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Topic: Uridine diphosphate

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5-BROMOURIDINE Deoxyuridine Diphosphate (dUDP): a nucleotide, the 5'-phosphate of deoxyuridine; an intermediate in the synthesis of deoxythymidine triphosphate. Uridine Diphosphate (UDP): a nucleotide, the 5'-pyrophosphate of uridine; acting as the chief transferring coenzyme in carbohydrate metabolism; acting as a carrier of hexoses, hexosamines, and hexuronic acids which are intermediates in the metabolism. Uridine Triphosphate (UTP): a nucleotide, the 5'-triphosphate of uridine; acting as a precursor in the synthesis of ribonucleic acid and of UDP-linked intermediates. www.chemicalland21.com /lifescience/UH/5-BROMOURIDINE.htm

AllRefer.com - uracil (Biochemistry) - Encyclopedia When combined with the sugar ribose in a glycosidic linkage, uracil forms a derivative called uridine (a nucleoside), which in turn can be phosphorylated with from one to three phosphoric acid groups, yielding respectively the three nucleotides UMP (uridine monophosphate), UDP (uridine diphosphate), and UTP (uridine triphosphate). The analogous nucleosides and nucleotides formed from uridine and deoxyribose occur only very rarely in living systems; such is not the case with the other pyrimidines. Since the uracil nucleotides contain only ribose and not deoxyribose, UTP is the source of uridine only in ribonucleic acid (RNA); there is no uridine in deoxyribonucleic acid (DNA). reference.allrefer.com /encyclopedia/U/uracil.html

Dorlands Medical Dictionary -triphosphate of uridine; it is an activated precursor in the synthesis of ribonucleic acid and of UDP-linked hexoses involved in glycogen and glycoprotein metabolism. -pyrophosphate of uridine, which serves as a carrier for hexoses, hexosamines, and hexuronic acids in the synthesis of glycogen, glycoproteins, and glycosaminoglycans. -phosphate of uridine; it is a component of ribonucleic acid. www.merckmedicus.com /pp/us/hcp/thcp_dorlands_content.jsp?pg=/ppdocs/us/common/dorlands/dorland/dmd-u-006.htm

Nucleotide - Wikipedia, the free encyclopedia The nucleobase can be purines or pyrimidines, the sugar can be deoxyribose in DNA or ribose in RNA, and the phosphate chain can be a monophosphate, diphosphate, or triphosphate. Adenosine- 5-Methyluridine - Uridine - Guanosine- Cytidine- Deoxyadenosine- Thymidine- Deoxyuridine- Deoxyguanosine- Deoxycytidine- Ribose- Deoxyribose A nucleotide that lacks the phosphate group is called nucleoside. en.wikipedia.org /wiki/Nucleotide

World Intellectual Property Organization Uridine 5'-triphosphate (UTP) and ATP have been shown to activate the P2Y subtypes of purinergic receptors in multiple glial cells of the central, peripheral, and sensory nervous systems, including oligociendrocytes, astrocytes, Müller cells, retinal pigment epithelium, and resident The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5'-triphosphate, cytidine 5'-triphosphate, adenosine 5'-triphosphate, or their analogs and derivatives, in an amount effective to stimulate tear fluid secretion. USPN 5,763,447 is directed to a method of preventing or treating pneumonia, including ventilator-associated pneumonia, in a bedridden or immobilized subject in need of such treatment. www.wipo.int /ipdl/IPDL-CIMAGES/view/pct/getbykey5?KEY=01/87913.011122&ELEMENT_SET=DECL

Uridine Diphosphate-Glucose Transport into the Endoplasmic Reticulum of Saccharomyces cerevisiae: In Vivo and In Vitro Evidence -- Castro et al. 10 (4): 1019 -- Molecular Biology of the Cell Wright, A., and Robbins, P.W. The enzymatic synthesis of uridine diphosphate [ Abeijón, C., Robbins, P.W., and Hirschberg, C.B. Molecular cloning of the Golgi apparatus uridine diphosphate N-acetylglucosamine transporter by phenotypic correction of a yeast mutant. Uridine Diphosphate-Glucose Transport into the Endoplasmic Reticulum of Saccharomyces cerevisiae: In Vivo and In Vitro Evidence -- Castro et al. www.molbiolcell.org /cgi/content/full/10/4/1019

A slave to sugars - for printer By simply adding the 'superbeads' to a solution of a starting sugar, uridine diphosphate galactose and galactose (the sugar activated by uridine diphosphate), galactose rings are successively added to the starting material to build up oligosaccharides. To tiny resin beads the team attached four enzymes that between them efficiently regenerate the molecule 'uridine diphosphate galactose'. Wong, C.-H., Haynie, S. and Whitesides, G. Enzyme-catalyzed synthesis of N-acetyllactosamine with in situ regeneration of uridine 5′ diphosphate glucose and uridine 5′-diphosphate galactose. www.nature.com /nsu_new/nsu_pf/010301/010301-9.html

Salmonella Uridine diphosphate glucose and polyprenyl phosphate are converted by the enzyme preparations into polyprenyl monophosphate glucose which may transfer a glucosyl residue onto the polyprenyl pyrophosphate oligosaccharides. Galactose residue is an initiator of a chain growth: transfer of galactosyl phosphate from uridine diphosphate galactose onto the acceptor is followed by two consecutive mannosyl transfers from guanosine diphosphate mannose and rhamnosyl transfer thymidine diphosphate rhamnose. The resulting pentasaccharide derivatives may be polymerised by enzymes present in cell envelope preparations. www.bionewsonline.com /4/2/salmonella_x.htm

Leloir, Luis F. Further work showed that uridine diphosphate glucose is involved in glycogen synthesis and adenosine diphosphate glucose in that of starch. Other sugar nucleotides such as uridine diphosphate acetylglucosamine and guanosine diphosphate mannose were also isolated. With his early collaborators, Ranwel Caputto, Carlos E. Cardini, Raul Trucco and Alejandro C. Paladini work was started on the metabolism of galactose which led to the isolation of glucose 1,6-diphosphate and uridine diphosphate glucose. www.cartage.org.lb /en/themes/Biographies/MainBiographies/L/Leloir/Leloir.htm

Crigler Najjar Syndrome Type I Crigler-Najjar syndrome type I is a very rare inherited metabolic disorder characterized by the complete absence of the enzyme uridine diphosphate glucuronosyltransferase (UDPGT), which is normally found in the liver. Crigler-Najjar Syndrome Type II, also called Arias Hyperbilirubinemia, is a very rare metabolic disorder characterized by a deficiency (not complete absence) of the enzyme uridine diphosphate glucuronosyltransferase (UDPGT), which aids in the conversion of unconjugated bilirubin to conjugated bilirubin and its subsequent clearance from the liver. Crigler-Najjar Syndrome Type I is a very rare inherited metabolic disorder characterized by the complete absence of the enzyme uridine diphosphate (UDP) glucuronosyltransferase in the liver. hw.healthdialog.com /kbase/nord/nord1084.htm

Search by disease Uridine diphosphate glycosyltransferase 1 family, polypeptide A1 Urod deficiency Should you not find the disease for which you are searching, please send an email to EDDNAL: eddnal@skypro.be www.eddnal.com /directory/disease.php?letter=U&page=3

eMedicine - Crigler-Najjar Syndrome : Article Excerpt by: Alessio Pigazzi, MD, PhD CNS is elicited by a lack or deficiency of the enzyme uridine diphosphate glycosyltransferase (UGT). Synonyms, Key Words, and Related Terms: CNS, Crigler-Najjar disease, Gilbert syndrome, Arias syndrome, congenital nonhemolytic jaundice, neonatal jaundice, inherited unconjugated hyperbilirubinemias, uridine diphosphate glycosyltransferase, UGT, kernicterus, bilirubin encephalopathy, plasma exchange transfusion Type 1 CNS is associated with an almost complete absence of the enzyme, which results in very high levels of unconjugated hyperbilirubinemia (up to 50 mg/dL) at birth. www.emedicine.com /med/byname/crigler-najjar-syndrome.htm

Galactose Metabolism by the Mouse with Galactose-1-Phosphate Uridyltransferase Deficiency -- NING et al. 48 (2): 211 -- Pediatric Research Ng WG, Xu YK, Kaufman FR, Donnell GN 1989 Deficit of uridine diphosphate galactose in galactosemia. Gibson JB, Reynolds RA, Palmieri MJ, States B, Berry GT, and Segal S 1994 Uridine diphosphate hexoses in leukocytes and fibroblasts of classic galactosemics and patients with other metabolic diseases. of uridine diphosphate galactose and uridine diphosphate glucose www.pedresearch.org /cgi/content/full/48/2/211

Crystal structures of the bovine beta 4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose -- Gastinel et al. 18 (13): 3546 -- The EMBO Journal The uridine diphosphate portion of UDP-Gal binds in an extended -glucosyltransferase in the presence or in the absence of the substrate uridine diphosphoglucose. Crystal structures of the bovine beta 4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose -- Gastinel et al. embojournal.npgjournals.com /cgi/content/full/18/13/3546

Prolonged Unconjugated Hyperbilirubinemia Associated With Breast Milk and Mutations of the Bilirubin Uridine Diphosphate- Glucuronosyltransferase Gene -- Maruo et al. 106 (5): 59 -- Pediatrics Akaba K, Kimura T, Sasaki A, Neonatal hyperbilirubinemia and mutation of the bilirubin uridine diphosphate-glucuronosyltransferase gene: a common missense mutation among Japanese, Koreans and Chinese. Onishi S, Kawade N, Itoh S, Isobe K, Sugiyama S Postnatal development of uridine diphosphate glucuronosyltransferase activity toward bilirubin and 2-aminophenol in human liver. Prolonged Unconjugated Hyperbilirubinemia Associated With Breast Milk and Mutations of the Bilirubin Uridine Diphosphate- Glucuronosyltransferase Gene -- Maruo et al. pediatrics.aappublications.org /cgi/content/full/106/5/e59

ARS Publication request: Free Galacytose Content of Fruits and Fruit and Vegetable Baby Foods: More Foods to Consider for the Galactose-Restricted Diet The disorder results from the defective function of galactokinase, galactose 1 phosphate uridyl transferase, or uridine diphosphate galactose 4 epimerase. Treatment of galactosemia is best instituted during the first week of life and involves dietary galactose restriction. www.ars.usda.gov /research/publications/publications.htm?SEQ_NO_115=101585

Isolation and Characterisation of the 5'-Nucleotidase from Escherichia coli Escherichia coli 5'-nucleotidase is a periplasmically localised enzyme capable of hydrolysing a broad range of substrates, including all 5'-ribo- and 5'-deoxyribonucleotides, uridine diphosphate sugars, and a number of synthetic substrates such as bis (r-nitrophenyl) phosphate. The enzyme has been shown to contain at least one zinc ion following purification, and to have two metal binding sites in the catalytic cleft. www4.gu.edu.au:8080 /adt-root/public/adt-QGU20030226.153545

Newborn Screening The third enzyme in the process, uridine diphosphate galactose ­4-epimerase (GALE) reconverts UDPGal to UDPG. The second step in the pathway exchanges the Gal-1-P for the glucose-1-phosphate (G-1-P) of uridine diphosphate glucose (UDPG) to form uridine diphosphate galactose (UDPGal) and release G-1-P. This step is mediated by the This is mediated by the enzyme galactokinase (GALK). www.childrenshospital.org /newenglandconsortium/NBS/gal/history_newborn2.htm

UGT2B23, a Novel Uridine Diphosphate-Glucuronosyltransferase Enzyme Expressed in Steroid Target Tissues That Conjugates Androgen and Estrogen Metabolites -- Barbier et al. 140 (12): 5538 -- Endocrinology UGT2B23, a Novel Uridine Diphosphate-Glucuronosyltransferase Enzyme Expressed in Steroid Target Tissues That Conjugates Androgen and Estrogen Metabolites -- Barbier et al. Distribution of Uridine Diphosphate-Glucuronosyltransferase (UGT) Expression and Activity in Cynomolgus Monkey Tissues: Evidence for Differential Expression of Steroid-Conjugating UGT Enzymes in Steroid Target Tissues UGT2B23, a Novel Uridine Diphosphate-Glucuronosyltransferase Enzyme Expressed in Steroid Target Tissues That Conjugates Androgen and Estrogen Metabolites endo.endojournals.org /cgi/content/abstract/140/12/5538

Muscle Uridine Diphosphate-Hexosamines Do Not Decrease Despite Correction of Hyperglycemia-Induced Insulin Resistance in Type 2 Diabetes -- Pouwels et al. 87 (11): 5179 -- Journal of Clinical Endocrinology & Metabolism Muscle Uridine Diphosphate-Hexosamines Do Not Decrease Despite Correction of Hyperglycemia-Induced Insulin Resistance in Type 2 Diabetes -- Pouwels et al. Muscle Uridine Diphosphate-Hexosamines Do Not Decrease Despite Correction of Hyperglycemia-Induced Insulin Resistance in Type 2 Diabetes jcem.endojournals.org /cgi/content/abstract/87/11/5179

Escherichia coli Degenerate oligonucleotide primers corresponding to two tryptic peptides common to both the full-length 120-kD SPS subunit and an 82-kD form that photoaffinity labeled with 5-azidouridine diphosphate-glucose (5-N3UDP-Glc) were used in a polymerase chain reaction to isolate a partial cDNA clone. Expression of a region of the protein that photoaffinity labels with 5-azidouridine diphosphate-glucose; Salvucci ME et al.; The uridine diphosphate-glucose (UDP-Glc) binding domain of sucrose-phosphate synthase (SPS) was identified by overexpressing part of the gene from spinach (Spinacia oleracea). www.bionewsonline.com /5/1/e_coli_bacter_i.htm

Metabolism of Uridine 5'-Diphosphate-Glucose in Golgi Vesicles from Pea Stems -- Neckelmann and Orellana 117 (3): 1007 -- PLANT PHYSIOLOGY Metabolism of Uridine 5'-Diphosphate-Glucose in Golgi Vesicles from Pea Stems -- Neckelmann and Orellana 117 (3): 1007 -- PLANT PHYSIOLOGY UDP and other nucleoside diphosphates have been described as inhibitors of glycosyltransferases (Ray et al., 1969 H in the uridine ring, and with these substrates we could follow www.plantphysiol.org /cgi/content/full/117/3/1007

sin188.htm (316aa) 10 TMS, N-term is IN Putative golgi uridine diphosphate-N-acetylglucosamine transporter biosci.cbs.umn.edu /pombe/sprotdb/sin188.htm

TAG: Position Paper on atazanavir (BMS-232623), brand name Reyataz® O'Mara E, Randall D, Passarell J, et al., Population pharmacodynamic assessment of atazanavir exposure, uridine diphosphate-glucuronosyl transferase (UGT) 1A1 genotype and safety in healthy subjects, abstract A-1253, 42nd ICAAC, San Diego, 27-30 September 2002. The utility of inhibitory quotients in determining the relative potency of protease inhibitors, AIDS 16(5); 2002. Long-term efficacy and safety of atazanavir with stavudine and lamivudine in patients previously treated with nelfinavir or ATV: 108-week results of BMS study 008/044. www.aidsinfonyc.org /tag/tx/atazanavir.html

Development of uridine diphosphate-glucuronyltransferase activity in cultures of chick-embryo liver. Development of uridine diphosphate-glucuronyltransferase activity in cultures of chick-embryo liver. www.arclab.org /medlineupdates/abstract_6049938.html

Uridine Diphosphate Glucose, [Glucose-14C(U)], 50µCi (1.85MBq) from PerkinElmer - USA Home > Radioactivity > Radiochemicals > Sugars > Uridine Diphosphate Glucose [Glucose-14C(U)]- An aliquot of the entire sample can be taken to dryness by directing a gently stream of inert gas (nitrogen) over the surface of the solution. las.perkinelmer.com /catalog/Product.aspx?ProductID=NEC403050UC

N-Acetyl-D-glucosamine Register Uridine Diphosphate N-Acetyl-D-Glucosamine, [Glucosamine-6-3H(N)] Product categories: Select a... The Life & Analytical Sciences (LAS) division of PerkinElmer provides drug discovery, genetic screening and chemical analysis instrumentation, reagents and services for scientific research and clinical applications. www.chemindustry.net /chemnames/N/N-Acetyl-D-glucosamine.html

Molecules To Go (Formerly known as Molecules R Us) HEADER TRANSFERASE 22-FEB-99 1B99 TITLE 3'-FLUORO-URIDINE DIPHOSPHATE BINDING TO NUCLEOSIDE TITLE 2 DIPHOSPHATE KINASE COMPND MOL_ID: 1; COMPND 2 MOLECULE: NUCLEOSIDE DIPHOSPHATE KINASE; COMPND 3 CHAIN: A, B, C, D, E, F; First 100 lines from the PDB structure record... molbio.info.nih.gov /cgi-bin/moldraw?1B99

National Academies Research Dashboard Current primary terms: detlev wulf, wulf bronk, advanced study, johnson foundation, uridine diphosphate, nerve cells, det bronk, scientific enterprise Oddities occur; select the terms most likely to provide you with high-value results. Special Search Options for National Academies Staff for Google, Yahoo, and MSN. www.nap.edu /nap-cgi/constr3.cgi?isbn=0309025494&act=dashboard&mw=

Inspire Pharmaceuticals, Inc. - Discovery's Intellectual Property Method of Treating Lung Diseases with Uridine 5'-diphosphate and Analogs Thereof Use of Uridine Triphosphates and Related Compounds for the Prevention and Treatment of Pneumonia in Immobilized Patients A Sterilized Isotonic and pH-Adjusted Pharmaceutical Formulation of Uridine Triphosphate www.inspirepharm.com /property.html

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