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Topic: Transient receptor potential

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receptor biochemistry

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	Transient receptor potential
		Drosophila transient receptor potential (Trp) serves dual roles as an essential cation channel during response to light and as a molecular anchor for the PDZ protein, INAD (inactivation no afterpotential D).
		The transient receptor potential (Trp) superfamily is comprised of a large group of related cation channels that function in sensory processes ranging from phototransduction to touch, hearing, taste, olfaction, osmosensation, and thermosensation (Montell, 2005b).
		Drosophila Trp is a multifunctional protein because it serves both as a cation channel and a molecular anchor required for the retention of the scaffold protein, INAD, in the rhabdomeres.
	www.sdbonline.org /fly/sturtevant/trpchannel1.htm (2898 words)

	Transient receptor potential - Wikipedia, the free encyclopedia
		The phrase Transient receptor potential or TRP is appended to at least three classes of ion channels which mediate the response of a cell to external stimuli (electrical charge, substances, and forces) by increasing or decreasing its selective permeability to particular ions.
		The effect of this change is to modify the potential difference between inside and outside of the cell.
		Transient receptor potential ion channels are named after the role of the channels in Drosophila phototransduction.
	en.wikipedia.org /wiki/Transient_receptor_potential (546 words)

	[No title]
		Transient receptor potential (Trp) and related proteins are thought to be Ca2+ ion channel subunits that mediate capacitative Ca2+ entry in response to a range of external and internal cell stimuli.
		Studies on the visual transduction system in Drosophila led to the molecular cloning of Trp and the cDNA of a related protein, Trp-like, which show similarity to voltage gated Ca2+ channels in the regions known as S3 through S6, including the S5-S6 linker that forms the ion-selective channel pore [2].
		The Trp family is thought to encode at least 20 Ca2+-permeable channel proteins.
	www.ebi.ac.uk /interpro/DisplayIproEntry?ac=IPR005458&format=nomenu (793 words)

	UCSC Known Genes Description and Page Index
		Transient receptor potential channel 4 alpha splice variant.
		Transient receptor potential channel 4 theta splice variant.
		Transient receptor potential channel 4 iota splice variant.
	www.genome.ucsc.edu /knownGeneList/rn3/8/kgList240.html (107 words)

	SIU-SOM Pharmacology Faculty Louis Premkumar (Site not responding. Last check: )
		It is a Ca2+ permeant polymodal receptor activated by protons, anandamide, lipoxygenase metabolites of AA, N-arachidonyl dopamine, capsaicin (an active ingredient in hot chilli peppers) and resiniferatoxin (RTX, an ultrapotent agonist obtained from a cactus, Euphorbia resinifera) (Premkumar and Ahern, 2000; Premkumar et al., 2004; Premkumar and Raisinghani 2005).
		Intriguingly, a receptor that is expressed in certain cancers, primarily prostate cancer, referred to as TRP-P8 is identical to that of TRPM8.
		Immunocytochemistry to determine expression of receptor proteins in DRGs, dissociated DRG neurons and to determine dendritic arborization in dorsal horn.
	www.siumed.edu /pharm/premkumar.htm (2189 words)

	Differential Role of Transient Receptor Potential Channels in Ca2+ Entry and Proliferation of Prostate Cancer ...
		Differential Role of Transient Receptor Potential Channels in Ca2+ Entry and Proliferation of Prostate Cancer Epithelial Cells -- Thebault et al.
		Differential Role of Transient Receptor Potential Channels in Ca Entry and Proliferation of Prostate Cancer Epithelial Cells
		Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function
	cancerres.aacrjournals.org /cgi/content/abstract/66/4/2038 (332 words)

	Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- ...
		Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels - Publication - RTI International
		Receptor-operated Ca2+ entry (ROCE) and store-operated Ca2+ entry (SOCE) are known to be inhibited by tyrosine kinase inhibitors and activation of C-type transient receptor potential channel (TRPC) isoform 3 (TRPC3), a cation channel thought to be involved in SOCE and/or ROCE, was recently shown to depend on src tyrosine kinase activity.
		Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels.
	www.rti.org /abstract.cfm?pubid=6274 (369 words)

	British Journal of Pharmacology - Transient receptor potential (TRP)
		TRP subunits contain six putative transmembrane domains and assemble as homo- or hetero-tetramers to form cation selective channels with varied permeation properties (reviewed by Owsianik et al.
		Established, or potential, physiological functions of the individual members of the TRP families are discussed in detail in the recommended reviews and are only briefly mentioned here.
		From TRPs to SOCs, CCEs, and CRACs: consensus and controversies.
	www.nature.com /bjp/journal/vgrac/ncurrent/full/0706607a.html (3090 words)

	TRPC3 mediates pyrimidine receptor-induced depolarization of cerebral arteries -- Reading et al. 288 (5): H2055 -- AJP ...
		Transient receptor potential channel (TRPC3) is expressed in rat cerebral artery vascular smooth muscle.
		Expression and relative abundance of short transient receptor potential channels in the rat renal microcirculation.
		Transient receptor potential channels regulate myogenic tone of resistance arteries.
	ajpheart.physiology.org /cgi/content/full/288/5/H2055 (4354 words)

	Transient Receptor Potential Cation Channels in Disease -- Nilius et al. 87 (1): 165 -- Physiological Reviews
		Transient Receptor Potential Cation Channels in Disease -- Nilius et al.
		TRP channels are involved in some systemic diseases due to their
		TRPs for which a causal pathogenic role might be anticipated.
	physrev.physiology.org /cgi/content/abstract/87/1/165 (414 words)

	Transient receptor potential ion channels as participants in thermosensation and thermoregulation -- Caterina 292 (1): ...
		Transient receptor potential ion channels as participants in thermosensation and thermoregulation -- Caterina 292 (1): R64 -- AJP - Regulatory, Integrative and Comparative Physiology
		Transient receptor potential ion channels as participants in thermosensation and thermoregulation
		Pharmacological Characterization and Molecular Determinants of the Activation of Transient Receptor Potential V2 Channel Orthologs by 2-Aminoethoxydiphenyl Borate
	ajpregu.physiology.org /cgi/content/abstract/292/1/R64 (448 words)

	Human protein: Q9BX84 - Transient receptor potential cation channel subfamily M member 6 (EC ) (Channel kinase 2) ...
		Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).
		In the N-terminal section; belongs to the transient receptor family.
		Transient receptor potential cation channel subfamily M member 6.
	harvester.embl.de /harvester/Q9BX/Q9BX84.htm (1094 words)

	Rat protein: Q9WUD2 - Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel ...
		Rat protein: Q9WUD2 - Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) (Stretch-activated channel 2B).
		Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1) (Stretch-activated channel 2B).
		Transient receptor potential cation channel subfamily V member 2.
	rat.embl.de /rat/Q9WU/Q9WUD2.htm (901 words)

	[No title]
		IPR013555 Transient receptor potential II 194 - 256
		IPR013555 Transient receptor potential II 82 - 144
		IPR013555 Transient receptor potential II 182 - 244
	www.ebi.ac.uk /interpro/IEntry?ac=IPR005459 (815 words)

	Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse -- Zhang et al. 286 (6): ...
		Thermosensitive transient receptor potential channels in vagal afferent neurons of the mouse -- Zhang et al.
		TRP channels are present in nodose ganglia, stomach, and small intestine.
		TRP channels are present in vagal afferent neurons in the nodose
	ajpgi.physiology.org /cgi/content/full/286/6/G983 (5412 words)

	Cytoskeletal Reorganization Internalizes Multiple Transient Receptor Potential Channels and Blocks Calcium Entry into ...
		TRP proteins are normally localized to the cell surface in a speckled pattern (upper panels; b–d) suggestive of signaling complexes.
		Transient receptor potential 1 regulates capacitative Ca entry and Ca release from endoplasmic reticulum in B lymphocytes.
		From TRPs to SOCs, CCEs, and CRACs: consensus and controversies.
	www.jimmunol.org /cgi/content/full/172/1/601 (5246 words)

	Orbigen Inc. - Orbigen Inc.
		Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels.
		Renton T, Yiangou Y, Baecker PA, Ford AP, Anand P: Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp.
		Mohapatra DP, Nau C: Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway.
	www.orbigen.com /commerce/catalog/product.jsp?product_id=1533 (318 words)

	Keystone Symposia Conference \| The Transient Receptor Potential Ion Channel Superfamily - Program
		In addition, mutations in TRP channels are known to be the basis for a number of inherited diseases, including mucolipidosis and polycystic kidney disease.
		However, there is a great deal of controversy regarding the mechanisms of activation and regulation of many TRPs, especially those thought to be involved in the long elusive mechanism of store-operated channels.
		Additionally, the roles of TRPs in diseases will be addressed, including the potential for treating diseases through knowledge of their regulation, and through design of therapeutic agents to modify their behavior.
	www.keystonesymposia.org /Meetings/ViewMeetings.cfm?MeetingID=865 (519 words)

	Canonical transient receptor potential TRPC7 can function as both a receptor- and store-operated channel in HEK-293 ...
		Wt-HEK-293 cells were transiently cotransfected with pcDNa3.1(–) vectors containing either the wt-TRPC7 construct or a mutant variant in which leucine at position 111 was replaced by proline (L111P-TRPC7) along with the pEYFP-C1 construct to identify transfected cells.
		Uptake and intracellular sequestration of divalent cations in resting and methacholine-stimulated mouse lacrimal acinar cells: dissociation by Sr and Ba of agonist-stimulated divalent cation entry from the refilling of the agonist-sensitive intracellular pool.
		Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem 278: 29031–29040, 2003.
	ajpcell.physiology.org /cgi/content/full/287/6/C1709 (5302 words)

	GeneCard for TRPC3
		ALL other users require a Commercial License from XenneX, Inc. Unauthorized usage of this service is in breach of the terms and conditions of this web site, and may cause the user to incur fees for usage.
		trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.
		Poteser M....Groschner K. Role of Src in C3 transient receptor potential channel function and evidencefor a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels.
	www.genecards.org /cgi-bin/carddisp.pl?gene=TRPC3 (751 words)

	UniProtKB/Swiss-Prot entry Q7Z2W7 [TRPM8_HUMAN] Transient receptor potential cation channel subfamily M member 8
		Tsavaler L. Shapero M.H. Morkowski S. Laus R. "Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins.";
		The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials.
		Transient receptor potential cation channel subfamily M member 8.
	www.expasy.org /uniprot/Q7Z2W7 (608 words)

	Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin -- Raisinghani et al. 567 (3): 771 -- ...
		Activation of transient receptor potential vanilloid 1 (TRPV1) by resiniferatoxin -- Raisinghani et al.
		Transient receptor potential vanilloid 1 (TRPV1) is a Ca permeable
		Transient Receptor Potential Vanilloid Subtype 1 Mediates Microglial Cell Death In Vivo and In Vitro via Ca2+-Mediated Mitochondrial Damage and Cytochrome c Release
	jp.physoc.org /cgi/content/abstract/567/3/771 (406 words)

	International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor ...
		TRPs are generally assumed to have six TM domains.
		and annexin 1 is one potential substrate (Dorovkov and Ryazanov,
		Bezzerides VJ, Ramsey IS, Greka A, Kotecha SA, and Clapham DE (2004) Rapid vesicular translocation and insertion of TRP channels.
	pharmrev.aspetjournals.org /cgi/content/full/57/4/427 (6100 words)

	Development of the First Ultra-Potent "Capsaicinoid" Agonist at Transient Receptor Potential Vanilloid Type 1 (TRPV1) ...
		Luo H, Cheng J, Han JS, and Wan Y (2004) Change of vanilloid receptor 1 expression in dorsal root ganglion and spinal dorsal horn during inflammatory nociception induced by complete Freund's adjuvant in rats.
		Rashid MH, Inoue M, Bakoshi S, and Ueda H (2003) Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice.
		(2004) Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells and epithelial cells of appendage structures.
	jpet.aspetjournals.org /cgi/content/full/312/2/561 (6610 words)

	Transient Receptor Potential 1 Regulates Capacitative Ca2+ Entry and Ca2+ Release from Endoplasmic Reticulum in B ...
		Transient Receptor Potential 1 Regulates Capacitative Ca2+ Entry and Ca2+ Release from Endoplasmic Reticulum in B Lymphocytes -- Mori et al.
		hallmark of Ca influx, was significantly potentiated in WT in comparison to that in mutant cells (Fig.
		Modulation of Ca entry by polypeptides of the inositol 1,4,5-trisphosphate receptor (IP R) that bind transient receptor potential (TRP): evidence for roles of TRP and IP R in store depletion-activated Ca entry.
	www.jem.org /cgi/content/full/195/6/673 (6218 words)

	International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential ...
		Architecture of TRP channels is that of the broader class of six transmembrane-spanning ion channels.
		Transient receptor potential (trp) ion channel subunit genes
		Ca(2+)-permeable cation channel that is constitutively activated and enhanced by stimulation of G protein-coupled receptor.
	pharmrev.aspetjournals.org /cgi/content/full/55/4/591 (4209 words)

	Bosentan Inhibits Transient Receptor Potential Channel Expression in Pulmonary Vascular Myocytes -- Kunichika et al. ...
		Bosentan Inhibits Transient Receptor Potential Channel Expression in Pulmonary Vascular Myocytes -- Kunichika et al.
		Bosentan Inhibits Transient Receptor Potential Channel Expression in Pulmonary Vascular Myocytes
		Transient receptor potential channels in cardiovascular function and disease.
	ajrccm.atsjournals.org /cgi/content/abstract/170/10/1101 (514 words)

	Transient Receptor Potential-Like Channels Are Essential for Calcium Signaling and Fluid Transport in a Drosophila ...
		Transient Receptor Potential-Like Channels Are Essential for Calcium Signaling and Fluid Transport in a Drosophila Epithelium -- MacPherson et al.
		Articles by MacPherson, M. Articles by Davies, S. Transient Receptor Potential-Like Channels Are Essential for Calcium Signaling and Fluid Transport in a Drosophila Epithelium
		, A. and L., 1992 Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene.
	www.genetics.org /cgi/content/full/169/3/1541 (5377 words)

	Phenotypes of trpl Mutants and Interactions between the Transient Receptor Potential (TRP) and TRP-Like Channels in ...
		Phenotypes of trpl Mutants and Interactions between the Transient Receptor Potential (TRP) and TRP-Like Channels in Drosophila -- Leung et al.
		The trp and trpl genes are thought to encode two classes of light-activated ion channels in Drosophila.
		Transient Receptor Potential-Like Channels Are Essential for Calcium Signaling and Fluid Transport in a Drosophila Epithelium
	www.jneurosci.org /cgi/content/abstract/20/18/6797 (476 words)

	The mouse C-type transient receptor potential 2 (TRPC2) channel: Alternative splicing and calmodulin binding to its N ...
		The mouse C-type transient receptor potential 2 (TRPC2) channel: Alternative splicing and calmodulin binding to its N terminus -- Yildirim et al.
		The mouse C-type transient receptor potential 2 (TRPC2) channel: Alternative splicing and calmodulin binding to its N terminus
		Channels of the C-type transient receptor potential (TRPC) are involved in agonist-stimulated and capacitative calcium entry.
	intl.pnas.org /cgi/content/short/100/5/2220 (579 words)

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