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Topic: Tissue plasminogen activator

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	Tissue plasminogen activator - Wikipedia, the free encyclopedia
		In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3.4.21.68) that activates plasminogen, leading to fibrinolysis.
		Recombinant tPA is used in diseases which feature blood clots, such as myocardial infarction and stroke.
		Since tPA dissolves blood clots, there is risk of hemorrhage with its use.
	en.wikipedia.org /wiki/Tissue_plasminogen_activator (110 words)

	Tissue plasminogen activator is a potent activator of PDGF-CC
		Tissue plasminogen activator (tPA) is a serine protease involved in the degradation of blood clots through the activation of plasminogen to plasmin.
		The identification of tPA as an activator of PDGF signaling establishes a novel role for the protease in normal and pathological tissue growth and maintenance, distinct from its well-known role in plasminogen activation and fibrinolysis.
		In tumor tissue sections, PDGF-C expression was observed mostly in tumor cells located at the center of the tumor in close apposition to larger blood vessels, while tPA was mainly expressed in the endothelium of the tumor blood vessels (Figure 7E and F).
	www.nature.com /cgi-taf/DynaPage.taf?file=/emboj/journal/v23/n19/full/7600397a.html (7194 words)

	Tissue Plasminogen Activator Activity (Site not responding. Last check: 2007-10-18)
		Tissue-type Plasminogen Activator; Vascular Plasminogen Activator; Extrinsic Activator
		Tissue plasminogen activator (tPA) is a serine protease with a molecular weight of 70,000 Daltons that is present in plasma at a concentration of approximately 5 ug/L. tPA is primarily synthesized by endothelial cells.
		Tissue plasminogen activator, fibrin D-dimer, and insulin resistance in the relatives of patients with premature coronary artery disease.
	www.labcorp.com /datasets/labcorp/html/chapter/mono/nf10004490.htm (667 words)

	Recombinant Human Tissue Plasminogen Activator - ENZ-263 (Site not responding. Last check: 2007-10-18)
		Tissue plasminogen activator mediated blood-brain barrier damage in transient focal cerebral ischemia in rats: Relevance of interactions between thrombotic material and thrombolytic agent.
		The use of intravenous recombinant tissue plasminogen activator in acute ischemic stroke.
		Atorvastatin downregulates tissue plasminogen activator-aggravated genes mediating coagulation and vascular permeability in single cerebral endothelial cells cap tured by laser microdissection.
	www.prospec.co.il /~prospec/cart/catalog/rHuTPA.html (399 words)

	Recombinant tissue plasminogen activator following paediatric cataract surgery -- Mehta and Adams 84 (9): 983 -- ...
		TPA (tissue plasminogen activator) is secreted by the vascular endothelial cells as well as the corneal epithelium/endothelium
		Recombinant tissue plasminogen activator is a fibrinolytic serine protease that is genetically cloned and obtained by expression
		Postoperative fluctuation of tissue plasminogen activator (t-PA) in aqueous humor of pseudophakes.
	bjo.bmjjournals.com /cgi/content/full/84/9/983 (2087 words)

	MedlinePlus Medical Encyclopedia: Thrombolytic therapy
		These drugs, of which tPA is the most commonly used, mimic the function of natural tissue plasminogen activator (TPA).
		Physicians base their decisions about whether to give tPA for a heart attack on many factors, including a history of chest pain and the results of an ECG test.
		The decision to administer the drug is based upon the history, physical exam consistent with a significant stroke, and a brain CT scan to exclude bleeding.
	www.nlm.nih.gov /medlineplus/ency/article/007089.htm (986 words)

	Tissue plasminogen activator and seizures: a clot-buster's secret life -- Pawlak and Strickland 109 (12): 1529 -- ...
		tPA immunoreactivity is observed almost exclusively in the mossy fiber pathway (24), suggesting that it plays a particularly important role in conducting impulses from the mossy fibers to the Schaffer collaterals.
		because of tPA hyperactivity in the absence of this proteinase
		Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway.
	www.jci.org /cgi/content/full/109/12/1529 (1897 words)

	Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein -- ...
		Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent.
		Tissue plasminogen activator (tPA) deficiency exacerbates cerebrovascular fibrin deposition and brain injury in a murine stroke model: studies in tPA-deficient mice and wild-type mice on a matched genetic background.
		Sobey, C.G., and Cocks, T.M. Activation of protease-activated receptor-2 (PAR-2) elicits nitric oxide-dependent dilatation of the basilar artery in vivo.
	www.jci.org /cgi/content/full/112/10/1533 (6379 words)

	Localization and Regulation of the Tissue Plasminogen Activator-Plasmin System in the Hippocampus -- Sallés and ...
		Plasminogen is present at high concentrations in the blood and in the extracellular space of most tissues.
		Baranes D, Lederfein D, Huang YY, Chen M, Bailey CH, Kandel ER (1998) Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway.
		Krystosek A, Seeds NW (1981) Plasminogen activator release at the neuronal growth cone.
	www.jneurosci.org /cgi/content/full/22/6/2125 (6182 words)

	Tissue plasminogen activator (t-PA) for stroke
		Tissue plasminogen activator can be used to treat some people who are having a stroke caused by a blood clot (ischemic stroke
		Tissue plasminogen activator should be given within the first 3 hours after the first symptoms of stroke start.
		Effects of tissue plasminogen activator for acute ischemic stroke at one year.
	www.webmd.com /hw/stroke/hw224370.asp (721 words)

	Encyclopedia: Tissue plasminogen activator (Site not responding. Last check: 2007-10-18)
		In blood coagulation, tissue plasminogen activator (tPA) is an enzyme (EC 3.4.21.68
		A stroke or cerebrovascular accident (CVA) occurs when the blood supply to a part of the brain is suddenly interrupted by occlusion (an ischemic stroke- approximately 90%of strokes) or by hemorrhage (a hemorrhagic stroke - approximately 10% of strokes).
		A thrombus is the final product of blood coagulation, through the aggregation of platelets and the activation of the humoral coagulation system.
	www.nationmaster.com /encyclopedia/Tissue-plasminogen-activator (359 words)

	TPA Tissue Plasminogen Activator antibody [2A153] (ab21049) datasheet (Site not responding. Last check: 2007-10-18)
		If TPA Tissue Plasminogen Activator antibody [2A153] (ab21049) does not perform as described on this datasheet, notify us within 90 days of delivery using this form, so that we can help you or offer you a replacement or a refund.
		TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen.
		It specifically cleaves the Arg--Val bond in plasminogen to form plasmin, and is comprised of a heterodimer of chain A and chain B held by a disulfide bond.
	www.abcam.com /?datasheet=21049 (493 words)

	Tissue Plasminogen Activator (tPA)
		The sooner tPA or other appropriate treatment is begun, the better the chances for recovery.
		Administering tPA or other clot-dissolving agents is complex and is done through an intravenous (IV) line in the arm by hospital personnel.
		tPA or other thrombolytics can reduce disability from a heart attack or stroke, but there is also a higher risk of bleeding.
	www.americanheart.org /presenter.jhtml?identifier=4751 (303 words)

	NGC - NGC Summary
		Tissue plasminogen activator (t-PA) for acute ischemic stroke.
		This guideline updates a previous version: Daniel Freeman Memorial Hospital, Inc. Tissue plasminogen activator (t-PA) for acute ischemic stroke.
		Administration of tissue plasminogen activator (t-PA) must be initiated within 3 hours of the onset of symptoms.
	www.guideline.gov /summary/summary.aspx?doc_id=3422 (601 words)

	Expression of Active Human Tissue-Type Plasminogen Activator in Escherichia coli -- Qiu et al. 64 (12): 4891 -- Applied ...
		(B) The specific rate of plasminogen activation in soluble fractions from cells harvested 3 h after induction was measured by the indirect chromogenic assay.
		The tPA activity was determined by the indirect chromogenic assay.
		the tPA gene was fused to the OmpA leader peptide (29a).
	aem.asm.org /cgi/content/full/64/12/4891 (4398 words)

	Tissue Plasminogen Activator (Site not responding. Last check: 2007-10-18)
		The structures involved in the enzymatic domain are in the B chain.
		Therefore, plasminogen bound to fibrin in the clot will be preferentially activated over plasmin-ogen that is free in the plasma.
		The plasmin that is formed on the surface of fibrin within the clot has both of its lysine binding sites occupied and is protected therefore from rapid inactivation by alpha-2 antiplasmin (t 1/2 is about 10 to 100 seconds).
	www.umich.edu /~pharm660/AnticoagAntiplat/tsld085.htm (143 words)

	tissue plasminogen activator
		Naturally occurring substance in the body tissues that activates the enzyme plasmin that is able to dissolve blood clots.
		Human tPA, produced in bacteria by genetic engineering, has, like streptokinase, been used to dissolve blood clots in the coronary arteries of heart-attack victims.
		It has been shown to be more effective than streptokinase when used in conjunction with heparin, but it is much more expensive.
	www.tiscali.co.uk /reference/encyclopaedia/hutchinson/m0024890.html (116 words)

	tissue plasminogen activator (Site not responding. Last check: 2007-10-18)
		Tissue plasminogen activator is a naturally-occurring enzyme derived from DNA technology.
		The enzyme binds to fibrin-bound plasminogen at the site of an arterial clot, thus converting plasminogen to plasmin.
		Plasmin digests the fibrin strands of the clot and restores perfusion to the occluded artery.
	www.templejc.edu /dept/ems/drugs/tpa.html (176 words)

	Tissue Plasminogen Activator-mediated Fibrinolysis Protects Against Axonal Degeneration and Demyelination after Sciatic ...
		phenotype in tPA- or plasminogen-deficient mice was ameliorated
		Reich, E. Activation of plasminogen: a widespread mechanism for generating localized extracellular proteolysis.
		Involvement of Tissue Plasminogen Activator in Onset and Effector Phases of Experimental Allergic Encephalomyelitis
	www.jcb.org /cgi/content/full/149/5/1157 (5303 words)

	NEJM -- Tissue Plasminogen Activator for Acute Ischemic Stroke (Site not responding. Last check: 2007-10-18)
		NEJM -- Tissue Plasminogen Activator for Acute Ischemic Stroke
		Halloran, J. I., Bekavac, I. Unsuccessful Tissue Plasminogen Activator Treatment of Acute Stroke Caused by a Calcific Embolus.
		Graham, G. Tissue Plasminogen Activator for Acute Ischemic Stroke in Clinical Practice: A Meta-Analysis of Safety Data.
	content.nejm.org /cgi/content/abstract/333/24/1581 (8651 words)

	Modulation of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 by Transforming Growth Factor-{beta} ...
		Modulation of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 by Transforming Growth Factor-{beta} in Human Retinal Glial Cells -- Schacke et al.
		Modulation of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 by Transforming Growth Factor-ß in Human Retinal Glial Cells
		(1999) Vitreous concentrations of tissue plasminogen activator and tissue plasminogen activator inhibitor are associated with vascular endothelial growth factor in proliferative diabetic vitreoretinopathy Retina 19,383-389
	www.iovs.org /cgi/content/full/43/8/2799 (4201 words)

	UniProtKB/Swiss-Prot entry P00750 [TPA_HUMAN] Tissue-type plasminogen activator
		Ny T. Elgh F. Lund B. "The structure of the human tissue-type plasminogen activator gene: correlation of intron and exon structures to functional and structural domains.";
		: Increased activity of TPA causes hyperfibrinolysis, with excessive bleeding as a consequence.
		Tissue-type plasminogen activator chain A. Tissue-type plasminogen activator chain B. Fibronectin type-I. EGF-like.
	www.expasy.org /uniprot/P00750 (1439 words)

	Stroke Treatment Advances
		Anticoagulants (blood thinners) and aspirin are shown to be effective in lowering the risk of stroke in people with atrial fibrillation.
		The FDA approves the use of tissue plasminogen activator (tPA) to treat ischemic stroke in the first three hours following the onset of symptoms.
		tPA is one of several drugs that can dissolve the blood clots responsible for causing many strokes.
	www.americanheart.org /presenter.jhtml?identifier=4738 (563 words)

	► Thrombolytic therapy (tissue plasminogen activator - tPA)
		► Thrombolytic therapy (tissue plasminogen activator - tPA)
		TPA; Alteplase; Reteplase; Tenecteplase; Activase thrombolytic agent; Clot-dissolving agents; Reperfusion therapy
		Please refer to the stroke and heart attack articles for specific symptoms for both conditions.
	www.umm.edu /ency/article/007089.htm (893 words)

	p990908b - Tissue Plasminogen Activator (TPA) Guidelines (Site not responding. Last check: 2007-10-18)
		Title: Recombinant tissue-type plasminogen activator: current concepts and guidelines for clinical use in acute myocardial infarction.
		Abstract: The extraordinarily high prevalence of coronary heart disease, coupled with the alarming incidence of MI in Western society, has encouraged the investigation and development of pharmacologic agents that can be employed widely, quickly, effectively, and safely.
		Future investigations must continue to focus on patient selection to allow treatment for all patients who would derive benefit and to establish dosing regimens and adjuvant therapies that will maximize coronary reperfusion while concomitantly limiting reocclusion and hemorrhagic complications.
	www.emory.edu /WHSCL/grady/amreport/litsrch99/p990908b.html (201 words)

	TPA Tissue Plasminogen Activator antibody (ab9030) datasheet (Site not responding. Last check: 2007-10-18)
		EC 3.4.21.73, PLAU, UPAM, Urinary plasminogen activator, URK, Urokinase plasmino...
		WB EC 3.4.21.73, PLAU, UPAM, Urinary plasminogen activator, URK, Urokinase plasmino...
		WB TIMP 3, Tissue Inhibitor of Metalloproteinase 3
	www.abcam.com /?datasheet=9030 (1260 words)

	Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations (Site not responding. Last check: 2007-10-18)
		To investigate the role of tissue plasminogen activator (tPA) in retinal damage, tPA-deficient and wild-type mice were employed.
		In contrast, neither intravitreal KA or transient ischemia produced significant difference in retinal damage in tPA vs. wild-type mice.
		These data show that tPA-deficient mice are resistant to retinal damage by intravitreal injection of NMDA, and indicate that tPA plays a role in the retinal cell damage induced by excitotoxins, especially NMDA.
	www.osti.gov /energycitations/product.biblio.jsp?osti_id=20574318 (311 words)

	NGC - NGC Summary
		Literature searches were completed via MEDLINE and PubMed to determine if any new data exist on the process for patient selection and administration of tissue plasminogen activator (t-PA).
		Adverse effects of tissue plasminogen activator (t-PA), including intracranial hemorrhage (6% in clinical trials)
		After approval of the guideline via the Medical Staff Committee structure, the guideline was disseminated by the Nurse Managers to the appropriate unit personnel.
	www.guideline.gov /summary/summary.aspx?ss=15&doc_id=3422&nbr=2648 (1121 words)

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