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Topic: Transketolase

	benfotiamine diabetes research
		They knew that both of these metabolic compounds (fructose-6-phosphate and glyceraldehyde-3-phosphate) are the end products of another biochemical pathway mediated by an enzyme called transketolase.
		By boosting transketolase's activity, the researchers reasoned, they might be able to reverse this pathway - essentially converting the two damage-triggering glucose metabolites into harmless chemicals and preventing all three damaging biochemical pathways from being activated.
		In preliminary studies involving arterial endothelial cells, adding standard thiamine boosted transketolase's activity by only 20 percent, so the researchers looked around for a more potent form of thiamine.
	www.benfotiamineinfo.com (773 words)

	[No title]
		Transketolase EC:2.2.1.1 (TK) catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3- phosphate.
		In the peroxisomes of methylotrophic yeast Hansenula polymorpha, there is a highly related enzyme, dihydroxy-acetone synthase (DHAS) EC:2.2.1.3 (also known as formaldehyde transketolase), which exhibits a very unusual specificity by including formaldehyde amongst its substrates.
		In the central section there are conserved acidic residues that are part of the active cleft and may participate in substrate-binding [4].
	www.ebi.ac.uk /interpro/IEntry?ac=IPR005475 (605 words)

	Transketolase - WrongDiagnosis.com
		Transketolase: An enzyme of the transferase class that catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate in the PENTOSE PHOSPHATE PATHWAY.
		The following terms can be used for Transketolase
		The following list attempts to classify Transketolase into categories where each line is subset of the next.
	www.wrongdiagnosis.com /medical/transketolase.htm (192 words)

	Compare Transketolase Antibodies — Biocompare Buyer’s Guide
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	www.biocompare.com /matrixsc/3194/2/6/78144/Transketolase.html (161 words)

	Chapter 3. Thiamin, riboflavin, niacin, vitamin B6, pantothenic acid and biotin
		Specifically the Mg -coordinated TPP participates in the formation of a-ketols (e.g., among hexose and pentose phosphates) as catalysed by transketolase and in the oxidation of a-keto acids (e.g., pyruvate, a-ketoglutarate, and branched-chain a-keto acids) by dehydrogenase complexes (10, 11).
		Indicators used to estimate thiamin requirements are urinary excretion, erythrocyte transketolase activity coefficient, erythrocyte thiamin, blood pyruvate and lactate, and neurologic changes.
		The erythrocyte transketolase assay, in which an activity coefficient based on a TPP stimulation of the basal level is given, continues to be a main functional indicator (9), but some problems have been encountered.
	www.fao.org /DOCREP/004/Y2809E/y2809e09.htm (8747 words)

	MedlinePlus Medical Encyclopedia: Beriberi
		Neurological examination may show a loss of vibratory sensation (the person is less able to sense vibration), decreased reflexes, loss of coordination, gait changes, nystagmus, drooping of the eyelids, and inability to move the eye outwards.
		Measurement of blood thiamine and whole-blood or erythrocyte transketolase activity
		Clinical response to administered thiamine (symptoms improve after the person is given thiamine supplements)
	www.nlm.nih.gov /medlineplus/ency/article/000339.htm (829 words)

	Vitamin B1 -- Thiamine
		50 chronic alcoholics reporting to the medical emergency ward of Basle University Hospital with alcohol-related illness were examined with respect to thiamine nutritional status by means of the transketolase activation test of erythrocytes (ETK).
		46% of the chronic alcoholics, compared to only 2% of the control population (1152 healthy adults), had transketolase activation quotients indicating a strong probability of thiamine deficiency (alphaETK greater than 1.25).
		The most important symptoms associated with the biochemical parameters of thiamine deficiency were: anemia, pathologic liver functions (bilirubin, gamma-globulins), low diastolic blood pressure and Wernicke's encephalopathy.
	www.oralchelation.com /ingred/vitaminb1.htm (5260 words)

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