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Topic: Tocolytic

Related Topics

Atosiban

Premature labour

Nifedipine

Premature birth

Forceps

Episiotomy

Birth

	Preterm Labor
		Tocolytic treatment is more likely to be successful when preterm labor is recognized and treated right away.
		Tocolytic medications are helpful for delaying birth for up to a week, depending on the medication.
		During tocolytic treatment, a woman is usually on continuous fetal monitoring and has her blood pressure checked at least once an hour.
	hw.healthdialog.com /kbase/topic/major/hw222237/drugtrt.htm (443 words)

	eMedicine - Preterm Labor : Article by Edward R Newton, MD (Site not responding. Last check: 2007-10-08)
		Tocolytics are not indicated in patients with either symptomatic or asymptomatic intrauterine infection.
		Tocolytics are contraindicated in the presence of symptomatic upper genital tract infection.
		Contraindications to the specific tocolytics are aspirin-induced asthma, coagulopathy, and significant liver disease (indomethacin); use of calcium channel blockers or gentamicin, myasthenia gravis, and neuromuscular disorders (magnesium sulphate); and cardiac arrhythmia, valvular disease, and ischemic heart disease (beta-mimetics, eg, ritodrine and terbutaline).
	www.emedicine.com /med/topic3245.htm (5254 words)

	Preterm Labor -- Medications
		Tocolytic treatment is more likely to be successful when preterm labor is recognized and treated right away, before membranes have ruptured or the cervix has effaced and dilated beyond 4 cm().
		Certain tocolytic medications can be dangerous when a fetus is showing signs of distress or for women with certain health conditions (such as heart problems, severe preeclampsia, or poorly controlled diabetes or high blood pressure).
		Tocolytics aren't likely to work at all once membranes have ruptured or the cervix is well effaced and dilated at or beyond 4 cm().
	www.webmd.com /hw/being_pregnant/hw222496.asp?printing=true (625 words)

	Tocolytic - Wikipedia, the free encyclopedia
		Tocolytics are medications used to suppress premature labor (toco refers to contractions, and lytic to removal).
		During administration of tocolytic medications, the mother's condition and the fetal heart rate pattern will be closely monitored by a health care professional to determine effects the medication is having on the mother and fetus' well being.
		Magnesium sulfate is the most commonly used tocolytic agent.
	en.wikipedia.org /wiki/Tocolytic (293 words)

	Tocolytic treatment for the management of preterm labor: a review of the evidence - Publication - RTI International
		Our objective was to evaluate the evidence on the benefits and harms of five classes of tocolytic therapy for treating uterine contractions related to preterm labor--beta-mimetics, calcium channel blockers, magnesium, nonsteroidal anti-inflammatory agents, and ethanol.
		In contrast to other tocolytic treatments, maternal harms from beta-mimetics were rated High; all tocolytics were rated as Low risk for short-term neonatal harms.
		Among the tocolytics, however, beta-mimetics appear not to be better than other drugs and pose significant potential harms for mothers; ethanol remains an inappropriate therapy.
	www.rti.org /abstract.cfm?pubid=1079 (433 words)

	OBLink Preterm Labor Resource - Tocolytics by Professor Peter Husslein
		This is due, in part, to the complex aetiology of preterm labour, and the limited ability of tocolytic agents to prolong pregnancy as a result of limited efficacy and poor safety profiles.
		Conventional tocolytic agents have been able to demonstrate a prolongation of pregnancy only for short periods of time, up to a maximum of 48 hours, and their use is further restricted by poor safety profiles.
		The principal objective is to delay pre-term labour for 48 hours, which allows maternal transfer to a perinatal centre with a delivery room adjacent to a neonatal intensive care unit (NICU) and the time to administer a full course of corticosteroids to promote fetal lung maturation.
	www.oblink.com /display.asp?page=articles_0309_hussein-tocolytics (277 words)

	Preterm Labor -- Treatment Overview
		For example, once your cervix is well effaced (thinned) and dilated (opened) beyond 4 cm(), tocolytic medication to slow labor is less likely to be effective.
		The benefit of the tocolytic medications used to delay labor versus their risks to you and your fetus.
		Tocolytic medications can be effective for delaying delivery for 1 to 2 days so that other medication (antenatal corticosteroids) can be given to help the fetus's lungs mature.
	www.webmd.com /hw/being_pregnant/hw222401.asp?printing=true (744 words)

	Tocolytic Therapy Prolongs Pregnancy in Preterm Labor Patients - Brief Article Family Pratice News - Find Articles (Site not responding. Last check: 2007-10-08)
		SARASOTA, FLA. - Tocolytic therapy may delay delivery for up to 48 hours in patients with preterm labor, but it may be of little value for prophylaxis or maintenance therapy, Dr. Washington Hill said at a pennatal symposium sponsored by Symposia Medicus.
		Antibiotics may also be of some benefit, and should be used in patients with asymptomatic bacteriuria, Trichomonas vaginalis, Neisseria gonorrhoeae, bacterial vaginosis, and Chlamydia trachomatis, he said.
		After 48 hours tocolytic treatment should be stopped.
	www.findarticles.com /p/articles/mi_m0BJI/is_6_30/ai_63591414 (599 words)

	January 15, 2002 - American Academy of Family Physicians
		Because indomethacin is a prostaglandin synthetase inhibitor, it acts as a tocolytic agent and is as effective as other conventional agents in delaying delivery.
		Because of its efficacy and benign side effect profile compared with other tocolytic drugs, indomethacin is often regarded as a first-line agent for the treatment of intraventricular hemorrhage.
		The infants with intraventricular hemorrhage were more likely than the control infants to have been exposed to chorioamnionitis and to be born vaginally at an early gestational age and a lower birth weight.
	www.aafp.org /afp/20020115/tips/19.html (494 words)

	OBGYN.net Journal Review: Is tocolytic magnesium sulphate associated with increased total paediatric mortality?
		In the tocolytic arms, women in preterm labour at less than 34 weeks' gestation and 4 cm dilated or less were randomised to either MgSO4 (4 g bolus, then 2-3 g/hour infusion) or other tocolytic (unblinded obstetrician's choice of ritodrine, terbutaline, indomethacin, or nifedipine).
		In the tocolytic arms, switchovers between MgSO4 and other tocolytic were permitted if the obstetrician believed initial tocolysis had failed.
		Interim safety monitoring showed nine paediatric deaths (one fetal, four neonatal, and four post-neonatal) of those randomised and exposed to MgSO4 (seven tocolytic, two preventive), one death in those randomised but not exposed to tocolytic MgSO4, and one death in the preventive arms in those randomised but not exposed to saline (precipitate labour).
	www.obgyn.net /jr/review16.htm (990 words)

	Letter on an Unapproved Use of Terbualine Sulfate
		Based on information available to the Agency, as well as a review of the published literature, it is clear that the demonstrated value of tocolytics in general is limited to an initial, brief period of treatment, probably no more than 48-72 hours.
		The impact of long-term use on maternal glucose metabolism and the risks of prolonged exposure of the fetus are largely unknown.
		In the absence of data establishing the effectiveness and safety of the drug/device, FDA is alerting practitioners, home health care agencies, insurance carriers, and others that continuous subcutaneous administration of terbutaline sulfate has not been demonstrated to be effective and is potentially dangerous.
	pharminfo.8media.org /medwatch/mwrpt24.html (712 words)

	Differential effects of rat pregnancy on uterine and lung atrial natriuretic factor receptors -- Vaillancourt et al. ...
		ANF is a general smooth muscle relaxant (3) and exerts a tocolytic effect on the rat uterus (2, 20, 21).
		Inhibition of the tocolytic activity of atrial natriuretic factor by progesterone and potentiation by progesterone receptor antagonist RU 486 in rats.
		Refractoriness of the gravid rat uterus to tocolytic and biochemical effects of atrial natriuretic peptide.
	ajpendo.physiology.org /cgi/content/full/274/1/E52 (2874 words)

	Adeza : About FullTerm : ACOG Recommendations (Site not responding. Last check: 2007-10-08)
		Antibiotics do not appear to prolong gestation and should be reserved for group B streptococcal prophylaxis in patients in whom delivery is imminent.
		Neither maintenance treatment with tocolytic drugs nor repeated acete tocoylsis improve perinatal outcome; neither should be undertaken as a general practice.
		Tocolytic drugs may prolong pregnancy for 2-7 days, which may allow for administration of steroids to improve fetal lung maturity and the consideration of maternal transport to a territory care facility.
	preterm-labor.ffntest.com /html/HCP_US_ForHealthcareProviders.htm (482 words)

	Preterm Labor - February 1, 1999 - American Academy of Family Physicians
		A short-term benefit of tocolytic therapy includes a delay in delivery that can be used to administer corticosteroids to enhance pulmonary maturity and reduce respiratory distress syndrome.
		Intravenous tocolytic therapy (decision should be influenced by such factors as gestational age, cause of preterm labor and contraindications)
		The study lacked a sufficient population, and the apparent benefits reported for twin gestations were mitigated when all enrolled women rather than individual newborns were used as the subgroup denominator.
	www.aafp.org /afp/990201ap/593.html (4502 words)

	World Experts Gather To Reduce Burden Of Premature Birth (Site not responding. Last check: 2007-10-08)
		The two-day congress covers several aspects of the management of preterm labour including its economic impact, the limits of foetal viability, preterm parturition syndrome, the prediction and prevention of preterm labour, the use of tocolytic and other therapies and future goals in the management of premature birth.
		Tocolytics are a relatively new class of drugs which are used to stop the uterine contractions of preterm labour, and thereby to delay premature birth.
		Tocolytics are extremely useful in the management of threatened preterm labour.
	medicalnewstoday.com /medicalnews.php?newsid=42495 (709 words)

	Cardiac stimulation during ritodrine hydrochloride tocolytic therapy -- Hosenpud et al. 62 (1): 52 -- Obstetrics & ...
		The effect of ritodrine hydrochloride tocolytic therapy on left ventricular size and performance was studied during pregnancy by M-mode echocardiography.
		Ritodrine, as currently used for tocolytic therapy, has potent inotropic and chronotropic effects on the maternal heart.
		These effects suggest that ritodrine tocolytic therapy should be used with caution in patients with latent or manifest heart disease.
	www.greenjournal.org /cgi/content/abstract/62/1/52 (151 words)

	Preterm Labor
		Extended observation is undesirable because the effectiveness of tocolytic therapy diminishes as labor advances.
		Basic maneuvers to improve uterine and fetal status should be initiated before instituting pharmacologic tocolytic therapy when either preterm labor or fetal distress is suspected.
		Because uterine, cervical, or urinary tract infections account for 30 to 40% of cases of preterm labor, a specific cause should be sought and treated as appropriate.
	webpages.charter.net /saabrio/OBGYN_Preterm_Labor.htm (653 words)

	Lancaster General Hospital - Care and Management of Multiple Pregnancy (Site not responding. Last check: 2007-10-08)
		Testing may be needed to monitor the health of the fetuses, especially if there are pregnancy complications.
		Tocolytic medications may be given, if preterm labor occurs, to help slow or stop contractions.
		Tocolytic medications often used include terbutaline and magnesium sulfate.
	www.lancastergeneral.org /content.asp?pageid=P08022 (478 words)

	Oxytocin receptor antagonists for inhibiting preterm labour
		Tocolytic agents may postpone preterm delivery long enough to improve neonatal outcome, allow corticosteroids to be given to help the baby's lungs and other organs to mature and, if necessary, to allow transfer of the mother to a hospital that has facilities to provide neonatal intensive care.
		This review found that, although the oxytocin receptor antagonist atosiban resulted in fewer maternal side-effects than other tocolytic drugs (betamimetics), no benefit was shown in delaying or preventing preterm birth, and atosiban was associated with more infant deaths in one placebo controlled trial.
		Oxytocin receptor antagonists have been proposed as effective tocolytic agents for women in preterm labour to postpone the birth, with fewer side-effects than other tocolytic agents.
	www.cochrane.org /reviews/en/ab004452.html (585 words)

	Subcutaneous Tocolytic Infusion Significantly Lengthens Gestation Time For Twins (Site not responding. Last check: 2007-10-08)
		MIAMI BEACH, FL -- February 4, 2000 -- A new study of twin gestation pregnancies released at this week's meeting of the Society of Maternal Fetal Medicine found that pregnancy outcomes for those experiencing recurrent preterm labor are significantly improved with the use of subcutaneous versus oral tocolytics.
		The study followed more than 700 women, half of whom were prescribed oral tocolytics and the other half, subcutaneous medication.
		The results strongly suggest that prescribing subcutaneous terbutaline promotes improved patient outcomes and decreased costs," said Fung Lam, MD, Vice Chairman of the Department of OB/GYN at California Pacific Medical Center (San Francisco) and lead researcher on this study.
	www.pslgroup.com /dg/1617ca.htm (421 words)

	Perinatal Death and Tocolytic Magnesium Sulfate -- SCUDIERO et al. 96 (2): 178 -- Obstetrics & Gynecology
		had received other tocolytics only, thus were excluded.
		that magnesium sulfate as a first-line tocolytic agent be reconsidered.
		the unproven tocolytic efficacy of magnesium sulfate and fetal
	www.greenjournal.org /cgi/content/full/96/2/178 (2142 words)

	Tocolytic Magnesium Sulfate Exposure and Risk of Cerebral Palsy among Children with Birth Weights Less Than 1,750 Grams ...
		Tocolytic Magnesium Sulfate Exposure and Risk of Cerebral Palsy among Children with Birth Weights Less Than 1,750 Grams -- Boyle et al.
		Tocolytic magnesium sulfate exposure among children with cerebral palsy and control children, by analytical subgroup, Atlanta, Georgia, 1991–1992
		Tocolytic magnesium sulfate exposure among children with cerebral palsy and control children, by birth weight, Atlanta, Georgia, 1991–1992
	aje.oxfordjournals.org /cgi/content/full/152/2/120 (2809 words)

	A Prospective Comparison of Nifedipine and Isoxsupine For Tocolysic
		The tocolytic drugs most frequently used in India are the b-sympathomimetic agents usually isoxsuprine.
		Intravenous administration of these agents has a rapid tocolytic effect, and oral administration may be used for maintenance therapy.
		We at the Nowrosjee Wadia Maternity Hospital decided to tackle preterm labour by using nifedipine, a dihydropyridone calcium channel blocker and comparing its tocolytic effectiveness and also maternal, neonatal effects with a known tocolytic, isoxsuprine, which is widely used in India.
	www.bhj.org /journal/1999_4102_apr99/original_259.htm (1579 words)

	Effect of maternal tocolysis on the incidence of severe periventricular/intraventricular haemorrhage in very low ...
		or those exposed to more than one tocolytic drug were excluded.
		It is thus evident that the effect of tocolytic drugs on the incidence
		The results of this study suggest that maternal tocolytic treatment with ritodrine was associated with lower incidence of
	fn.bmj.com /cgi/content/full/85/1/F13 (2797 words)

	Information on terbutaline, preterm labor, the terbutaline pump and preterm labor drugs
		When used as a preterm labor drug (tocolytic), terbutaline is believed to have a similar effect on the uterus, relaxing the muscle walls to halt labor.
		However, the FDA has not approved terbutaline for prevention of preterm labor, so this is considered an off-label use of the drug.
		In 1997, the FDA issued a cautionary letter, warning doctors against prescribing terbutaline for prolonged treatment of preterm labor.
	www.terbutalinelawyers.com /html/pretermlabor.html (941 words)

	Tocolysis for assisting delivery at caesarean section
		Medication to relax the uterus (tocolytic drugs) has been suggested to facilitate the birth of the baby at difficult caesarean section and reduce the risk of birth trauma, like fractures and nerve damage.
		Use of tocolytic agents (routine or selective) at caesarean section versus no use of tocolytic or placebo at caesarean section to facilitate the birth of the baby.
		There is currently insufficient information available from randomised trials to support or refute the routine or selective use of tocolytic agents to facilitate infant birth at the time of caesarean section.
	www.cochrane.org /reviews/en/ab004944.html (430 words)

	KUR-1246, a Novel {beta}2-Adrenoceptor Agonist, as a Tocolytic Agent -- Kiguchi et al. 100 (3): 487 -- Obstetrics & ...
		KUR-1246, a Novel {beta}2-Adrenoceptor Agonist, as a Tocolytic Agent -- Kiguchi et al.
		In addition, to block the metabolic processes acted on by cathechol-O-methyltransferase and to prolong the duration of activity, the hydroxyethyl substitution was introduced into position 3 of the aromatic ring.
		Based on the results of screening tests for pharmacological efficacy and toxicity of over 300 compounds with such basic structures, KUR-1246 was identified as the most promising potential tocolytic agent.
	www.greenjournal.org /cgi/content/full/100/3/487 (3111 words)

	Clinical Trial: Two Dose Regimens of Nifedipine for the Management of Preterm Labor
		Prevention and treatment of preterm labor is important, not as an end in itself, but as a means of reducing adverse events for the neonate.
		Magnesium sulfate (MgSO4) is the most widely used tocolytic at the American University of Beirut Medical Center despite the fact that an effective tocolytic role of MgSO4 has never been established.
		Moreover, the currently available data are suggestive of deleterious fetal effects of MgSO4 in the setting of preterm labor to the extent that some authorities are recommending abandoning it for routine use as a tocolytic therapy.
	www.clinicaltrials.gov /ct/show/NCT00137501 (1608 words)

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