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| | Imigraine.Net B. Todd Troost, M.D. |
 | | In 1954, Edvardo Tolosa of Barcelona described a 47-year-old male with signs and symptoms of severe retro-orbital and supraorbital pain, followed later by paralysis of the third, fourth, and sixth cranial nerves, and a diminished corneal reflex. |
 | | (1961), in a study, of the histologic material from Tolosa's (1954) case, noted that: ``The region where the carotid artery enters the cranial cavity by penetrating the outer wail of the cavernous sinus is the site of a low-grade, non-specific, inflammatory process. |
 | | Lakke described a 47-year-old man who was admitted to the Neurosurgical Clinic in Utrecht with violent right-sided, stabbing headaches, radiating from the right retro-orbital region along the right side of the skull to the neck. |
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