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Topic: Triclabendazole

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	Triclabendazole in the treatment of established human fascioliasis
		The use of triclabendazole for the treatment of human fascioliasis was found to be justified.
		Triclabendazole was supplied in the form of tablets of 250 mg active principle.
		Tolerability of triclabendazole was assessed clinically and by follow-up of laboratory investigations.
	www.emro.who.int /Publications/EMHJ/0402/07.htm (1710 words)

	773. Triclabendazole (WHO Food Additives Series 31)
		C-labelled triclabendazole to rats, excretion was rapid with approximately 93% of the dose eliminated in 48 h.
		Triclabendazole sulfoxide was the main plasma metabolite during the first 24 h, with the sulfone at similar or slightly higher levels thereafter.
		Triclabendazole was rapidly and extensively degraded in rabbits, dogs, and humans, the sulfoxide and sulfone being the main metabolites found in plasma.
	www.inchem.org /documents/jecfa/jecmono/v31je05.htm (5631 words)

	[No title]
		Triclabendazole is given, after consumption of food, in a single dose of 10 mg/kg body weight.
		Different doses of triclabendazole were studied during these trials and it was concluded that the most efficient dosage for fascioliasis was 10 mg/kg body weight, while for paragonimiasis it was 20 mg/kg, given in two equal doses.
		Following the registration of triclabendazole for human use and noting its use for public health purposes, the WHO Expert Committee on the Use of Essential Drugs recommended, at its December 1997 meeting, that the drug be put on the list of essential drugs.
	sleekfreak.ath.cx:81 /3wdev/CD3WD/HEALTH/S0469E/B634_2.HTM (1510 words)

	[No title] (Site not responding. Last check: 2007-10-21)
		The pharmacokinetics and flukicidal efficacy of triclabendazole delivered in low doses on a daily basis through urea molasses blocks were studied in cattle and buffaloes experimentally infected with Fasciola gigantica.
		After receipt of triclabendazole by cattle and buffaloes at 0.83 and 3.0 mg/kg body weight, respectively, on a daily basis, both the animal species exhibited equilibrium between its absorption and disposition of its metabolites in plasma on day 4 and remained almost unchanged thereafter.
		The continuous subtherapeutic dosing of triclabendazole through urea molasses block at 0.83 mg/kg body weight in cattle and 3.0 mg/kg body weight in buffalo proved to be efficacious against mature liver flukes.
	www.elsevier.com /cdweb/journals/03044017/articles/76/1-2/S030440179700058.abstract.en (131 words)

	Triclabendazole (Systemic) (Site not responding. Last check: 2007-10-21)
		Triclabendazole is used to treat the following flatworms: sheep liver flukes (fascioliasis) and giant liver flukes that occasionally infect man.
		Childrenâ” Although there is no specific information comparing use of triclabendazole in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		Triclabendazole is best taken after meals, especially with food containing fat, to help your body absorb the medicine better.
	www.usadrugcare.com /information/uspdi_203624.html (771 words)

	The efficacy and tolerability of triclabendazole in Cuban patients with latent and chronic Fasciola hepatica infection ...
		The efficacy and tolerability of triclabendazole in Cuban patients with latent and chronic Fasciola hepatica infection -- Millan et al.
		The efficacy and tolerability of triclabendazole in Cuban patients with latent and chronic Fasciola hepatica infection
		Triclabendazole 20 mg/kg is an effective therapy for the treatment of F. hepatica infection in patients who have failed to respond to other antihelminthic agents.
	www.ajtmh.org /cgi/content/abstract/63/5/264 (450 words)

	Triclabendazole in the treatment of Paragonimiasis skrjabini
		Triclabendazole as a chemically pure powder was given orally in the dosage of 10 mg/kg bid for 3 days.
		In the second experiment, the dose of triclabendazole was increased to 150 mg・kg(-1)・d(-1) and 200 mg・kg(-1)・d(-1), for 3 days with a total dosage of 450 mg/kg and 600 mg/kg, respectively, and worm reduction rates of 80.8% and 86.7%, respectively.
		The mechanism of action of triclabendazole may be due to inhibition of protein synthesis of flukes［10］ leading to protein depletion, generalized atrophy of internal organs and death.Clinically triclabendazole is highly effective in treatment of various forms of P. skrjabini including pulmonary, pleural, cerebral and subcutaneous tissue lesions.
	www.cmj.org /periodical/PaperList.asp?id=LW9123 (1570 words)

	Triclabendazole - Wikpedia (Site not responding. Last check: 2007-10-21)
		Triclabendazole (commercial name Fasinex) is a member of the Benzimidazole family of anthelmintics.
		Triclabendazole displays high efficacy against both immature and adult liver fluke.
		It is generally accepted that benzimidazoles like triclabendazole bind to beta-tubulin and prevent the polymerisation of the microtubules of which they are part.
	www.bostoncoop.net /~tpryor/wiki/index.php?title=Triclabendazole (78 words)

	Healthopedia.com Drugs Information - Triclabendazole : Before Using (Fasinex)
		However, triclabendazole has not been shown to cause birth defects or other problems in animal studies.
		Triclabendazole has not been reported to cause problems in nursing babies.
		Children—Although there is no specific information comparing use of triclabendazole in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
	www.healthopedia.com /drugs/detailed/triclabendazole/before-using.html (446 words)

	[No title] (Site not responding. Last check: 2007-10-21)
		A controlled test of the efficacy of triclabendazole against all stages (early immature, late immature and mature) of Fasciola hepatica has been performed in experimentally infected goats.
		The influence of triclabendazole treatment on the pathophysiology of the disease, in terms of haematological parameters and serum enzyme levels, and in the dynamics of production of specific antibodies to excretory/secretory products (ESP) of F. hepatica were also examined.
		In those animals in which triclabendazole was highly effective, antibody levels fell back to negative values similar to those recorded preinoculation at 18-21 weeks PI.
	www.elsevier.com /cdweb/journals/03044017/articles/68/1-2/S030440179601067.abstract.en (283 words)

	Efficacy of triclabendazole against fascioloidiasis (Fascioloides magna) in naturally infected white-tailed deer ...
		The efficacy of triclabendazole was evaluated in the treatment of naturally acquired Fascioloides magna infections in white-tailed deer (Odocoileus virginianus).
		Ten deer were given a 5% suspension of triclabendazole orally at a dosage of 10 mg/kg body weight and 10 deer were given a placebo.
		All specimens of F. magna from the tissues of the triclabendazole treated deer were dead or severely affected by the drug as indicated by changes in their size, color, movement and texture relative to those from control deer.
	www.jwildlifedis.org /cgi/content/abstract/25/3/378 (212 words)

	Triclabendazole
		Our Triclabendazole conforms to Originator’s Standards in all respects and is perfectly suited for use in all dosage forms available for veterinary use.
		Triclabendazole is with a single mono spot with TCL Chromatogram, which can be found only with the originator’s product.
		Micronized Triclabendazole is available with various micron sizes upto 5 microns for use in suspension grade, oral suspension or drenches.
	www.shamrockindia.com /medivet/triclabendazole.htm (235 words)

	CLINICAL EVALUATION OF THREE CHEMOPROPHYLACTIC REGIMES AGAINST OVINE HELMINTHOSIS
		Albendazole, triclabendazole and a combination of diamphenethide and rafoxanide oral suspensions were given respectively at their recommended prophylactic dose regimes to 3 groups of 12-month-old West African dwarf sheep of 13 to 15 in each group for a period of five months.
		In view of its exclusive fasciolicidal activity, the mild anaemia seen in the group D sheep might be ascribed to haemonchosis as evidenced again from the low percentage egg reduction for the blood-sucking helminths in Table 2.
		Kinabo, L.D. and Bogan, J.A. : Pharmacokinetics and efficacy of triclabendazole in goats with induced fascioliasis.
	www.isrvma.org /article/56_1_5.htm (3707 words)

	fasinex - Novartis.com
		It binds to tubulin impairing intracellular transport mechanisms and interferes with protein synthesis.
		Triclabendazole is specifically active against Fasciola, Fascioloides and Paragonimus.
		FASINEX is indicated for the treatment and control of acute, subacute and chronic fasciolosis due to early immature, immature and adult stages of Fasciola hepatica and Fasciola gigantica in cattle, sheep and goats.
	www.ah.novartis.com /products/en/fab/fasinex.shtml (553 words)

	Healthopedia.com Drugs Information - Triclabendazole (Fasinex)
		Triclabendazole (tri-cla-BEN-da-zole) is used to treat infections caused by some flatworms.
		Triclabendazole probably works by immobilizing the worm so that the worm dies.
		Triclabendazole is used to treat the following flatworms: sheep liver flukes (fascioliasis) and giant liver flukes that occasionally infect man.
	www.healthopedia.com /drugs/detailed/triclabendazole (256 words)

	Eastern Mediterranean Health Journal, Vol. 5 No. 5, Triclabendazole in the treatment of human fascioliasis: a ...
		ABSTRACT The efficacy of triclabendazole in the treatment of chronic Fasciola infection was assessed.
		A total of 134 asymptomatic cases of established Fasciola infection were treated: 68 individuals received a single dose of 10 mg/kg and 66 individuals received 2 doses of 10 mg/kg on 2 consecutive days.
		Therapeutic effect of triclabendazole in patients with fascioliasis in Egypt: a preliminary study.
	www.emro.who.int /publications/emhj/0505/04.htm (2265 words)

	[No title]
		Triclabendazole inhibits colchicine binding to microtubular proteins suggesting interference of the drug with microtubular structure and function.
		When used at the recommended dose rate, the product is effective against all stages of triclabendazole susceptible Fasciola hepatica from 2 day old early immature forms to adult fluke.
		Triclabendazole overdosage may produce transient inappetance and loss of bodyweight.
	www.vmd.gov.uk /espcsite/documents/145075.doc (1084 words)

	IngentaConnect Triclabendazole for the treatment of fascioliasis and paragonimia... (Site not responding. Last check: 2007-10-21)
		Triclabendazole, a benzimidazole derivative, has been routinely used since 1983 in veterinary medicine to control infections with Fasciola spp.
		In 1986, a veterinary formulation of triclabendazole was first administered to two human patients with fascioliasis.
		Clinical data obtained thus far suggest that triclabendazole is the most efficacious and best tolerated drug for the treatment of fascioliasis.
	www.ingentaconnect.com /content/apl/eid/2005/00000014/00000012/art00005 (298 words)

	Fasimec
		The active ingredient, triclabendazole, is highly effective against all stages of the liver fluke (Fasciola hepatica).
		At the recommended dose rate, triclabendazole effectively controls the susceptible early immature and immature migrating stages and the mature bile duct stages of liver fluke in cattle (and other animal species).
		This equates to 12mg triclabendazole and 0.2mg ivermectin per kg.
	www.nrrbs.com.au /animalhealthfasimec.htm (640 words)

	Triclabendazole - Drug information from Medic8.com
		Triclabendazole (commercial name Fasinex) is a member of the Benzimidazole family of anthelmintics.
		The benzimidazole drugs share a common molecular structure, triclabendazole being the exception in having a chlorinated benzene ring but no carbamate group.
		It is generally accepted that benzimidazoles like triclabendazole bind to beta-tubulin and prevent the polymerisation of the microtubules of which they are part.
	www.medic8.com /medicines/Triclabendazole.html (196 words)

	Endex - Novartis.com
		ENDEX 19.5% for cattle containing 7.5 mg of levamisole hydrochloride and 12 g of triclabendazole per 100 ml.
		Triclabendazole is specifically effective against all 3 stages of Fasciola.
		ENDEX is indicated for the treatment and control of mature and immature gastrointestinal nematodes (Ostertagia, Haemonchus, Trichostrongylus, Cooperia, Nematodirus, Bunostomum, Gaigeria, Chabertia, Oesophagostomum), lungworms (Dictyocaulus) and all 3 stages of liver fluke (Fasciola) infections in cattle and sheep.
	www.ah.novartis.com /products/en/fab/endex.shtml (411 words)

	Australian Wool Innovation Limited - Triclabendazole
		Triclabendazole is the most effective and widely used active ingredient against liver fluke (Fasciola hepatica).
		It is highly effective against mature and immature stages of the fluke and resistance to triclabendazole is still very rare in Australia.
		If you have been using triclabendazole regularly over the years, it will pay to conduct a drench resistance test to ensure efficacy against fluke is still effective.
	www.wormboss.com.au /LivePage.aspx?pageId=506 (282 words)

	MEDLINE Search on Medscape.com
		Compartive studies on the effect of bithionol, praziqantel and triclabendazole in rabbit's fascioliasis.
		Comparative studies on the effect of bithionol, praziquantel and triclabendazole in rabbit's fascioliasis.
		Triclabendazole is recommended as the first-line agent for the treatment of F. hepatica infection, with bithionol as an alternative...
	search.medscape.com /medline-search?queryText=Bithionol (309 words)

	Comparative efficacy of triclabendazole, nitroxynil and rafoxanide against immature and mature Fasciola hepatica in ...
		In two trials the fasciolicidal activities of triclabendazole, nitroxynil and rafoxanide were assessed in cattle naturally infected with predominantly immature stages of Fasciola hepatica.
		Based on faecal egg counts nine weeks after treatment the efficacies were calculated to be 100 per cent for triclabendazole and 95.0 per cent for nitroxynil in the first trial and 98.4 per cent for triclabendazole and 52.9 per cent for rafoxanide 15 weeks after treatment in the second trial.
		Compared with the untreated control group the reductions in the fluke burdens were 96.9 per cent in triclabendazole treated cattle and 76.4 per cent in the nitroxynil treated group.
	veterinaryrecord.bvapublications.com /cgi/content/abstract/122/3/59 (237 words)

	Healthopedia.com Drugs Information - Triclabendazole : Proper Use (Fasinex)
		Triclabendazole is best taken after meals, especially with food containing fat, to help your body absorb the medicine better.
		A second treatment with this medicine may be needed to clear up the infection completely.
		The number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking triclabendazole.
	www.healthopedia.com /drugs/detailed/triclabendazole/proper-use.html (446 words)

	Triclabendazole Systemic - (Site not responding. Last check: 2007-10-21)
		Triclabendazole Systemic may also be used for another flatworm infection as determined by your doctor.
		Although there is no specific information comparing use of triclabendazole in children with use in other age groups, Triclabendazole Systemic is not expected to cause different side effects or problems in children than it does in adults.
		A second treatment with Triclabendazole Systemic may be needed to clear up the infection completely.
	www.uspharmd.com /packageinsert/tn/Triclabendazole_Systemic.html (699 words)

	Triclabendazole (Systemic) - MayoClinic.com (Site not responding. Last check: 2007-10-21)
		Tell your doctor if you have ever had any unusual or allergic reaction to triclabendazole.
		Although there is no specific information comparing use of triclabendazole in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.
	mayoclinic.com /invoke.cfm?objectid=E74AC5AC-1AC9-4BC5-8F6EA9F761502D2F (883 words)

	DHEA, antibiotics, Weight Loss drugs, weight loss herbs, weight loss herbal formula, hair loss, hair growth, buy Rx ...
		In the current study, adult triclabendazole-susceptible flukes were treated with triclabendazole sulphoxide in vitro, and the metabolism of the drug was monitored by high performance liquid chromatography.
		Parallel experiments using triclabendazole-resistant flukes showed that the conversion of triclabendazole sulphoxide to triclabendazole sulphone was on average 20.29% greater in the resistant flukes compared with the susceptible flukes.
		The results are discussed with regard to the mechanism of triclabendazole resistance in F. hepatica.
	pharmacy-online-usa.com /ref-albendazole/albendazole-research-abs4.180.html (1136 words)

	Tratamiento de la Fasciolasis Hepática
		We conclude that triclabendazole is highly efficient and good against liver fasciolasis in humans.
		Para realizar este trabajo se recogieron las referencias bibliográficas existentes a nivel mundial sobre el tratamiento de la fasciolasis con triclabendazole, y se dió tratamiento a todos los pacientes referidos a nuestro hospital con diagnóstico de fasciolasis ya los casos diagnosticados en nuestro laboratorio; entre los años de 1,996 y 1999.
		El triclabendazole es una droga eficiente con 83 % de curación con un primer tratamiento, y puede ser eficaz en 100% si fuera necesario administrar dosis repetidas.
	sisbib.unmsm.edu.pe /BVRevistas/gastro/Vol_19N3/trabajos05.htm (1738 words)

	"Off label" use of flukicide
		Triclabendazole is not registered for use in lactating animals under any circumstances.
		Treatment with flukicide capable of killing immature and adult fluke at 5 months, 9 months and 12 months of age and then as determined by monitoring faecal counts or clinical disease.
		Triclabendazole residues in food are totally unacceptable both nationally and internationally and could severly damage local and export markets.
	www.vsb.nsw.gov.au /Boardtalk/pre2002/mar2001/March2001_2.htm (252 words)

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