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 | | Anthony Raine Research Laboratories, St. Bartholomews Hospital, Dominion House, 59 Bartholomew Close, West Smithfield, London EC1A 7BE, U.K. Some aspects of vascular reactivity are altered in mild experimental uraemia, as shown by increased myogenic tone and a reduced lumen diameter in the femoral artery. |
 | | This study was conducted to investigate the prevention of these uraemia-induced vascular abnormalities by the angiotensin-converting enzyme inhibitor (ACE-I) Ramipril. |
 | | These results suggest that these specific vascular abnormalities in uraemia may be mediated by renin or bradykinin, or by the direct action of angiotensin II on vascular smooth muscle. |
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