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Topic: Transferase

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	Transferase - Wikipedia, the free encyclopedia
		In biochemistry, a transferase is an enzyme that catalyzes the transfer of a functional group (e.g.
		The common names of transferases are often formed as "acceptor grouptransferase" or "donor grouptransferase." For example, a DNA methyltransferase is a transferase that catalyzes the transfer of a methyl group to a DNA acceptor.
		Transferases are classified as EC 2 in the EC number classification.
	en.wikipedia.org /wiki/Transferase (231 words)

	Catechol-O-methyl transferase - Wikipedia, the free encyclopedia
		Catechol-O-methyl transferase is involved in the breakdown of the catecholamine neurotransmitters, dopamine, epinephrine and norepinephrine.
		A functional polymorphism (a common normal variant) of the gene for catechol-O-methyl transferase has been shown to affect cognitive tasks broadly related to executive function, such as set shifting, response inhibition, abstract thought and the acquisition of rules or task structure.
		The link between impairments in these sorts of cognitive tasks and the COMT gene is thought to be mediated by an effect on dopamine signalling in the frontal lobes.
	en.wikipedia.org /wiki/Catechol-O-methyl_transferase (199 words)

	Catechol-O-methyl transferase (Site not responding. Last check: 2007-11-06)
		Catechol-O-methyl transferase is involved in the breakdown of the catecholamine neurotransmitter s, dopamine, epinephrine and norepinephrine.
		A functional polymorphism (a common normal variant) of the gene for catechol-O-methyl transferase has been shown to affect cognitive tasks such as set shifting, response inhibition, abstract thought and the acquisition of rules or task structure.
		The link between impairments in these sorts of cognitive tasks and the COMT gene is thought to be mediated by an effect on dopamine signalling in the frontal lobe s.
	www.serebella.com /encyclopedia/article-Catechol-O-methyl_transferase.html (399 words)

	Degradation of Aromatics and Chloroaromatics by Pseudomonas sp. Strain B13: Purification and Characterization of ...
		involvement of the transferase in the degradation of 3-oxoadipate.
		(i) Succinyl-CoA:3-oxoacid CoA transferase (EC 2.8.3.5) is responsible
		Characterization of the genes encoding ß-ketoadipate:succinyl-coenzyme A transferase in Pseudomonas putida.
	jb.asm.org /cgi/content/full/184/1/207 (6203 words)

	Robert Edwards Group Abstracts (Site not responding. Last check: 2007-11-06)
		Differential induction of glutathione transferases and glucosyltransferases in wheat, maize and Arabidopsis thaliana by herbicide safeners
		Characterisation of glutathione transferases and glutathione peroxidases in pea ( Pisum sativum).
		Glutathione transferases (GSTs) catalysing the conjugation of 1- chloro-2,4-dinitrobenzene, the chloro-s-triazine herbicide atrazine, the chloroacetanilide herbicides metolachlor and alachlor and the diphenyl ether herbicide fluorodifen have been identified in suspension-cultured cells derived from the grass weed giant foxtail (Setaria faberi Herrm.).
	www.dur.ac.uk /d.p.dixon/abstracts.htm (13401 words)

	Reactive Intermediates and The Dynamics of Glutathione Transferases -- Rinaldi et al. 30 (10): 1053 -- Drug Metabolism ...
		The existence of a distinct "microsomal" glutathione transferase was proposed by Kraus (1975)
		The dechlorination of a-hexachlorocyclohexane by microsomes and cytosol of rat liver.
		Ooi SG, Jernstrom B and Ahokas J (1994) Effects of microsomes and liposomes on glutathione transferase catalysed conjugation of benzo[a]pyrene diol epoxide with glutathione.
	dmd.aspetjournals.org /cgi/content/full/30/10/1053 (4418 words)

	Chloramphenicol acetyl transferase (Site not responding. Last check: 2007-11-06)
		Chloramphenicol exerts its antibiotic effect by binding to the ribosomal peptidyl transferase in bacteria and thus preventing protein biosynthesis.
		The enzyme chloramphenicol acetyl transferase ( E.C.2.3.1.28) transfers an acetyl group from acetyl coenzyme A to the primary hydroxyl on C6 of chloramphenicol.
		Often chloramphenicol acetyl transferase is coded by plasmids.
	www.biologie.uni-hamburg.de /lehre/bza/3cla/e3clae.htm (146 words)

	Galactose consumption and metabolism in relation to the risk of ovarian cancer (Site not responding. Last check: 2007-11-06)
		In a case-control study, consumption of dairy foods by 235 white women with epithelial ovarian cancer and by 239 control women, and activity of red blood cell galactose-1-phosphate uridyl transferase (transferase) in a subset of 145 cases and 127 controls were determined.
		When a ratio of lactose consumption to transferase (L/T) was calculated, cases had a mean L/T of 1.17 compared with 0.98 for controls; there was a highly significant trend for increasing ovarian cancer risk with increasing L/T ratio.
		Lactose consumption may be a dietary risk factor and transferase a genetic risk factor for ovarian cancer.
	www.meb.uni-bonn.de /cgi-bin/mycite?ExtRef=MEDL/89294850 (156 words)

	Tissue-specific Expression and Subcellular Distribution of Murine Glutathione S-transferase Class Kappa -- Thomson et ...
		and the microsomal transferases (Hayes and McLellan 1999
		Harris JM, Meyer DJ, Coles B, Ketterer B (1991) A novel glutathione transferase (13–13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes.
		Hayes JD (1986) Purification and physical characterization of glutathione S-transferase K. Differential use of S-hexylglutathione and glutathione affinity matrices to isolate a novel glutathione S-transferase from rat liver.
	www.jhc.org /cgi/content/full/52/5/653 (4044 words)

	Transferase [Definition]
		[click for more], a transferase is an enzyme An enzyme (in Greek en = in and zyme = blend) is a protein, or protein complex, that catalyzes a chemical reaction and also controls the 3D orientation of the catalyzed substrates.
		Like any catalyst, enzymes work by lowering the activation energy of a reaction, thus allowing the reaction to proceed to its steady state or completion much faster than it otherwise would; the enzyme (again, as with any catalyst) remains unaltered by the completed reaction and can therefore continue catalysis....
		The common names of transferases are often formed as "acceptor grouptransferase" or "donor grouptransferase." For example, a DNA methyltransferase is a transferase that catalyzes the transfer of a methyl In chemistry a methyl-group is a hydrophobic Alkyl functional group which is derived from methane (CH4).
	www.wikimirror.com /Transferase (737 words)

	catechol-o-methyl_transferase (Site not responding. Last check: 2007-11-06)
		Dopamine is metabolized by monoamine oxidase and catechol-O-methyl transferase.
		The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy...
		Catechol-O-methyl transferase inactivates norepinephrine by converting it to a.
	catechol-o-methyl_transferase.networklive.org (209 words)

	Immunolocalization of Microsomal Glutathione S-TraNsferase in Rat Tissues -- Otieno et al. 25 (1): 12 -- Drug ...
		Ketterer: A novel glutathione transferase (13-13) isolated from the matrix of rat liver mitochondria having structural similarity to class theta enzymes.
		Dallner: Glutathione transferase in the urine: a marker for post-transplant tubular lesions.
		Meyer: Glutathione transferases: a possible role in the detoxication and repair of DNA and lipid hydroperoxides.
	www.dmd.org /cgi/content/full/25/1/12 (4181 words)

	Tramadol, buy tramadol, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, hair loss, hair ... (Site not responding. Last check: 2007-11-06)
		Glutathione transferase isozyme genotypes in patients with prostate and bladder carcinoma.
		Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol.
		An ensemble of theta class glutathione transferases with novel catalytic properties generated by stochastic recombination of fragments of two mammalian enzymes.
	drugs-online-usa.com /ref-glutathione/glutathione-refs.html (9285 words)

	Genomics\|HuGENet\|Reviews\|Glutathione S-Transferase Ovarian Cancer
		Zeta, a novel class of glutathione transferases in a range of species from plants to humans.
		Cotton SC, Sharp L, Little J, Brockton N. Glutathione S transferase polymorphisms and colorectal cancer.
		Ryberg D, Skaug V, Hewer A, Phillips DH, Harries LW, Wolf CR, Ogreid D, Ulvik A, Vu P, Haugen A. Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk.
	www.cdc.gov /genomics/hugenet/reviews/GSTovarian.htm (4238 words)

	Novel Compounds in the Therapy of Breast Cancer: Opportunities for Integration with Docetaxel -- Tolcher 6 (Supplement ...
		The farnesyl transferase inhibitor SCH 66336 induces a G(2)
		A phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.
		A phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced breast cancer.
	theoncologist.alphamedpress.org /cgi/content/full/6/suppl_3/40 (2513 words)

	Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary ...
		Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia -- Peters et al.
		Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.
		Novel tricyclic inhibitors of farnesyl protein transferase: biochemical characterization and inhibition of Ras modification in transfected Cos cells.
	www.bloodjournal.org /cgi/content/full/97/5/1404 (6641 words)

	Genomics\|HuGENet\|Reviews\|Glutathione S-Transferase and Colorectal Cancer
		Glutathione transferase null genotype, broccoli, and lower prevalence of colorectal adenomas.
		Ethnic distribution of the glutathione transferase Mu 1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibility.
		Genotypic and phenotypic determination of polymorphic glutathione transferase T1 in a Swedish population.
	www.cdc.gov /genomics/hugenet/reviews/glutathione.htm (8000 words)

	Parasitology: glutathione s-transferase refs
		Brophy, P.M. and Barrett, J. Blocking factors and the isolation of glutathione transferases from Hymenolepis diminuta (Cestoda : Cyclophyllidea).
		Brophy, P.M., Crowley, P. and Barrett, J. Relative distribution of glutathione transferase, glyoxalase I and glyoxalase II in helminths.
		Brophy, P.M. and Barrett, J. Glutathione transferase in helminths.
	www.aber.ac.uk /~mpgwww/GlutTran/GlutRef.html (821 words)

	Genetic characterization of pcpS, encoding the multifunctional phosphopantetheinyl transferase of Pseudomonas ...
		Genetic characterization of pcpS, encoding the multifunctional phosphopantetheinyl transferase of Pseudomonas aeruginosa -- Barekzi et al.
		Genetic characterization of pcpS, encoding the multifunctional phosphopantetheinyl transferase of Pseudomonas aeruginosa
		Finking, R., Solsbacher, J., Konz, D., Schobert, M., Schaefer, A., Jahn, D. and Marahiel, M. Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa.
	mic.sgmjournals.org /cgi/content/full/150/4/795 (4122 words)

	Exoenzyme C3 Transferase (CT03) (Site not responding. Last check: 2007-11-06)
		Material: Exoenzyme C3 transferase is an ADP ribosyl transferase that selectively ribosylates
		C3 transferase has been produced by expression in E. Coli.
		Biological Activity: Biological activity of C3 transferase was verified by the ability of the protein to ribosylate Rho-GST protein in vitro.
	www.cytoskeleton.com /CT03.htm (178 words)

	Human protein: P30711 - Glutathione S-transferase theta 1 (EC ) (GST class-theta 1) (Glutathione transferase T1-1). ...
		Characterization of the glutathione S-transferase GSTT1 deletion: discrimination of all genotypes by polymerase chain reaction indicates a trimodular genotype-phenotype correlation.
		The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human.
		There are no restrictions on its use as long as its content is in no way modified and this statement is not removed.
	harvester.embl.de /harvester/P307/P30711.htm (1124 words)

	Distribution of microsomal glutathione transferase 1 in mammalian tissues: A predominant alternate first exon in human ... (Site not responding. Last check: 2007-11-06)
		Distribution of microsomal glutathione transferase 1 in mammalian tissues: A predominant alternate first exon in human tissues -- Estonius et al.
		Distribution of microsomal glutathione transferase 1 in mammalian tissues
		transferase 1 in human and rat tissues was performed.
	www.ejbiochem.org /cgi/content/abstract/260/2/409 (413 words)

	=== Alcohol Abuse gamma glutamyl transferase and alcohol abuse ===
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	www.troublesome-teens.com /alcohol-abuse/gamma-glutamyl-transferase-and-alcohol-abuse.htm (241 words)

	Homology Modeling of Cephalopod Lens S-Crystallin: A Natural Mutant of Sigma-Class Glutathione Transferase with ...
		Armstrong, R. Structure, catalytic mechanism, and evolution of the glutathione transferase.
		The glutathione S- transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance.
		The three-dimensional structure of a glutathione S- transferase from the mu gene class: structural analysis of the binary complex of isoenzyme 3-3 and glutathione at 2.2 Å resolution.
	www.biophysj.org /cgi/content/full/76/2/679 (4827 words)

	Monocyte Adhesion and Spreading on Human Endothelial Cells Is Dependent on Rho-regulated Receptor Clustering -- ...
		C3 transferase was microinjected at a concentration of 4 µg/ml,
		In d and f, cells were incubated for 3 h with C3 transferase before addition of antibodies; in h and j cells were incubated with cytochalasin D for 1 h before antibody addition.
		In j, VCAM-1 distribution is shown in cells incubated with C3 transferase for 3 h before antibody addition; i corresponds to j and shows F-actin distribution.
	www.jcb.org /cgi/content/full/145/6/1293 (7135 words)

	Glutathione Prostate Cancer and PCBs
		Glutathione-s- transferases (GSTs) are a family of detoxification enzymes which catalyze the conjugation of a wide variety of endogenous and exogenous toxins with glutathione.
		In ongoing studies with researchers at the NIEHS, National Cancer Institute, Columbia University, University of North Carolina and University of Keele, England, the group is testing the impact of these cancer susceptibility genes in case- control studies of cancer of the bladder, lung, liver, colon, stomach, prostate, breast and the myelodysplastic syndromes.
		The glutathione transferase M1 (GSTM1) gene defect has recently been shown to be a risk factor among Japanese gastric cancer patients who were also smokers (6).
	www.foxriverwatch.com /prostate_glutathione.html (5509 words)

	Phase I and Pharmacokinetic Study of Farnesyl Protein Transferase Inhibitor R115777 in Advanced Cancer -- Zujewski et ...
		This reaction is catalyzed by the enzyme farnesyl protein transferase.
		Feldkamp M, Lau N, Guha A: Astrocytomas are growth-inhibited by farnesyl transferase inhibitors through a combination of anti-proliferative and antiangiogenic activities.
		Liu M, Bryant MS, Chen J, et al: Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and wap-ras transgenic mice.
	www.jco.org /cgi/content/full/18/4/927 (7998 words)

	Distribution of microsomal glutathione transferase 1 in mammalian tissues: A predominant alternate first exon in human ... (Site not responding. Last check: 2007-11-06)
		Meyer, D.J. and Thomas, M. (1995) Characterization of rat spleen prostaglandin h d-isomerase as a sigma class GSH transferase.
		Segura-Aguilar, J., Baez, S., Widersten, M., Welch, C.J. and Mannervik, B. (1997) Human class mu glutathione transferases, in particular isoenzyme M2, catalyze detoxication of the dopamine metabolite aminochrome.
		Jakobsson, P.J., Mancini, J.A., Riendeau, D. and Ford-Hutchinson, A.W. (1997) Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities.
	www.ejbiochem.org /cgi/content/full/260/2/409 (2183 words)

	Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer ...
		Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer -- Heymach et al.
		Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer
		transferase inhibitor that blocks the farnesylation of proteins
	annonc.oupjournals.org /cgi/content/abstract/15/8/1187 (228 words)

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