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Topic: Trimethylamine

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	Trimethylamine dehydrogenase
		The enzyme catalyses the oxidative demethylation of trimethylamine to dimethylamine and formaldehyde, passing the pair of reducing equivalents thus obtained individually to its physiological oxidant, an electrontransferring flavoprotein (ETF) [2 and references therein].
		Trimethylamine dehydrogenase (EC 1.5.99.7) (TMADH); Methylotrophus methylophilus (bacterium W3A1)
		Lim, L.W., Mathews, F.S. and Steenkamp, D.J. Identification of ADP in the iron-sulfur flavoprotein trimethylamine dehydrogenase.
	metallo.scripps.edu /PROMISE/TMADH.html (309 words)

	Trimethylamine
		Trimethylamine is also a sensory irritant causing a 50 percent reduction in the respiratory rate of mice at a concentration of 61 ppm [ACGIH 1991].
		Before a worker is placed in a job with a potential for exposure to trimethylamine, a licensed health care professional should evaluate and document the worker's baseline health status with thorough medical, environmental, and occupational histories, a physical examination, and physiologic and laboratory tests appropriate for the anticipated occupational risks.
		Containers of trimethylamine should be protected from physical damage and should be stored separately from mercury, strong oxidizing materials (such as chlorine, bromine, and fluorine) ethylene oxide, nitrosating agents (e.g., sodium nitrite), strong acids, and metals (such as zinc, brass, aluminum, and copper).
	www.osha.gov /SLTC/healthguidelines/trimethylamine/recognition.html (3630 words)

	CIGNA - Trimethylaminuria
		When the normal metabolic process fails, trimethylamine accumulates in the body, and its odor is detected in the person’s sweat, urine and breath.
		Trimethylamine is normally formed by bacterial action in the intestine on choline (found in foods such as soya, liver, kidneys, wheat germ, brewer's yeast, and egg yolk), or trimethylamine-oxide (found in salt water fish).
		For mild cases, and to detect possible carriers of trimethylaminuria, urine analysis after the administration of large doses of trimethylamine or choline is used.
	www.cigna.com /healthinfo/nord997.html (1421 words)

	Trimethylamine - Information from Reference.com
		Trimethylamine has a boiling point of 2.9 °C and is a gas at room temperature.
		Trimethylamine is a nitrogenous base and its positively charged cation is called trimethylammonium cation.
		Trimethylamine is used in the chemical synthesis of choline, tetramethylammonium hydroxide, plant growth regulators, strongly basic anion exchange resins, and dye leveling agents.
	www.reference.com /search?q=Trimethylamine (334 words)

	[2.2]PARACYCLOPHANE
		A boiling chip is added to the cold trimethylamine, the trap is connected to the gas inlet tube and is then removed from the cooling bath.
		The trimethylamine is allowed to distil into the flask during a period of 2 hours, during which time p-methylbenzyltrimethylammonium bromide separates as a white solid (Note 2).
		A convenient, alternative procedure consists in slowly passing trimethylamine directly from a cylinder through a trap into the reaction mixture until an excess is present.
	www.orgsyn.org /orgsyn/orgsyn/prepContent.asp?prep=cv5p0883 (871 words)

	Femalepatient.com
		The observation that the group of patients diagnosed with BV had higher levels of trimethylamine in their vaginal secretions than would have been expected when compared with healthy subjects supports the view that trimethylamine is a major contributor to the malodor associated with this condition.
		That trimethylamine is generated by the vaginal microbial flora is implied in the successful treatment of BV with metronidazole and the subsequent loss of malodor.
		Modification of the diet to decrease trimethylamine intake has led to a reduction in odor problems, and appears to be an appropriate step in the management of this condition.
	www.femalepatient.com /html/features/031_03_010.asp (1794 words)

	Trimethylamine \| English \| Dictionary & Translation by Babylon
		Trimethylamine, also known as NMe3, N(CH3)3, and TMA, is a colorless, hygroscopic, and flammable simple amine with a typical fishy odor in low concentrations and an ammonia-like odor in higher concentrations.
		Trimethylamine is a nitrogenous base and its positively charged cation is called trimethylammonium cation.
		A common salt of trimethylamine is trimethylammonium chloride, a hygroscopic colorless solid.
	www.babylon.com /definition/Trimethylamine (104 words)

	genome.gov \| Learning About Trimethylaminuria
		Trimethyaminuria is a metabolic disorder characterized by an individual's inability to metabolize (oxidize) trimethylamine (TMA) to triemthylaminoxide (TMAO).
		FMO3 is the enzyme involved in breaking down trimethylamine (the compound responsible for the fish odor) usually requires two altered genes to cause symptoms, typically neither parent of an individual with trimethylaminuria have any symptoms.
		In this case also, the person would be given a high dose of choline (one of the precursors of trimethylamine) and then have their urine tested for elevated levels of trimethylamine over a 24 hour time frame.
	www.genome.gov /11508983 (1292 words)

	Classic diseases revisited: Fish odour syndrome -- Rehman 75 (886): 451 -- Postgraduate Medical Journal
		by abnormal excretion of a tertiary aliphatic amine (trimethylamine)
		The N-oxidation of trimethylamine in a Jordanian population.
		Trimethylamine: the substance mainly responsible for the fishy odour often associated with bacterial vaginosis.
	pmj.bmj.com /cgi/content/full/75/886/451 (1151 words)

	Rare Pediatric Disease Database (Site not responding. Last check: )
		Trimethylamine is produced when bacteria that are present in the intestine digest proteins.
		Trimethylamine is produced as a result of protein digestion.
		Trimethylamine is produced from the breakdown of certain amino acids named choline and trimethylamine-oxide.
	www.madisonsfoundation.org /content/3/1/display.asp?did=476 (872 words)

	Moose Pass and Crown Point Chemical Exposure Interim Health Hazard Assessment
		The major exposure of residents was to formaldehyde and trimethylamine.
		Trimethylamine was detected in samples taken from the tank car on March 17.
		Formaldehyde and trimethylamine will not persist in the environment, will not bioaccumulate, will not enter the food chain, and will not cause human health problems if present at these very low levels in water or food.
	www.epi.hss.state.ak.us /bulletins/docs/b1986_06.htm (576 words)

	Choline
		Some choline is metabolized in the gut to betaine (trimethylglycine) and trimethylamine, which are also absorbed by the gut.
		Trimethylamine, a choline metabolite, is oxidized to trimethylamine oxide in the liver.
		Trimethylamine, which is produced from choline, is excreted from the body via the urine, sweat, breath and other bodily secretions.
	www.pdrhealth.com /drug_info/nmdrugprofiles/nutsupdrugs/cho_0283.shtml (1814 words)

	BioMed Central \| Full text \| Transient trimethylaminuria related to menstruation
		The decreased enzyme capacity to form non-odorous trimethylamine N-oxide could be a result by an inherited deficiency (primary genetic trimethylaminuria) and/or by hormonal modulation or liver damage (transient trimethylaminuria) [2,3].
		FMO3 metabolic capacity (conversion of trimethylamine to trimethylamine N-oxide) was defined as the urinary ratio of trimethylamine N-oxide to total trimethylamine (% of trimethylamine N-oxide/[trimethylamine + trimethylamine N-oxide]) determined by GC The FMO3 DNA sequence of genomic DNA prepared from peripheral lymphocytes or buccal cells from the study participants was also analyzed [3,5].
		Decreased metabolic capacity of FMO3 (△), as indicated as percent free trimethylamine (TMA, ●) to total trimethylamine (○) excreted in the urine, in relation to menstruation.
	www.biomedcentral.com /1471-2350/8/2 (1137 words)

	DuPont Methylamines: Uses
		Trimethylamine reacted with sulfur dioxide has been used to produce a volatile insecticide.
		The largest use for trimethylamine (TMA) is in the production of choline chloride, a B vitamin supplement in animal feed for chickens, turkeys, and swine.
		Trimethylamine is used to make paper chemicals such as its reaction with epichlorohydrin to make 3-chloro-2-hydroxypropyltrimethylammonium chloride and the epoxy product glyciditrimethylammonium chloride.
	www.dupont.com /methylamines/uses.html (1793 words)

	FISH ODOR SYNDROME (TRIMETHYLAMINURIA)
		Choline and carnitine that are not absorbed in your upper intestinal tract, pass to your colon where bacteria ferment these two chemicals to form trimethylamine which smells like rotten fish.
		This chemical is absorbed from the colon into the bloodstream and travels to the liver which breaks trimethylamine down to odorless trimethylamine N-oxide which is then excreted in the urine.
		However, some people inherit a condition in which they lack the liver enzyme that breaks down the fishy-smelling trimethylamine to its odorless product and their breath, sweat, tears, saliva, urine and vaginal secretions smell like rotting fish.
	www.drmirkin.com /morehealth/7983.html (198 words)

	FMO3 - flavin containing monooxygenase 3 - Genetics Home Reference (Site not responding. Last check: )
		One of these compounds is trimethylamine, which is the molecule that gives fish their fishy smell.
		Trimethylamine is produced as bacteria in the intestine digest certain proteins obtained from eggs, meat, legumes (such as soybeans and peas), and other foods.
		As a result, trimethylamine builds up in the body and is released in an affected person's sweat, urine, and breath.
	ghr.nlm.nih.gov /gene=fmo3 (625 words)

	Reconstitution of the Trimethylamine Oxide Reductase Regulatory Elements of Shewanella oneidensis in Escherichia coli ...
		Reconstitution of the Trimethylamine Oxide Reductase Regulatory Elements of Shewanella oneidensis in Escherichia coli -- Gon et al.
		An unorthodox sensor protein (TorS) mediates the induction of the tor structural genes in response to trimethylamine N-oxide in Escherichia coli.
		Trimethylamine oxide counteracts effects of hydrostatic pressure on proteins of deep-sea teleosts.
	jb.asm.org /cgi/content/full/184/5/1262 (4328 words)

	Body Odor Support (Site not responding. Last check: )
		It may also be acquired as a result of treatment with large doses of the amino acid derivative L-carnitine (levocarnitine).
		This disorder occurs when there is an impairment in the ability of a liver enzyme (trimethylamine-N-oxide synthetase) to break down trimethylamine from choline and trimethylamine-oxide in the diet.
		When trimethylamine is not properly metabolized it is excreted in the urine, sweat and breath, causing a strong fishy odor.
	groups.msn.com /BodyOdorSupport/whatistmau.msnw (364 words)

	75-50-3
		Stridor and temporary salivation, decrease in total protein and albumin concentrations, inflammation, ulceration and/or hyperplasia of squamous epithelium and edema of submucosa in the gastrointestinal tract were observed in the 200 mg/kg group.
		Trimethylamine did not induce gene mutations in bacteria under the conditions of this study.
		Trimethylamine induced chromosomal aberrations in cultured cells under the conditions of this study.
	wwwdb.mhlw.go.jp /ginc/cgi-bin/db1_search.pl?CAS=75-50-3&MID=160 (808 words)

	Utilization of Trimethylamine and other N-methyl Compounds for Growth and Methane Formation by Methanosarcina barkeri ...
		Methylamine, dimethylamine, trimethylamine, and ethyldimethylamine were fermented by pure cultures of Methanosarcina barkeri; except for ethyldimethylamine, these amines are considered important substrates of this methanogenic microorganism.
		During growth of M. barkeri on methyl-, dimethyl-, or trimethylamine, methanol was not excreted into the medium.
		The fermentation of trimethylamine gave rise to an intermediary accumulation of methyl- and dimethylamine in the medium.
	www.pnas.org /cgi/content/abstract/76/1/494 (643 words)

	Trimethylaminuria: The Fish Malodor Syndrome -- Mitchell and Smith 29 (4): 517 -- Drug Metabolism and Disposition
		Ackerman BR, Lemass H, Chow LM, Lambert DM, Greenberg C, Bibeau C, Mamer OA and Treacy EP (1999b) Trimethylaminuria is caused by mutations of the FMO3 gene in a North American cohort.
		Pearson AW, Butler EJ, Curtis F, Fenwick GR, Hobson-Frohock A and Land DG (1979) Effect of rapeseed meal on hepatic trimethylamine oxidase activity in the domestic fowl in relation to egg taint.
		Zhang AQ, Mitchell SC and Smith RL (1996a) Discontinuous distribution of N-oxidation of dietary-derived trimethylamine in a British population.
	dmd.aspetjournals.org /cgi/content/full/29/4/517 (4387 words)

	Effects of ISSo2 Insertions in Structural and Regulatory Genes of the Trimethylamine Oxide Reductase of Shewanella ...
		Trimethylamine oxide (TMAO) is a widespread osmoprotective constituent
		Reconstitution of the trimethylamine oxide reductase regulatory elements of Shewanella oneidensis in Escherichia coli.
		High contents of trimethylamine oxide correlating with depth in deep-sea teleost fishes, skate, and decapod crustaceans.
	jb.asm.org /cgi/content/full/185/6/2042 (2181 words)

	Substituted O-.alpha.-D and O-.beta.-D-multi-galactopyranosyl and glucopyranosyl 1.fwdarw.4 and 1.fwdarw.6 ...
		In this instance, these compounds are given both by their full name according to Chemical Abstracts nomenclature and then by an abbreviated nomenclature which is used throughout the balance of the specification and claims.
		The sugars (H) are converted to the poly (H-sulfate) poly salts with trimethylamine (J) where X is SO.sub.3 H.N(CH.sub.3).sub.3, by treatment with trimethylamine sulfur trioxide in dimethylformamide with heat for several hours.
		A 4.5 g portion of trimethylamine sulfur trioxide is dissolved in 25 ml.
	www.freepatentsonline.com /4221907.html (6864 words)

	Trimethylaminuria
		Trimethylaminuria is a rare disorder in which the body’s metabolic processes fail to alter the chemical trimethylamine.
		When the normal metabolic process fails, trimethylamine accumulates in the body, and its odor is detected in the person’s sweat, urine and breath.
		This secondary form of the disorder is a result of an overload of trimethylamine.
	children.webmd.com /Trimethylaminuria (660 words)

	Trimethylamine oxide accumulation in marine animals: relationship to acylglycerol storage -- Seibel and Walsh 205 (3): ...
		We were unable to analyze trimethylamine oxide (TMAO) content as a function of total lipid content because of the variable presentation of lipid data in the literature.
		Agustsson, I. and Strøm, A. Biosynthesis and turnover of trimethylamine oxide in the teleost cod, Gadus morhua.
		Raymond, J. Seasonal variations of trimethylamine oxide and urea in the blood of a cold-adapted marine teleost, the rainbow smelt.
	jeb.biologists.org /cgi/content/full/205/3/297 (5779 words)

	トリメチルアミン基準 - trimethylamine base (Japanese to English translation glossary) Chemistry; Chem ...
		Formation of a Michaelis complex with trimethylamine base is consistent with a mechanism of amine oxidation that we...
		Stabilisation of trimethylamine base in the Michaelis complex over that in free solution is key to optimising...
		Recent stopped-flow studies with trimethylamine and perdeuterated trimethylamine have now established that trimethylamine base is in fact the reactive species in the enzyme–substrate complex [29] and this has led to a mechanism...
	www.proz.com /kudoz/1665848 (286 words)

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