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Topic: Tobramycin

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	Tobramycin (Ophthalmic) - MayoClinic.com (Site not responding. Last check: 2007-11-04)
		Ophthalmic tobramycin (toe-bra-MYE-sin) is used in the eye to treat bacterial infections of the eye.
		Tobramycin ophthalmic preparations may be absorbed into the eye.
		However, tobramycin is unlikely to pass into the breast milk in large amounts and little would be absorbed by the infant.
	www.mayoclinic.com /health/drug-information/DR202570 (1195 words)

	Drugs and Treatments - Tobramycin Sulfate IV - Patient Handout from WebMD
		Tobramycin belongs to a class of drugs known as aminoglycoside antibiotics.
		Before using tobramycin injection, tell your doctor or pharmacist if you are allergic to it; or to other aminoglycoside antibiotics (e.g., gentamicin, amikacin); or if you are allergic to sulfites; or if you have any other allergies.
		Tobramycin is not recommended for use during pregnancy.
	www.webmd.com /drugs/drug-16699-Tobramycin+Sulfate+IV.aspx?drugid=16699&drugname=Tobramycin+Sulfate+IV (1586 words)

	Howstuffworks "Tobramycin: A Profile of an Ophthalmic Antibiotic"
		Tobramycin ophthalmic is used for the short-term treatment of bacterial infections of the eyes.
		Tobramycin is an aminoglycoside antibiotic, which acts to prevent the growth and multiplication of infecting bacteria.
		Tobramycin should not interact with other medications as long as it is used according to directions.
	health.howstuffworks.com /define-tobramycin-ophthalmic.htm (895 words)

	tobramycin and dexamethasone ophthalmic - [Medication]
		Tobramycin and dexamethasone ophthalmic is used to treat bacterial infections of the eyes.
		Tobramycin and dexamethasone ophthalmic may also be used for purposes other than those listed in this medication guide.
		Tobramycin and dexamethasone ophthalmic is available with a prescription under the brand name Tobradex in suspension and ointment formulations.
	www.peacehealth.org /kbase/multum/d03536a1.htm (1203 words)

	Chiron Canada - TOBI - The History of Inhaled Antibiotics (Site not responding. Last check: 2007-11-04)
		Tobramycin, which was approved for parenteral administration over 25 years ago, is the most frequently prescribed aminoglycoside antibiotic for the treatment of pulmonary infections in CF patients.
		Tobramycin is frequently administered intravenously during periods of acute exacerbation of symptoms when patient's airways are more occluded than usual.
		Parenteral formulations of tobramycin are not approved for aerosolization anywhere in the world; therefore, a formulation designed specifically for inhalation was clearly needed.
	www.chironcanada.ca /aboutia.htm (240 words)

	MedlinePlus Drug Information: Tobramycin (Ophthalmic) (Site not responding. Last check: 2007-11-04)
		Ophthalmic tobramycin may be used alone or with other medicines for eye infections.
		There is no specific information comparing use of ophthalmic tobramycin in the elderly with use in other age groups.
		After using tobramycin eye ointment, wipe the tip of the ointment tube with a clean tissue and keep the tube tightly closed.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202570.html (1165 words)

	Tobramycin
		Tobramycin is an intravenous antibiotic which is used in treatment of severe infections.
		Tobramycin has been available for many years and its use is limited to infections that are resistant to routinely used antibiotics.
		Patients who are treated with Tobramycin should have frequent blood tests to monitor their kidney function tests as well as the Tobramycin level.
	tirgan.com /tobra.htm (122 words)

	Tobramycin(Ophthalmic) - [Medication] (Site not responding. Last check: 2007-11-04)
		Ophthalmic tobramycin toe-bra-MYE-sin is used in the eye to treat bacterial infections of the eye.
		However, tobramycin ophthalmic preparations have not been shown to cause birth defects or other problems in animals even when given at high doses.
		However, tobramycin is unlikely to pass into the breast milk in large amounts and little would be absorbed by the infant.
	www.luhs.org /health/kbase/htm/mdx-/drde/2025/70/mdx-drde202570.htm (1131 words)

	TOBRAMYCIN
		Tobramycin treatment was associated with a significant improvement in lung function compared to placebo.
		They occurred with a similar frequency in tobramycin and placebo treated patients and are common symptoms of CF.The only two adverse events reported significantly more frequently with tobramycin than placebo in clinical trials were tinnitus (3% vs 0%) and voice alteration (13% vs 7%).
		The recommended dosage schedule for nebulised tobramycin is repeated cycles of 300mg inhaled tobramycin twice daily for 28 days followed by a 28-day drug free period.
	www.keele.ac.uk /depts/mm/MTRAC/ProductInfo/verdicts/T/TOBRAMYCINv.html (497 words)

	Q-MED TOBRAMYCIN 20 mg/2 mL INJECTION; Q-MED TOBRAMYCIN 80 mg/2 mL INJECTION
		Tobramycin is an aminoglycoside antibiotic with bactericidal activity against gram negative aerobic organisms, including Pseudomonas aeruginosa which results mainly from inhibition of protein synthesis in susceptible micro-organisms.
		It may be given with an anti-pseudomonas penicillin or cephalosporin for the treatment of pseudomonas infections, with ampicillin or benzylpenicillin for enterococcal and streptococcal infections, or with metronidazole or clindamycin for mixed aerobic-anaerobic infections.
		Tobramycin possesses a neuromuscular blocking action and respiratory depression and muscular paralysis have been reported and care is required when another neuromuscular blocking agent is given concomitantly.
	home.intekom.com /pharm/quatrom/tobram.html (996 words)

	Tobramycin Sulfate
		Chemistry - An aminoglycoside derived from Streptomyces tenebrarius, tobramycin occurs as a white to off-white, hygroscopic powder that is freely soluble in water and very slightly soluble in alcohol.
		The inherent toxicity of the aminoglycosides limit their systemic use to serious infections when there is either a documented lack of susceptibility to other less toxic antibiotics or when the clinical situation dictates immediate treatment of a presumed gram negative infection before culture and susceptibility results are reported.
		Pharmacokinetics - Tobramycin, like the other aminoglycosides is not appreciably absorbed after oral or intrauterine administration, but it is absorbed from topical administration (not skin or urinary bladder) when used in irrigations during surgical procedures.
	www.elephantcare.org /Drugs/tobram.htm (1548 words)

	Tobramycin - Talk Medical
		Tobramycin inhalation is used to treat lung infections in patients with cystic fibrosis.
		Tobramycin is known to cause deafness in the baby when taken during pregnancy.
		Tobramycin stored at room temperature may become a darker color of yellow.
	www.talkmedical.com /medications/6101/Tobramycin (1002 words)

	Tobramycin And Dexamethasone(Ophthalmic) - [Medication] (Site not responding. Last check: 2007-11-04)
		Tobramycin toe-bra-MYE-sin and dexamethasone dex-a-METH-a-sone is a combination of an antibiotic and a corticosteroid kor-ti-ko-STER-oid.
		Breast-feeding—It is not known how much ophthalmic tobramycin and dexamethasone is absorbed into the body, or how much passes into breast milk.
		There is no specific information comparing use of ophthalmic tobramycin and dexamethasone in the elderly with use in other age groups.
	www.luhs.org /health/kbase/htm/mdx-/drde/2037/76/mdx-drde203776.htm (1035 words)

	Forschung/mukoviszidose/Tobramycin-Inhalation
		Patients with a known sensibilisation against tobramycin were excluded from the study.
		In 8 of these patients serum concentrations of tobramycin were measured one hour after inhalation.
		This findings are in agreement to prior experience with inhalation of the lower concentrated tobramycin solution of the same company.
	www.uniklinikum-giessen.de /pneumologie/Tobramycin_Inhalation.html (526 words)

	Tobramycin
		Tobramycin is usually administered by intravenous (i.v.) infusion, intramuscular (i.m.) injection, or inhalation.
		Calcium, magnesium, and potassium depletion requiring prolonged replacement were reported in a child with tetany who had just completed a three-week course of i.v.
		tobramycin should ask their doctor about monitoring calcium, magnesium, and potassium levels and the possibility of mineral replacement.
	www.gianteagle.com /healthnotes/Drug/Tobramycin.htm (941 words)

	CIGNA - loteprednol and tobramycin ophthalmic (Site not responding. Last check: 2007-11-04)
		Loteprednol and tobramycin ophthalmic is used to treat eye inflammation caused by surgery, infection, allergies, and other conditions.
		Loteprednol and tobramycin ophthalmic is in the FDA pregnancy category C. This means that it is not known whether loteprednol and tobramycin ophthalmic will be harmful to an unborn baby.
		An overdose of loteprednol and tobramycin ophthalmic is unlikely to threaten life.
	www.cigna.com /healthinfo/d05425a1.html (1453 words)

	Tobrex - Tobrex Side Effects - Tobrex Information - Canada Pharmacy - Canada Drugs
		Like other aminoglycosides, the bactericidal activity of tobramycin is accomplished by specific inhibition of normal protein synthesis in susceptible bacteria, but at the present time, very little is known about this action.
		Because the ocular concentrations of tobramycin achieved after topical application are higher than those which can be safely used in systemic therapy, standardized susceptibility tests may not be appropriate to predict its effectiveness.
		Lactation: Because of the potential for adverse reactions in nursing infants from tobramycin, a decision should be made whether to discontinue nursing the infant or discontinue the drug, taking into account the importance of the drug to the mother.
	www.rxcarecanada.com /Tobrex.asp?prodid=1713 (977 words)

	TOBRAMYCIN, Buy TOBRAMYCIN Online
		A remarkable drug that combats bacteria in the body, Tobramycin is effective in treating lung infections in cystic fibrosis sufferers.
		Listed in FDA pregnancy category D, Tobramycin is expected to cause adverse effects on the growing fetus by cause hearing impairment if taken during pregnancy.
		It is often seen that users of Tobramycin may experience sudden change in voice, unpleasant taste or odor of the medicine, irregular urination, quenching thirst, stomach upset, vomiting, lack of sensation, muscle cramp.
	www.drugdelivery.ca /s3834-s-TOBRAMYCIN.aspx (805 words)

	Inhaled Tobramycin : Nektar
		Tobramycin Inhalation Powder (TIP) is in development for the treatment of Pseudomonas aeruginosa, a type of bacteria that can cause infections and worsening of symptoms in some patients with cystic fibrosis.
		Cystic fibrosis is a chronic genetic disease that causes the body to produce thick mucus that can clog airways and result in chronic respiratory infections.
		This novel approach may allow patients to safely receive higher doses of tobramycin than would be safe to administer systemically.
	www.nektar.com /wt/page/inhaled_tobramycin (95 words)

	Acute renal failure associated with inhaled tobramycin -- Cannella and Wilkinson 63 (19): 1858 -- American Journal of ...
		Efficacy of aerosolized tobramycin in patients with cystic fibrosis.
		A randomized clinical trial of nebulized tobramycin or colistin in cystic fibrosis.
		Inhaled tobramycin in non-cystic fibrosis patients with bronchiectasis and chronic bronchial infection with Pseudomonas aeruginosa.
	www.ajhp.org /cgi/content/full/63/19/1858 (1531 words)

	Tobramycin injection
		Tobramycin is not absorbed from the gut and is therefore only given by injection or infusion (drip).
		To make sure the bacteria causing an infection are susceptible to tobramycin, your doctor may take a tissue sample, for example a swab from the skin, or a blood, urine or sputum sample.
		Tobramycin may oppose the effects of neostigmine and pyridostigmine, used to treat myasthenia gravis.
	www.netdoctor.co.uk /medicines/100001805.html (1024 words)

	Clinical Trial: The Tobramycin Study
		Evaluate if tobramycin given once a day is at least as efficacious as the traditional tobramycin given three times a day, given with penicillin G, til patients with febrile neutropenia.
		It has been questioned if tobramycin once a day is safe in patients with low levels of granulocytes when it is given with a drug like penicillin G which is not covering Gram-negative rods.
		Treatment of febrile neutropenia with penicillin G and an aminoglycoside is standard of care in Norway, and it is probably a regimen that is promoting antimicrobial resistance less than a broad spectrum beta-lactam.
	clinicaltrials.gov /ct/show/NCT00257790 (521 words)

	Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers - preliminary reports CHEST - Find ... (Site not responding. Last check: 2007-11-04)
		Peak tobramycin concentration in serum (Cmax) values were 0.6 [micro]g/mL with PStob and 0.28 [micro]g/mL after nebulized tobramycin.
		Capsules were filled with 25 mg of PStob powder that contained nominally 90% weight/weight tobramycin sulfate, corresponding to a potency of active tobramycin free base of 13.5 mg per actuation.
		Nebulized tobramycin was administered as directed using a hand-held PARI LC Plus Nebulizer (PARI GmbH; Starnberg, Germany) in combination with the PARI Master compressor over a period of 15 min, the time recommended by the manufacturer.
	www.findarticles.com /p/articles/mi_m0984/is_1_124/ai_106096400 (753 words)

	The use of nebulised TOBI (tobramycin) in cystic fibrosis (Site not responding. Last check: 2007-11-04)
		Despite tremendous advances in understanding the pathophysiology of cystic fibrosis (CF), chronic respiratory disease remains the principle clinical problem in caring for patients with CF[1] and continues to be the major cause of morbidity and mortality.
		Intermittent administration of inhaled tobramycin in patients with cystic fibrosis.
		Quittner AL, Buu A. Effects of tobramycin solution for inhalation on global ratings of quality of life in patients with cystic fibrosis and Pseudomonas aeruginosa infection.
	www.cysticfibrosismedicine.com /htmldocs/CFText/tobi.htm (1017 words)

	Once daily tobramycin in children (Site not responding. Last check: 2007-11-04)
		The pharmacodynamic benefits may be even more relevant in the treatment of acute pulmonary exacerbations of cystic fibrosis (CF) given the characteristics of tobramycin against Pseudomonas aeruginosa and the airway environment associated with CF.
		In a study of 18 CF patients given between 7-15mg/kg tobramycin as a single dose over 20 minutes, the derived pharmacokinetic data was compared to that from historical multiple daily dosing (3).
		Patients with CF admitted to the WCH for an acute pulmonary exacerbation are routinely treated with tobramycin given as a once-daily dose.
	www.cysticfibrosismedicine.com /htmldocs/CFText/odtob.htm (1523 words)

	Tobramycin (Ophthalmic)
		Tell your doctor if you have ever had any unusual or allergic reaction to ophthalmic tobramycin or to any related medicines, such as amikacin (e.g., Amikin), gentamicin (e.g., Garamycin), kanamycin (e.g., Kantrex), neomycin (e.g., Mycifradin), netilmicin (e.g., Netromycin), streptomycin, or tobramycin by injection (e.g., Nebcin).
		Tobramycin ophthalmic preparations may be absorbed into the eye.
		Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
	allnutritionals.com /drugs/t/tobramycin-ophthalmic.shtml (1162 words)

	Lilly: Tobramycin Sulfate Injection
		The initial intervention in a tobramycin overdose is to establish an airway and ensure oxygenation and ventilation.
		Patients who have received an overdose of tobramycin and who have normal renal function should be adequately hydrated to maintain a urine output of 3 to 5 mL/kg/hr.
		Tobramycin sulfate - Rabbit, 500 mg/kg, mortality, diarrhea.
	ehs.lilly.com /msds/msds_tobramycin_sulfate_injection.html (952 words)

	NEJM -- Efficacy of Aerosolized Tobramycin in Patients with Cystic Fibrosis
		tobramycin to the lower airways of patients with cystic fibrosis
		Drobnic, M E., Sune, P., Montoro, J B., Ferrer, A., Orriols, R. Inhaled Tobramycin in Non-Cystic Fibrosis Patients with Bronchiectasis and Chronic Bronchial Infection with Pseudomonas aeruginosa.
		Nikolaizik, W.H., Trociewicz, K., Ratjen, F. Bronchial reactions to the inhalation of high-dose tobramycin in cystic fibrosis.
	content.nejm.org /cgi/content/abstract/328/24/1740 (1419 words)

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