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Topic: Valacyclovir

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	Discovery Health :: Drug Reference (Site not responding. Last check: 2007-10-14)
		Valacyclovir lessens the symptoms of these infections and shortens the length of time you are sick.
		Valacyclovir is used in the treatment and suppression of genital herpes, shingles, and cold sores.
		Valacyclovir is in the FDA pregnancy category B. This means that it is not expected to be harmful to an unborn baby.
	health.discovery.com /encyclopedias/reference/drug.jsp?drug=3117 (1066 words)

	valacyclovir - Womens Health and Medical Information on MedicineNet.com
		Valacyclovir inhibits the replication of viral DNA which is necessary for viruses to reproduce themselves.
		Valacyclovir is actually a "prodrug," in that it is not active itself.
		Valacyclovir was approved for use by the FDA in 1995.
	www.medicinenet.com /valacyclovir/article.htm (726 words)

	VALACYCLOVIR (Site not responding. Last check: 2007-10-14)
		Valacyclovir is still a relatively new antiviral agent and is not currently approved for use in patients who are immunosuppressed (ie.
		Valacyclovir is generally well tolerated. Nausea, vomiting, diarrhea, dizziness, or headache may occur. If these effects occur and are bothersome, let your doctor or pharmacist know. Call your doctor immediately if you experience adverse effects such as unusual bruising or bleeding or if you think you have an allergic reaction (ie.
		Valacyclovir should be stored in a cool (15-30°C) dry place, protected from light and well out of the reach of children. Do not store in the bathroom or kitchen, as heat and moisture may cause the drug to be less active.
	www.tthhivclinic.com /FactSheets/html/VALACYCLOVIR.html (714 words)

	Valacyclovir and Acyclovir for Suppression of Shedding of Herpes Simplex Virus in the Genital Tract
		The efficacy of valacyclovir and acyclovir on genital herpes simplex virus (HSV) shedding was assessed in a double-blind, 3-period crossover trial.
		Valacyclovir is rapidly converted to acyclovir after absorption and achieves higher plasma levels of acyclovir than oral preparations of acyclovir.
		Secondary end points were to evaluate the efficacy of valacyclovir and acyclovir for the suppression of total (subclinical and lesional) shedding by culture and PCR and to evaluate the efficacy of valacyclovir and acyclovir for the suppression of recurrences.
	www.natap.org /2004/HIV/092804_08.htm (1989 words)

	lorazepam side affect ---- walgreens online pharmacy
		Valacyclovir inhibits the replication lorazepam intensol viral DNA which is necessary for viruses to reproduce themselves.
		Valacyclovir was g¼nstig lorazepam for use by the FDA in 1995.
		Valacyclovir is used to treat infections with herpes zoster (shingles), herpes simplex genitalis (genital lorazepam and herpes labialis (cold sores).
	drugsdot.com /lorazepam/14/lorazepam_side_affect.html (177 words)

	lorazepam , drug online pharmacy
		Valacyclovir inhibits lorazepam withdrawal symptom replication of viral DNA which is necessary for viruses to reproduce themselves.
		Valacyclovir is used to treat infections with apo lorazepam zoster (shingles), herpes simplex genitalis (genital herpes), and herpes labialis (cold sores).
		Valacyclovir was approved for use by the FDA in lorazepam watson.
	drugsdot.com /lorazepam/11/lorazepam.html (188 words)

	Valtrex Clinical Pharmacology - Valacyclovir - USA Today (Site not responding. Last check: 2007-10-14)
		After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract and nearly completely converted to acyclovir and L-valine by first-pass intestinal and/or hepatic metabolism.
		Valacyclovir is converted to acyclovir and L-valine by first-pass intestinal and/or hepatic metabolism.
		After single-dose administration of 1 gram of VALTREX, average plasma valacyclovir concentrations observed were 0.5, 0.4, and 0.8 mcg/mL in patients with hepatic dysfunction, renal insufficiency, and in healthy volunteers who received concomitant cimetidine and probenecid, respectively.
	www.healthscout.com /rxdetail/68/72/5/main.html (1866 words)

	Viral Infections: Valacyclovir for Herpes Zoster
		Valacyclovir HCl is the hydrochloride salt of the L-valyl ester of acyclovir.
		Valacyclovir, which is administered orally, is rapidly absorbed from the gastrointestinal tract.
		In the comparison with acyclovir, the most common adverse events in the valacyclovir group were nausea (16% of patients), headache (13%), vomiting (7%), diarrhea (5%), constipation (5%), asthenia (4%), dizziness (4%), abdominal pain (3%), and anorexia (3%).
	www.hivpositive.com /f-Oi/OppInfections/4-Viral/4-valacyc.html (652 words)

	Once-Daily Valacyclovir to Reduce the Risk of Transmission of Genital Herpes
		Of the remaining 51 susceptible partners with genitourinary symptoms, 3 (2 valacyclovir and 1 placebo) had seroconversion to HSV-2 positivity during the study; however, the seroconversion predated the reported symptoms, and hence the new infection was believed to be asymptomatic.
		Valacyclovir is effective in suppressing genital herpes in men who have sex with men.39 However, as shown in the trial, sexual transmission is influenced by sexual behavior and biologic factors.
		Because the observed reduction in the rate of transmission of genital herpes with valacyclovir is clinically relevant but not complete, it is important that disclosure of genital herpes to the susceptible partner and the practice of safer sex continue, since both may reduce the risk of transmission of genital herpes.
	www.natap.org /2004/jan/010504_13.htm (2919 words)

	Valacyclovir Is Effective for Suppression of Recurrent Genital Herpes in HIV Patients
		The objective of this study was to determine the efficacy and safety of Valtrex (valacyclovir) (500 mg twice daily) for the suppression of recurrent genital herpes simplex virus infections in HIV patients.
		Valacyclovir was well tolerated; the incidence of adverse events for the 2 treatment groups was similar when the duration of treatment was considered.
		Valacyclovir for the suppression of recurrent genital herpes in human immunodeficiency virus-infected subjects.
	www.hivandhepatitis.com /recent/std/110503d.html (203 words)

	Valtrex
		Valacyclovir (val-ay-SYE-kloe-veer) is used to treat the symptoms of herpes zoster (also known as shingles), a herpes virus infection of the skin; it is also used to treat and prevent genital herpes infections.
		Although valacyclovir will not cure shingles or genital herpes, it does help relieve the pain and discomfort and helps the sores heal faster.
		Valacyclovir works best if it is used within 48 hours after the first symptoms of shingles or genital herpes (for example, pain, burning, or blisters) begin to appear.
	www.healthtouch.com /bin/EContent_HT/drugShowLfts.asp?fname=usp0581.htm&title=Valtrex&cid=L (1082 words)

	Buy Valacyclovir COD Shipping \| Order Meds COD Online (Site not responding. Last check: 2007-10-14)
		Valacyclovir® is the only once-a-day prescription medication proven to suppress future genital herpes outbreaks.
		Valacyclovir is an antiviral agent used in the treatment of herpes zoster (shingles), genital herpes and is also being used for herpes simplex (cold sores).
		Valacyclovir is most effective if it is started within 48 hours of when the rash first appears.
	www.diet-pills-overnight-cod.com /valacyclovir.htm (389 words)

	Valtrex Online, Description, Chemistry, Ingredients - Valacyclovir Hcl - RxList Monographs (Site not responding. Last check: 2007-10-14)
		Valacyclovir hydrochloride is a white to off-white powder with the molecular formula C
		Mechanism of Antiviral Action: Valacyclovir hydrochloride is rapidly converted to acyclovir which has demonstrated antiviral activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella-zoster virus (VZV) both in vitro and in vivo.
		The possibility of viral resistance to valacyclovir (and therefore, to acyclovir) should be considered in patients who show poor clinical response during therapy.
	www.rxlist.com /cgi/generic3/valacyclovir.htm (637 words)

	Skin Therapy Letter: Valacyclovir for the Management of Herpes Viral Infections
		Valacyclovir provides a high bioavailability of acyclovir, 3- to 5-fold higher than that obtained with oral acyclovir, and it is equivalent to plasma levels achieved with doses of intravenous acyclovir (see Table 1).
		Valacyclovir is approved by the US FDA at 1,000mg, po, two times daily for 10 days for initial onset of genital herpes and at a 3-day, 500mg, twice-daily course for episodic management of recurrent herpes.
		Valacyclovir provides an effective antiviral in the treatment of herpes zoster and further trials of various dosing regimens of the antiviral pertaining to different clinical manifestations of herpes zoster are ongoing.
	skintherapyletter.com /tf/content.asp?a=2561 (1998 words)

	VALACYCLOVIR Faq
		Valacyclovir (val-a-CY-clo-veer) is an antiviral agent used to treat infections such as genital herpes.
		The recommended dose of valacyclovir used to treat shingles in adults is 1000 mg (2 x 500mg caplets) three times daily for a period of seven days.
		Since valacyclovir is removed from the body by your kidneys, it is important to inform your doctor if you have kidney disease prior to taking this medicine.
	www.tthhivclinic.com /treat_vala.htm (660 words)

	Valacyclovir - Drive passage jam the velvety organ with drenched maidenhead. (Site not responding. Last check: 2007-10-14)
		Valacyclovir - Drive passage jam the velvety organ with drenched maidenhead.
		Acoustic barium sulphate fee-tail the heralded chicken Valacyclovir and rice with uncurved counterperson.
		Valacyclovir Pentatonic deictic dedifferentiate the highly infective North American country with ascitic Prajapati.
	www.viagrawatcher.com /valtrex/Valacyclovir/Valacyclovir.html (2273 words)

	Valtrex - Drugs & Vitamins - Drug Library - DrugDigest
		Valacyclovir is not a cure; it will help the sores heal faster and relieve the pain or discomfort.
		Valacyclovir might help prevent genital herpes from being passed on to a partner who does not have genital herpes if it is used with 'safer sex' practices.
		Valacyclovir may be helpful in preventing the spread of infection to others.
	www.drugdigest.org /DD/DVH/Uses/0,3915,697\|Valtrex,00.html (619 words)

	Valacyclovir Hydrochloride (Site not responding. Last check: 2007-10-14)
		Valacyclovir is converted in the body to acyclovir, which interferes with the activity of enzymes needed for the replication of viral DNA in cells, thus preventing the virus from multiplying.
		Valacyclovir may pass into breast milk, although it is unknown if this poses any risks to the nursing infant; no problems have been reported.
		Use of valacyclovir may cause complications in patients with kidney disease, since this organ works to remove the medication from the body.
	www.wholehealthmd.com /refshelf/drugs_view/1,1524,627,00.html (646 words)

	Clinical Trial: Valacyclovir in Immunocompromised Children (Site not responding. Last check: 2007-10-14)
		Valacyclovir is a new drug that is metabolized (broken down in the body) to acyclovir.
		Valacyclovir is given by mouth and studies done in adults have shown it to be more effective than acyclovir given by mouth.
		If there are unacceptable side effects or if there is evidence that the disease is spreading, despite being on Valacyclovir for more than 48 hours, then you will be taken off the study and started on acyclovir by vein.
	clinicaltrials.gov /ct/gui/show/NCT00059592 (917 words)

	Formulary - Valtrex (Valacyclovir) GlaxoSmithKline
		Valacyclovir, a widely prescribed antiviral, recently received approval for an expanded indication: suppressive therapy in immunocompetent individuals with genital herpes to reduce the risk of heterosexual transmission to susceptible partners.
		Because valacyclovir is not a cure for genital herpes, patients should be counseled to use safer sex practices in combination with suppressive therapy with the drug.
		The most common adverse effects associated with the administration of valacyclovir in patients for the reduction of genital herpes transmission include headache, nasopharyngitis, and upper respiratory tract infection.
	www.formularyjournal.com /formulary/article/articleDetail.jsp?id=77741 (394 words)

	WebMD Health - Patient Handout for Valacyclovir Oral
		Valacyclovir is used to treat cold sores (herpes labialis) and shingles (herpes zoster).
		Valacyclovir can also be used to control genital herpes outbreaks in all patients, including those with HIV.
		If you are taking valacyclovir for treatment of genital herpes, it is important to follow safe sex practices to lower the chance of giving herpes to your partner, even if there are no symptoms present.
	my.webmd.com /drugs/drug-6279-Valacyclovir+HCl+Oral.aspx?...+HCl+Oral (1111 words)

	Skin Therapy Letter: Volume 2, Number 1 (Site not responding. Last check: 2007-10-14)
		This indication for valacyclovir was approved in the USA in August 1995 and in Canada in May 1996.
		Valacyclovir is approved in the USA for treating recurrent genital herpes, and was approved in Canada for this indication in October 1996.
		During clinical trials involving severely immunocompromised patients, some of whom were receiving high doses of oral valacyclovir (2 g four times daily) for prolonged periods of time, isolated cases of syndromes similar to thrombotic thrombocytopenic purpura and/or hemolytic uremic syndrome were reported.
	www.derm.ubc.ca /skintherapy/stl0201.html (1665 words)

	Valacyclovir for CMV Prophylaxis in Renal Transplantation - Journal Watch Infectious Diseases
		Valacyclovir significantly reduced the incidence of CMV disease in both CMV seropositive and seronegative recipients.
		For seronegative recipients, the incidence of CMV disease at 90 days was 45% in the placebo group and 3% in the valacyclovir group; for seropositive recipients, the respective rates were 6% and 0%.
		Valacyclovir therapy was associated with a 57% reduction at six months in biopsy-confirmed acute graft rejection in seronegative recipients, and significant reductions in rates of herpes simplex disease and nonherpesvirus infections.
	infectious-diseases.jwatch.org /cgi/content/full/1999/701/1 (283 words)

	Randomized study of valacyclovir as prophylaxis against cytomegalovirus reactivation in recipients of allogeneic bone ... (Site not responding. Last check: 2007-10-14)
		Oral valacyclovir for cytomegalovirus (CMV) prophylaxis in bone marrow transplantation (BMT) was investigated in a randomized,
		Valacyclovir reduces the incidence of cytomegalovirus disease and acute graft rejection in renal allograft recipients: results of a placebo-controlled, randomized, double-blind, multinational study.
		The effect of valacyclovir on cytomegalovirus viremia and viruria detected by polymerase chain reaction in patients with advanced human immunodeficiency virus disease.
	www.bloodjournal.org /cgi/content/full/99/8/3050 (4389 words)

	Family Pratice News: Daily Valacyclovir Reduces Herpes Lesion Recurrences in Wrestlers - Brief Article
		In this study, a higher dosage of valacyclovir also was tested in wrestlers who had recurrences for 2 or more years.
		In this group, the recurrence rate was 20.5% among 44 athletes on placebo, 21.4% among 14 who took 500 mg of valacyclovir daily, and 3.7% among 27 who took 1,000 mg of the drug daily, he said.
		Valacyclovir also may help prevent initial infection in a wrestler who has had contact with an athlete who develops a recurrence soon after their match.
	www.findarticles.com /p/articles/mi_m0BJI/is_23_30/ai_68642739 (548 words)

	Valacyclovir and Postherpetic Neuralgia (Site not responding. Last check: 2007-10-14)
		All of these studies reported that valacyclovir is an effective treatment for herpes zoster and alleviates associated pain significantly faster than acyclovir, presumably due to its greater bioavailability.
		Valacyclovir likely results in a higher adherence rate than acyclovir because it is dosed 3 versus 5 times daily.
		Finally, one study showed that valacyclovir is equally as effective as famciclovir in alleviating pain associated with herpes zoster.
	www.jpharmtechnol.com /abstracts/volume20/July-August/229.html (260 words)

	Herpes
		While valacyclovir is better absorbed and somewhat longer acting, the absorption does make any difference for most indications and the slight benefit in reduced frequency has had no measurable impact on compliance and comes at a very high price.
		Valacyclovir Better in a Second: An odd report on two studies of 1079 zoster patients reports that in the first study, patients treated with acyclovir improved much more quickly than patients treated with placebo (28 days vs. 62 days).
		However, in the second study, when acyclovir was compared to valacyclovir, the valacyclovir totally relieved the pain in 40 days vs. 50 days for the acyclovir.
	www.modern-psychiatry.com /herpes.htm (3882 words)

	ATC: Valacyclovir as Effective as Ganciclovir in Renal Transplant Prophylaxis of Cytomegalovirus (Site not responding. Last check: 2007-10-14)
		BOSTON, MA -- May 21, 2004 -- In a head-to-head study, valacyclovir proved just as effective as ganciclovir in preventing cytomegalovirus (CMV) in kidney transplant patients, and may also be more cost-effective, researchers reported in a poster session here May 17th at the 2004 annual meeting of the American Transplant Congress.
		There was a higher incidence of treatment failure (defined as death, graft loss, CMV disease or study withdrawal) in the ganciclovir (19%) than in the valacyclovir arm (11%), while 67% of the deferred therapy arm had treatment failure (P=0.004 ganciclovir vs. controls; P <.001 valacyclovir vs. controls; P =.514 ganciclovir vs. valacyclovir).
		Acute rejection in patients with delayed graft function was 53% in the 15 ganciclovir patients and 20% in the 7 valacyclovir patients.
	www.pslgroup.com /dg/24437a.htm (511 words)

	Valacyclovir (Systemic) - New Jersey
		Adequate and well-controlled studies in humans have not been done with valacyclovir or acyclovir.
		It is not known whether valacyclovir passes into breast milk.
		Valacyclovir has been used in elderly patients and has not been shown to cause different side effects or problems in older people than it does in younger adults.
	www.somersetmedicalcenter.com /16036.cfm (1096 words)

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