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Topic: Ursodiol

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Primary biliary cirrhosis

Primary sclerosing cholangitis

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Ted Koppel

	MedlinePlus Drug Information: Ursodiol (Systemic) (Site not responding. Last check: 2007-10-20)
		Ursodiol (ur-so-DYE-ole) is used in the treatment of gallstone disease.
		Ursodiol is used in patients with gallstones who do not need to have their gallbladders removed or in those in whom surgery should be avoided because of other medical problems.
		Ursodiol is also used in patients with cirrhosis of the liver.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/202587.html (1375 words)

	Hepatitis Central, Ursodiol Tablets 250 mg
		For equimolar doses of ursodiol and chenodiol, steady state levels of lithocholic acid in biliary bile acids are lower during ursodiol administration than with chenodiol administration.
		Ursodiol was not genotoxic in the Ames test, the mouse lymphoma cell (L5178Y, TK+/-) forward mutation test, the human lymphocyte sister chromatid exchange test, the mouse spermatogonia chromosome aberration test, the Chinese hamster micronucleus test and the Chinese hamster bone marrow cell chromosome aberration test.
		Ursodiol at oral doses of up to 2,700 mg/kg/day (16,200 mg/m2/day, 29 times the recommended maximum human dose based on body surface area) was found to have no effect on fertility and reproductive performance of male and female rats.
	hepatitis-central.com /hcv/drugs/urso/description.html (2236 words)

	ursodiol
		Ursodiol is a bile acid (a naturally occurring acid) that works in several ways to control cholesterol levels in your body.
		Ursodiol is not used to treat gallstones that are calcified or otherwise complicated by other medical conditions such as cholecystitis, biliary obstruction, gallstone pancreatitis, or biliary-gastrointestinal fistula.
		Ursodiol is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby.
	hw.healthdialog.com /kbase/multum/d01005a1.htm (1119 words)

	Ursodiol Reduces Colonic Dysplasia in Patients with Ulcerative Colitis and Primary Sclerosing Cholangitis - Journal ...
		Ursodiol is used often to treat patients with PSC because it improves liver function; it also has been shown to have a chemoprotective effect against colon cancer in animals.
		Ursodiol users were significantly less likely to develop dysplasia than were nonursodiol users (odds ratio, 0.18); the decreased risk persisted after adjustment for sex, age of onset of ulcerative colitis, duration of ulcerative colitis, duration of PSC, Child-Pugh class, and use of sulfasalazine.
		Ursodiol use is associated with lower prevalence of colonic neoplasia in patients with ulcerative colitis and primary sclerosing cholangitis.
	gastro.jwatch.org /cgi/content/full/2001/226/1 (281 words)

	Data Sheet
		Ursodiol in bile is concentrated in the gallbladder and expelled into the duodenum in gallbladder bile via the cystic and common ducts by gallbladder contractions provoked by physiologic responses to eating.
		Free ursodiol, 7-keto-lithocholic acid and lithocholic acid are relatively insoluble in aqueous media and larger proportions of these compounds are lost from the distal gut into the faeces.
		Reabsorbed free ursodiol is reconjugated by the liver.
	www.medsafe.govt.nz /profs/Datasheet/a/Actigallcap.htm (1841 words)

	ursodiol, Eastern Carolina
		Ursodiol decreases the amount of cholesterol in bile and bile stones by reducing the amount of cholesterol the liver produces.
		Ursodiol reduces the amount of cholesterol that is absorbed from food and increases the breakdown of cholesterol, especially cholesterol that has formed into stones in the gallbladder.
		Ursodiol is used to treat small, noncalcified gallbladder stones in people who cannot undergo surgery, to prevent gallstone formation in obese patients who are undergoing rapid weight loss, and to treat people with primary biliary cirrhosis.
	www.uhseast.com /148774.cfm (1063 words)

	Ursodiol (Site not responding. Last check: 2007-10-20)
		Ursodiol treatment is not likely to be effective if gallstones are not partially dissolved after 12 months of therapy.
		Ursodiol should be continued for at least three months after the gallstones have dissolved.
		Ursodiol treatment is usually inappropriate when complications of gallstone disease, such as obstruction of the bile duct, cholecystitis (inflammation of the gallbladder) or pancreatitis (inflammation of the pancreas) are present.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,744,00.html (529 words)

	ursodiol - Cholesterol: health and medical information about high cholesterol and heart disease
		It is used to dissolve and prevent cholesterol gallstones and to treat primary biliary cirrhosis, a disease of the liver.
		Ursodiol blocks the enzyme in the liver that produces cholesterol and thereby decreases production of cholesterol by the liver and the amount of cholesterol in bile.
		Ursodiol must be used for one or more years, and 50% of patients who have successful dissolution of their gallstones will have the gallstones return within five years.
	www.medicinenet.com /ursodiol/article.htm (474 words)

	ursodiol Information and Resources Online at The Drug Database - Find Useful Articles and Websites on ursodiol Right ... (Site not responding. Last check: 2007-10-20)
		Ursodiol is used to dissolve gallstones in patients who do not want surgery or cannot have surgery to remove gallstones.
		Urso (Ursodiol) Whether you are able to purchase certain pharmaceuticals online will depend on the laws of the jurisdiction where you reside and the guidelines of the pharmacy where you make the purchase.
		Ursodiol is a gallstone dissolving agent used to treat certain types of gallstones.
	www.thedrugdatabase.com /directory/U/ursodiol (436 words)

	Patient Education - Drugs - ursodiol
		Ursodiol is one of the naturally occurring bile salts.
		Ursodiol is ranked B. Always consult your physician before taking any drug during or when planning pregnancy.
		Gastroenterologists have been using ursodiol for years to treat primary biliary cirrhosis and primary sclerosing cholangitis because the drug lowers the abnormally elevated blood liver enzymes.
	www.gicare.com /pated/ursodiol.htm (827 words)

	Urso Warnings, Precautions, Pregnancy, Nursing, Abuse - Ursodiol - RxList Monographs
		Ursodiol produced a significantly (p < 0.5, Fisher’s exact test) increased incidence of pheochromocytomas of the adrenal medulla in females of the highest dose group.
		Ursodiol was not genotoxic in the Ames test, the mouse lymphoma cell (L5178Y, TK) forward mutation test, the human lymphocyte sister chromatid exchange test, the mouse spermatogonia chromosome aberration test, the Chinese hamster micronucleus test and the Chinese hamster bone marrow cell chromosome aberration test.
		It is not known whether ursodiol is excreted in human milk.
	www.rxlist.com /cgi/generic2/urso_wcp.htm (515 words)

	Axcan Announces Positive Study for the New Sulfated Version of Ursodiol as a Potent Chemopreventive Agent in Colorectal ...
		However, Ursodiol is efficiently absorbed in the small intestine and extensively biotransformed by intestinal bacteria to LCA, factors that reduce delivery to the colon and produce pro-carcinogenic bile acids.
		Ursodiol disulfate overcomes these limitations by preventing intestinal absorption, permitting site-specific delivery to the colon, increasing its membrane protective hydrophilic property, and preventing biotransformation to hydrophobic membrane-damaging bile acids.
		The objective of the study conducted by Dr. Schetchell and Nadine M. Brown, was to determine the effectiveness of ursodiol disulfate in preventing colonic tumors chemically-induced by AOM a carcinogen, in 344 rats, and to compare this analog with ursodiol.
	www.prnewswire.com /cgi-bin/stories.pl?ACCT=109&STORY=/www/story/05-18-2004/0002176966&EDATE= (1061 words)

	Ursodiol for Hepatobiliary Disorders -- Rubin et al. 121 (3): 207 -- Annals of Internal Medicine
		Ursodiol is absorbed along the length of the jejunum and ileum
		The effect of ursodiol on the efficacy and safety of extracorporeal shock-wave lithotripsy of gallstones.
		The effects of ursodiol on the normal gallbladder are rapid, reversible, and dose-dependent (Abstract).
	www.annals.org /cgi/content/full/121/3/207 (7754 words)

	Ursodiol (Systemic)
		Ursodiol has not been studied in pregnant women.
		It is not known whether ursodiol passes into the breast milk.
		Although there is no specific information comparing use of ursodiol in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
	allnutritionals.com /drugs/u/ursodiol-systemic.shtml (1323 words)

	URSODIOL FOR PRIMARY BILIARY CIRRHOSIS - Journal Watch (General)
		In 1991, a French randomized study of 145 patients showed that the bile acid ursodiol slows the short-term progression of primary biliary cirrhosis.
		At the end of the two-year study, all ursodiol recipients continued their treatment and 79 percent of placebo recipients agreed to take ursodiol in an open trial.
		The patients who had taken ursodiol for all four years had significantly fewer treatment failures (hyperbilirubinemia, variceal bleeding, ascites, or encephalopathy) than the patients initially assigned to placebo (9 vs. 20); they also had significantly fewer liver transplantations or referrals for transplantations (4 vs. 13).
	general-medicine.jwatch.org /cgi/content/full/1994/527/1 (226 words)

	Ursodiol Treatments
		Made by Anxcan Pharma, Inc. are the only ursodiol treatment product specifically for Primary Biliary Cirrhosis, as it has the FDA approved PBC indication and extensive research testing was done on the product.
		Proper dosing for ursodiol treatments is confusing not only to the patients but some of the medical community.
		Some doctors prescribe ursodiol treatments according to the manufacturers recommended dosing instructions such as Actigall which is approved for gallstone treatment which has a dosing recommendation of 2-3 capsules per day.
	pbcers.org /ursodioltreatments.htm (557 words)

	neonatal cholestasis and ursodiol
		The field related to neonatal cholestasis and ursodiol is a wonderful field and discovering more about it can be very pleasing.
		One notion to dwell on as you weed through the abundance of neonatal cholestasis and ursodiol material out there is that the scoop and scoop you find won't be all true.
		We have been seeking a lot of top rated authorities on the subject of neonatal cholestasis and ursodiol and we have discovered there is great reporting and poor reporting.
	www.baby-birth-info.com /neonatal-cholestasis-and-ursodiol (430 words)

	Ursodiol - Drugs & Vitamins - Drug Library - DrugDigest
		Ursodiol may be used with a procedural device that fragments the gallstone into smaller pieces; the procedure, called lithotripsy, allows the drug to dissolve the stones more quickly.
		Ursodiol is also useful for certain liver diseases of adults, children and infants; the drug reduces itching and other symptoms.
		Take ursodiol at least 1 hour before or 2 hours after an antacid dose.
	www.drugdigest.org /DD/DVH/Uses/0,3915,6271\|Ursodiol,00.html (611 words)

	Ursodiol Prophylaxis against Hepatic Complications of Allogeneic Bone Marrow Transplantation: A Randomized, ...
		The incidence of veno-occlusive disease was lower in the ursodiol
		the curve were not affected by ursodiol administration [30].
		Pilot trial of prophylactic ursodiol to decrease the incidence of veno-occlusive disease of the liver in allogeneic bone marrow transplant patients.
	www.annals.org /cgi/pmidlookup?view=full&pmid=9625683 (3298 words)

	TUDCA - Ursodiol Treats HD
		A starting point for the treatment for HD might be 50 mg/kg/day (A 150 lb person may take 3 grams a day from 10 300mg ursodiol caps).
		Ursodiol seems to be very safe and it is used during pregenancy.
		Ursodiol is expensive, about $US600/mo for HD treatment, www.mhrx.com/drugs/showdrug.asp?dn_Id=881.
	www.hdlighthouse.org /see/treat/ursodiol.htm (392 words)

	Hepatitis Central, Actigall, Ursodiol
		Breast-feeding—It is not known whether ursodiol passes into the breast milk.
		Children—Although there is no specific information comparing use of ursodiol in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
		Although there is no specific information comparing use of ursodiol in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
	hepatitis-central.com /hcv/drugs/actigall.html (1756 words)

	AmJSurg (Site not responding. Last check: 2007-10-20)
		This study was designed to determine if a 6-month regimen of prophylactic ursodiol might prevent the development of gallstones.
		RESULTS: Of 233 patients with at least one postoperative sonogram, 56 were randomized to placebo, 53 to 300 mg ursodiol, 61 to 600 mg ursodiol, and 63 to 1,200 mg ursodiol.
		Gallstones were significantly (P 0.001) less frequent with ursodiol 600 and 1,200 mg than with placebo.
	www.obesity-online.com /AmJSurg.htm (256 words)

	MedlinePlus Drug Information: Ursodiol
		Ursodiol is also used to prevent the formation of gallstones in overweight patients who are losing weight very quickly.
		Ursodiol is a bile acid, a substance naturally produced by the body that is stored in the gallbladder.
		It is usually taken two or three times a day to treat gallstones and two times a day to prevent gallstones in patients who are losing weight quickly.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a699047.html (661 words)

	Ursodiol Side Effects - Ursodiol
		This registry is a place to share positive or negative side effects of using Ursodiol.
		If you directly experienced a side effect while using Ursodiol, then we encourage you to enter it here.
		Please note that entries here are the experiences of individual users, and in no way means that you or anyone else will experience the same side effect, since the same medication affects people in different ways.
	www.medications.co.uk /go/se/Ursodiol (134 words)

	Ursodiol
		If the liver is in failure, reabsorbed bile acids are not captured by the liver but are instead released into the bodyâs circulation (hence the basis for the âbile acidsâ test that has become a popular diagnostic in the evaluation of veterinary liver patients.)
		Ursodeoxycholic acid, also called âursodiol,â is one of the bile acids produced by the Chinese fl bear and it has been used in the treatment of liver disease for centuries.
		Nowadays, it is produced in the laboratory and not extracted from bear gall bladders.
	www.marvistavet.com /html/body_ursodiol.html (629 words)

	Ursodiol
		The drug brand “Actigall” (chemical name: ursodiol), manufactured by Ciba, is indicated for human-use for the dissolution of gall stones.
		Over the last ten years IPS has been called on to compound hundreds of special prescriptions of ursodiol for pets (dogs and cats.) These doses are small fractions of the larger human doses.
		Ursodiol is also available compounded in an oral liquid, for example, 50mg/ml.
	www.islandpharmacy.com /ursodiol.htm (299 words)

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