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Topic: Tocotrienol

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	Tocotrienols
		Tocotrienols comprise one of the two groups of molecules belonging to the vitamin E family, the other group being the tocopherols.
		The possible greater antioxidant activity of the tocotrienols, compared with alpha-tocopherol, may be accounted for by a more efficient interaction of the chromanol ring with reactive oxygen species, a higher recycling efficiency of the chromanoxyl radicals of the tocotrienols and a more uniform distribution of the tocotrienols in cellular membranes.
		Tocotrienols should also be used with caution in those with lesions with a propensity to bleed (e.g., bleeding peptic ulcers), those with a history of hemorrhagic stroke and those with inherited bleeding disorders (e.g., hemophilia).
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/toc_0254.shtml (0 words)

	Dr. Murray's Natural Facts
		Tocotrienols may prove more valuable in protecting the interior cell membranes, such as those that surround the cell nucleus and mitochondria, because of their greater ease in being incorporated into cellular membranes.
		Tocotrienols have been shown to exert additional benefits to the cardiovascular system including an ability to decrease in the amount of cholesterol plaque in arteries, lower the level of the extremely damaging lipoprotein (a), prevent the aggregation of platelets, and inhibit the expression of cellular adhesion molecules.
		Tocotrienol is the most effective vitamin E for reducing endothelial expression of adhesion molecules and adhesion to monocytes.
	www.doctormurray.com /newsletter/1-06-2003.htm (1444 words)

	Yasoo Health Inc.
		In addition, tocotrienol has been suggested to have an anti-thrombotic and anti-tumor effect indicating that tocotrienol may serve as an effective agent in the prevention and/or treatment of cardiovascular disease and cancer.
		Tocotrienols administered together with AAF significantly decrease the activities of plasma GGT after 12 and 20 wk (P less than 0.01, P less than 0.002, respectively) and liver microsomal UDP-GT after 20 wk (P less than 0.02) when compared with the controls and with rats treated only with tocotrienols.
		Tocotrienols have anticarcinogenic effects that are currently being investigated in vitro and in vivo.
	www.yasoo.com /tocotrienols_protective.html (1284 words)

	Tocotrienol From Rice Bran 50mg - Vitamins
		Tocotrienol Complex contains four different compounds of the vitamin E family which some studies suggest may be as much as 40 times more potent per milligram than standard alpha-tocopherol for protecting against elevated cholesterol, LDL oxidation, and atherosclerotic plaque formation.
		Many alternative doctors are recommending tocotrienols as a potential cholesterol-lowering nutrient in place of FDA approved drugs.
		A recent study showed that mice given tocotrienols survived longer than mice given regular vitamin E. The scientists speculated about identifying one component of tumor growth-suppressive action in specific plants.
	www.health-marketplace.com /Tocotrienol-Rice-Bran.htm (148 words)

	Comparison between Palm & Rice Tocotrienols
		University of Hawaii (in a yet to be published research paper/will be presented at the American Association for Clinical Chemistry, July 2000), found that delta-tocotrienol was the most effective vitamin E for reducing the endothelial expression of adhesion molecules, hence as a means to reduce the risk of developing cardiovascular disease.
		The level of gamma tocotrienol is as high as in rice based tocotrienols.
		Palm tocotrienol complex is a natural phytonutrient complex that is extracted through a mild process from crude palm oil.
	www.tocotrienol.org /compare.htm (0 words)

	Palm Oil Truth Foundation - Health Benefits of Tocotrienols
		Tocotrienols which are naturally occurring in palm oil have been shown to suppress lower plasma cholesterol in humans.
		Palm based tocotrienols is the first natural compound shown by human studies to have the ability to reverse arteriosclerosis.
		Tocotrienols topically applied onto the skin was found to penetrate rapidly through the skin and the highest concentrations were found in the uppermost 5 microns.
	www.palmoiltruthfoundation.com /index.php?option=com_content&task=view&id=43&Itemid=78 (560 words)

	Tocotrienol -- a form of vitamin E -- may protect against stroke at Fresh. Healthy. Useful.
		Tocotrienol -- a form of vitamin E -- may protect against stroke at Fresh.
		Tocotrienol — a form of vitamin E — may protect against stroke
		But to reduce free-radical activity and resulting neurotoxicity, the scientists found that a higher concentration of TCT was needed: Tocotrienol does not exhibit antioxidant properties until it reaches a concentration 10 to 25 times stronger than the concentration that prevented the cell death signal.
	freshhealthyuseful.com /2006/07/tocotrienol-a-form-of-vitamin-e-may-protect-against-stroke (0 words)

	Palm Oil Truth Foundation - Tocotrienol intake helps bioactive concentrations
		Tocotrienols, the least studied form of vitamin E, can achieve levels in the blood that may give protection against a wide range of diseases such as cancer and stroke, says a new study from the US.
		But news that absorption of tocotrienols may result in bioactive blood concentrations could be welcomed by tocotrienol supplement makers whose form of vitamin E is currently less well known and less studied than the tocopherol form of the vitamin.
		While the majority of research on vitamin E has focused on alpha-Toc, studies into tocotrienols account for less than one per cent of all research into vitamin E. Previous studies have suggested that tocotrienol cannot be carried to the organs because it is not transported well by the tocopherol transfer protein (TTP).
	www.palmoiltruthfoundation.com /index.php?option=com_content&task=view&id=40&Itemid=79 (663 words)

	Palm Oil Protects Your Brain Article
		Tocotrienols are a special, super potent form of vitamin E found in palm oil.
		It was found that the free-form was preferentially absorbed by the cells and due to this preferential uptake of the free-form tocotrienol, it confers higher protection against glutamate-induced death of brain cells.
		Tocotrienols with their ability to inhibit the activation of Src kinase activity holds potential as natural complimentary phytonutrient in preventing these cancers.
	www.coconutresearchcenter.org /po-protects-your-brain-article.htm (964 words)

	Tocotrienol-containing powder, a process for preparing it and a tablet comprising compressed said powder into a tablet ...
		A tocotrienol-containing powder prepared by a process wherein an oil containing a tocotrienol is treated with a lecithin, a cellulose and an emulsifying agent in water to form an emulsion, a powder substance is mixed with the formed emulsion to form a suspension and then the formed suspension is spray-dried.
		As tocotrienols have 3 double bonds in the intramolecular side chain and are colorless to yellow, clear and oily materials, they have disadvantages that they are more sensitive to air and light than vitamin E (tocopherol) and further that blending and metering procedures with other solid substances and handling are inconvenient.
		Tocotrienols are different from tocopherols in the molecular structure, only in the presence of three double bonds in the isoprenoid side chain, and are more susceptible to undergo decomposition and change in quality under the influence of heat, light, oxygen etc. than tocopherols.
	www.freepatentsonline.com /6562372.html (8090 words)

	[No title]
		Vitamin E is comprised of two groups of molecules, tocopherols and tocotrienols, each with four forms (alpha-, beta-, gamma-, and delta-tocopherol, and alpha-, beta-, gamma- and delat-tocotrienol).
		Tocotrienols have also been shown to reduce the risk of stroke by reversing atherosclerosis, and to reduce the level of LDL ("bad") cholesterol.
		Tocotrienols and tocopherols are similar in chemical structure, but tocotrienols are more unsaturated, which means they are more mobile and more reactive, while tocopherols tend to cluster.
	www.mercola.com /2003/sep/24/tocotrienols.htm (0 words)

	Ginnovay Tocotrienol and Mixed Tocopherol in Vitamin E family
		Micromolar amounts of tocotrienol suppress the activity of HMG-CoA reductase, the hepatic enzyme responsible for cholesterol synthesis.
		Tocotrienols are thought to have more potent antioxidant properties than α-tocopherol.
		Along these lines, it may not be prudent to express frustrations about the net yield of vitamin E research as a whole (Meta-Analysis in Vitamin E, 2005) when all that has been tested for efficacy on a limited basis in clinical trials is α-tocopherol mainly.
	www.nutraingredients-usa.com /news-by-product/productpresentation.asp?id=627&k=Gingko-Jinke-Vitamin-E (0 words)

	Malaysian National News Agency :: BERNAMA
		Vitamin E is a family of related compounds known as tocopherols and tocotrienols and these compounds have been linked to health benefits such as reducing the risk of cardiovascular disease and cancer, boosting immune system function and acting as an antioxidant.
		Tocotrienol was also found to cross the blood-brain barrier and protects neurons, conferring protection against stroke.
		Tocotrienols are concentrated in cereal grains such as oat, barley, and rye, rice bran, with the richest source found in fruits of palms, such as locally grown oil palms.
	www.bernama.com.my /bernama/v3/news_business.php?id=157649 (513 words)

	Jenasol Toco Roto. Vitamin E Alpha-Tocotrienol
		Tocotrienol has shown to be effective in reversing this plaque buildup.
		Tocotrienols have anticarcinogenic properties due to its superior antioxidant activity.
		Animal studies of the use of Tocotrienols have also shown it to be successful in combating various other forms of cancer, including carcinoma, melanoma and lymphoma.
	www.vitaminforless.com /vitamin-E.htm (868 words)

	Palm Tocotrienol Protects Against Stroke Injury of Brain
		Vitamin E is a family of related compounds known as tocopherols and tocotrienols and these compounds have been linked to health benefits such as reducing the risk of cardiovascular disease and cancer, boosting immune system function and acting as an antioxidant.
		Tocotrienol was also found to cross the blood-brain barrier and protects neurons, conferring protection against stroke.
		Tocotrienols are concentrated in cereal grains such as oat, barley, and rye, rice bran, with the richest source found in fruits of palms, such as locally grown oil palms.
	www.lifeextensionvitamins.com /patopragstin.html (533 words)

	Tocotrienols
		Tocotrienols and tocopherols are nearly identical chemically, but have important molecular differences that affect their functions.
		Tocotrienols occur naturally in cereal brans (such as barley, rice, and oats).
		And by the way: Another way to get tocotrienols is simply to eat wheat bran, wheat germ, barley, oat bran, and rice bran, which contain other healthful substances as well.
	www.berkeleywellness.com /html/ds/dsTocotrienols.php (669 words)

	Food & Nutrition Information
		In the present study we sought: (1) to develop an HPLC method for the simultaneous assessment of serum tocotrienol and tocopherol isomer status, applicable to clinical and population-based studies; and (2) to assess the status of these compounds in those with disparate food cultures, Caucasian and Japanese.
		Tocotrienol and tocopherol isomers are measurable in physiological concentration in human serum by this method.
		That serum tocotrienol level is usually less than tocopherol level would be consistent with conversions of tocotrienol to tocopherol, although this may simply reflect intake.
	www.healthyeatingclub.com /APJCN/Volume1/vol1.3/lo.htm (1051 words)

	Tocotrienols
		A new perspective is presented for applications of delta-tocotrienol, gamma-tocotrienol, delta-tocopherol and gamma-tocopherol that are consistent with the emerging science of vitamin E. The paper concludes that formulated vitamin E should be “appropriate spectrum” and not merely “full spectrum” based on 35-40 mg of daily consumption (DC) of vitamin E in foods.
		Tocotrienols’ ability to lower lipids was first reported in the early 1980s, and in the 1990s they were implicated for inhibition of cancers and reduction of cardiovascular diseases.
		Tocotrienols reduce hepatic cholesterol synthesis by inhibiting the HMG-CoA reductase and by accelerating the degradation of the reductase protein.
	www.ky-anisun.com /legacy/pops/tocotrienols-pop.htm (3937 words)

	www.tocotrienol.de Das Beste Vitamin-E
		Tocotrienole dringen schnell in die Haut ein und wirken effizient gegen oxidativen Stress [z.B.] durch UV-Strahlen oder Ozon.
		Tocotrienols penetrate rapidly through skin, and its topical application is an efficient means with which to enrich skin with vitamin E (Traber et al.
		Tocotrienole scheinen in der deutschsprachigen Literatur noch weitgehend ignoriert zu werden.
	tocotrienol.de (727 words)

	deltagold
		Tocotrienols are fat-soluble, water-insoluble oils and modulate several mechanisms associated with the aging process and aging-related diseases.
		Tocotrienols are more valuable than tocopherols in protecting the interior cell membranes, such as those that surround the cell nucleus and mitochondria, because of their greater fluidity and ease in being incorporated into cellular membranes.
		Tocotrienols, especially δ- and γ-tocotrienols, were shown to be effective nutritional agents to treat high cholesterol in recent research studies.
	www.geronova.com /deltagold.htm (2391 words)

	Tocotrienols - vitamin E family
		Tocopherols are the most common form used for vitamin E fortification, but tocotrienols may be a more potent source of vitamin E. Tocotrienols have similar structure to tocopherols but contain three double bonds in the carbon side chain of the molecule.
		Tocotrienols are found in numerous sources in nature, with oil extracted from palm fruit being the source with the highest tocotrienol content.
		Tocotrienol researchers suggest a dosage of 30-50 mg / day is best to help maintain a healthy level of cholesterol, healthy cardiovascular system and healthy breasts.
	www.lycored.com /web/content/Tocotrienols.asp (234 words)

	DAVOS LIFE SCIENCE
		It has recently been shown that tocotrienols are the components of vitamin E responsible for inhibiting the growth of human breast cancer cells in vitro, through an estrogen-independent mechanism.
		Tocotrienols, which are Vitamin E isoforms, are known to inhibit the growth of human breast cancer cells due partly to apoptosis.
		The objective of this study was to clarify the apoptotic effects of tocotrienols, with especial emphasis in determining if the mitochondria-mediated death pathway is activated when human breast cancer cells are incubated with a specific tocotrienol isomer.
	www.davoslife.com /morernd.htm (1342 words)

	Tocotrienols : by Ray Sahelian, M.D. health benefit
		Tocotrienols are vitamin E compounds that have an unsaturated side chain with three double bonds, selectively inhibit the activity of mammalian DNA polymerase lambda (pol lambda) in vitro.
		Tocotrienols inhibit the proliferation of and formation of tubes by bovine aortic endothelial cells, with delta-tocotrienol having the greatest effect.
		Tocotrienols may act as potent anti-cancer agents by inhibiting pol lambda and angiogenesis.
	www.raysahelian.com /tocotrienols.html (723 words)

	Fuji Bulk Tocotrienol Products,
		Tocotrienols complex is a fractionated and concentrated extract of either palm oil or rice bran oil.
		Tocotrienols are naturally occurring lipid-soluble isomers of Vitamin E. There are 8 naturally occurring isomers of Vitamin E (4 tocopherols and 4 tocotrienols).
		Tocotrienols differ from tocopherols in that they have an isoprenoid (polyunsaturated) instead of a phytyl (saturated) side chain.
	www.fujihealthscience.com /tocotrienol.html (218 words)

	NPICenter.com : Study Shows that Tocotrienol Prevents Development of Increased Blood Pressure
		All tocotrienol treated SHR have reduced plasma lipid peroxides compared to the normal and non-treated SHR group but was only significant for group gamma1 (gamma1 : 0.109±0.026, HC : 0.132 ± 0.008; p = 0.034).
		Both tocotrienols and tocopherols are Vitamin E. Tocotrienols differ from tocopherols in their molecular structure only by having an unsaturated isoprenoid side chain.
		Tocotrienols are widely distributed in the plant kingdom, with the highest concentration found in palm oil.
	www.npicenter.com /anm/anmviewer.asp?a=6110&print=yes (870 words)

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