira
		Initial in vitro studies indicated that TIRAP is specifically involved in TLR4-mediated signaling, including both the MyD88-dependent and the MyD88-independent pathways.
		Therefore, we concluded that TIRAP is not responsible for the MyD88-independent pathway, rather a molecule for the MyD88-dependent pathways shared by TLR2(TLR1/TLR6) and TLR4.
		The reason why this study has been highly cited is because this is the first evidence showing the involvement of a TIR domain-containing adaptor molecule other than MyD88 in fractionating the MyD88-dependent pathway as well as the existence of additional adaptor molecule(s) involved in the MyD88-independent pathway.
	www.esi-topics.com /nhp/2004/january-04-Yamamoto-Akira.html (731 words)

	Tibet, state, groups, McMahon, local, tribal, parts, control, British, Tirap, people, disputed, Category - Arunachal ... (Site not responding. Last check: 2007-10-13)
		Of late, Arunachal Pradesh faces threat from terrorist groups, notably the National Socialist Council of Nagalim (NSCN), who were believed to have base camps in the districts of Changlang and Tirap.
		Much of Arunachal Pradesh is covered by the Himalayas, although parts of Lohit, Changlang and Tirap are covered by the Patkai.
		Christianity is widely practiced by several Naga tribes in Changlang and Tirap adjacent to Nagaland.
	www.alphasearch.org /directory/Arunachal-Pradesh.html (1635 words)

	mouse/rat/human TIRAP antibody: purified antibody
		The polyclonal antibody reacts with human, mouse, and rat Toll-interleukin 1 receptor (TIR) domain-containing adapter protein, TIRAP, and was generated using 15 amino acid residues near the C-terminus of mouse TIRAP.
		TIRAP, a signaling adapter molecule also known as myeloid differentiation protein 88 adapter-like (Mal) is involved in the signaling pathway of TLR4.
		Rabbit anti-human, mouse, rat TIRAP poly has been tested by immunoblotting (WB) of human heart lysate (1-2ug/ml).
	www.ebioscience.com /ebioscience/specs/antibody_14/14-9058.htm (273 words)

	India Locations List - Tingpibung to Tirap River
		Tirap, Arunachal Pradesh, Second-order Administrative Division, Long: 96.5 Lat: 27.5
		Tirap, Arunachal Pradesh, Populated Place, Long: 95.8 Lat: 27.16667
		Tirap Frontier Tract, Arunachal Pradesh, Second-order Administrative Division, Long: 96.5 Lat: 27.5
	www.traveljournals.net /explore/india/locations/t/31.html (507 words)

	TIRAP (MAL, Toll-interleukin 1 Receptor Domain containing Adaptor Protein, TIRAP)
		It has 235 amino acids and is commonly seen as a 32-37 kD protein (4).
		Synthetic peptide corresponding to a portion of human TIRAP.
		This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
	www.usbio.net /Product.aspx?ProdSku=T5500 (265 words)

	GeneCard for TIRAP
		Browse Antibodies Central at Invitrogen for antibodies and assays
		Antibodies from Abcam (TIRAP), each with their Abpromise
		Applied Biosystems TaqMan ® Gene Expression Assays for TIRAP
	www.genecards.org /cgi-bin/carddisp.pl?gene=TIRAP (496 words)

	ExactAntigen tirap -- reagents, researchers, and patents (Site not responding. Last check: 2007-10-13)
		tirap known tirap monoclonal antibodies webpages for: tirap antibodies, tirap ELISA, tirap siRNA, tirap recombinant proteins
		(2002) The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors Nature 420:329-33.
		(2002) Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4 Nature 420:324-9.
	www.exactantigen.com /gene/tat/tirap.html (176 words)

	Mycobacterium Tuberculosis Heat Shock Proteins Use Diverse Toll-like Receptor Pathways to Activate Pro-inflammatory ...
		TIRAP inhibited LPS-, Mtb HSP65-, and Mtb HSP70-induced NF-
		B can be blocked by dominant negative MyD88 and dominant negative TIRAP.
		TIRAP (0.1 µg) as well as with reporter genes.
	www.jbc.org /cgi/content/full/280/22/20961 (4356 words)

	Send Flowers to Tirap - Fresh Flowers, Flower Tirap Florist Association (Site not responding. Last check: 2007-10-13)
		I should also thank Parul and Amar, for being patient and prompt in dealing with all the queries, any time of the day.It is very well appreciated.Above all 24hrs.customer care,great experience,wish you all the success."...
		We take your orders online and pass-on the order to the concerned top local florist where you want the delivery to maintain the same Freshness and Quality that can never be achieved in courier Deliveries.
		The Internet has given the Florists all over Tirap to serve a wider Clientele.
	www.indiafloristassociation.com /Arunachal_Pradesh/Tirap (282 words)

	Toll-Like Receptor 4 and Toll-IL-1 Receptor Domain-Containing Adapter Protein (TIRAP)/Myeloid Differentiation Protein ...
		DMSO was used to reconstitute the TIRAP-BP and control peptide, and incubation of cells with DMSO (without and with LPS) shows that there is no effect of DMSO on LPS stimulation.
		It has been reported that PKR is a downstream mediator of TIRAP signaling
		TIRAP: an adapter molecule in the Toll signaling pathway.
	www.jimmunol.org /cgi/content/full/169/10/5874 (5167 words)

	Common Interaction Surfaces of the Toll-Like Receptor 4 Cytoplasmic Domain Stimulate Multiple Nuclear Targets -- Ronni ...
		and the binding of MyD88 and TIRAP are sufficient for TLR4 signaling
		Bacterial lipopolysaccharide induces the association and coordinate activation of p53/56lyn and phosphatidylinositol 3-kinase in human monocytes.
		Drosophila MyD88 is an adapter in the Toll signaling pathway.
	mcb.asm.org /cgi/content/full/23/7/2543 (6448 words)

	‘Army failing to check entry of NSCN-IM in Arunachal’ (Site not responding. Last check: 2007-10-13)
		GUWAHATI, MAY 30: The general secretary and the member of the Union Territory Demand Committee of Tirap district, P Arangham and Wangja Lowang has alleged that the Army has failed to discover the infiltration of ISI backed NSCN(IM) into the Tirap district.
		Although, NSCN(IM) has no mass base with local support, it is bound to have a serious consequence in Arunachal where NSCN(K) have been existed for decades who as a matter of policy have been maintaining peace.
		It is irony that the fate of ongoing peace process in Tirap and Changlang will hang in uncertainity with the two factions clashing and Army will be something like silent observer who will gain nothing but loose in terms of honour and credibility.
	www.assam.org /news/ab/army_failing_to_check_entry_of_n.htm (307 words)

	Toll-IL-1 Receptor Domain-Containing Adaptor Protein Is Critical for Early Lung Immune Responses against Escherichia ...
		role of TIRAP signaling in the human system.
		this is the first study illustrating the crucial role of TIRAP
		Toll/IL-1R Domain-Containing Adaptor Protein (TIRAP) Is a Critical Mediator of Antibacterial Defense in the Lung against Klebsiella pneumoniae but Not Pseudomonas aeruginosa
	www.jimmunol.org /cgi/content/abstract/175/11/7484 (352 words)

	TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces ...
		TIRAP and TICAM-2, to its cytoplasmic domain that are indirectly
		b, alignment of the TIR domains of TICAM-2, TICAM-1, TIRAP, MyD88, and the TIR of TLR2.
		MyD88 and TIRAP did not block the TICAM-2-mediated activation
	www.jbc.org /cgi/content/full/278/50/49751 (6938 words)

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