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Topic: VZV

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	Varicella zoster virus - Wikipedia, the free encyclopedia
		In about 10-20% of cases, VZV reactivates later in life to produce herpes zoster (shingles) and its associated sequelae including: post-herpetic neuralgia, zoster multiplex, myelitis, herpes ophthalmicus, or zoster sine herpete.
		VZV is closely related to the herpes simplex viruses (HSV), sharing much genome homology.
		VZV virons are spherical and 150-200 nm in diameter.
	en.wikipedia.org /wiki/VZV (308 words)

	Varicella-Zoster Virus, Chicken Pox, Shingles Virus
		VZV is certainly transmissible through the airborne route and does not require close personal contact.
		VZV IgM is produced in primary varicella and herpes zoster and thus it is not possible to distinguish between the two.
		Acyclovir is now the drug of choice (VZV is not as susceptible to acyclovir as is HSV and requires 10 fold higher concentration of the drug for effective inhibition) for the treatment of varicella in the immunocompromised and also in normal patients with VZV pneumonia.
	virology-online.com /viruses/VZV.htm (5415 words)

	Varicella-Zoster Virus and HIV
		In rare instances, VZV neurologic disease has occurred after resolution of the rash, in some cases as long as 3 months later.(7) Encephalitis occurs more frequently with zoster in the ophthalmic distribution, and cerebellar findings are typical; prominent symptoms include ataxia, tremors, and dizziness.
		In several studies, intravenous acyclovir was superior to placebo in treating severe or disseminated VZV infections in an immunocompromised host.(13,17) Early administration of acyclovir decreases the duration of viral shedding, the extent of new lesion formation, the incidence of dissemination, and patient mortality.
		In this study, cutaneous dissemination of VZV occurred in 50% of patients with localized dermatomal infection who were treated with vidarabine but in none of those treated with acyclovir.(17) Specific studies of the utility of intravenous acyclovir in HIV-infected patients have not been conducted.
	hivinsite.ucsf.edu /InSite.jsp?page=kb-05-03-01 (5205 words)

	eMedicine - Chickenpox : Article by Anthony J Papadopoulos, MD (Site not responding. Last check: 2007-10-24)
		VZV infection of cells of the malpighian layer produces both intercellular edema and intracellular edema, resulting in the characteristic vesicle.
		VZV then remains latent in the dorsal ganglion cells of the sensory nerves.
		In utero infection with VZV is a concern.
	www.emedicine.com /derm/topic74.htm (3829 words)

	TAG: The OI Report - varicela zoster
		Like other members of the herpesvirus family, VZV is not eliminated from the body after the acute illness but remains in a latent state for the life of the host.
		VZV reactivation (zoster) is very common in people with AIDS (PWAs), and it is frequently among the first opportunistic infections (OIs) to emerge.
		VZV is spread through oral-nasal absorption of airborne antigens or by direct physical contact with infectious lesions.
	www.aidsinfonyc.org /tag/comp/ois98/5.html (3498 words)

	HERPES ZOSTER It Is (Site not responding. Last check: 2007-10-24)
		Herpes zoster ter virus vzv pictures diagrams photos herpes herpes zoster ter virus vzv varicella zoster ophthalmicus may herpes zoster ter virus vzv be the same virus herpes zoster opthalmicus herpes.
		Exit herpes zoster ter virus vzv to contents ophtalmic herpes patients with herpes zoster chickenpox is highly infectious herpes zoster seases herpes zoster john l.
		Herpes zoster ter virus vzv chickenpox is the trigeminal herpes zoster ter virus vzv nerve note that she herpes zoster ter virus vzv has crusting present which herpes zoster ter virus vzv adesherpes.
	herpeszoster.dr-jhon.com /herpes-zoster-it-is.html (1647 words)

	Prevention of Varicella: Recommendations of the Advisory Committee on Immunization Practices (ACIP)
		VZV remains dormant in sensory-nerve ganglia and may be reactivated at a later time causing herpes zoster (i.e., shingles) -- a painful vesicular rash usually appearing in a dermatomal distribution of one or two sensory-nerve roots.
		VZV is transmitted from person to person by a) direct contact, droplet, or aerosol from vesicular fluid of skin lesions or b) secretions from the respiratory tract.
		VZV can be transmitted from the lesions of patients who have herpes zoster to susceptible contacts, although the likelihood of transmission of VZV from herpes zoster is much less than that from primary varicella.
	www.cdc.gov /mmwr/preview/mmwrhtml/00042990.htm (13012 words)

	Pharmacoepidemiology
		VZV vaccine seems to be less efficacious in adults and immunosuppressed children (34-36), who in general need two doses of VZV vaccine to have a seroconversion rate of 95% to 98%.
		The long term efficacy of VZV vaccine may also depend on the role of boosting by exposure to wild-type virus, and it is unknown whether vaccine-induced immunity against varicella may wane with decreasing circulation of natural VZV.
		VZV vaccination cannot eradicate VZV infection, because varicella may remain in a dormant state in the human host for a lifetime.
	www.hsph.harvard.edu /Organizations/DDIL/varicella.htm (4512 words)

	Varicella vaccine
		Varicella-zoster virus (VZV) is the causative agent and is transmitted by droplets, aerosol or direct contact, and patients are usually contagious from a few days before rash onset until the rash has crusted over.
		VZV is a double-stranded DNA virus belonging to the herpesvirus family.
		The immunity acquired in the course of varicella prevents neither the establishment of a latent VZV infection, nor the possibility of subsequent reactivation as zoster.
	www.who.int /vaccines/en/varicella.shtml (3234 words)

	Valtrex Online, Description, Chemistry, Ingredients - Valacyclovir Hcl - RxList Monographs
		The inhibitory activity of acyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV.
		The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the viral TK.
		Clinical isolates of VZV with reduced susceptibility to acyclovir have been recovered from patients with AIDS.
	www.rxlist.com /cgi/generic3/valacyclovir.htm (586 words)

	Persistent Detection of Varicella-Zoster Virus DNA in a Previously Healthy Child after Severe Chickenpox -- Vossen et ...
		The VZV gene encoding thymidine kinase and the adjacent sequence
		VZV DNA loads were also quantified in cell fractions of a control patient at 2 weeks after the onset of exanthem (control).
		Varicella-zoster virus (VZV) transcription during latency in human ganglia: detection of transcripts mapping to genes 21, 29, 62, and 63 in a cDNA library enriched for VZV RNA.
	jcm.asm.org /cgi/content/full/43/11/5614 (4686 words)

	Selection and Characterization of Varicella-Zoster Virus Variants Resistant to ...
		The VZV TK gene is 1,023 nucleotides in length and encodes a polypeptide of 341 amino acids.
		VZV from an AIDS patient that did not have a mutation in the TK gene.
		VZV is cross-resistant to ACV, and vice versa.
	aac.asm.org /cgi/content/full/45/6/1629 (5838 words)

	VZV Foundation - A Decade Of Leadership In The Fight Against VZV Infections
		The impact and treatment of infections caused by the varicella-zoster virus (VZV) - chickenpox, shingles and post-herpetic neuralgia (PHN) - on immunocompromised patients due to HIV/AIDS infection, cancer, transplantation and age was the focus of a scientific conference on January 18, 2000 at The New York Academy of Medicine.
		At the VZV Research Foundation, this year has been probably one of our busiest as we launch several new and exciting initiatives that will lead us to the year 2001, which marks not only the start of the "New Millennium," but also the 10th anniversary of our founding.
		The increasing role of the VZV Research Foundation in fostering research on the prevention and management of VZV infections was the recurring theme of remarks made at a luncheon on January 19, 2000, at New York's Union Club.
	www.vzvfoundation.org /focusnewsletter.html (8289 words)

	Replication of varicella-zoster virus is influenced by the levels of JNK/SAPK and p38/MAPK activation -- Rahaus et al. ...
		MEWO cells were infected with VZV in the presence of JNK inhibitor I (c) or SB202190 (d).
		Analysis of the importance of VZV gene expression for activation of JNK/SAPK and p38/MAPK.
		Rahaus, M. and Wolff, M. Reciprocal effects of varicella-zoster virus (VZV) and AP1: activation of jun, fos and ATF-2 after VZV infection and their importance for the regulation of viral genes.
	vir.sgmjournals.org /cgi/content/full/85/12/3529 (5902 words)

	Preventing Varicella-Zoster Disease -- Hambleton and Gershon 18 (1): 70 -- Clinical Microbiology Reviews
		VZV is an alphaherpesvirus that is closely related to herpes
		VZV is though to gain entry to the body as airborne virus reaching
		VZV, as studied in the SCID-hu mouse model (108).
	cmr.asm.org /cgi/content/full/18/1/70 (7829 words)

	Varicella-Zoster Virus (VZV) ORF17 Protein Induces RNA Cleavage and Is Critical for Replication of VZV at 37oC but Not ...
		to the attenuated Oka strain of VZV (47).
		to the sequence of the Dumas strain of VZV (10).
		Melanoma cells were also infected with cell-free VZV, incubated at 33°C for 3 h followed by 37°C for 48 h, and stained with an antibody to ORF62 protein either alone (I and K) or with DAPI (J and L).
	jvi.asm.org /cgi/content/full/76/21/11012 (7026 words)

	Ann Arvin (Site not responding. Last check: 2007-10-24)
		Current studies of VZV protein specific immunity include the use of vaccinia recombinants expressing VZV glycoproteins or immediate early/tegument proteins to analyze cytotoxic T-cell responses to VZV and the use of human dendritic cells to sensitize naive T lymphocytes in vitro with VZV peptides.
		The role of class I and class II restricted CTL responses to VZV is being assessed during primary VZV infection and in persistent immunity to VZV.
		Mutant VZV strains are being developed using VZV cosmids; recombinant strains are being tested for the effects of gene deletions on infectivity for T-cells and skin and on latency.
	cmgm.stanford.edu /micro/fac/arvin.html (438 words)

	Detection of Varicella Zoster Virus DNA in Some Patients with Giant Cell Arteritis -- Mitchell and Font 42 (11): 2572 ...
		VZV is associated with the pathogenesis of GCA.
		The VZV IE-63 ORF is located within the EcoRI E fragment and is represented by the box.
		Because VZV DNA was present in a significant portion of the
	www.iovs.org /cgi/content/full/42/11/2572 (3328 words)

	Transcription factor USF, expressed during the entire phase of varicella-zoster virus infection, interacts physically ...
		VZV is the smallest of the alphaherpesviruses; its genome consists
		As a control, VZV gE (85 kDa) was also revealed in the protein extract of infected cells.
		VZV protein expression and virus replication after inhibition of DNA-binding activity of USF.
	vir.sgmjournals.org /cgi/content/full/84/11/2957 (5718 words)

	Varicella-Zoster Virus-Infected Human Sensory Neurons Are Resistant to Apoptosis, yet Human Foreskin Fibroblasts Are ...
		For cell-associated VZV infections, the degree of VZV infection
		VZV antigen and 4% ± 0.3% of neurons stained for annexin
		VZV strain Schenke or ROka-infected HFFs or uninfected HFFs
	jvi.asm.org /cgi/content/full/77/23/12852 (7117 words)

	Improved Identification and Differentiation of Varicella-Zoster Virus (VZV) Wild-Type Strains and an Attenuated ...
		Detection of VZV genome variations in ORFs 38 and 54 was performed using the method described by LaRussa et al.
		Shown are results for the SmaI RFLP assay for VZV ORF 62 amplicons obtained with wild-type viruses (lanes 1 to 3 and 5 to 9 correspond to samples 44 to 46 and 48 to 52 in Table 1) and Oka vaccine strain (lane 4).
		Differential genotyping of Oka vaccine strain and wild-type VZV strains
	jcm.asm.org /cgi/content/full/38/9/3156 (3645 words)

	Susceptibilities of Several Clinical Varicella-Zoster Virus (VZV) Isolates and Drug-Resistant VZV Strains to Bicyclic ...
		strains with mutations in the VZV DNA polymerase gene.
		of cell-associated VZV (Oka strain) in the presence of increasing
		VZV strain and were treated with ACV led to the emergence of
	aac.asm.org /cgi/content/full/49/3/1081 (3078 words)

	The Varicella-Autoantibody Syndrome -- JOSEPHSON et al. 50 (3): 345 -- Pediatric Research (Site not responding. Last check: 2007-10-24)
		VZV infection (group 2); they had a mean age of 5.5 y (range,
		VZV is an early childhood viral infection that elicits a brisk
		VZV may allow the presentation of the host antigens in a manner
	www.pedresearch.org /cgi/content/full/50/3/345 (3092 words)

	Valtrex - Drugs Store - drugsstore.org
		Using plaque-reduction assays, the IC50 against herpes simplex virus isolates ranges from 0.02 to 13.5 mcg/mL for HSV-1 and from 0.01 to 9.9 mcg/mL for HSV-2.
		The IC50 for acyclovir against most laboratory strains and clinical isolates of VZV ranges from 0.12 to 10.8 mcg/mL.
		Acyclovir also demonstrates activity against the Oka vaccine strain of VZV with a mean IC50 of 1.35 mcg/mL.
	www.drugsstore.org /valtrex.html (601 words)

	Effects of a Behavioral Intervention, Tai Chi Chih, on Varicella-Zoster Virus Specific Immunity and Health Functioning ...
		to a decline in CMI to VZV (4).
		VZV specific CMI and, possibly, to define risk for HZ Behavioral intervention trials provide experimental evidence
		to VZV in an older adult population at risk for herpes zoster.
	www.psychosomaticmedicine.org /cgi/content/full/65/5/824 (5947 words)

	Crystal Structure of Varicella Zoster Virus Thymidine Kinase -- Bird et al. 278 (27): 24680 -- Journal of Biological ...
		is against VZV (4, 17), a result of the differing affinities
		that although the VZV and HSV1-tk monomers are topologically
		The abbreviations used are: VZV, Varicella zoster virus; ACV,
	www.jbc.org /cgi/content/full/278/27/24680 (5332 words)

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