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Topic: Trifluoroacetic acid

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	HHMI Lab Safety: LCSS: TRIFLUOROACETIC ACID (Site not responding. Last check: 2007-11-03)
		Trifluoroacetic acid has not been found to be carcinogenic or to show reproductive or developmental toxicity in humans.
		Trifluoroacetic acid should be handled in the laboratory using the "basic prudent practices" described in Chapter 5.C. In particular, trifluoroacetic acid should be stored in an acid cabinet away from other classes of compounds.
		Trifluoroacetic acid and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.
	www.hhmi.org /about/labsafe/lcss/lcss86.html (485 words)

	[No title]
		Attempts to prepare lysergic acid amides amides by the usual methods of preparing amides, such as reacting an amine with lysergic acid chloride or with ester of lysergic acid, have been unsuccessful.
		It appears that one molecule of the anhydride associates with or favors an ionic adduct with one molecule of the lysergic which contains a basic nitrogen atom and that it is the adduct which reacts with a second molecule of trifluoroacetic anhydride to form the mixed anhydride along with one molecule of trifluoroacetic acid.
		The di-iso-lysergic acid N,N-diethyl amide which remains absorbed on the alumia column as the second fluroescent zone is removed from the column by elution with chloroform.
	www.textfiles.com /drugs/lablsd.txt (2259 words)

	Atmospheric Production and Fate of Trifluoroacetic Acid
		Trifluoroacetic acid is widely used in the chemical industry in processes where it is either consumed or becomes part of a chemical waste stream.
		A generalized scheme for the atmospheric oxidation of a haloalkane that could degrade to give trifluoroacetic acid is given in Figure 6.4.
		To assess the potential for a halocarbon to produce trifluoroacetic acid, it is necessary to quantify the yield of trifluoroacetyl halide in its gas phase oxidation mechanism.
	www.gcrio.org /UNEP1998/UNEP98p56.html (1260 words)

	Citebase - Acyclic sugars: the ring-opening of 2-acetamido-2-deoxyhexopyranoses in trifluoroacetic acid
		Acyclic sugars: the ring-opening of 2-acetamido-2-deoxyhexopyranoses in trifluoroacetic acid
		During an investigation of solvent effects on the anomeric equilibria of 2-acetomido-2-deoxyhexoses, we have observed a novel, reversible reaction of these sugars with trifluoroacetic acid that is described herein.
		Evaporation of the trifluoroacetic acid in vacuo yielded an unstable oil that showed the presence of acetamido and trifluoroacetyl groups (Vco 1680 1795 cm-1).
	citebase.eprints.org /cgi-bin/citations?id=oai:iiscePrints.OAI2:1158 (384 words)

	TFA (Trifluoroacetic Acid)
		Trifluoroacetic acid (TFA) is the most commonly used ion pairing agent in reverse-phase peptide separations because TFA:
		Pierce trifluoroacetic acid is manufactured to the highest specifications to ensure the integrity of your data, maximize sensitivity in your assay and to prolong the life of your equipment.
		Each lot of trifluoroacetic acid is tested to meet the following minimum specifications.
	www.piercenet.com /Products/Browse.cfm?fldID=02040623 (222 words)

	Aromatic Formylation with HMTA and TFA - [www.rhodium.ws]
		When the hexamethylenetetramine is used in conjunction with trifluoroacetic acid, a variety of aromatic compounds, including simple hydrocarbons, can be converted to imine products which are transformed to the aryl aldehydes on hydrolysis (eq 1).
		Thus, a mixture of 12.2 g of 2,6-xylenol (100 mmol), 14.0 g of hexamethylenetetramine (100 mmol), and 150 ml of trifluoroacetic acid was heated at reflux (83-90°C) for 12 hr.
		2 (15%) were isolated after evaporation of the acid and fractional crystallization of the residue from acetonitrile-ether.
	erowid.org /archive/rhodium/chemistry/formylation.duff-hmta-tfa.html (509 words)

	Sciencemadness Discussion Board - Powered by XMB
		If trichloroacetic acid isn't possible, being able to synthesize monochloroacetic acid without having to bother with P / Cl2 would also be an achievement.
		Methyl chloroacetate is made from monochloroacetic acid and can be used with KF to form methyl fluoroacetate, which can be used to prepare fluoroacetic salts and the free acid.
		You can apparently start with monochloracetic acid and fluorinate it to trifluoroacetyl fluoride, which can be hydrolyzed to give trifluoroacetic acid.
	www.sciencemadness.org /talk/viewthread.php?tid=80 (1398 words)

	Choice of Buffer for the Analysis of Basic Peptides in Reversed-Phase HPLC - LCGC
		Volatile buffers-additives such as formic acid, trifluoroacetic acid, or heptafluorobutyric acid are used because they do not lead to contamination of the source, which occurs with involatile inorganic buffers such as phosphate.
		One of the reasons for this finding is the possibility of ion-pairing between charged peptides and trifluoroacetic acid, which contributes to this loss of sensitivity.
		In a later paper (3), the same group recommended the use of trifluoroacetic acid due to the relatively poor resolution of peptides obtained with formic acid.
	www.lcgcmag.com /lcgc/article/articleDetail.jsp?id=147854&pageID=8 (526 words)

	Replacement of Trifluoroacetic Acid with HCl in the Hydrophobic Purification Steps of Pediocin PA-1: a Structural ...
		Trifluoroacetic acid (TFA) is a purification contaminant associated
		Trichloroacetic acid and trifluoroacetic acid-induced unfolding of cytochrome c: stabilization of a native-like folded intermediate.
		Trifluoroacetate, a contaminant in purified proteins, inhibits proliferation of osteoblasts and chondrocytes.
	aem.asm.org /cgi/content/full/68/10/4803 (3459 words)

	JCE 1996 (73) 465 [May] The Esterification of Trifluoroacetic Acid: A Variable Temperature NMR Kinetics Study
		The Esterification of Trifluoroacetic Acid: A Variable Temperature NMR Kinetics Study
		This paper describes an addition to a previously published experiment in which NMR is used to follow the kinetics of the reaction of trifluoroacetic acid with alcohols.
		A variable temperature accessory is used to determine the energy of activation and reaction order with respect to the alcohol concentration.
	jchemed.chem.wisc.edu /Journal/issues/1996/may/abs465.html (199 words)

	electro.htm (Site not responding. Last check: 2007-11-03)
		These two molecules were chosen to look at different electrostatic surfaces because they have similar structure but different electrostatic properties.
		Trifluoroacetic acid has more evenly distributed charge than acetic acid because the fluorine is more negative and pulls electros toward it more than hydrogen.
		Notice the difference in electrostatic potential between acetic acid and trifluoroacetic acid.
	www.mtholyoke.edu /acad/chem/mmlab/advanced/electro.htm (186 words)

	TFA in WATER
		Synonyms: Trifluoroacetic Acid in Water; 0.1% TFA in WATER; 0.15% TFA in WATER; 0.05% TFA in WATER
		Concentrated trifluoroacetic acid is a corrosive and can cause burns to any area of contact.
		Hazards of this dilute solution are expected to be less severe than effects from higher concentrations of the trifluoroacetic acid.
	www.jtbaker.com /msds/englishhtml/T5526.htm (930 words)

	TRIFLUOROACETIC ACID
		Store in a cool, dry, ventilated storage area with acid resistant floors and good drainage.
		When diluting, always add the acid to water; never add water to the acid.
		Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product.
	www.jtbaker.com /msds/englishhtml/T5525.htm (900 words)

	PharmPC Discussion List Archive - PC1999030.html - 2099 (Site not responding. Last check: 2007-11-03)
		The Merck Index shows the pKa of Trifluoroacetic acid to be 0.3.
		PKa of trifluoroacetic acid is 0.3 (Ref: Merck Index p1523.
		The Merck Index (10th ed.) gives the pKa of trifluoroacetic acid as 0.3.
	www.boomer.org /pc/PC99/PC1999030.html (223 words)

	Synthesis of Tri- and Tetrasubstituted Furans Catalyzed by Trifluoroacetic Acid (Site not responding. Last check: 2007-11-03)
		Substituted 2-hydroxy-3-acetylfurans are synthesized by alkylation of tert-butyl acetoacetate with an
		-haloketone followed by treatment of the obtained intermediate with trifluoroacetic acid (TFA).
		A second alkylation of the intermediate followed by treatment with trifluoroacetic acid provides access to disubstituted 2-methylfurans.
	pubs.acs.org /cgi-bin/abstract.cgi/orlef7/2000/2/i23/abs/ol0063205.html (93 words)

	Chemical Toxicity Studies for Trifluoroacetic acid, sodium salt on All Organism Groups Chemical Toxicity Studies
		Chemical Toxicity Studies for Trifluoroacetic acid, sodium salt on All Organism Groups Chemical Toxicity Studies
		Home > Chemical Search > Trifluoroacetic acid, sodium salt Information
		Toxicity Studies for Trifluoroacetic acid, sodium salt on All Organism Groups - Toxicology studies from the primary scientific literature on aquatic organisms
	www.pesticideinfo.org /List_AquireAll.jsp?Rec_Id=AQ4256 (133 words)

	Chemical Toxicity Studies for Trifluoroacetic acid, Ethyl ester on All Organism Groups Chemical Toxicity Studies
		Chemical Toxicity Studies for Trifluoroacetic acid, Ethyl ester on All Organism Groups Chemical Toxicity Studies
		Home > Chemical Search > Trifluoroacetic acid, Ethyl ester Information
		Toxicity Studies for Trifluoroacetic acid, Ethyl ester on All Organism Groups - Toxicology studies from the primary scientific literature on aquatic organisms
	www.pesticideinfo.org /List_AquireAll.jsp?Rec_Id=AQ2117 (144 words)

	(WO 01/17940) PROCESS FOR THE PREPARATION OF ALKANOYLOXY-BENZENESULFONIC ACIDS AND SALTS THEREOF (Site not responding. Last check: 2007-11-03)
		(WO 01/17940) PROCESS FOR THE PREPARATION OF ALKANOYLOXY-BENZENESULFONIC ACIDS AND SALTS THEREOF
		PROCESS FOR THE PREPARATION OF ALKANOYLOXY-BENZENESULFONIC ACIDS AND SALTS THEREOF
		The process provides the economic advantage inherent in using the product of esterification of step (1) without isolation in the sulfonation of step (2).
	wipo.int /cgi-pct/guest/getbykey5?KEY=01/17940.010315&ELEMENT_SET=DECL (143 words)

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