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Topic: Trihexyphenidyl

	Parkinsn's List Drug DataBase trihexyphenidyl / Artane
		Pharmacokinetics: Trihexyphenidyl is administered orally and is rapidly absorbed from the GI tract.
		Trihexyphenidyl is relatively contraindicated in patients with cardiac disease, such as ischemic heart disease, or with atherosclerosis and hypertension because of its positive chronotropic effect, which could cause tachycardia and/or coronary ischemia.
		Trihexyphenidyl is relatively contraindicated in patients with GI obstruction or urinary tract obstruction due to its antimuscarinic effects.
	www.parkinsons-information-exchange-network-online.com /drugdb/133.html (1106 words)

	Trihexyphenidyl
		Trihexyphenidyl is rapidly absorbed from the gastrointestinal tract.
		Trihexyphenidyl should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts, and in elderly males with possible prostatic hypertrophy.
		The size and frequency of doses of trihexyphenidyl needed to control drug induced extrapyramidal reactions, attributable especially to reserpine and phenothiazine derivatives, must be determined empirically.
	www.mentalhealth.com /drug/p30-t04.html (782 words)

	Trihexyphenidyl hydrochloride, side effects, drug interactions, overdose, dosage
		Trihexyphenidyl is used, in conjunction with other drugs, for the relief of certain symptoms of Parkinson's disease, a brain disorder that causes muscle tremor, stiffness, and weakness.
		Trihexyphenidyl is not a cure for Parkinson's disease; it merely minimizes and reduces the frequency of symptoms such as tremors.
		Do not take trihexyphenidyl if you are known to be sensitive to it or if you have ever had an allergic reaction to it or to other antiparkinson medications of this type.
	www.pdrhealth.com /drug_info/rxdrugprofiles/drugs/tri1030.shtml (875 words)

	MedlinePlus Drug Information: Trihexyphenidyl
		Trihexyphenidyl is used to treat the symptoms of Parkinson's disease and tremors caused by other medical problems or drugs.
		Trihexyphenidyl comes as a tablet, liquid, and extended-release (long-acting) capsule to take by mouth.
		However, trihexyphenidyl may only be needed for a short period to treat other conditions.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a682160.html (661 words)

	MDVU - Pediatric Movement Disorders - Treatments: Trihexyphenidyl (Artane®)
		Trihexyphenidyl is probably the most effective medication to treat dystonia of unknown cause.
		It is an anticholinergic medicine, meaning that it acts to block acetylcholine receptors in the brain.
		Trihexyphenidyl's effect on the brain seems to be more specific.
	www.mdvu.org /library/pediatric/treatments/tre_med_trihex.html (157 words)

	Trihexyphenidyl, Artane Pharmacology - HealthyPlace.com
		Trihexyphenidyl is an anticholinergic agent used to treat Parkinson's disease.
		Trihexyphenidyl should be used with caution in patients with glaucoma, obstructive disease of the gastrointestinal or genitourinary tracts, and in elderly males with possible prostatic hypertrophy.
		Safe use of trihexyphenidyl during pregnancy and lactation has not been established; therefore, when the drug is administered to pregnant patients, nursing mothers, or women of childbearing potential, the potential benefits must be weighed against the possible hazards.
	www.healthyplace.com /medications/trihexyphenidyl.htm (823 words)

	Trihexyphenidyl Health Web Links
		Trihexyphenidyl - Familydoctor.org - Information for patients in English and Spanish.
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		-- Alphonse Allais Trihexyphenidyl blah "Each friend represents a world in us; a world possibly not born until they arrive, and it is only in meeting them that a new world is born." (Anais Nin) Don't be afraid your life will end; be afraid that it will never begin.
	www.internet-health-directory.com /Pharmacy_Drugs_and_Medications_T_Trihexyphenidyl.html (1456 words)

	Drug Information (Site not responding. Last check: 2007-10-16)
		Generic trihexyphenidyl oral elixir is not yet available.
		Trihexyphenidyl may cause dry eyes and blurred vision.
		Trihexyphenidyl may increase your chance of a heat stroke (symptoms may include: stomach upset or cramps, fever, heat intolerance).
	www.muschealth.com /cds/CPDrugInfo.details.aspx?cpnum=629&language=english (566 words)

	Trihexyphenidyl Hydrochloride (Site not responding. Last check: 2007-10-16)
		Trihexyphenidyl is also used to treat Parkinson-like syndromes that can occur as a result of injury to or infection of the central nervous system, damage to blood vessels in the brain, or exposure to certain toxins.
		The exact mechanism of action of trihexyphenidyl is unknown, although it is thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
		Trihexyphenidyl passes into breast milk; this drug should not be used by nursing mothers.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,620,00.html (533 words)

	Drug Directory: Trihexyphenidyl (Site not responding. Last check: 2007-10-16)
		Trihexyphenidyl is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease.
		Trihexyphenidyl may be taken with or without meals.
		Trihexyphenidyl is available with a prescription under the brand name Artane.
	www.netpediatrics.com /drugs/t-73.htm (911 words)

	Trihexyphenidyl, Artane Pharmacology - HealthyPlace.com
		Trihexyphenidyl is an anticholinergic agent used to treat Parkinson's disease.
		Patients hypersensitive to trihexyphenidyl should not be given the drug.
		Safe use of trihexyphenidyl during pregnancy and lactation has not been established; therefore, when the drug is administered to pregnant patients, nursing mothers, or women of childbearing potential, the potential benefits must be weighed against the possible hazards.
	www.concernedcounseling.com /Medications/trihexyphenidyl.asp (841 words)

	Chin Med J (Taipei) 1996;57:157-60. (Site not responding. Last check: 2007-10-16)
		Trihexyphenidyl is a synthetic anticholinergic used in psychiatric patient for the relief of neuroleptic-induced extrapyramidal symptoms.
		The case presented is of anti-cholinergic abuse by a chronic schizophrenic who abused trihexyphenidyl, up to 200 mg per day, to achieve an euphoric effect.
		A high dose of trihexyphenidyl may precipitate anticholinergic toxic psychosis and interfere with the therapeutic effects of antipsychotics by impeding their absorption.
	www.vghtpe.gov.tw /~cmj/5702/570212.htm (198 words)

	TRIHEXYPHENIDYL (ARTANE) DEPENDENCE: A CONTROLLED (Site not responding. Last check: 2007-10-16)
		This controlled study aims to identify the socioclinical factors predisposing psychiatric patients to abuse trihexyphenidyl (artane) and to document the extrapyramidal symptoms in artane abusers and users.
		Thirty patients (n=30), with mainly two major functional psychoses and who were abusing trihexyphenidyl, were compared with 90 artane user patients (n=90), who were matched for both the diagnosis and treatment.
		The analysis of data showed that, compared with users, trihexyphenidyl abusers were significantly characterized by being unmarried, unemployed, smokers and having past and concurrent history of multiple drug abuse, and genetic loading of mental disorders.
	www.kfshrc.edu.sa /annals/172/96-188.html (3249 words)

	Patent 6,146,656
		Biperiden or trihexyphenidyl to be incorporated in the percutaneous absorption preparation of the present invention as an active ingredient is employed mainly for the treatment of the Parkinson disease, but is not limited to such purpose and it may exhibit another pharmacological action.
		Described specifically, a pharmacologically acceptable salt of biperiden or trihexyphenidyl is changed to its free form, that is, biperiden or trihexyphenidyl in the skin contact base by allowing the salt to exist together with a freeing agent such as sodium hydroxide, potassium hydroxide, tetraethylamine, tetraethylammonium, ammonia or sodium caprylate.
		In the percutaneous absorption preparation of the present invention, it is possible to incorporate at least one active ingredient selected from the group consisting of biperiden, trihexyphenidyl and pharmacologically acceptable salt thereof in an amount of 0.5 to 60% by weight, preferably 1 to 30% by weight.
	www.pharmcast.com /Patents/November2000/111400OG/6146656_Percutaneous111400.htm (2247 words)

	Trihexyphenidyl (Site not responding. Last check: 2007-10-16)
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	TRIHEX: buy trihex, discount trihex, side effects trihex - Swiftrx (Site not responding. Last check: 2007-10-16)
		Trihexyphenidyl is used to treat symptoms of Parkinson's disease or involuntary movements due to the side effects of certain psychiatric drugs (antipsychotics such as chlorpromazine/haloperidol).
		Trihexyphenidyl belongs to a class of medication called anticholinergics that work by blocking a certain natural substance (acetylcholine).
		Before taking trihexyphenidyl, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
	www.meds4u.com /quick_search.jsp?criteria=TRIHEX (1427 words)

	Anticholinergic drugs used in Parkinson's disease: An overlooked class of drugs from a pharmacokinetic perspective.
		For example, in muscarinic receptors of rat brain, the IC values for atropine, benztropine, trihexyphenidyl, procyclidine, and orphenadrine were found to be 0.0022, 0.018, 0.026, 0.070, and 0.37 mM, respectively (8).
		For example, in humans, Cmax of trihexyphenidyl have been reported to be 10 ng/mL (n=1 subject); 7.15±2.58 ng/ml (n=8 subjects), and approximately 50 ng/mL (n=2 subjects) after single oral doses of 2, 4, and 15 mg, respectively, of trihexyphenidyl HCl (9-11).
		A recent paper has indicated that high tissue uptake of trihexyphenidyl and biperiden were facilitated by intralysosomal uptake of drug (23).
	www.ualberta.ca /~csps/JPPS2(2)/D.Brocks2/anticholinergic.htm (4328 words)

	Nathan Kline Institute
		The present study examined the epsilon4 allele as a possible modulator of the effects of trihexyphenidyl hydrochloride (Artane(trade mark)), an anticholinergic drug, on memory functioning.
		All participants were tested after receiving a single oral dose of trihexyphenidyl (1 or 2 mg) or placebo, with a 7-day washout period between sessions.
		These results provide evidence suggesting that the epsilon4 allele plays a significant role in increasing cognitive sensitivity to trihexyphenidyl and that a temporal component of memory consolidation may be especially vulnerable.
	www.rfmh.org /nki/pubs/open_publication.cfm?id=1801 (274 words)

	Trihexyphenidyl (Site not responding. Last check: 2007-10-16)
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	Trihexyphenidyl (Site not responding. Last check: 2007-10-16)
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	Artane Side Effects, and Drug Interactions - Trihexyphenidyl - RxList Monographs
		Minor side effects, such as dryness of the mouth, blurred vision, dizziness, mild nausea or nervousness, will be experienced by 30 to 50 percent of all patients.
		Prophylactic administration of anticholinergic agents, such as trihexyphenidyl, as a prevention of drug-induced parkinsonism during neuroleptic therapy is not recommended.
		Therefore, trihexyphenidyl should only be used if the expected benefit to the mother outweighs the potential risk to the infant.
	www.rxlist.com /korean.php?u=http://www.rxlist.com/cgi/generic/trihexyphen_ad.htm (551 words)

	Trihexyphenidyl (Site not responding. Last check: 2007-10-16)
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	Trihexyphenidyl (Site not responding. Last check: 2007-10-16)
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	Trihexyphenidyl (Site not responding. Last check: 2007-10-16)
		The number of states using any type of trihexyphenidyl managed Medicaid program increased from 29 in 1990 to 49 in 1998.
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	Trihexyphenidyl Hydrochloride at Absolute Authority :: Trihexyphenidyl Hydrochloride Information, Products, Services, ...
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	trihexyphenidyl Hydrochloride - Resources from the U.S. Government (Site not responding. Last check: 2007-10-16)
		United States Patent Application: 0020044968 :...trichorfon, trichlormethiazide, trientine hydrochloride, trifluoperazine hydrochloride, triflupromazine, trihexyphenidyl hydrochloride, trimeprazine tartrate...
		Entrez PubMed : No abstract, A controlled study comparing trihexyphenidyl hydrochloride plus levodopa with placebo plus levodopa in patients with Parkinson's disease.
		: Trihexyphenidyl hydrochloride was given for the treatment of extrapyramidal side effects, if needed.
	drugs.mongabay.com /resources/trihexyphenidyl_Hydrochloride.html (315 words)

	MDVU - Pediatric Movement Disorders - Dystonia: Treatment
		L-dopa may also be helpful in some children with dystonia due to cerebral palsy, or perhaps in other metabolic disorders or structural abnormalities.
		The most commonly used medication for children with dystonia is trihexyphenidyl (Artane®).
		Treatment with trihexyphenidyl sometimes requires very high doses of 50 mg or 100 mg per day, or even more in some children.
	www.mdvu.org /library/pediatric/dystonia/dys_tre.html (536 words)

	Successful treatment of rubral tremor by high-dose trihexyphenidyl: a case report.
		Successful treatment of rubral tremor by high-dose trihexyphenidyl: a case report.
		The tremor was successfully controlled by a single high daily dose of trihexyphenidyl (38 mg) without severe or uncomfortable side effects.
		This article was last updated on Wednesday, 12th April 2006 at 1:05 am and is filed in the Clonazepam section.
	counsellingresource.com /medications-research/2006/04/12/successful-treatment-of-rubral-tremor-by-high-dose-trihexyphenidyl-a-case-report (397 words)

	Trihexyphenidyl (Site not responding. Last check: 2007-10-16)
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