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Topic: Triptans

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	Triptans (serotonin receptor agonists) for migraine headaches
		Triptans have other properties that may help treat migraine symptoms.
		While the cause of migraines is not well understood, it seems to involve a complex process of widening and narrowing of the blood vessels in the brain, triggering changes in brain chemicals, inflammation, and pain.
		Some triptan drugs may also help to prevent migraines in women who get them only around the time of their menstrual period.
	www.webmd.com /migraines-headaches/triptans-serotonin-receptor-agonists-for-migraine-headaches (825 words)

	Headache Causes, Symptoms, Diagnosis, and Treatment on MedicineNet.com
		The triptans attach to serotonin receptors on the blood vessels and nerves and thereby reduce inflammation and constrict the blood vessels.
		Therefore, triptans should not be given to patients who have had heart attacks and strokes, or to patients who have symptoms of atherosclerosis such as angina, transient ischemic attacks, and intermittent claudication.
		Ergots, like triptans, cause constriction of blood vessels, but ergots tend to cause more constriction of vessels in the heart and other parts of the body than the triptans, and their effects on the heart are more prolonged than the triptans.
	www.medicinenet.com /headache/page8.htm (1067 words)

	Triptans (serotonin receptor agonists) for migraine headaches - Medications - Medical Encyclopedia - MSN Health & ... (Site not responding. Last check: )
		Triptans narrow (constrict) blood vessels in the brain and relieve swelling.
		While the cause of migraines is not well understood, it seems to involve a complex process of widening and narrowing of the blood vessels in the brain, triggering changes in brain chemicals, inflammation, and pain.
		Triptans should not be taken with other drugs such as monoamine oxidase inhibitors (MAOIs) or other migraine drugs such as ergotamines.
	health.msn.com /encyclopedia/medications/articlepage.aspx?cp-documentid=100062111 (712 words)

	Triptan definition - Migraine Headaches and Other Neurological Disorders, Treatment, Symptoms and Medications on ...
		Triptan: A class of drugs introduced in the 1990s for the treatment of migraine that act as agonists for 5-hydroxytryptamine (5-HT) receptors.
		The triptans are often very effective in relieving migraine but do not prevent future attacks or lessen their frequency.
		The antimigraine activity of the triptans likely lies in their agonist effects on the 5-HT receptors in the intracranial blood vessels and nerves of the trigeminal system which result in cranial vessel constriction and inhibition of pro-inflammatory neuropeptide release.
	www.medterms.com /script/main/art.asp?articlekey=25211 (328 words)

	Heart Disease Symptoms > Cardiac Risk Minimal for Migraine Patients Using Triptans
		Migraines are caused by abnormal nerve activation and inflammation.
		However, in the arm of the virtual clinical trial that treated everyone with triptans, there were 70 percent fewer migraines than the group that gave triptans to no one.
		The researchers acknowledge that the study is limited because there are little data on the true cardiac risk of triptans; therefore, researchers had to recreate risk using general statistics on heart disease and also on trial and adverse event reporting.
	www.emaxhealth.com /92/1598.html (861 words)

	Migraine Addendum
		The Triptans mostly act as agoists (that is having the same action as the transmitter) at Serotonin 1B/1D receptor.
		Triptans don’t differ too much in their efficacy especially if you take into consideration that they have rarely been compared in the same study "head to head".
		There are newer triptan agents being studied which promise a longer duration of action but they have not been released yet.
	www.pneuro.com /publications/migraine/triptans.html (1129 words)

	Information
		Triptans are not a “miracle cure” for migraines but do have the best evidence for efficacy of any drug designed specifically to treat migraine.
		Triptans can be prescribed from the beginning, as first-line therapy to patients with moderate to severe migraine who do not have contraindications for their use.
		Triptans act on dilated blood vessels and return them to normal size, as well as reducing neuronal firing and the release of inflammatory factors on the trigeminal nerves (the nerve that delivers sensory stimuli to the brain from the face, teeth and tongue).
	www.w-h-a.org /wha2/Newsite/resultsnav.asp?idContentNews=644 (624 words)

	Emergency Medicine
		Triptans are contraindicated in pregnancy and should be used with extreme caution to treat basilar migraine and migraine with prolonged aura.
		Triptans are known to constrict coronary blood vessels as well as meningeal arteries.
		All of the triptans are highly effective in the acute treatment of migraine and are similar in their mechanism of action.
	www.emedmag.com /html/pre/fea/features/091503.asp (3317 words)

	Imigraine.Net B. Todd Troost, M.D.
		It is believed this agonist activity is the primary mechanism of the therapeutic effect of the drugs which have three potential mechanisms of action: cranial vasoconstriction, peripheral neuronal inhibition, and inhibition of transmission through second-order neurons in the trigeminocervical complex.
		In selecting the initial treatment for an acute attack, it should be recognized that migraine is a polygenetic heterogeneous disorder and, therefore, treatment of the initial attacks depend upon the severity and frequency of the attacks and the prior history of treatment.
		In patients with significant disability, a triptan should be prescribed early in the course of treatment in keeping with a stratified approach to care.
	imigraine.net /migraine/ttriptans.html (366 words)

	Tips from Other Journals - June 15, 2002 - American Family Physician
		Triptans can probably be safely continued, if needed, unless there is other evidence that the chest pain is ischemic.
		Because of their mechanism of action, triptans should not be used in patients with uncontrolled hypertension; however, triptans may be an appropriate treatment for migraine if blood pressure is well controlled.
		Studies of patients younger than 18 years show that triptans appear to be safe and effective, although they are not labeled by the U.S. Food and Drug Administration for use in children.
	www.aafp.org /afp/20020615/tips/5.html (599 words)

	USNews.com: Health: Headache: Triptans
		Triptans are approved by the Food and Drug Administration for the treatment of acute migraine attacks and are the most useful class of abortive agents.
		Triptans are taken when a headache starts, to stop the process that causes the headache.
		You should not use triptans if you have uncontrolled high blood pressure, a history of heart attack, heart disease, cerebrovascular disease, peripheral vascular disease, liver or kidney dysfunction, or if you are pregnant.
	www.usnews.com /usnews/health/brain/headache/head.treat.meds.triptan.htm (292 words)

	Triptans for migraine (Site not responding. Last check: )
		Triptans are believed to effect migraine relief by binding to serotonin (5-hydroxy-tryptamine) receptors in the brain, where they act to induce vasoconstriction of extracerebral blood vessels and also reduce neurogenic inflammation.
		Although the pharmacological mechanism of the triptans is similar, their pharmacokinetic properties are distinct.
		Finally, the performance of the triptans is considered in the context of direct head-to-head comparative trials that have assessed the efficacy profile of the compounds.
	www.biopsychiatry.com /triptans.htm (277 words)

	Allodynia Predicts Triptans’ Ability to Abort Migraines
		Based on the timetable for the development of cutaneous allodynia, Dr. Burstein introduced triptans during the developing phase and the established phase in migraineurs with allodynia and during early and late phases in migraineurs without allodynia, and compared the results.
		In contrast, when migraine attacks are associated with allodynia at the time of treatment, triptans can only reduce the pain partially (by 20% to 40%), but not eliminate it completely” when the patient does not receive triptans within the first hour of the migraine onset, he said.
		In a migraine patient with allodynia, however, when triptans were administered four hours after onset of migraine, when skin sensitivity had been abnormal for several hours and the patient was probably in the established phase of allodynia, the triptan injection did not abort the migraine or treat the allodynia, he reported.
	www.neurologyreviews.com /dec03/nr_dec03_allodynia.html (508 words)

	Headlines : Feature Article
		The triptans are a category of medication that act specifically on a chemical (serotonin) that is involved in the transmission of pain from migraines.
		The triptans are believed to work by binding to receptors at the site of these dilated blood vessels, constricting them, and also helping to inhibit release of the chemicals that cause inflammation and pain.
		Triptans are for abortive treatment of migraines-that is, to stop migraine headaches in their tracks, not to prevent them.
	www.headaches.org /consumer/headlines/archives/109/headlinesindex.html (1829 words)

	Comparing Oral Triptans in Treatment of Acute Migraine American Family Physician - Find Articles
		Triptans (selective 5-hydroxytryptamine1B/1D serotonin agonists) are a new class of agents used in the treatment of migraine.
		As the number of available triptans increases, comparisons of the various agents become more important, and evidence-based guidelines are needed to pinpoint the triptan that will be most effective in an individual patient.
		Triptans should not be used in patients with cardiovascular disease or major risk factors for cardiovascular disease.
	findarticles.com /p/articles/mi_m3225/is_7_65/ai_84378084 (893 words)

	Triptans/SSRIs
		On July 19, 2006, the FDA issued a Public Health Advisory warning of the potential danger associated with the use of 5-hydroxytryptamine agonists (triptans) in patients who are also taking selective serotonin reuptake inhibitors (SSRIs) and selective serotonin/norepinephrine reuptake inhibitors (SNRIs).
		The following sites will require you to enter the topic into their search field:
		If any of the links do not work, please let us know by sending us an email.
	www.pswi.org /irx/triptan.htm (72 words)

	Public Health Advisory: Drug Combination May Result in Serotonin Syndrome
		A life-threatening condition called serotonin syndrome may occur when triptans are used together with a SSRI or a SNRI.
		Triptans are drugs used to treat migraine headaches, and SSRIs and SNRIs are drugs used to treat depression and other mood disorders.
		The FDA has requested that all manufacturers of triptans, SSRIs and SNRIs update their prescribing information to warn of the possibility of serotonin syndrome when triptans and SSRIs or SNRIs are taken together.
	www.fda.gov /cder/drug/advisory/SSRI_SS200607.htm (472 words)

	Triptans
		Triptans are the first class of drugs designed to relieve migraine symptoms by targeting the disease pathology.
		Binding of triptans to these receptors aborts migraine attacks and represent a key milestone in the evolution of migraine therapy.
		The subsequent introduction of these improved drugs has increased their use considerably and triptans are identified as the most effective acute treatment for migraine and recommended by all evidence-based guidelines for migraine management.
	www.zomig.info /Information/Triptans.aspx?l1=_2 (714 words)

	Welcome to the Houston Headache Clinic
		The triptans are highly effective, specifically developed migraine medications useful for acute episodes of migraine as well as acute attacks of cluster headache.
		Triptans are generally not used in patients with known coronary artery disease or very high uncontrolled blood pressure.
		Triptans are very safe medications and help patients a lot if they are taken early enough.
	www.houstonheadacheclinic.com /pharmocological.html (980 words)

	IHC: Established Cutaneous Allodynia Thwarts Triptans Ability to Abort Migraine Headaches
		Based on the timetable for the development of cutaneous allodynia, Dr. Burstein introduced triptans in patients during both the migraine developing phase and the established migraine phase, as well as during early and late phases in non-allodynic patients.
		In an allodynic patient, however, when triptans were administered at 4 hours after onset of migraine, skin sensitivity had been abnormal for several hours, and probably in the established phase of allodynia, it was noted.
		Triptan injection did not abort the migraine nor treat the allodynia.
	www.docguide.com /dg.nsf/PrintPrint/525A80B36818E44285256DA3004BC44A (834 words)

	Triptans (serotonin receptor agonists) for migraine headaches - [Medication]
		Triptans narrow (constrict) blood vessels in the brain and relieve swelling.
		While the cause of migraines is not well understood, it seems to involve a complex process of widening and narrowing of the blood vessels in the brain, triggering changes in brain chemicals, inflammation, and pain.
		Triptans should not be taken with other drugs such as monoamine oxidase inhibitors (MAOIs) or other migraine drugs such as ergotamines.
	www.peacehealth.org /kbase/topic/detail/drug/hw116449/detail.htm (650 words)

	IHC: Established Cutaneous Allodynia Thwarts Triptans Ability to Abort Migraine Headaches (Site not responding. Last check: )
		Based on the timetable for the development of cutaneous allodynia, Dr. Burstein introduced triptans in patients during both the migraine developing phase and the established migraine phase, as well as during early and late phases in non-allodynic patients.
		In an allodynic patient, however, when triptans were administered at 4 hours after onset of migraine, skin sensitivity had been abnormal for several hours, and probably in the established phase of allodynia, it was noted.
		Triptan injection did not abort the migraine nor treat the allodynia.
	www.pslgroup.com /dg/23a2b2.htm (811 words)

	Migraine Headaches
		Triptans (also referred to as serotonin agonists) were the first drugs specifically developed for use against migraine and are the most important migraine agents currently available.
		Triptans are now recommended as first-line agents for many adult patients with moderate to severe migraines when NSAIDs are not effective.
		Triptans also affect serotonin and so people taking antidepressants that increase serotonin levels (which are most antidepressants) should avoid taking both.
	www.adam.com /democontent/wci/articles/000097_7.htm (2178 words)

	Migraine Headache Causes, Symptoms, Diagnosis and Treatment on MedicineNet.com
		Examples of migraine-specific abortive medications are the triptans and ergot preparations.
		Using a triptan early in an attack increases its effectiveness, reduces side effects, and decreases the chance of recurrence of another headache during the following 24 hours.
		Therefore, triptans should not be given to patients who have had heart attacks and strokes, or to patients who have symptoms of atherosclerosis such as angina, transient ischemic attacks, and intermittent
	www.medicinenet.com /migraine_headache/page4.htm (981 words)

	Target Migraine - Migraine and the pharmaceutical industry - The triptans — the migraine medicines of today
		Yet again, some types of triptan such as naratriptan are slower to provide relief and yet may be more acceptable in specific individuals who suffer from an early return of their headache.
		Also, some triptans should not be taken by people being treated with some other types of medicines.
		The availability of the four triptans is, therefore, a considerable advantage, because without it patients and doctors would have less choice and fewer people would achieve acceptable control of their illness.
	www.abpi.org.uk /publications/publication_details/targetMigraine/section4d.asp (885 words)

	Understanding Migraine and Cluster Headache Medications
		Triptans stimulate serotonin (a chemical needed to transmit various nerve signals to the brain), decrease inflammation, and reverse blood vessel dilation (expansion) around the brain, thereby relieving the migraine or cluster headache symptoms.
		Use: Triptans are available in a variety of dosage forms designed to be swallowed, dissolved in the mouth, injected under the skin, or sprayed up the nose.
		Triptans may cause a bad or unusual taste in mouth, and the nasal spray may cause nose and throat irritation.
	www.emedicinehealth.com /understanding_migraine_and_cluster_headache_medic/page7_em.htm (426 words)

	Information for Healthcare Professionals: Triptans
		The FDA recommends that patients treated concomitantly with a triptan and an SSRI/SNRI be informed of the possibility of serotonin syndrome (which may be more likely to occur when starting or increasing the dose of an SSRI, SNRI, or triptan) and be carefully followed.
		When prescribing an SSRI or a triptan, physicians should discuss the possibility of serotonin syndrome with patients if an SSRI and a triptan will be used concomitantly.
		Therefore, it is expected that concomitant use of SSRIs or SNRIs and triptans would result in higher serotonin levels than the serotonin levels observed with the use of SSRIs, SNRIs, or triptans alone, potentially leading to serotonin syndrome.
	www.fda.gov /CDER/drug/InfoSheets/HCP/triptansHCP.htm (573 words)

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