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| | Peptic Ulcer: Peptic Disorders: Merck Manual Home Edition |
 | | Ulcers develop when the normal defense and repair mechanisms of the lining of the stomach or duodenum are weakened, making the lining more likely to be damaged by stomach acid. |
 | | Also, when severe ulcers resist treatment, particularly if a person has several ulcers or the ulcers are in unusual places, a doctor may suspect an underlying condition that causes the stomach to overproduce acid. |
 | | Surgery is used primarily to deal with complications of a peptic ulcer, such as a perforation, an obstruction that fails to respond to drug therapy or that recurs, two or more major episodes of bleeding ulcers, a gastric ulcer suspected of being cancerous, or severe and frequent recurrences of peptic ulcers. |
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