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Topic: Tissue microarray

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	Tissue microarray - Wikipedia, the free encyclopedia
		Tissue microarrays (also TMAs) consist of paraffin blocks in which up to 1000 separate tissue cores are assembled in array fashion to allow simultaneous histological analysis.
		In the tissue microarray technique, a hollow needle is used to remove tissue cores as small as 0.6 mm in diameter from regions of interest in paraffin embedded tissues such as clinical biopsies or tumor samples.
		Tissue microarrays are particularly useful in analysis of cancer samples.
	en.wikipedia.org /wiki/Tissue_microarray (304 words)

	Tissue Microarray from Tissuemicroarray.com
		Tissue microarray Network provides maximum numbers of tissue array, tissue microarray of normal, malignant or metastatic formats, to validate the clinical relevance of potential biological targets in the development of new diagnostics, therapeutics and study new protein markers and genes
		Tissue microarray (TMA) or short term tissue array is a right tool for target validation by analyzing expression of genes and proteins in the multiple tissue samples (tens or hundreds of human tumor or normal).
		Precise pathology diagnosis - Every 10th sections of tissue microarray has been stained with H and E and viewed by two board certified pathologists to make sure the pathology diagnosis are concurrent and matched to the adjacent serial sections.
	tissuemicroarray.com (500 words)

	Oncogenomics: Tissue Microarray Analysis in Oncology Research: TMA Background
		Tissue Microarray technology is a novel bridging of advanced array-based approaches to data gathering with standardized Medical Pathology Laboratory practices.
		Tissue Microarray is a methodology developed to allow investigators to query up to 1000 patient samples simultaneously with up to a theoretical 300 assays.
		Although the above listed qualities of tissue microarray are grouped into "Advantages" and "Limitations", it must be stated that this technology was not designed to assay biological material in the same way or for the same needs/applications that DNA based microarray systems were developed.
	www.dartmouth.edu /~brenner/gene144-05/Gleeson_TMA_background.html (791 words)

	Validation of Tissue Microarray Technology in Breast Carcinoma
		A major obstacle to broad acceptance of microarrays is that they reduce the amount of tissue analyzed from a whole tissue section to a disk, 0.6 mm in diameter, that may not be representative of the protein expression patterns of the entire tumor.
		We compared the staining of 2 to 10 microarray disks and the whole tissue sections from which they were derived and determined that analysis of two disks is comparable to analysis of a whole tissue section in more than 95% of cases.
		We conclude that the tissue microarray technique, with 2-fold redundancy, is a valuable and accurate method for analysis of protein expression in large archival cohorts.
	info.med.yale.edu /labinvest/abstracts/00months/0012Dec/0012_1943.html (271 words)

	Beecher Instruments Tissue Microarray Technology
		Tissue microarray technology has been used in more than 200 scientific papers.
		The term tissue array could perhaps be most suitable for arrays containing relatively large specimens (also called tissue macroarrays) whereas the term "tissue microarray" is descriptive of the arrays made with small, 0.6 mm punches.
		For example, reagents and conditions that worked well with regular sections may not be optimal for tissue microarrays simply because tissue arrays contain many different tissues types on the same slide.
	www.beecherinstruments.com (374 words)

	Tissue microarray references 2003
		Dolled-Filhart, M., Camp, R. L., Kowalski, D. P., Smith, B. L., and Rimm, D. Tissue microarray analysis of signal transducers and activators of transcription 3 (Stat3) and phospho-Stat3 (Tyr705) in node-negative breast cancer shows nuclear localization is associated with a better prognosis.
		Conventional and tissue microarray immunohistochemical expression analysis of mismatch repair in hereditary colorectal tumors.
		Limitations of tissue microarrays in the evaluation of focal alterations of bcl-2 and p53 in whole mount derived prostate tissues.
	www.beecherinstruments.com /references2.html (2998 words)

	Cybrdi tissue array, Tissue Microarray and Tissue Array from Cybrdi, Inc.- Products
		CYBRDI manufactures hundreds of pre-developed human tissue arrays that can be used to survey hundreds or even thousands of clinical specimens in a single experiment using common probes, such as DNA, RNA, peptide, protein and antibodies.
		Tissue arrays permit for a rapid and large-scale molecular analysis of tissue specimens with various probes in parallel.
		Cybrdis tissue chip lines bridge the gap between genomics and drug discovery, and effectively decrease time and cost of the drug discovery processes.
	www.cybrdi.com /products.php (842 words)

	Tissue Microarrays
		Tissue microarrays (TMAs) are used to analyze the expression of genes simultaneously in multiple individual tissue samples on one slide.
		TMAs are composed of small 0.6 - 3.0 mm cores of tissue from donor tissue paraffin blocks which are arrayed at a high density on a slide.
		Tissue Microarrays have allowed tissue traditional analysis of conventional histologic paraffin blocks to become miniturized and high-throughput.
	www.microarraystation.com /tissue-microarray (586 words)

	Histology/Tissue Microarray (TMA) Protocols
		Summary: Tissue Microarrays (TMAs) or tissue array or tissue chips, originally described by in 1987 by Wan, Fortuna and Furmanski and popularized by Juha Kononen, is a powerful new technology for high throughput analysis of protein expression in a large number of tissue samples.
		Hundreds or thousands of tissue cores are arranged on a single slide, and then analyzed by a single immuno-staining or in situ hybridization reaction.
		The major problem of using tissue microarray is how to simultaneously examine each core at the microscope, know its identity and input the score in a database next to the correct identifier.
	www.protocol-online.org /prot/Histology/Tissue_Microarray__TMA_ (191 words)

	Cybrdi tissue array, Tissue Microarray and Tissue Array from Cybrdi, Inc.- Cybrdi Website Home
		By offering various high-quality tissue arrays in a format of single, paired, combined and multiple panels, CYBRDI enables scientists to identify, verify and validate molecules of diagnostic and therapeutic importance.
		Together with DNA (gene) array technique, tissue microarray technology is a powerful tool for the rapid analysis of molecular targets, discovery and assessment of new therapeutics, and determining prognosis of a disease.
		Cybrdi has developed more than 140 types of human tissue arrays including not only common tumors, such as colon cancer, prostate cancer, breast cancer, cervical cancer, ovarian cancer, lung cancer, stomach cancers, esophageal cancer, rectum cancer, kidney and liver cancer, etc., but also rare types of malignancies, e.g.
	cybrdi.com (374 words)

	Tissue array, Tissue microarray from USBiomax
		USBiomax has established a comprehensive and integrated system to collect various normal and diseased human tissues, and continuing throughout the manufacturing process of hundreds of tissue microarrays.
		By offering various high-quality tissue arrays in a format of single, paired, combined and multiple panels, USBiomax enables scientists to identify, verify and validate molecules of diagnostic and therapeutic importance.
		With DNA (gene) array technique, tissue microarray technology is a powerful tool for the rapid analysis of molecular targets, discovery and assessment of new therapeutics, and determining prognosis of a disease.
	usbiomax.com (294 words)

	BioMed Central \| Full text \| The tissue microarray data exchange specification: A community-based, open source tool for ... (Site not responding. Last check: 2007-10-12)
		Tissue Microarrays (TMAs) allow researchers to examine hundreds of small tissue samples on a single glass slide.
		Tissue Microarrays (TMAs), first introduced in 1998, are collections of hundreds of tissue cores arrayed into a single paraffin histology block [1].
		The source of tissue is only restricted by its availability in paraffin and ranges from cores of embedded cultured cells to tissues from any higher organism.
	www.biomedcentral.com /1472-6947/3/5 (4027 words)

	TMAscore - Quantitative Tissue Microarray Scoring
		TMAscore is image analysis software designed for quantitative Tissue Microarray scoring utilizing WebSlide virtual slides, operating either locally or across a network.
		When tissue microarray slides are scanned into virtual slides and placed on a network, multiple people can collaborate, visually score or use the quantitative measurements and the built in classifier to automatically score each core.
		The BLISS virtual slide scanner did this automatically during the scan and only scanned the core tissue on the slide ignoring the blank areas surrounding the cores.
	www.bacuslabs.com /tmascore.html (661 words)

	Tissue Microarray Analysis
		TMA analysis is accomplished with the automated tissue analysis approach discussed under Tissue Section Analysis.
		Using phantom contour analysis (a random stereological sampling approach) allows tissue maps to be drawn to show the diversity of expression levels for a specific tissue component.
		This approach allows for rapid identification of tissue elements in the array that are either high, moderate, or low expressors for multiple markers (two in the case shown above).
	www.compucyte.com /tissuemicroarray.htm (287 words)

	microarray
		The primary objective of TARP is to develop and disseminate Multi-Tumor Tissue Microarray slides and the related technology to the cancer research investigators.
		survey in 1999-2000 to construct a current portrait of the microarray field that reflects the ongoing dynamic changes in both microarray methodologies and instrumentation and reflects the expanding range of investigators utilizing the technology.
		Key objectives are to provide a guide to the rapidly developing resources and technology in genomics and its impact on biological research, to publish large datasets and extensive results that are not readily accommodated in traditional journals, and to help establish new standards and nomenclature for post-genomic biology.
	ihome.cuhk.edu.hk /~b400559/array.html (5894 words)

	US Tissue Array, Tissue Microarray Provider Listing
		US Tissue Array maintains website tissue-array.us for tissue microarray community for better understanding tissue array and it’s application in biomedical and biopharmaceutical field.
		Tissue array is a composite paraffin block that contains tens and hundreds
		arranging the punched tissue cores in a grid-like fashion in a tissue
	tissue-array.us (112 words)

	New ATA100 Tissue MicroArray Instrument from Chemicon
		Eugene Mechetner, Ph.D., VP, Discovery at CHEMICON International and one of the developers of the instrument, said, “It is not coincidental that Chemicon's new Tissue Arrayer was introduced to the cancer research community at the AACR Meeting.
		The most recent breakthroughs in cancer biology, diagnostics, prevention, and treatment were driven by the development of new approaches based on proteomic analyses of human and animal tissues.
		Chemicon's Tissue Arrayer will expand the company’s markets by providing our customers with an instrument that is complementary to our immunological and molecular biology technology platforms.
	www.chemicon.com /company/PR/Arrayer.asp (495 words)

	Tissue MicroArray Facility (Site not responding. Last check: 2007-10-12)
		In the tissue microarray technology, small tissue cylinders (diameter 0.6mm) are removed from hundreds formalin-fixed and paraffin-embedded different tumors (the donor blocks) and placed into a single empty "recipient" block, using a custom-built precision instrument (Tissue Arrayer - Beecher Instruments, Sun Prairie, WI 53590, USA - Kononen J, Bubendorf L, Kallioniemi A, et al.
		"Tissue microarrays for high-throughput molecular profiling of tumor specimens." Nat Med.
		The Tissue Microarrays allow hundreds of cores to be placed in a single paraffin block from which multiple slides can be sectioned
	www.ctg.queensu.ca /TissueBank/tissuemicroarray.htm (168 words)

	Frozen Tumor Tissue Microarray Technology for Analysis of Tumor RNA, DNA, and Proteins -- Schoenberg Fejzo and Slamon ...
		Tissue microarray technology is a new method used to analyze several
		of tissue and subsequent paraffin embedding circumvents formalin
		The tissue in the needle was kept frozen by holding the needle
	ajp.amjpathol.org /cgi/content/full/159/5/1645 (3640 words)

	Tissue Microarray Network
		TMA NET has been serving the Tissue Microarray community since Feb. 25, 2005.
		We specialize in building comprehensive information about producing tissue array, analyzing and interpreting results on immuniohistochemistry staining, in situ hybridization, and our staff offers quality and reliable service you can count on.
		Whether you need find sources of tissue microarray maker, or list your institution (or website) in our contents, we have what you need at prices you can afford.
	www.tissue-microarray.net (170 words)

	Yale Tissue Microarray Facility
		Whole mount tissue of the larynx cases from Dr. Lesnik,Dr. Sassaki
		Tissue from YTMA 21,52,48,58 as well as cell lines Oropharynx,ovarian,PFL,Laryngeal
		Blocks will be submitted in increments from Derm path.
	tissuearray.org /facility/inventory/list.php (103 words)

	CBCTR 1st Generation Breast Cancer Progression Tissue Microarray (TMA)
		The CBCTR has designed a breast cancer Tissue microarray (TMA) that can be used to investigate differences in prevalence of potential markers in three stages of invasive breast cancer: node-negative, node-positive and metastatic disease.
		Each array is created in quadruplicate to address possible tissue heterogeneity: four cores are taken from each specimen block, with one core per specimen appearing in each of the four replicate array blocks.
		NORMAL BREAST TISSUE: 40 cores (20 from individuals without breast cancer and 20 from individuals with breast cancer represented elsewhere on the TMA).
	cbctr.nci.nih.gov /tma.html (400 words)

	Tissue Microarray Network
		Tissue microarray Network provides maximum numbers of tissue array, tissue micro-array of normal, malignant or metastatic formats, to validate the clinical relevance of potential biological targets in the development of new diagnostics, therapeutics and study new protein markers and genes
		Single malignant tissue microarray with its matched normal or metastasis panel
		Tissue micro-array (TMA) or short term tissue array, also called tissue chip, is a tool for target validation by analyzing expression of genes and proteins in the multiple tissue samples (tens or hundreds of human tumor or normal).
	www.tissuemicroarray.net (99 words)

	Stanford TMA Consortium Web Portal -- Home
		Use GeneXplorer and CaseXplorer to interactively browse the Gene Microarray and Tissue Microarray data, including stained tissue cores.
		Apo D in Soft Tissue Tumors: A Novel Marker for Dermatofibrosarcoma Protuberans.
		Visit the web supplement to Nielsen et al., Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology.
	microarray-pubs.stanford.edu /tma_portal/index.shtml (474 words)

	White Rose Consortium ePrints Repository - TmaDB: a repository for tissue microarray data
		Sharma-Oates, A. Quirke, P. and Westhead, D.R. TmaDB: a repository for tissue microarray data.
		Background: Tissue microarray (TMA) technology has been developed to facilitate large, genome-scale molecular pathology studies.
		As a vast quantity of data can be generated in a single TMA experiment a systematic approach is required for the storage and analysis of such data.
	eprints.whiterose.ac.uk /archive/00000851 (462 words)

	Tissue MicroArray (TMA)
		Microarrays and the Genetic Analysis of Brain Tumors
		Tissue array slides for IHC and ISH studies
		Tissue Array Slides For In Situ Gene Expression Analysis
	www.ihcworld.com /tissuearray.htm (68 words)

	Tissue Microarray Service
		Numerous tissue arrays have been developed for translation studies, either through the Tissue Core by the automated tissue arrayer or by a histotechnologist in Dr. Giordano’s research laboratory.
		Together, tissues arrays have been constructed that represent the following tumor types:
		Since the development of this tissue array resource requires significant effort by a surgical pathologist, they are generally constructed under a collaborative agreement with Dr. Giordano or another pathologists rather than a pure service.
	www.pathology.med.umich.edu /giordano_lab/tms.htm (74 words)

	Demystified ... Tissue microarray technology -- Packeisen et al. 56 (4): 198 -- Molecular Pathology
		longterm tissue banking, and the continuing education of pathologists.
		Prognostic significance of expression patterns of c-erbB-2, p53, p16INK4A, p27KIP1, cyclin D1 and epidermal growth factor receptor in oesophageal adenocarcinoma: a tissue microarray study
		Pitfalls in immunohistochemical assessment of EGFR expression in soft tissue sarcomas
	mp.bmjjournals.com /cgi/content/abstract/56/4/198 (413 words)

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