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Topic: Trimethoprim

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	Trimethoprim - Wikipedia, the free encyclopedia
		Trimethoprim is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections (cystitis).
		Trimethoprim acts by interfering with the action of bacterial dihydrofolate reductase, inhibiting synthesis of tetrahydrofolic acid.
		Trimethoprim, used as monotherapy, is indicated for the prophylaxis and treatment of urinary tract infections (cystitis).
	en.wikipedia.org /wiki/Trimethoprim (296 words)

	Trimethoprim (Systemic)
		Trimethoprim (trye-METH-oh-prim) is used to treat infections of the urinary tract.
		However, in the few reports where trimethoprim was taken by pregnant women, trimethoprim has not been reported to cause birth defects or other problems in humans.
		Trimethoprim may be taken on an empty stomach or, if it upsets your stomach, it may be taken with food.
	allnutritionals.com /drugs/t/trimethoprim-systemic.shtml (1423 words)

	Antimicrobial treatment of cystitis [May 1995; 15-7] (Site not responding. Last check: 2007-10-13)
		A number of readers have pointed out that there is no convincing evidence that this combination is any more effective than trimethoprim alone, and that the combination may carry a higher rate of adverse effects, especially in the elderly.
		They also point out that present prescribing policies in the UK favour trimethoprim alone rather than the combination, and that prescribing advice to GPs is to restrict their use of Co-trimoxazole on the grounds of safety.
		With trimethoprim, DTB indicated that there were no reports of toxic epidermal necrolysis.
	www.jr2.ox.ac.uk /bandolier/band15/b15-7.html (432 words)

	Trimethoprim - Family factsheets - GOSH and ICH (Site not responding. Last check: 2007-10-13)
		Trimethoprim is a useful drug, which helps prevent urine infections.As your child has been diagnosed with a problem with the urinary system, he or she is more likely to suffer urine infections than other children.
		Trimethoprim is given by mouth as a liquid.
		Trimethoprim is one of the most widely-used antibiotics used to prevent urine infections and when given according to instructions is safe.
	www.ich.ucl.ac.uk /factsheets/families/F000267 (671 words)

	Bactrim Pharmacology, Pharmacokinetics, Studies, Metabolism - Trimethoprim and Sulfamethoxazole - Bactrim.Net
		The principal metabolites of trimethoprim are the 1- and 3-oxides and the 3'- and 4'-hydroxy derivatives.
		Approximately 44% of trimethoprim and 70% of sulfamethoxazole are bound to plasma proteins.
		Both trimethoprim and sulfamethoxazole distribute to sputum, vaginal fluid and middle ear fluid (for tablets and suspensions only); trimethoprim also distributes to bronchial secretion, and both pass the placental barrier and are excreted in breast milk.
	www.bactrim.net /clinical.htm (588 words)

	Metabolism of Trimethoprim to a Reactive Iminoquinone Methide by Activated Human Neutrophils and Hepatic Microsomes -- ...
		The concentration of trimethoprim was 0.4 mM and that of NAC was 5 mM.
		The concentration of trimethoprim was 0.5 mM and that of HOCl was 1 mM.
		Proposed pathway for the bioactivation of trimethoprim to a reactive pyrimidine iminoquinone methide intermediate and its reactions with NAC and protein.
	jpet.aspetjournals.org /cgi/content/full/291/1/292 (4350 words)

	Trimethoprim Sulfa
		This makes trimethoprim sulfa a good choice for skin infections or as a general antibiotic when the actual identity of the infecting organism is not known.
		Another advantage of trimethoprim sulfa is that it has minimal effect on the normal flora of the GI tract of the patient.
		Trimethoprim sulfa should not be used with cyclosporine (used for allergies, perianal fistulas, and immune suppression after organ transplant).
	www.marvistavet.com /html/body_trimethoprim_sulfa.html (947 words)

	Bactrim side-effects - Septra side-effects - Trimethoprim
		Trimethoprim is reasonably well tolerated in general, and the most frequent adverse effects at usual doses are pruritis and skin rash (in about 3 to 7% of patients) and mild gastrointestinal disturbances including nausea, vomiting, and sore mouth.
		Trimethoprim may cause a depression of haematopoiesis due to interference of the drug in the metabolism of folic acid, particularly when given over a prolonged period or in high doses.
		Trimethoprim should not be given to patients with a history of hypersensitivity to the drug, and it should be discontinued if a skin rash appears.
	briandeer.com /septrin/bactrim-martindale2.htm (543 words)

	Trimethoprim (Site not responding. Last check: 2007-10-13)
		Trimethoprim is contra-indicated in patients hypersensitive to trimethoprim and in those with megaloblastic anaemia due to folate deficiency, severe renal impairment and breast-feeding mothers.
		Trimethoprim should be given with caution to patients with possible folate deficiency, impaired renal or hepatic function, during pregnancy (category C, teratogenic effects) and with children.
		Trimethoprim interferes with folate synthesis in susceptible bacteria.
	wwwcmc.pharm.uu.nl /edu/Drug_tri.html (1360 words)

	TRIMETHOPRIM - a patient's guide
		Trimethoprim alone is probably most commonly used for urinary tract infections (cystitis).
		Trimethoprim may also be used for some other bacterial infections; in this case it is often combined with another antibiotic as co-trimoxazole.
		Trimethoprim works by stopping a step in the process of making DNA in bacteria.
	www.medic8.com /healthguide/articles/trimethoprim.html (553 words)

	ADAP drugs: trimethoprim (Site not responding. Last check: 2007-10-13)
		Trimethoprim is used in combination with dapsone to treat PCP.
		Trimethoprim alone is used at lower doses to treat upper respiratory infections and uncomplicated urinary tract infections.
		High doses of trimethoprim may cause hyperkalemia, which is abnormally high levels of potassium in the blood.
	www.atdn.org /access/drugs/trim.html (327 words)

	trimethoprim (Trimpex, Proloprim) - drug class, medical uses, medication side effects, and drug interactions by ...
		Trimethoprim was approved by the FDA in combination with sulfamethoxazole (e.g., Bactrim, Septra) in 1973.
		PRESCRIBED FOR: Trimethoprim is used for the treatment and prevention of urinary tract infections, traveler's diarrhea, respiratory and middle ear infections, and, when combined with either sulfamethoxazole or dapsone, for prevention and treatment of Pneumocystis infections.
		When trimethoprim and dapsone are used together, increased blood concentrations of both drugs can occur, sometimes with side effects that include a toxic condition called methemoglobinemia.
	www.medicinenet.com /trimethoprim/article.htm (719 words)

	Septra Suspension Drug Information Septra Suspension
		Both trimethoprim and sulfamethoxazole distribute to sputum, vaginal fluid, and middle ear fluid; trimethoprim also distributes to bronchial secretions, and both pass the placental barrier and are excreted in human milk.
		SEPTRA is contraindicated in patients with a known hypersensitivity to trimethoprim or sulfonamides and in patients with documented megaloblastic anemia due to folate deficiency.
		Because trimethoprim and sulfamethoxazole may interfere with folic acid metabolism, SEPTRA should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
	www.drugs.com /pdr/septra_suspension.html (3592 words)

	trimethoprim - [Medication] (Site not responding. Last check: 2007-10-13)
		Trimethoprim is used to treat urinary tract infections.
		Trimethoprim is in the FDA pregnancy category C. This means that it is not known whether trimethoprim will harm an unborn baby.
		Trimethoprim is not approved for use by children younger than 2 months of age.
	www.peacehealth.org /kbase/multum/d00123a1.htm (828 words)

	Trimethoprim news articles (Site not responding. Last check: 2007-10-13)
		Lannett said it is selling both single- and double-strength tablets of sulfamethoxazole with trimethoprim, generic versions of which had sales of $260 million...
		Trimethoprim drug is used to treat bladder infections.
		However, long-term exposure to the sulfone component of co-trimoxazole (which is a combination of trimethoprim and sulfamethoxazole, and sometimes referred to...
	www.mongabay.com /drugs/drugs/Trimethoprim.html (1342 words)

	Trimethoprim/Sulfamethoxazole (Site not responding. Last check: 2007-10-13)
		Both trimethoprim and sulfamethoxazole kill or inhibit growth of bacteria by disrupting their ability to make necessary proteins.
		Trimethoprim with sulfamethoxazole passes into breast milk; avoid or discontinue use while nursing.
		Nonetheless, trimethoprim with sulfamethoxazole remains valuable for treating a number of problems associated with this disease.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,622,00.html (588 words)

	Characterization of Dihydrofolate Reductase Genes from Trimethoprim-Susceptible and Trimethoprim-Resistant Strains of ...
		Transfer of trimethoprim resistance from strain DEL was not achieved by broth, filter, or cross-streak matings (17) or in
		Trimethoprim resistance in enterococci: microbiological and biochemical aspects.
		Trimethoprim resistance transposon Tn4003 from Staphylococcus aureus encodes genes for a dihydrofolate reductase and thymidylate synthetase flanked by three copies of IS257.
	aac.asm.org /cgi/content/full/43/1/141 (3998 words)

	MedlinePlus Drug Information: Trimethoprim
		Trimethoprim eliminates bacteria that cause urinary tract infections.
		Trimethoprim comes as a tablet to take by mouth.
		Trimethoprim may be taken with or without food.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a684025.html (548 words)

	N101 \| Trimethoprim (Site not responding. Last check: 2007-10-13)
		Trimethoprim is an antibacterial drug used to treat people with urinary tract infections.
		Trimethoprim and TMP/SMX should be used with caution in patients with folic acid deficiency, for which blood tests are available.
		A common side effect of antibiotics is diarrhea, which may be caused by the elimination of beneficial bacteria normally found in the colon.
	www.n101.com /Static/HNs/Drug/Trimethoprim.htm (1302 words)

	High-Level Resistance to Trimethoprim in Clinical Isolates of Campylobacter jejuni by Acquisition of Foreign Genes ...
		Detection of the trimethoprim resistance genes, dfr9 and dfr1, on the chromosome of C.
		Massive overproduction of dihydrofolate reductase in bacteria as a response to the use of trimethoprim.
		Appearance of a new trimethoprim resistance gene, dhfrIX, in Escherichia coli from swine.
	aac.asm.org /cgi/content/full/42/12/3059 (4471 words)

	Bactrim DS Drug Information
		Sulfamethoxazole and trimethoprim combination should not be given to infants less than 2 months of age unless directed by the child's doctor.
		Sulfadiazine and trimethoprim combination should not be given to infants less than 3 months of age, and sulfamethoxazole and trimethoprim combination should not be given to infants less than 2 months of age unless directed by the child's doctor.
		The usual dose is 18.75 to 25 mg of sulfamethoxazole and 3.75 to 5 mg of trimethoprim per kg (8.5 to 11.4 mg of sulfamethoxazole and 1.7 to 2.3 mg of trimethoprim per pound) of body weight every six hours.
	www.drugs.com /cons/bactrim_ds.html (2487 words)

	polymyxin B and trimethoprim ophthalmic - [Medication]
		The ophthalmic form of polymyxin B and trimethoprim is used to treat bacterial infections of the eyes.
		It is not known whether polymyxin B and trimethoprim ophthalmic passes into breast milk.
		Polymyxin B and trimethoprim ophthalmic is available with a prescription under the brand name Polytrim Ophthalmic Solution.
	www.peacehealth.org /kbase/multum/d03529a1.htm (1031 words)

	Renal Mechanism of Trimethoprim-induced Hyperkalemia -- Velazquez et al. 119 (4): 296 -- Annals of Internal Medicine
		trimethoprim inhibited renal potassium excretion by 40% (CI,
		of trimethoprim needed to inhibit the transepithelial voltage
		The effect of each dose of trimethoprim on the distal tubule voltage is plotted as percentage change compared with its own control voltage.
	www.annals.org /cgi/content/full/119/4/296 (2808 words)

	MedlinePlus Drug Information: Sulfonamides and Trimethoprim (Systemic) (Site not responding. Last check: 2007-10-13)
		Sulfamethoxazole and trimethoprim combination is used to treat infections, such as bronchitis, middle ear infection, urinary tract infection, and traveler's diarrhea.
		Adults and children older than 2 months—The usual total daily dose is 40 to 50 mg of sulfamethoxazole and 8 to 10 mg of trimethoprim per kg (18.2 to 22.7 mg of sulfamethoxazole and 3.6 to 4.5 mg of trimethoprim per pound) of body weight.
		Adults and children older than 2 months—The usual dose is 18.75 to 25 mg of sulfamethoxazole and 3.75 to 5 mg of trimethoprim per kg (8.5 to 11.4 mg of sulfamethoxazole and 1.7 to 2.3 mg of trimethoprim per pound) of body weight.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202781.html (2489 words)

	Bactrim and Septra (sulfamethoxazole and trimethoprim)
		This drug is an antibiotic used to treat a wide variety of bacterial and protozoal infections, particularly of the urinary tract.
		In combination with trimethoprim, sulfamethoxazole has increased blood levels of potassium, accompanied by increases in other constituents of blood (creatinine and BUN).
		Trimethoprim is an antibiotic used to treat urinary tract and other infections.
	www.vitaminevi.com /Drug/Bactrim_Septra.htm (401 words)

	Trimethoprim for urinary tract infections (UTIs) - [Medication]
		Trimethoprims treat uncomplicated urinary tract infections, which are ones that are not caused by an obstruction or structural problem or some other medical condition that affects urinary function, such as diabetes.
		With trimethoprim treatment, you can expect relief of symptoms of a UTI within 2 to 3 days.
		You can take trimethoprim for either 3 or 7 days to treat an uncomplicated bladder infection.
	www.bchealthguide.org /kbase/topic/detail/drug/aa134785/detail.htm (314 words)

	Sulfamethoxazole With Trimethoprim (Bactrim, Septra) (Site not responding. Last check: 2007-10-13)
		Sulfamethoxazole with trimethoprim is sometimes referred to as SMZ/TMP.
		Sulfamethoxazole with trimethoprim is a combination antibiotic used to treat infections.
		Sulfamethoxazole with trimethoprim is taken orally or given by injection, The oral form is available as single-strength (80/400-mg) or double-strength (160/800-mg) tablets or as a liquid.
	www.sti.upmc.edu /Medications/Prophylactic/Sulfamethoxazole.htm (269 words)

	Prior trimethoprim use and trimethoprim-resistant urinary tract infection: a nested case-control study with ...
		The increasing prevalence of infections caused by antibiotic-resistant
		Young, H. and Hillyear, J. Trimethoprim resistance in urinary pathogens in northern Scotland; epidemic spread of a resistance plasmid encoding the type Ib trimethoprim-resistant dihydrofolate reductase.
		Impact of guidelines for the diagnosis of urinary tract infection on trimethoprim susceptibility of Escherichia coli
	jac.oxfordjournals.org /cgi/content/full/47/6/781 (3039 words)

	Trimethoprim - Patient UK
		Trimethoprim is used to treat bacterial infections of the chest and urinary tract by killing or stopping the growth of the bacteria responsible.
		Trimethoprim is available in tablet and liquid form.
		If you suspect that you or someone else has taken an overdose of Trimethoprim contact your doctor or go to the accident and emergency department of your local hospital at once.
	www.patient.co.uk /showdoc/30002329 (560 words)

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