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Topic: Tumor necrosis factor

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	Tumor necrosis factor - Wikipedia, the free encyclopedia
		TNFα is a member of a group of other cytokines that all stimulate the acute phase reaction.
		Inhibition of TNFα with a monoclonal antibody or a circulating receptor such as infliximab (Remicade®), etanercept (Enbrel®), or adalimumab (Humira®) are used in modern treatment of various autoimmune disorders such as rheumatoid arthritis, Crohn's disease and psoriasis.
		TNF or the effects of TNF are also inhibited by a number of natural compounds, including curcumin (an ingredient in turmeric) and catechins (in green tea).
	en.wikipedia.org /wiki/Tumor_necrosis_factor (312 words)

	Tumor necrosis factor (Site not responding. Last check: 2007-11-07)
		Tumor necrosis factor alpha is a cytokine produced primarily by monocytes and macrophages.
		The receptors for the Tumor necrosis factor are on several mononuclear cells, in the synovial membrane, as well as the peripheral blood and synovial fluid.
		Abstract : Tumor necrosis factor alpha (TNF alpha) is a critical inflammatory mediator in rheumatoid arthritis, and may therefore be a useful target for specific immunotherapy.
	www.arthritis.co.za /tnf.htm (620 words)

	Untitled Document
		TNF is a regulator of both inflammation and immunity and is presently in clinical trials as an anticancer drug at a number of centers (2, 3).
		TNF-or rather the TNFs, for this is turning out to be a class of chemicals-are thus a group of proteins that are able to destroy tumor cells.
		Antineoplastic effects of tumor necrosis factor alone and in combination with gamma-interferon on tumor biopsies in clonogenic assay.
	www.ralphmoss.com /tnf.html (718 words)

	Tumor Necrosis Factor
		TNF is widely regarded as one of the most important of the vast array of known cytokines.
		TNF is a cytokine produced by many cell types, including macrophages, monocytes, lymphoid cells and fibroblasts in response to inflammation, infection, and other environmental challenges.
		TNF elicits a wide spectrum of cellular responses, including fever, shock, tissue injury, tumor necrosis, anorexia, induction of other cytokines and immunoregulatory molecules, cell proliferation, differentation and apoptosis.
	www.ypatent.com /CytokinesTNF.htm (394 words)

	Tumor necrosis factor (Site not responding. Last check: 2007-11-07)
		In medicine tumor necrosis factor alpha (TNFα cachexin or cachectin) is an cytokine involved in systemic inflammation and the acute phase response.
		Inhibition of TNFα with a monoclonal antibody or a circulating receptor is used modern treatment of various autoimmune disorders most notably rheumatoid arthritis (infliximab /Remicade® and etanercept/Enbrel®).
		Tumor Necrosis Factor: Structure, Mechanism of Action, Role in Disease and Therapy : 2nd International Conference on Tumor Necrosis Factor and Relat
	www.freeglossary.com /TNF-alpha (287 words)

	Tumor Necrosis Factor and Dioxin (Site not responding. Last check: 2007-11-07)
		In the present studies, the role of the proinflammatory cytokines interleukin 1 (IL-1) and tumor necrosis factor (TNF) in TCDD-induced hyperinflammation was examined.
		Tumor necrosis factor involvement in the toxicity of TCDD: the role of endotoxin in the response.
		Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus.
	www.bphata.com /TNF_AO.htm (3453 words)

	HON Allergy Glossary TNF
		The genes that encode both TNF forms are found in the MHC.
		TNF is also chemotactic for neutrophils and monocytes, as well as increasing neutrophil activity.
		TNF causes the symptoms associated with bacterial infections (septic shock, fever, muscle ache, lethargy, headache, nausea and inflammation).
	www.hon.ch /Library/Theme/Allergy/Glossary/tnf.html (133 words)

	Tumor necrosis factor definition - Medical Dictionary definitions of popular medical terms
		Tumor necrosis factor: A member of a superfamily of proteins, each with 157 amino acids, which induce necrosis (death) of tumor cells and possess a wide range of proinflammatory actions.
		Tumor necrosis factor is a multifunctional cytokine with effects on lipid metabolism, coagulation, insulin resistance, and the function of endothelial cells lining blood vessels.
		Blocking the action of TNF has been shown to be beneficial in reducing the inflammation in inflammatory diseases such as Crohn's disease and rheumatoid arthritis.
	www.medterms.com /script/main/art.asp?articlekey=25458 (239 words)

	Effect of nutrition on tumor necrosis factor receptors in weight-gaining and -losing rats -- Raina et al. 277 (3): 464 ...
		TNF bioactivity, or as TNF agonists, by prolonging the circulating
		Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.
		Tumor necrosis factor is delivered to mitochondria where a tumor necrosis factor-binding protein is localized.
	ajpendo.physiology.org /cgi/content/full/277/3/E464 (5190 words)

	Tumor Necrosis Factor Blood Test
		A variety of cells are shown to produce TNF-.TNF- is a growth factor for fibroblasts and stimulates the synthesis of collagenase and prostaglandin E2.
		In the absence of IL-2, TNF- induces the proliferation and differentiation of beta cells.
		TNF- levels may be elevated in sepsis, cachexia, AIDS, Hepatitis C, transplant rejection, various infectious and autoimmune diseases.
	www.lef.org /newshop/items/itemLC140673.html (113 words)

	Tumor Necrosis Factor and Neuropathy (Site not responding. Last check: 2007-11-07)
		Neutralizing antibodies to TNF, to the TNF receptor 1 (TNFR1), and to the TNF receptor 2 (TNFR2) were administered by epineurial injection once daily to mice with CCI.
		Acta Neuropathol (Berl) 1998 Jan;95(1):57-62 Immunocytochemical expression of tumor necrosis factor-alpha (TNF-alpha) was examined in nerve biopsy samples of patients with various disorders, focusing on nerve injury.
		Direct infection of neurons by HIV is unlikely, and the axonal injury may be an indirect effect mediated by cytotoxic factors such as tumor necrosis factor-alpha (TNF-alpha) which we have previously demonstrated to cause axonal degeneration in the rabbit optic nerve.
	www.bphata.com /TNFNeuro.htm (2919 words)

	Tumor necrosis factor (TNF)-alpha induces leptin production through the p55 TNF receptor -- Finck and Johnson 278 (2): ...
		hypersensitive to the induction of leptin by TNF-
		Tumor necrosis factor receptors (TNFR) in mouse fibroblasts deficient in TNFR1 or TNFR2 are signaling competent and activate the mitogen-activated protein kinase pathway with differential kinetics.
		Cooperative signaling by tumor necrosis factor receptors CD120a (p55) and CD120b (p75) in the expression of nitric oxide and inducible nitric oxide synthase by mouse macrophages.
	ajpregu.physiology.org /cgi/content/full/278/2/R537 (3634 words)

	LAH Publications #300 - #399
		To investigate the activity of a single transcription factor in individual viable cells, we have applied an assay that uses the fluorescence-activated cell sorter to quantitate beta-galactosidase (beta-gal).
		Furthermore, because NAC reverses tumor necrosis factor alpha toxicity both in cells and in animals and is a well-known drug that can be administered orally without known toxicity in humans, these results suggest that NAC is a possible therapeutic agent in AIDS.
		In an inflammatory-cytokine signaling model, the failure of tumor necrosis factor alpha to stimulate more than minimal tyrosine phosphorylation in lymphocytes is overcome by buthionine sulfoximine pretreatment--i.e., tumor necrosis factor alpha stimulates extensive tyrosine phosphorylation in glutathione-depleted lymphocytes.
	herzenberg.stanford.edu /Publications/300-399.htm (12219 words)

	CHEST: Tumor Necrosis Factor Polymorphism in Sarcoidosis (Site not responding. Last check: 2007-11-07)
		There is little doubt that genetic factors play an important role in the genesis of sarcoidosis.[3] During the later half of the last century, many reports of familial sarcoidosis appeared.
		Polymorphism of the tumor necrosis factor region in relation to disease: an overview.
		Genetic polymorphisms at the tumor necrosis factor loci (TNFA and TNFB) in cardiac sarcoidosis.
	www.findarticles.com /p/articles/mi_m0984/is_3_119/ai_72730247 (1132 words)

	Recombinant Human Tumor Necrosis Factor-alpha (TNF-a) - CYT- 223 (Site not responding. Last check: 2007-11-07)
		TNF is secreted by macrophages, monocytes, neutrophils, T-cells, NK-cells following their stimulation by bacterial LPS.
		Recombinant Human Tumor Necrosis Factor-alpha produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 158 amino acids and having a molecular mass of 17483.77 Dalton.
		The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1.
	www.prospec.co.il /~prospec/cart/catalog/rHuTNFa.html (451 words)

	Roles of tumor necrosis factor p55 and p75 receptors in TNF-alpha -induced vascular permeability -- Ferrero et al. 281 ...
		receptors of 55- to 60-kDa and 75- to 80-kDa [tumor necrosis factor
		Tumor necrosis factor activates human endothelial cells through the p55 tumor necrosis factor receptor but the p75 receptor contributes to activation at low tumor necrosis factor concentration.
		A human tumor necrosis factor p75 receptor agonist stimulates in vitro T cell proliferation but does not produce inflammation or shock in the baboon.
	ajpcell.physiology.org /cgi/content/full/281/4/C1173 (4259 words)

	Pulmonary-specific expression of tumor necrosis factor-alpha alters surfactant lipid metabolism -- Carroll et al. 282 ...
		Tumor necrosis factor-alpha-induced inhibition of phosphatidylcholine synthesis by human type II pneumocytes is partially mediated by prostaglandins.
		Tumor necrosis factor-induced release of endogenous fatty acids analyzed by a highly sensitive high-performance liquid chromatography method.
		Effects of tumor necrosis factor-alpha on peroxidation of plasma lipoprotein lipids in experimental animals and patients.
	ajplung.physiology.org /cgi/content/full/282/4/L735 (4339 words)

	Carleton University - Psychology - Directory - Shawn Hayley (Site not responding. Last check: 2007-11-07)
		Mice lacking the tumor necrosis factor- or Fas receptors are resistant to MPTP induced death of dopaminergic neurons.
		Corticosterone changes in response to stressors, acute and protracted actions of tumor necrosis factor-, and lipopolysaccharide treatments in mice lacking the tumor necrosis factor- p55 receptor gene.
		The acute and sensitization effects of tumor necrosis factor-a: implications for immunotherapy as well as psychiatric and neurological conditions.
	www.carleton.ca /psychology/directory/hayley_s.html (1669 words)

	The Role of Tumor Necrosis Factor-alpha (TNF-{alpha}) in Skeletal Muscle Regeneration: Studies in TNF-{alpha}(-/-) and ...
		Fiers W (1991) Tumor necrosis factor: characterization at the molecular, cellular and in vivo level.
		Szalay K, Duda E (1997) TNF inhibits myogenesis and downregulates the expression of myogenic regulatory factors myoD and myogenin.
		Tracey KJ, Cerami A (1990) The biology of cachectin/tumor necrosis factor.
	www.jhc.org /cgi/content/full/49/8/989 (5691 words)

	Central and peripheral concentrations of tumor necrosis factor-{alpha} in Chinese Meishan pigs stimulated with ...
		Central and peripheral concentrations of tumor necrosis factor-{alpha} in Chinese Meishan pigs stimulated with lipopolysaccharide -- Sakumoto et al.
		An endotoxin-induced serum factor that causes necrosis of tumors.
		In vivo relationship of tumor necrosis factor-alpha to blood-brain barrier damage in patients with active multiple sclerosis.
	jas.fass.org /cgi/content/full/81/5/1274 (2662 words)

	TNFR2-mediated apoptosis and necrosis in cisplatin-induced acute renal failure -- Ramesh and Reeves 285 (4): 610 -- AJP ...
		Activation of p55 tumor necrosis factor-alpha receptor-1 coupled to tumor necrosis factor receptor-associated factor 2 stimulates intercellular adhesion molecule-1 expression by modulating a thapsigargin-sensitive pathway in human tracheal smooth muscle cells.
		TNF receptors in the microvascular pathology of acute respiratory distress syndrome and cerebral malaria.
		Mice deficient for the 55kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L.
	ajprenal.physiology.org /cgi/content/full/285/4/F610 (4256 words)

	Metabolic and Lactational Responses during Recombinant Bovine Tumor Necrosis Factor-{alpha} Treatment in Lactating Cows ...
		TNF and nitrite/nitrate responses during acute mastitis induced by Escherichia coli infection and endotoxin in dairy cows.
		TNF increases the rate of lipolysis in primary cultures of adipocytes without altering levels of hormone-sensitive lipase.
		Role of endotoxin and TNF in the pathogenesis of experimentally induced coliform mastitis in periparturient cows.
	jds.fass.org /cgi/content/full/86/3/819 (4121 words)

	Selected Treatment Strategies for Septic Shock Based on Proposed Mechanisms of Pathogenesis -- Natanson et al. 120 (9): ...
		Induction of tumor necrosis factor-alpha in murine Candida albicans infection.
		An endothelial cell surface factor(s) induced in vitro by lipopolysaccharide, interleukin-1, and tumor necrosis factor-alpha increases neutrophil adherence by a CDw18-dependent mechanism.
		-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide.
	www.annals.org /cgi/content/full/120/9/771 (8500 words)

	tumor necrosis factor alpha
		what is the relation between testosterone,estradiol and tumor necrosis factor alpha levels in serum and tytosolic of breast cancer?
		Tumor necrosis factor is a cytokine (a substance found in the body's immune system that helps to communicate between the various cells in the immune system).
		Each of these factors may have some relationship to breast cancer, but I'm not sure what you are asking in this question.
	www.medhelp.org /forums/BreastCancer/messages/966a.html (110 words)

	Tumor Necrosis Factor (Site not responding. Last check: 2007-11-07)
		Lopez-Soriano J., Llovera M., Carbo N., Garcia-Martinez C., Lopez-Soriano FJ, Argiles JM.: Lipid metabolism in tumor-bearing mice: studies with kncokout mice for tumor necrosis factor receptor 1 protein.
		For the targeting vector used to generate mice lacking a functional tumor necrosis factor receptor 1 (TNFR1), a genomic fragment containing exons ll and lll and 5' se....
		The DNA construct for the p55 TNFR (tumor necrosis factor receptor) has not been described in detail.
	www.bioscience.org /knockout/tumornec.htm (208 words)

	Roles of tumor necrosis factor p55 and p75 receptors in TNF-alpha -induced vascular permeability -- Ferrero et al. 281 ...
		Roles of tumor necrosis factor p55 and p75 receptors in TNF-alpha -induced vascular permeability -- Ferrero et al.
		We have investigated the role of p55 and p75 tumor necrosis factor receptors 1 and 2 (TNFR1 and TNFR2, respectively) in TNF-induced
		Isolated Limb Perfusion With Tumor Necrosis Factor and Melphalan for Nonresectable Stewart-Treves Lymphangiosarcoma
	ajpcell.physiology.org /cgi/content/abstract/281/4/C1173 (589 words)

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