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| | Research from University of Basel, Division of Pharmacology yields new findings on epilepsy: The Epilepsy Therapy ... |
 | | The molecular mechanisms underlying this response are not well understood, however, and the spectrum of CBZ-inducible genes in human liver has not been thoroughly investigated," scientists in Basel, Switzerland report. |
 | | In transactivation studies in CV-1 cells, we demonstrated that both CBZ and its major metabolite, CBZ-10,11-epoxide, activate the nuclear receptor PXR in a concentration-dependent fashion and at therapeutic concentrations with 50% inhibitory concentration values of approximately 50 micromol/L," wrote M. Oscarson and colleagues, University of Basel, Division of Pharmacology. |
 | | For additional information, contact M. Oscarson, University of Basel, Division of Pharmacology, Neurobiology, Biozentrum, Basel, Switzerland. |
| www.epilepsytdp.org /xml/pr_1165588260 (372 words) |
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