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	Urokinase - Wikipedia, the free encyclopedia
		Urokinase is a 411 residue protein, consisting of three domains: the serine protease domain, the kringle domain and the growth factor domain.
		Urokinase is synthesized as a zymogen form (prourokinase or single chain urokinase), and is activated by proteolytic cleavage between L158 and I159.
		Urokinase is used clinically as a thrombolytic agent in the treatment of severe or massive deep venous thrombosis, pulmonary embolism, myocardial infarction, and occluded intravenous or dialysis cannulas.
	en.wikipedia.org /wiki/Urokinase (466 words)

	Purification of urokinase - Patent 4106992
		A urokinase, mixed with foreign proteins, especially pyrogens, is purified by a partial saturation of an aqueous solution of this mixture by ammonium sulphate to a value for which the precipitate formed would not entrain more than 5% of the total activity of urokinase of the initial solution.
		Urokinase heparinate is a complex occurring in the form of aggregates and whose molecular weight is a function of that of the heparin used and of the original proteinic impurities accompanying, as the case may be, the urokinase.
		Urokinase heparinate obtained from purified and depyrogenated urokinase according to the invention is itself devoid of pyrogenic substances within the standards which have been applied in examples V and VI.
	www.freepatentsonline.com /4106992.html (10029 words)

	Urokinase (Abbokinase)
		Urokinase was developed in the 1950’s due to severe febrile reactions associated with the first thrombolytic agent, streptokinase.
		Intravenous urokinase is rapidly cleared by the liver with small fractions excreted in the bile and urine.
		Urokinase is contraindicated in patients with a history of hypersensitivity to the product, active internal bleeding, recent cerebrovascular accident, recent intracranial or intraspinal surgery, recent trauma including cardiopulmonary resuscitation, intracranial neoplasm, arteriovenous malformation or aneurysm, known bleeding diatheses, and severe uncontrolled arterial hypertension.
	uuhsc.utah.edu /pharmacy/bulletins/urokinase.html (779 words)

	Adsorbent for urokinase containing agarose - Patent 4321363 (Site not responding. Last check: 2007-10-08)
		An adsorbent for urokinase consisting of a carrier, a spacer and a ligand wherein the carrier is agarose, the spacer is NH.sub.2 (CH.sub.2).sub.6 NHCOCH.sub.2 CH.sub.2 COOH and the ligand is 2,5-diaminobenzthiazole.
		An adsorbent for urokinase consisting of a carrier, a spacer and a ligand wherein the carrier is agarose, the spacer is NH.sub.2 (CH.sub.2).sub.6 NHCOCH.sub.2 CH.sub.2 COOH and the ligand is 2,5-diaminobenzimidazole.
		Urokinase is a plasminogen-activating enzyme found in trace amount in human urine and is used as an effective thrombolytic agent and a drug used together with anticancer.
	www.freepatentsonline.com /4321363.html (1722 words)

	[Full text] Urokinase Separation from Cell Culture Broth of a Human Kidney Cell Line
		Urokinase (UK; EC 3.4.21.73), a plasminogen activating proteolytic enzyme, was first described in 1951 as occurring in trace quantities in mammalian urine [1].
		Urokinase catalyzes the conversion of plasminogen to plasmin by cleaving the Arg-Val linkage in the Pro-Gly-Arg-Val sequence of the former.
		Purification of urokinase by monoclonal antibody affinity chromatography.
	www.biolsci.org /v03p0064.htm (4239 words)

	W. F. Mangel, Nature 344, 488-489 (1990).
		The importance of the interaction of urokinase with its receptor is illustrated by the reduction in efficiency of invasion of resealed chick embryo chorioallantoic membranes by tumour cells to 25 per cent when urokinase is not bound to its receptor (12).
		The urokinase receptor has a dissociation constant of 0.3 nM, and is found on the surface of monocytes at a density of 40,000 receptors per cell, and is also present on many other cell types (3,4).
		Urokinase consists of domains, a growth-factor domain at the amino terminus followed by a connecting peptide, a kringle and the protease domain.
	www.biology.bnl.gov /cellbio/nature_344.html (1102 words)

	Production of Urokinase in 3-Dimensional Kidney Cell Culture (Site not responding. Last check: 2007-10-08)
		Urokinase is an enzyme that activates the process that forms plasmin, which is used as therapy for thrombosis and thromboembolism.
		The subject technology produces urokinase from an immortalized human kidney cell line grown in three-dimensional suspension culture on beads as a support matrix.
		This technology appears to represent a novel, cost-effective way of producing urokinase and shows promise for related molecules such as pro-urokinase, which is the subject of recent patents.
	www.vard.org /tts/avail/02-018.htm (540 words)

	Use of Urokinase to Treat Intraabdominal Abscesses with Radiological Drainage
		Lavages were scheduled every 8 h with saline solution and 50,000 IU of urokinase with the catheter clamped for 15 minutes as per the Haaga protocol (4).
		With purulent intra-abdominal collections there is the theoretical fear of the possible consequences of fibrinolytics in certain cases such as pancreatic abscesses and in abscesses close to gastro-intestinal anastomoses due to the possible alteration in the healing process, which may favour dehiscence.
		We cannot guarantee that their resolution was due to the instillation of urokinase, although we do believe their evolution was favoured by the use of this fibrinolytic, since multiloculated collections are not usually resolved with simple placement of a catheter.
	www.abdominalsurg.org /journalWinter06_4.htm (864 words)

	Urokinase / Methods / Tech Support / Support / Home - DiaPharma Group, Inc.
		The correlation between DeltaA/min (or absorbance) and the urokinase activity is linear in the range 5-40 Ploug or CTA units.
		The urokinase concentration should preferably be given in units of substrate hydrolysing activity, but may be calculated by using standards prepared from a standard urokinase preparation.
		The urokinase standard is dissolved in or diluted with Solvent (Reagent 3) to a concentration of 400 units/ml (Ploug or CTA units).
	www.diapharma.com /support/tech_support/methods__1/urokinase (544 words)

	Urokinase Induces Basophil Chemotaxis through a Urokinase Receptor Epitope That Is an Endogenous Ligand for Formyl ...
		a chemotactic urokinase receptor epitope that is an endogenous
		Urokinase receptor-deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection.
		Shedding and cleavage of the urokinase receptor (uPAR): identification and characterisation of uPAR fragments in vitro and in vivo.
	www.jimmunol.org /cgi/content/full/173/9/5739 (6730 words)

	Structure, Function and Expression on Blood and Bone Marrow Cells of the Urokinase-Type Plasminogen Activator Receptor, ...
		Identification of the urokinase receptor as all adhesion receptor for vitronectin.
		The receptor for urokinase-type plasminogen activator and urokinase is translocated from two distinct intracellular compartments to the plasma membrane on stimulation of human neutrophils.
		The receptor for urokinase plasminogen activator is present in plasma from healthy donors and elevated in patients with paroxysmal nocturnal haemoglobinuria.
	stemcells.alphamedpress.org /cgi/content/full/15/6/398 (6532 words)

	Urokinase.Html
		The increased synthesis of urokinase is related to the ability of increased metastasis.
		Urokinase activates plasmin from plasminogen, which is located everywhere in extracellular space.
		In the second reaction pro-urokinase behaves as a substrate and is converted to urokinase by plasmin generated in the first reaction.
	www.cs.stedwards.edu /chem/Chemistry/CHEM44/serenil/metastasis.html (588 words)

	Urokinase signal transduction and its role in cell migration -- Carlin et al. 19 (2): 195 -- The FASEB Journal
		Urokinase stimulation reduced the association of caveolin with uPAR (A, n=3), increased the amount of Src in the membrane fraction (B, n=5), but we found no significant change of Grb2 in the membrane fraction (C, n=3).
		Urokinase binds to its receptor and causes recruitment of SHP2.
		The net effect of urokinase is to remove FAK from the membrane (and focal adhesions) and thus free the cell for migration when a chemotactic signal is present.
	www.fasebj.org /cgi/content/full/19/2/195 (4121 words)

	Urokinase potentiates PDGF-induced chemotaxis of human airway smooth muscle cells -- Carlin et al. 284 (6): 1020 -- AJP ...
		Urokinase and its receptor urokinase-type plasminogen activator (uPAR) are well established as factors influencing cell migration.
		Urokinase is a protease secreted by many cell types as an inactive form and is activated to a serine protease by proteolytic
		Contrasting effects of plasminogen activators, urokinase receptor, and LDL receptor-related protein on smooth muscle cell migration and invasion.
	ajplung.physiology.org /cgi/content/full/284/6/L1020 (4609 words)

	The Urokinase Receptor Can Be Induced by Borrelia burgdorferi through Receptors of the Innate Immune System -- Coleman ...
		The urokinase plasminogen activator receptor (UPAR) is preferentially induced by nerve growth factor in PC12 pheochromocytoma cells and is required for NGF-driven differentiation.
		Soluble urokinase plasminogen activator receptor in plasma of patients with inflammatory rheumatic disorders: increased concentrations in rheumatoid arthritis.
		Identification of the urokinase receptor as an adhesion receptor for vitronectin.
	iai.asm.org /cgi/content/full/71/10/5556 (6086 words)

	Urokinase receptor is a key player in tumour progression -- TANIGUCHI et al. 43 (6): 739 -- Gut
		Urokinase receptor is a key player in tumour progression -- TANIGUCHI et al.
		Transcriptional activation of the urokinase receptor gene in invasive colon cancer.
		Proteolytic cleavage of the urokinase receptor substitutes for the agonist-induced chemotactic effect.
	gut.bmjjournals.com /cgi/content/full/43/6/739 (1152 words)

	ISET: Few Differences in Complication Rate Between t-PA and Urokinase in Patients with Peripheral Artery Disease (Site not responding. Last check: 2007-10-08)
		The removal of urokinase from the market in November 1998 resulted in limited use of urokinase, as noted in the study, Dr. Ouriel said.
		Urokinase was removed from the market when the US FDA discovered flaws in its manufacturing processes.
		However, since the number of patients treated with urokinase was low, analysis of more urokinase-treated patients in the RETRO II is expected.
	www.pslgroup.com /dg/2132BE.htm (605 words)

	Regulation of Integrin Function by the Urokinase Receptor -- Wei et al. 273 (5281): 1551 -- Science (Site not responding. Last check: 2007-10-08)
		The soluble D2D388-274 fragment of the urokinase receptor inhibits monocyte chemotaxis and integrin-dependent cell adhesion.
		Urokinase receptor expression on human microvascular endothelial cells is increased by hypoxia: implications for capillary-like tube formation in a fibrin matrix.
		Role of urokinase and its receptor in basal and stimulated colonic epithelial cell migration in vitro.
	www.sciencemag.org /cgi/content/abstract/273/5281/1551 (2925 words)

	Intracavitary Urokinase for Enhancement of Percutaneous Abscess Drainage: Phase II Trial -- Haaga et al. 174 (6): 1681 ...
		urokinase and saline were used as abscess-cavity irrigants.
		Urokinase is a hydrolase enzyme that cleaves plasminogen to
		Fluid flow during percutaneous drainage procedures: an in vitro study of the effects of fluid viscosity, catheter size, and adjunctive urokinase.
	www.ajronline.org /cgi/content/full/174/6/1681 (3132 words)

	UROKINASE - INJECTION (Abbokinase) side effects, medical uses, and drug interactions. (Site not responding. Last check: 2007-10-08)
		UROKINASE - INJECTION (Abbokinase) side effects, medical uses, and drug interactions.
		It should be started as soon as possible after lung blood clots have been noticed (pulmonary embolism), preferably within 7 days.
		Urokinase should be given within 6 hours of the first symptoms of a heart attack associated with evolving myocardial infarction.
	www.medicinenet.com /urokinase-injection/article.htm (445 words)

	Urokinase and the intestinal mucosa: evidence for a role in epithelial cell turnover -- Gibson et al. 43 (5): 656 -- Gut
		Urokinase and the intestinal mucosa: evidence for a role in epithelial cell turnover -- Gibson et al.
		Urokinase and the intestinal mucosa: evidence for a role in epithelial cell turnover
		Urokinase expression was examined immunohistochemically in human intestinal mucosa.
	gut.bmj.com /cgi/content/full/43/5/656 (4734 words)

	Activation Mechanisms of the Urokinase-type Plasminogen Activator Promoter by Hepatocyte Growth Factor/Scatter Factor ... (Site not responding. Last check: 2007-10-08)
		Studies on the regulation of urokinase expression have shown that the urokinase gene is regulated at the transcriptional level
		cells were transiently transfected with the urokinase CAT reporter (uPA-CAT) and 2.5 µg of an expression vector that inhibits DNA binding of AP-1 proteins (A-Fos) or equimolar amounts of the empty expression vector (pCMV 500) and stimulated with 200 ng/ml HGF/SF, and the cells were lysed and assayed for CAT activity.
		The observation that dominant-negative mutants of Ha-Ras, RhoA, and c-Raf inhibit inducible and basal activation of the urokinase
	www.jbc.org /cgi/content/full/274/23/16377 (6897 words)

	Intrathecal Urokinase for Intraventricular Hemorrhage
		Nevertheless, we believe that this relatively simple method of treatment will greatly improve the grave prognosis of severe IVH and should be attempted in appropriate cases of IVH.
		Coplin WM, Vinas FC, Agris JM, et al: A cohort study of the safety and feasibility of intraventricular urokinase for nonaneurysmal spontaneous intraventricular hemorrhage.
		Murry KR, Rhoney DH, Coplin WM: Urokinase in the treatment of intraventricular hemorrhage.
	www.medschool.lsuhsc.edu /neurosurgery/nervecenter/ITUKIVH.html (1674 words)

	Urokinase Activates the Jak/Stat Signal Transduction Pathway in Human Vascular Endothelial Cells -- Dumler et al. 19 ...
		Urokinase Activates the Jak/Stat Signal Transduction Pathway in Human Vascular Endothelial Cells -- Dumler et al.
		Urokinase Activates the Jak/Stat Signal Transduction Pathway in Human Vascular Endothelial Cells
		and upregulation of urokinase receptors in response to vascular
	atvb.ahajournals.org /cgi/content/abstract/19/2/290 (846 words)

	Medical Dictionary: Urokinase - WrongDiagnosis.com
		Urokinase: Encoded by human PLAU Gene (Peptidase S1 Family), 431-aa 48.5-kD single-chain Urokinase precursor contains a kringle and an EGF-like domain.
		A potent activator of plasminogen to plasmin conversion by Arg-Val cleavage, the two-chain serine protease is composed of disulfide-linked A (18,000 D) and B (33,000 D) chains that arise from precursor Lys(158)-Ile(159) cleavage by plasmin.
		Urokinase occurs in high and low mass forms, each consisting of A and B chains.
	www.wrongdiagnosis.com /medical/urokinase.htm (249 words)

	Local Intraarterial Urokinase Thrombolysis of Acute Ischemic Stroke with or without Intravenous Abciximab: A Pilot ...
		Local Intraarterial Urokinase Thrombolysis of Acute Ischemic Stroke with or without Intravenous Abciximab: A Pilot Study -- Lee et al.
		Safety and efficacy of delayed intraarterial urokinase therapy with mechanical clot disruption for thromboembolic stroke.
		Rashdan I, Schechter E. Safety and efficacy of abciximab use in conjunction with intracoronary urokinase in patients requiring angioplasty.
	www.jvir.org /cgi/content/full/13/8/769 (3003 words)

	Prophylactic Urokinase in the Management of Long-Term Venous Access Devices in Children: A Children's Oncology Group ...
		Prophylactic Urokinase in the Management of Long-Term Venous Access Devices in Children: A Children's Oncology Group Study -- Dillon et al.
		Lawson M, Bottino JC, Hurtubise MR, et al: The use of urokinase to restore the patency of occluded central venous catheters.
		Solomon B, Moore J, Arthur C, et al: Lack of efficacy of twice-weekly urokinase in the prevention of complications associated with Hickman catheters: A multicentre randomized comparison of urokinase and heparin.
	www.jco.org /cgi/content/full/22/13/2718 (3109 words)

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