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Topic: Trandolapril

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	Mavik - Mavik Side Effects - Mavik Information - Canadian Pharmacy
		Trandolapril undergoes extensive first-pass metabolism in the liver, and this is the reason that its bioavailability is low: 7.5% (ranging from 4 to 14%).
		Trandolapril should normally be used in patients in whom treatment with a diuretic or a beta-blocker was found ineffective or has been associated with unacceptable adverse effects.
		Trandolapril can also be tried as an initial agent in those patients in whom use of diuretics and/or beta-blockers are contraindicated or in patients with medical conditions in which these drugs frequently cause serious adverse effects.
	www.rxcanadapharmacy.com /htmfiles/Mavik.asp (4890 words)

	MedlinePlus Drug Information: Trandolapril
		Trandolapril is used alone or in combination with other medications to treat high blood pressure.
		Trandolapril is in a class of medications called angiotensin-converting enzyme (ACE) inhibitors.
		Trandolapril controls high blood pressure but does not cure it.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a697010.html (769 words)

	Tarka Online, Description, Chemistry, Ingredients - Trandolapril and Verapamil - RxList Monographs
		Trandolapril Component Trandolapril is the ethyl ester prodrug of a nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, trandolaprilat.
		Trandolapril is a colorless, crystalline substance with a molecular weight of 430.54.
		The tablet strengths are trandolapril 2 mg/verapamil hydrochloride ER 180 mg, trandolapril 1 mg/verapamil hydrochloride ER 240 mg, trandolapril 2 mg/verapamil hydrochloride ER 240 mg, and trandolapril 4 mg/verapamil hydrochloride ER 240 mg.
	www.rxlist.com /cgi/generic2/tarka.htm (373 words)

	Data Sheet
		Trandolapril Capsules 1.0 mg: Size 4 gelatin capsules with a red opaque body and an orange opaque cap, filled with a practically white granulate.
		Use of trandolapril was associated with a 22 percent reduction in all-cause mortality, a 25 percent reduction in cardiovascular mortality, a 24 percent reduction in the risk of sudden death, a 29 percent reduction in the occurrence of severe/resistant heart failure and a 14 percent reduction of recurrent myocardial infarction.
		Trandolapril may be administered in combination with other antihypertensive agents and an additional reduction in blood pressure may occur.
	www.medsafe.govt.nz /profs/datasheet/g/Goptencap.htm (2964 words)

	INVEST-Trial.org - INVEST CAD and Hypertension Study: Drug Strategies (Site not responding. Last check: 2007-11-05)
		Trandolapril was recommended for all patients with diabetes, renal impairment, or heart failure.
		Trandolapril, an angiotensin-converting enzyme (ACE) inhibitor, also has demonstrated efficacy and safety in several large-scale clinical trials in patients with hypertension, in those who have suffered a myocardial infarction (MI), and in those with heart failure and/or left ventricular dysfunction.
		Treatment with trandolapril (1 to 4 mg/d) starting 3 to 7 days after MI and continuing for 2 to 4 years significantly reduced (compared with placebo) the risk of overall mortality, cardiovascular mortality, sudden death, and progression to severe heart failure.
	invest-trial.org /professionals/trial/drug.asp (643 words)

	University of Miami School of Medicine - Glossary - trandolapril
		Trandolapril is an inhibitor of ACE and blocks the formation of angiotensin II thereby lowering blood pressure.
		Trandolapril was approved by the FDA in 1996.
		It is recommended that trandolapril not be taken at the same time as aluminum- or magnesium- based antacids, such as Mylanta or Maalox; these antacids bind to trandolapril in the intestine and decrease its absorption into the body.
	www.med.miami.edu /glossary/art.asp?articlekey=12528 (645 words)

	British Journal of Pharmacology - Improvement of exercise capacity of rats with chronic heart failure by long-term ... (Site not responding. Last check: 2007-11-05)
		Trandolapril suspended in 0.3 ml of 0.25% sodium carboxymethyl cellulose was administered into the stomach through a probe.
		trandolapril were lower than those of rats with CHF not treated with the drug, whereas the increase in LVEDP of rats with CHF was attenuated by treatment with the drug.
		Long-term trandolapril treatment of rats with CHF ameliorates the changes in energy utilization and thus enhances the exercise capacity at a dose that does not affect arterial blood pressure.
	www.nature.com /bjp/journal/v126/n7/full/0702471a.html (5754 words)

	ACC: Trandolapril Has Long-Term Benefits Post-Myocardial Infarction (Site not responding. Last check: 2007-11-05)
		The relative risk of death for the trandolapril group versus the placebo group was 0.78 (P =.001) for the treatment phase and 1.03 for the remaining follow-up (P =.75).
		Over the 10 to 12 years of follow -up, trandolapril reduced all-cause hospital admissions by 8% compared to placebo, cardiovascular hospital admission by 5%, and non-cardiovascular hospital admissions by 15%.
		The findings show that although the mortality benefit decreases over time, post- MI treatment with trandolapril in patients with left ventricular dysfunction is estimated to save about 20 lives per 1000 people treated for at least 2 years, Dr. Buch said.
	www.pslgroup.com /dg/24393a.htm (455 words)

	Data Sheet
		Trandolapril is an orally active plasma and tissue angiotensin converting enzyme inhibitor without an SH group.
		Trandolapril as a prodrug is rapidly metabolised to the active trandolaprilat which binds with high affinity and long duration to the angiotensin converting enzyme.
		In trandolapril animal studies, maternal toxicity is found along with foetotoxicity at high doses in both the rat and, particularly, the rabbit.
	www.medsafe.govt.nz /Profs/Datasheet/z/ziaxelcap.htm (2530 words)

	TARKA® capsules
		The administration of trandolapril causes decreases in the concentrations of angiotensin II, aldosterone and atrial natriuretic factor and increases in plasma renin activity and concentrations of angiotensin I. Trandolapril thus modulates the renin-angiotensin-aldosterone system which plays a major part in regulating blood volume and blood pressure.
		Trandolapril is hydrolysed to the active component trandolaprilat, a specific angiotensin converting enzyme inhibitor.
		As trandolapril is a prodrug metabolised to its active moiety in the liver, particular caution and close monitoring should be applied to patients with impaired liver function.
	home.intekom.com /pharm/knoll/tarka.html (2436 words)

	trandolapril and verapamil - Connecticut (Site not responding. Last check: 2007-11-05)
		Trandolapril and verapamil is used to treat hypertension (high blood pressure).
		Trandolapril and verapamil is in the FDA pregnancy category D. This means that trandolapril and verapamil is known to harm an unborn baby.
		Symptoms of a trandolapril and verapamil overdose are unknown but might include extreme dizziness, weakness, fainting, fatigue chest pain, shortness of breath, an unusually fast or slow heartbeat, coma, slurred speech, and confusion.
	www.saintfranciscare.com /111031.cfm (1338 words)

	Diabetes Care: The effect of trandolapril and its fixed-dose combination with verapamil on proteinuria in normotensive ... (Site not responding. Last check: 2007-11-05)
		Patients who received trandolapril experienced a statistically significant (P < 0.05) decrease in mean creatinine clearance (91.1 [+ or -] 3.4 to 75.3 [+ or -] 3 ml/min: P < 0.05) compared with patients who received FDTV (88.3 [+ or -] 3.6 to 82.9 [+ or -] 3.5 ml/min; P > 0.05).
		This study was conducted to compare the effect of FDTV with that of trandolapril on proteinuria and glomerular filtration rate (GFR) in normotensive, type 2 diabetic patients with nephropathy.
		In patients who received trandolapril, proteinuria decreased from 1,105 [+ or -] 212 to 750.9 [+ or -] 134 mg (P < 0.005), and GFR decreased from 91.1 [+ or -] 3.4 to 75.3 [+ or -] 3 ml/min (P < 0.05).
	www.findarticles.com /p/articles/mi_m0CUH/is_7_27/ai_n6124326 (1423 words)

	trandolapril - High Blood Pressure (hypertension) and related information on MedicineNet.com
		Trandolapril also can be useful in the treatment of congestive heart failure, and ACE inhibitors have been shown to reduce symptoms and hospitalization and improve survival in patients with heart failure.
		Combining trandolapril with potassium supplements, potassium containing salt substitutes, or potassium-conserving diuretics such as amiloride (Moduretic), spironolactone (Aldactone), and triamterene (Dyazide, Maxzide), can lead to dangerously high blood levels of blood potassium.
		Trandolapril can cause an increase in the amount of lithium in the body in patients taking lithium, sometimes with associated side effects of lithium toxicity.
	www.medicinenet.com /trandolapril/article.htm (862 words)

	Trandolapril (Site not responding. Last check: 2007-11-05)
		Trace amounts of trandolapril can be found in breast milk; however, adverse effects in infants have not been documented.
		Trandolapril should be used with caution by patients with severe kidney disease or renal artery stenosis (narrowing of one or both of the arteries that supply blood to the kidneys).
		Fever and chills, sore throat and hoarseness, sudden difficulty breathing or swallowing, swelling of the face, mouth, or extremities, impaired kidney function (ankle swelling, decreased urination), confusion, yellow discoloration of the eyes or skin (indicating liver disorder), intense itching, chest pain or palpitations, abdominal pain.
	www.wholehealthmd.com /refshelf/drugs_view/0,1524,741,00.html (635 words)

	Trandolapril And Verapamil Drug Information
		Trandolapril (tran-DOHL-a-pril) and verapamil (ver-AP-a-mil) combination belongs to the class of medicines called high blood pressure medicines (antihypertensives).
		Trandolapril is a type of medicine known as an angiotensin-converting enzyme (ACE) inhibitor.
		It is not known whether trandolapril passes into breast milk; however, it does pass into the milk of lactating rats.
	www.drugs.com /cons/Trandolapril_and_Verapamil.html (1665 words)

	ACC: Verapamil-trandolapril Antihypertensive Matches Current Standard, Reduces Diabetes Risk
		CHICAGO, IL -- April 2, 2003 -- The combination of verapamil and trandolapril significantly reduced diabetes-related complications while matching the mortality prevention and blood pressure control of a widely used beta-blocker strategy in high-risk hypertensive patients with coronary artery disease (CAD), according to results from INVEST, the second largest cardiovascular outcomes trial to date.
		In one arm, therapy was initiated with verapamil, followed by the addition of trandolapril as needed to achieve blood pressure control.
		Trandolapril could be added if the first two drugs did not bring blood pressure to target levels.
	www.docguide.com /dg.nsf/PrintPrint/50B7F77272F973A785256CFE00514694 (888 words)

	Trandolapril - Drugs & Vitamins - Drug Library - DrugDigest
		Trandolapril controls high blood pressure (hypertension) by relaxing blood vessels; it is not a cure.
		Do not treat yourself for a fever or sore throat; check with your prescriber or health care professional as these may be the result of a trandolapril side effect.
		Do not treat yourself for coughs, colds, or pain while you are using trandolapril without asking your prescriber or health care professional for advice.
	www.drugdigest.org /DD/DVH/Uses/0,3915,676\|Trandolapril,00.html (713 words)

	trandolapril - [Medication]
		Before taking trandolapril, tell your doctor if you have ever had an allergic reaction that involved swelling of your lips, face, tongue, or throat or difficulty breathing.
		Trandolapril is used to lower high blood pressure.
		Trandolapril is in the FDA pregnancy category D. This means that trandolapril is known to be harmful to an unborn baby.
	www.peacehealth.org /kbase/multum/d04008a1.htm (1243 words)

	Trandolapril,Low Cost Trandolapril,No Cost Trandolapril,Canadian Trandolapril,Free Trandolapril,Discount ... (Site not responding. Last check: 2007-11-05)
		Do not take trandolapril if you are pregnant or breast-feeding.
		Trandolapril is used to treat high blood pressure.
		Although side effects from trandolapril are not common, they can occur.
	www.wecaremedicalmall.org /trandolapril.htm (481 words)

	Medbroadcast Drug Info
		After two days, the recommended dose is increased to 2 mg once daily and after one month, the recommended dose is increased to 4 mg once daily if the medication is tolerated.
		Trandolapril may be taken with or without food.
		If you experience angioedema with trandolapril, you should not take any of the other ACE inhibitors, such as enalapril, lisinopril, or quinapril.
	www.medbroadcast.com /drug_info_details_pf.asp?brand_name_id=85 (1269 words)

	Karger Publishers
		Objectives: The aim of this study was to investigate the hemodynamic and neurohumoral effects of combined verapamil SR plus trandolapril treatment (verapamil SR/trandolapril) versus trandolapril monotherapy at rest and during exercise in patients with essential hypertension (WHO I-II) and mild left ventricular dysfunction.
		A total of 84 patients (18-75 years) were randomized to double-blind treatment (42 in the verapamil SR/trandolapril and 42 in the trandolapril group) to whom verapamil SR (180 mg) plus trandolapril (2 mg) or trandolapril alone (2 mg) were administered orally once daily for 2 weeks.
		Mean reduction of pulmonary capillary wedge pressure was significantly higher in the trandolapril group compared to the verapamil SR/trandolapril group both at rest (-1.6 ± 5.3 vs. -0.8 ± 4.6 mm Hg, p < 0.05) and during exercise (-2.9 ± 8.7 vs. -1.7 ± 8.5 mm Hg, p < 0.05).
	content.karger.com /ProdukteDB/produkte.asp?Doi=48981 (629 words)

	Trandolapril and Verapamil (Systemic)
		Tell your doctor if you have ever had any unusual or allergic reaction to trandolapril or to any other ACE inhibitor (benazepril, captopril, enalapril, fosinopril, lisinopril, moexipril, quinapril, or ramipril) or to verapamil.
		Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of trandolapril and verapamil in children with use in other age groups.
		Although this medicine has not been shown to cause different side effects or problems in older people than it does in younger adults, blood levels of trandolapril and verapamil may be increased in the elderly.
	allnutritionals.com /drugs/t/trolaprilverapamil-systemic.shtml (1624 words)

	trandolapril - Connecticut (Site not responding. Last check: 2007-11-05)
		Do not take trandolapril if you are pregnant or could become pregnant.
		It is not known whether trandolapril passes into breast milk.
		Do not take trandolapril without first talking to your doctor if you are breast-feeding a baby.
	www.saintfranciscare.com /19157.cfm (1205 words)

	Myocardial infarction: trandolapril decreased atrial fibrillation. (Site not responding. Last check: 2007-11-05)
		Patients with myocardial infarction who were given trandolapril, were less likely to have atrial fibrillation than those given placebo (NNT = 39 at 2 years).
		Patients in the trandolapril group had slightly higher diastolic blood pressure and nitrate treatment.
		Pedersen OG, Bagger H, Kober L, et al: Trandolapril reduces the incidence of atrial fibrillation after acute myocardial infarction in patients with left ventricular dysfunction.
	www.eboncall.org /CATs/1238.htm (132 words)

	MedlinePlus Drug Information: Verapamil and Trandolapril
		The combination of verapamil and trandolapril is used to treat high blood pressure.
		Take verapamil and trandolapril with food or milk.Talk to your doctor before using salt substitutes containing potassium.
		Although side effects from verapamil and trandolapril are not common, they can occur.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a601128.html (726 words)

	Trandolapril - Patient UK
		It is used to treat hypertension (high blood pressure) and is also sometimes used to treat people who have suffered from a heart attack.
		Trandolapril works by causing blood vessels to relax, lowering blood pressure and increasing the supply of blood and oxygen to the heart.
		Trandolapril may occasionally cause your skin to become more sensitive to the sun.
	www.patient.co.uk /showdoc/30002677 (817 words)

	trandolapril and verapamil
		When used during the second and third trimesters of pregnancy, ACE inhibitors (trandolapril) can cause injury and even death to the developing fetus.
		Trandolapril and verapamil may also be used for purposes other than those listed in this medication guide.
		Trandolapril and verapamil is available with a prescription under the brand name Tarka.
	hw.healthdialog.com /kbase/multum/d04065a1.htm (1526 words)

	Abbott Laboratories Acquires Manufacturing and Commercial Rights to Trandolapril From Aventis
		Trandolapril, an angiotensin-converting enzyme (ACE) inhibitor, is marketed by Abbott under the trademarks of Mavik(R) and Gopten(R), and by Aventis under the trademark Odrik(R).
		Trandolapril is also marketed by Abbott as a fixed-combination product with verapamil, a calcium channel blocker, under the trademark of Tarka(R), and by Aventis under the trademark Ocadrik(R).
		"We believe that trandolapril and the trandolapril/verapamil combination have the potential to be significant global brands and strong contributors to Abbott's pharmaceutical portfolio." About Aventis Aventis is dedicated to treating and preventing disease by discovering and developing innovative prescription drugs and human vaccines.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=109&STORY=/www/story/06-03-2004/0002186527&EDATE= (965 words)

	PharmaDeals E-News (Site not responding. Last check: 2007-11-05)
		Abbott Laboratories and Aventis have reached an agreement for Abbott to acquire the remaining commercial rights for the cardiovascular agents trandolapril and the trandolapril/verapamil combination, except in Japan, and the global manufacturing rights for trandolapril and the trandolapril/verapamil combination.
		Trandolapril, an angiotensin-converting enzyme (ACE) inhibitor, is marketed by Abbott under the trade marks of Mavik® and Gopten®, and by Aventis under the trade mark Odrik®.
		Trandolapril is also marketed by Abbott as a fixed-combination product with verapamil, a calcium channel blocker, under the trade mark of Tarka®, and by Aventis under the trade mark Ocadrik®.
	www.worldpharmaweb.com /enews/feature0406_4.html (249 words)

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