
	Where results make sense

Topic: Torsades de pointes

Related Topics

Familial long QT syndrome

Tikosyn

Polymorphic ventricular tachycardia

Magnesium sulfate

Cardiology

Atrial fibrillation

In the News (Fri 17 Feb 12)

EXECUTIVE POWER

Iran

ANALYSIS

Pakistan

Family compact

	s000626a - Torsades de Points (Site not responding. Last check: 2007-11-04)
		Abstract: Torsades de pointes is a polymorphic form of ventricular tachycardia that is usually associated with prolongation of the QT interval.
		In torsade de pointes associated with the hereditary long QT interval syndromes, early diagnosis leading to treatments designed to both shorten the QT interval and block the beta-adrenergic-induced instability of the QT interval is essential.
		Torsades de pointes spontaneously progressed to ventricular tachycardia with a uniform morphology in three patients and to ventricular fibrillation in four.
	www.emory.edu /WHSCL/grady/amreport/litsrch99/s000626a.html (3453 words)

	Torsades de Pointes in Patients Receiving Terfenadine or Astemizole.
		Torsades de pointes is a form of polymorphic ventricular tachycardia that is preceded by a prolongation of the QT interval (Monahan et al, 1990).
		Torsades de pointes occurred in one patient whose daily dosage had been increased steadily over six weeks to 360 mg daily; this was the first reported case of torsades de pointes caused by an enhanced therapeutic dose of terfenadine in isolation (MacConnell and Stanners, 1991).
		Torsades de pointes occurring in association with terfenadine use.
	www.hsph.harvard.edu /Organizations/DDIL/torsades.html (2238 words)

	s000626b - Torsades de Points - Treatment (Site not responding. Last check: 2007-11-04)
		The patient experienced angina pectoris followed by episodes of torsades de pointes, which were interpreted as the result of bradycardia, and the bradycardia as the result of high grade AV block induced by increased vagal tone caused by ischaemia in the presence of digoxin intoxication (serum digoxin was 2.5 micrograms/l).
		In drug-induced torsade de pointe the QT interval was moderately prolonged.
		Torsade de pointes is most commonly precipitated by QT prolonging drugs, mainly type IA antiarrhythmic therapy such as quinidine and disopyramide, and other antiarrhythmic agents are reported to cause torsade de pointes as well.
	www.emory.edu /WHSCL/grady/amreport/litsrch99/s000626b.html (7107 words)

	eMedicine - Torsades de Pointes : Article Excerpt by: Syed Nazeer, MD
		Background: Torsades de pointes, literally meaning twisting of points, is a distinctive form of polymorphic ventricular tachycardia (VT) characterized by a gradual change in the amplitude and twisting of the QRS complexes around the isoelectric line.
		Torsades de pointes (torsades) is associated with a prolonged QT interval, which may be congenital or acquired.
		Mortality/Morbidity: Torsades de pointes is a life-threatening arrhythmia and may present as sudden cardiac death in patients with structurally normal hearts.
	www.emedicine.com /med/byname/torsades-de-pointes.htm (611 words)

	Clinical Reviews
		Torsades de pointes, an unusual ventricular arrhythmia, is often a consequence of a prolonged QT interval.
		Torsades de pointes is initiated by premature ventricular beats occurring during the period of abnormal repolarization and prolonged QT interval.
		Ventricular fibrillation and anoxic encephalopathy secondary to astemizole overdose.
	www.ascp.com /publications/tcp/1996/oct/clinical.html (6535 words)

	Torsades de Pointes
		The phrase "Torsades de Pointes" is French and literally means "twisting of the points", referring to the characteristic appearance of the electrocardiogram during the rhythm abnormality.
		Torsades de Pointes usually occurs in the setting of a prolonged QT interval on the electrocardiogram.
		Torsades de pointes occurs in individuals with genetic mutations in genes that control expression of sodium or potassium channels and is a frequent cause of sudden death in these individuals.
	www.torsades.org /info-center/torsades.htm (440 words)

	Arrhythmias
		Torsades de Pointes: QTc Prolongation Possible from Risperdal, Seroquel, Geodon: The author found nine cases were available in which drug-induced QTc interval prolongation was associated with new generation antipsychotic drug administration involving risperidone, quetiapine, and ziprasidone.
		Torsade de pointes associated with the administration of intravenous haloperidol:a review of the literature and practical guidelines for use.
		Torsades de pointes appeared to occur with mirtazapine.
	www.modern-psychiatry.com /arrhythmias.htm (2270 words)

	Influence of IV haloperidol on ventricular repolarization and monophasic action potential duration in anesthetized dogs ... (Site not responding. Last check: 2007-11-04)
		Torsades de pointes is a potentially life-threatening polymorphic ventricular tachycardia that is characterized on a surface ECC by a twisting QRS morphology that is associated with prolongation of the QTc interval.
		Although the precise mechanism of torsades de pointes remains unknown, substantial evidence suggests that the arrhythmia is provoked by the initiation of early afterdepolarizations.
		Therefore, the purpose of this study was to determine the effect of IV haloperidol on these parameters that are known to be associated with torsades de pointes.
	www.findarticles.com /p/articles/mi_m0984/is_5_125/ai_n6094563 (894 words)

	Atrial Fibrillation Foundation
		Torsades de pointes (or torsades) is a lower chamber (ventricular) heart rhythm disturbance that can cause dizziness, fainting, and a potentially fatal cardiac arrest or sudden death.
		Torsades may be provoked by certain heart rhythm medications as well as other medications (for a complete list, see www.qtdrugs.org).
		The risk of torsades can be minimized by selecting appropriate drugs for the individual patients, making sure that the body chemistry is corrected as much as possible, and by initiating medications in a closely supervised hospital setting in patients with a particular risk of this disorder.
	www.affacts.org /Questions/torsades.html (171 words)

	Torsades de pointes - Wikipedia, the free encyclopedia (via CobWeb/3.1 planetlab2.cs.umd.edu) (Site not responding. Last check: 2007-11-04)
		Torsades de pointes is a medical condition, the name of which means in French "twisting of the points".
		The etiology of TdP (Torsades de pointes) is prolongation of the QT interval.
		The primary cause for torsades de pointes is hypomagnesemia (low blood levels of magnesium).
	en.wikipedia.org.cob-web.org:8888 /wiki/Torsades_de_pointes (261 words)

	CPCS: Call Us!... Newsletter (Feb 2002)
		Torsades de pointes is a polymorphic ventricular tachycardia with twisting polarity of the QRS that tends to terminate and recur spontaneously with either no symptoms, syncope or presyncope.
		Other risk factors for torsades de pointes among patients treated with these medications include female gender, heart disease, hypokalemia, hypomagnesemia, excessive dose, drug interactions and preexisting long QT or a family history of long QT.
		Risk factors for torsades de pointes include ingestion of one or more QT prolonging medications or a drug that interferes with metabolism of the QT-prolonging medication, female sex, heart disease, hypokalemia, excessive dose, drug interactions and preexisting long QT or a family history of long QT.
	www.calpoison.org /hcp/Cal_us_archives/cal_us_apr04.htm (1191 words)

	Sotacor - Sotacor Side Effects - Sotacor Information - Canada Pharmacy - Canada Drugs (Site not responding. Last check: 2007-11-04)
		Sotalol, like some antiarrhythmic agents, has been associated with a specific form of arrhythmia, torsades de pointes, which is defined as a polymorphic ventricular tachycardia with prolongation of the QT interval and QRS complexes of changing amplitude that appear to twist around the isoelectric axis.
		Torsades de pointes is dose dependent, usually occurs early after initiating therapy or escalation of the dose, and terminates spontaneously in the majority of patients.
		In patients with a history of sustained ventricular tachycardia, the incidence of torsades de pointes was 4%, and worsened VT was approximately 1%; in patients with other, less serious, ventricular arrhythmias and supraventricular arrhythmias, the incidence of torsades de pointes was 1% and 1.4%, respectively.
	www.rxcarecanada.com /Sotacor.asp?prodid=1597 (5293 words)

	Torsades de pointes secondary to intravenous haloperidol after coronary bypass grafting surgery -- Perrault et al. 47 ...
		Torsade de pointes associated with the use of intravenous haloperidol.
		Torsades de pointes caused by high-dose intravenous cardiac haloperidol in cardiac patients.
		Torsades de pointes complicating the treatment of bleeding oesophageal varices: association with neuroleptics, vasopressm, and electrolite imbalance.
	www.cja-jca.org /cgi/content/full/47/3/251 (1299 words)

	New Page 0
		Torsades de pointes is a rare type of arrhythmia that may progress to ventricular fibrillation and death.
		The French term torsades de pointes (twisting of the points), literally translates into the appearance on the ECG during the rhythm abnormality.
		No U.S. cases of TdP were reported with moxifloxacin from 1996-2001, however 3 foreign cases were reported, suggesting the potential of moxifloxacin to produce QT prolongation and TdP as well.
	www.uic.edu /pharmacy/services/di/qt.htm (546 words)

	Drug-induced Prolongation of the QT Interval - January 1, 2005 - American Family Physician
		There is an increased risk for the development of torsades de pointes, a potentially fatal arrhythmia, when the QT interval is prolonged.
		Because the risk of torsades de pointes is sufficiently high at typical clinical dosages of sotalol, dofetilide, and ibutilide, the review author recommends in-hospital cardiac monitoring when therapy with these agents is initiated.
		The risk of torsades de pointes is not related linearly to the degree of QT prolongation, although any drug that prolongs the QT interval beyond 500 msec is thought to confer an elevated risk.
	www.aafp.org /afp/20050101/tips/7.html (635 words)

	Torsades de pointes - RNweb
		Torsades de pointes is a lethal form of ventricular tachycardia.
		Torsades de pointes, a French term that literally means "twisting of the points," is a lethal form of ventricular tachycardia named for its hallmark feature: polymorphic QRS complexes that appear to twist around the isoelectric line.
		If the patient is asymptomatic (meaning that he's not having bursts of TdP accompanied by fainting or lightheadedness), the only intervention needed for most acquired cases of LQTS is to stop the offending drug.
	www.rnweb.com /rnweb/article/articleDetail.jsp?id=126073 (1241 words)

	Canadian Adverse Drug Reaction Newsletter-Volume 8, Number 1, January 1998
		The worldwide reporting of torsades de pointes (TdP) associated with the use of terfenadine and astemizole has prompted the Therapeutic Products Directorate to change the status of these drugs from nonprescription to prescription.
		TdP may also result from the use of drugs causing QT prolongation in patients with medical conditions such as hepatic dysfunction or congenital long QT syndrome or in those with electrolyte disturbances (particularly hypokalemia and hypomagnesemia).
		Because the list of drugs causing QT prolongation and TdP is continually increasing, we encourage health care professionals to report suspected adverse drug reactions to the Adverse Drug Reaction (ADR) Reporting Unit (fax 613 957-0335) or to their regional ADR reporting centre.
	www.hc-sc.gc.ca /dhp-mps/medeff/bulletin/carn-bcei_v8n1_e.html (2113 words)

	eMedicine - Torsade de Pointes : Article by Michael Bessette, MD (Site not responding. Last check: 2007-11-04)
		Pathophysiology: Torsade is defined as a polymorphous VT in which the morphology of the QRS complexes varies from beat to beat.
		This was symbolically termed torsade de pointes, or "twisting of the point" about the isoelectric axis, because it reminded the original authors of the torsade de pointes movement in ballet.
		In primary and secondary torsade, overdrive pacing is an appropriate secondary therapy.
	www.emedicine.com /emerg/topic596.htm (3107 words)

	Torsades de pointes arrhythmia in a patient with left ventricular myxoma CHEST - Find Articles (Site not responding. Last check: 2007-11-04)
		Torsades de pointes arrhythmia in a patient with left ventricular myxoma
		A 38-year-old woman suffered from syncopes due to torsades de pointes arrhythmias.
		To our knowledge, this is the first case of a left ventricular myxoma associated with a torsades de pointes arrhythmia.
	www.findarticles.com /p/articles/mi_m0984/is_n6_v105/ai_15537504 (742 words)

	Suppression of torsades de pointes by atropine -- Tan et al. 79 (1): 99 -- Heart
		QT syndrome, torsades de pointes is associated with bradycardia.
		Initiation of the tachycardia shows a typical short-long-short RR interval sequence (the 3rd beat is followed after a short pause by the 4th beat, which is followed after a long pause by the 5th beat, which is followed after a short pause by the 6th beat, which constitutes the first beat of the tachycardia).
		QT prolongation and torsades de pointes in patients with congenital
	heart.bmj.com /cgi/content/full/79/1/99 (935 words)

	Sotalol-induced torsades de pointes in patients with renal failure
		The risk of torsades de pointes in patients on sotalol is increased in the setting of renal failure.
		Four cases of torsades de pointes caused by low dose sotalol in patients with renal failure are reported.
		Ces quatre cas ont permis de confirmer qu’un électrocardiogramme à 12 dérivations avec allongement marqué des intervalles QT et dispersion accrue des QT auraient pu être utilisés pour prédire la proarythmie.
	www.pulsus.com /CARDIOL/13_01/danc_ed.htm (238 words)

	Quinolone Safety and Efficacy, (Responses) \| CDC EID
		With the exception of labeling changes regarding glucose homeostasis abnormalities associated with gatifloxacin therapy, the subject of quinolone safety is centered on torsades de pointes.
		Data published in 2001 are cited; these consist of a review of crude rates of US cases of torsades de pointes from January 1996 through May 2, 2001 (3).
		However, the incidence of torsades de pointes associated with each of these agents is ripe for further investigation as we pass the 5-year mark of approval for the new respiratory quinolones.
	www.cdc.gov /ncidod/EID/vol11no06/04-0740_05-0581.htm (1408 words)

	ACCP: How to Evaluate the Risk of Torsades Within Drug Development Programs?
		Torsades de pointes are the result of a mechanical dysfunction, he said.
		While there is increased knowledge on the infrastructure of QT prolongation and Torsades de Pointes, more information is needed, he said.
		There are a number of drugs that lead to QT prolongation, but don't lead to Torsades pointes, he said, adding that some of these drugs make the heart less likely to have malignant arrhythmias
	www.docguide.com /dg.nsf/PrintPrint/12E479D07D21F1DD85256F27004C19B0 (759 words)

	Pacemaker induced torsades de pointes tachycardia -- BÖHM et al. 80 (5): 466 -- Heart
		Pacemaker induced torsades de pointes tachycardia -- BÖHM et al.
		Torsades de pointes tachycardia may be triggered by several factors, including antiarrhythmic drugs, hypokalaemia, and acquired
		Pacemaker reprogramming to 100 beats/min prevented further triggering of torsades de pointes.
	heart.bmjjournals.com /cgi/content/full/80/5/466 (258 words)

	The Fluoroquinolone Toxicity Research Foundation
		Torsades de pointes (literally "twists of points") was first described in 1966 by Dessertenne in France and is a potentially fatal polymorphic ventricular tachycardia characterized by the finding of a long QT interval on an electrocardiogram.
		The FDA had hoped that measuring the effect of a drug on the rapid potassium channel would be a good predictor of torsades de pointes and sudden death.
		Another goal of the task force is to identify people with preexisting sodium- and potassium-channel problems and determine whether they are at increased risk for torsades de pointes, said Temple.
	www.fqresearch.org /body_14.htm (633 words)

	The pause that refreshes, or does it? Mechanisms in torsades de pointes -- RODEN and ANDERSON 84 (3): 235 -- Heart
		Dessertenne, who coined the term "torsades de pointes", was one of the first to draw attention to the association of long
		de pointes in patients with the congenital form of the syndrome.
		Spontaneous sequences of onset of torsade de pointes in patients with acquired prolonged repolarization: quantitative analysis of Holter recordings.
	heart.bmjjournals.com /cgi/content/full/84/3/235 (1915 words)

Try your search on: Qwika (all wikis)