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Topic: Uridine


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In the News (Sat 16 Dec 17)

  
  Uridine
Uridine is a pyrimidine or a two ring structure that hydrogen bonds to a purine to complete a stable structure.
Uridine is one of four nucleosides used in genetic coding for RNA, and its complement is the nucleoside adenosine.
Uridine is a biological compound essential for the synthesis of DNA and RNA, and numerous other factors essential for cell metabolism.
www.greatvistachemicals.com /proteins-sugars-nucleotides/uridine.html   (457 words)

  
 Uridine   (Site not responding. Last check: 2007-10-13)
The effect of uridine treatment in the field of neurodegenerative disorders is well known.
This is due to the fact that uridine can increase the cytidine level in the brain, it may act as nerve growth factor, has an influence on the dopaminergic system and can improve the energy utilization in the brain.
A uridine containing drug is used for the therapy of pain caused by neuritis or myopathy, such as back pain, lumbago or shoulder-arm syndrome.
www.aminoactives.com /uridine.cfm   (165 words)

  
 Experimental Uridine Therapy for Lipoatrophy
Uridine was eliminated from the serum with an initial half-life of 2 hrs and a terminal half-life of 11.1 hrs.
The purpose of the uridine study was to evaluate whether it may be suitable to prevent and treat nucleoside reverse transcriptase inhibitor related mitochondrial toxicity.
Uridine is a compound occasionally utilized in patients with congenital mitochondrial diseases and is the standard treatment for hereditary orotic aciduria.
www.natap.org /2004/IWADRL/iwadrl_02.htm   (2812 words)

  
 Repligen Corporation
RG2417 is a proprietary formulation of uridine, a biological compound essential for the synthesis of DNA and RNA, the basic hereditary material found in all cells.
Uridine is synthesized by the mitochondria, the power plant of the human cell.
The rationale for uridine therapy in neuropsychiatric disorders is supported by preclinical and clinical research, which indicates that certain genes that encode for mitochondrial proteins are significantly down regulated in the brains of bipolar patients.
www.repligen.com /content.php?page_id=14   (295 words)

  
 Olympus MIC-D: Polarized Light Gallery - Uridine
As one of the four nucleosides used in genetic coding for RNA, uridine contains a pyrimidine base (uracil), which is structurally related to thymidine (linked to a ribose sugar) found in DNA strands.
In RNA, the complement to uridine is the nucleoside adenosine and when a phosphate is attached, the nucleotide uridine monophosphate (UMP) is formed.
Crystalline needles of purified uridine melt at 165 degrees Celsius and are soluble in water.
www.olympusmicro.com /micd/galleries/polarized/uridine.html   (276 words)

  
 Na(+)-dependent and -independent uridine uptake in an established renal epithelial cell line, OK, from the opossum ...   (Site not responding. Last check: 2007-10-13)
The characteristics of Na(+)-dependent and Na(+)-independent uridine uptake at 22 degrees C were determined for monolayers of OK renal epithelial cells.
Na(+)-dependent uridine uptake was minor in subconfluent OK monolayers, but increased 8-fold with time after confluency reaching a stable plateau at 8 days postconfluency.
Inhibition of Na(+)-dependent 1 microM uridine uptake by inosine, guanosine, adenosine and uridine was biphasic with approx.
www.arclab.org /medlineupdates/abstract_8476915.html   (337 words)

  
 Mahmoud el Kouni, Ph.D.
Furthermore, they were shown to elevate the concentration and prolong the half-life of uridine in the plasma, as well as increase the salvage of uridine by various tissues.
The use of uridine phosphorylase inhibitors in manipulating uridine pool is not limited to the treatment of cancer or AIDS but can also be extended to treat other pathological and physiological disorders, where administration of uridine has been shown to be useful.
The circadian rhythm of uridine phosphorylase was the opposite of that of plasma uridine levels and toxicity of 5-fluoro-2'-deoxyuridine.
main.uab.edu /show.asp?durki=10122   (769 words)

  
 Uridine as a potential treatment for NRTI related mitochondrial toxicity
An intriguing in vitro study was presented at the 2nd IAS Conference in Paris evaluating the potential of uridine to prevent and treat nucleoside reverse transcriptase inhibitor (NRTI) related mitochondrial toxicity.
Uridine serum levels were also followed in individuals for 24 hours after a single dose (36 grams) of Mitocnol, a new dietary supplement derived from sugar cane.
Uridine also fully abrogated the increase in lactate and all the cell toxicity of the combination of zidovudine (ZDV) and lamivudine (3TC).
www.i-base.org.uk /pub/htb/v4/htb4-7/potential.html   (418 words)

  
 Discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis -- Liu ...
correlate with the uridine phosphorylase and dihydrouracil dehydrogenase
Uridine uptake was evaluated in nonparenchymal cells, and in this cell population we observed a Na
Uridine transport in basolateral plasma membrane vesicles from rat liver.
ajpgi.physiology.org /cgi/content/full/274/6/G1018   (3548 words)

  
 Biospace.com   (Site not responding. Last check: 2007-10-13)
Uridine is a biological compound essential for the synthesis of DNA and RNA, the basic hereditary material found in all cells, and numerous other factors essential for cell metabolism.
The rationale for uridine therapy in neuropsychiatric disorders is supported by pre-clinical and clinical research.
Researchers at McLean Hospital previously demonstrated that uridine is active in a well-validated animal model of depression.
www.biospace.com /b2/news_story.aspx?StoryID=219&full=1   (897 words)

  
 RNA Editing
These modifications are uridine insertion or deletion in the mitochondria, and the trans splicing of the spliced leader RNA onto chromosomal mRNA.
If a uridine needs to be added, then the adenine nucleotide in the guideRNA doesn't match the nucleotide in the mRNA, but if a uridine needs to be deleted, then the uridine nucleotide in the mRNA molecule doesn't match the nucleotide in the guideRNA.
If a uridine needs to be added, then a 3'-terminal uridylyl transferase or a TUTase adds however many uridines to the 3' end that are needed.
www.earlham.edu /~sargeer/seniorseminar/tryptemplate.htm   (1387 words)

  
 Uridine release correlates with seizure activity - Epilepsy : Epilepsy.com
Uridine, like adenosine, is released under sustained depolarization and it can inhibit hippocampal neuronal activity, suggesting that uridine may be released during seizures and can be involved in epileptic mechanisms, scientists in Hungary explained.
The release of uridine correlated with seizure activity.
These findings demonstrate that uridine is released during epileptic activity, and suggest that as a neuromodulator, uridine may contribute to epilepsy-related neuronal activity changes, although uridine analogues having slower turnover would be needed for further investigation of physiological role of uridine, the researchers concluded.
www.epilepsy.com /newsfeed/pr_1097242202.html   (314 words)

  
 Omega-3 Fats and Uridine May Act as Antidepressants   (Site not responding. Last check: 2007-10-13)
Dr Carlezon and colleagues found that injections of Omega 3 fatty acids and a substance called uridine helped the animals to put in greater efforts in overcoming adversity and completing the task, a sign that they were increasing a feeling of optimism in times of difficulty.
Uridine's best natural source appears to be sugar beets and molasses made from the beets, although it has not yet been clinically tested on people with depression.
Less of each substance was needed and the anti-depressant effect was even greater and compared favourably to depression drugs that were also used in the same trial.
www.nutritionfocus.com /news_stories/feb_21/Omega_3_Fats.htm   (239 words)

  
 Mg2+ as activator of uridine phosphorylation in coordination with other cellular responses to growth factors -- Vidair ...
uptake of uridine is gratuitous for the coordinate response
Stimulation of uridine uptake by Mg in the presence or absence of insulin.
to Mg inhibits the phosphorylation of uridine by uridine kinase
www.pnas.org /cgi/content/full/102/3/662   (3490 words)

  
 The Body: Can Uridine Supplements Protect People With HIV/AIDS From Drug Toxicity?
Uridine levels in the blood appear to be carefully regulated by the liver.
Sommadossi J-P, Carlisle R, Schinazi RF and Zhou Z. Uridine reverses the toxicity of 3'-azido-3'-deoxythymidine in normal human granulocyte-macrophage progenitor cells in vitro without impairment of antiretroviral activity.
Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update.
www.thebody.com /catie/uridine.html?m47o   (1117 words)

  
 News 11/20/2001
In another article, AMINO GmbH discusses the research the company has gathered on uridine, a nucleoside compound with the potential to treat a number of disorders.
One patent indicates that uridine may be useful in the treatment of rheumatoid arthritis.
The most promising use of uridine, however, may be in the area of neurodegenerative disorders, where research is still evolving to demonstrate its efficacy as a treatment or preventive.
www.aminoactives.com /news_20020617.cfm   (278 words)

  
 Prolactin, Cortisol, and Insulin Regulation of Nucleoside Uptake Into Mouse Mammary Gland Explants -- Rillema et al. ...
Uridine is a pyrimidine base nucleoside that is involved in
The reciprocals of the substrate concentration and intracellular uridine accumulations were then plotted.
are all involved in regulating uridine uptake for lactogenesis.
www.ebmonline.org /cgi/content/full/228/7/795   (2160 words)

  
 Functional Analysis of the EWS/ETS Target Gene Uridine Phosphorylase -- Deneen et al. 63 (14): 4268 -- Cancer Research
This blot is representative of the levels of uridine phosphorylase expression in the cells used in the agar and tumorigenesis assays.
Uridine phosphorylase is able to support colony formation in soft agar at levels comparable with EWS/FLI1.
Growth inhibition for each drug concentration is represented as the number of cells present in the treated samples compared with the number of cells present in the untreated controls.
cancerres.aacrjournals.org /cgi/content/full/63/14/4268   (4968 words)

  
 Uridine Phosphorylase from Salmonella typhimurium
Uridine phosphorylase from Salmonella typhimurium (StUP) catalyzes the reversible phosphorolysis of uridine with the formation of ribose-1-phosphate and uracil.
The crystals belong to space group P6 with a = 91.37 Å and c = 266.38 Å, and diffract to 2.5 Å resolution.The structure was determined by molecular replacement method using 1RYZ as the search model.
Preliminary Investigation of the Three-dimensional Structure of Salmonella typhimurium Uridine Phosphorylase in the Crystal State.
arginine.chem.cornell.edu /Structures/StUP.html   (312 words)

  
 Genomic Structure, Chromosomal Mapping, and Promoter Region Analysis of Murine Uridine Phosphorylase Gene -- Cao et al. ...
Martin D. S., Stolfi R. L., Sawyer R. Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine.
Monks A., Ayers O., Cysyk R. Effect of 5-benzylacyclouridine, a potent inhibitor of uridine phosphorylase, on the metabolism of circulating uridine by the isolated rat liver.
Liu M-P., Beigelman L., Levy E., Handschumacher R. E., Pizzorno G. The discrete roles of hepatocytes and nonparenchymal cells in uridine catabolism as a component of its homeostasis.
cancerres.aacrjournals.org /cgi/content/full/59/19/4997   (3906 words)

  
 FUI1 - Uridine permease
We have constructed S. cerevisiae strains carrying genomic deletions of six ORFs from the left arm of chromosome II (YBL018c, YBL019w, YBL024w, YBL042c, YBL043w and YBL046w) in both FY1679 and W303 backgrounds.
The deduced protein sequence shares strong similarities with five open reading frames from Saccharomyces cerevisiae, namely the uracil permease encoded by the FUR4 gene, the allantoin permease encoded by DAL4, a putative uridine permease (YBL042C) and two unknown ORFs YOR071c and YLR237w.
These synonyms are used for gene FUI1 (Uridine permease): YBL0406, YBL042C.
www.ihop-net.org /UniPub/iHOP/gg/32610.html   (136 words)

  
 POUL MOELLER.   (Site not responding. Last check: 2007-10-13)
At the end I ask you to comment on the preliminary form of the proposal for funding.
Recently omega-3-oils and uridine containing nutrients were reported to be prior to drugs in treating depression and other “mood disorders”, Carlezon WA et al, Harvard, Biol.
Uridine is found in molasses, it binds Hg.
www.amalgam.se /moeller.html   (7873 words)

  
 Site-specific creation of uridine from cytidine in apolipoprotein B mRNA editing -- Hodges et al. 19 (6): 1197 -- ...
Site-specific creation of uridine from cytidine in apolipoprotein B mRNA editing -- Hodges et al.
Site-specific creation of uridine from cytidine in apolipoprotein B mRNA editing
editing specifically creates a uridine from a cytidine.
nar.oxfordjournals.org /cgi/content/abstract/19/6/1197   (465 words)

  
 Energy Citations Database (ECD) - Energy and Energy-Related Bibliographic Citations   (Site not responding. Last check: 2007-10-13)
Energy Citations Database (ECD) Document #7350783 - Characteristics of the uridine uptake system in normal and polyoma transformed hamster embryo cells
Availability information may be found in the Availability, Publisher, Research Organization, Resource Relation and/or Author (affiliation information) fields and/or via the "Full-text Availability" link.
Characteristics of the uridine uptake system in normal and polyoma transformed hamster embryo cells
www.osti.gov /energycitations/product.biblio.jsp?osti_id=7350783   (126 words)

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