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Topic: Valdecoxib

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	valdecoxib (Bextra) - drug class, medical uses, medication side effects, and drug interactions by MedicineNet.com
		Valdecoxib also is approved for the relief of pain of menstrual cramps (primary dysmenorrhea).
		Valdecoxib may be taken with or without food.
		Valdecoxib should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
	www.medicinenet.com /valdecoxib/article.htm (812 words)

	Bextra Side Effects, and Drug Interactions - Valdecoxib - RxList Monographs
		In vitro studies indicate that valdecoxib is a moderate inhibitor of CYP 2C19 (IC50 = 6 µg/mL or 19 µM) and 2C9 (IC50 = 13 µg/mL or 41 µM), and a weak inhibitor of CYP 2D6 (IC50 = 31 µg/mL or 100 µM) and 3A4 (IC50 = 44 µg/mL or 141 µM)..
		Valdecoxib did not have a statistically significant effect on the pharmacokinetics of phenytoin (a CYP 2C9 and CYP 2C19 substrate).
		Coadministration with valdecoxib (40 mg BID for 7 days) resulted in a significant increase in dextromethorphan plasma levels suggesting that, at these doses, valdecoxib is a weak inhibitor of 2D6.
	www.rxlist.com /cgi/generic/bextra_ad.htm (1813 words)

	Bextra Molecular Structure -- Valdecoxib Molecule
		Bextra (Valdecoxib) is approved by the FDA for treatment of osteoarthritis and rheumatoid arthritis at a dose of 10 mg daily.
		Valdecoxib also is approved for the treatment of dysmenorrhea (that is, the abdominal pain sometimes associated with menstrual periods) at a dose of 20 mg twice daily.
		Valdecoxib has been reported to have a much lower risk of stomach ulceration compared to older, nonselective COX inhibitors (such as naproxen, indomethacin, aspirin etc).
	www.worldofmolecules.com /drugs/bextra.htm (309 words)

	WCA: Valdecoxib Relieves Dental Pain With Few Adverse Effects (Site not responding. Last check: 2007-10-12)
		Valdecoxib is a potent cyclcooxygenase-2 (COX-2)-specific inhibitor that is effective and well tolerated for management of acute pain in a variety of surgical patients.
		The pooled NNT estimates were similar with valdecoxib 20 mg (1.93), valdecoxib 40 mg (1.59-1.71), rofecoxib 50 mg (1.66), and oxycodone 10 mg/acetaminophen 1000 mg (2.03-2.12).
		Valdecoxib 20 mg and 40 mg, and rofecoxib 50 mg, were associated with incidences of adverse event and individual opioid-type adverse events similar to those seen with placebo.
	www.pslgroup.com /dg/243d86.htm (477 words)

	New COX-2 Specific Inhibitor Valdecoxib Compared to Oxycodone/Acetaminophen for Pain Relief After Dental Surgery (Site not responding. Last check: 2007-10-12)
		Valdecoxib was recently approved by the U.S. Food and Drug Administration under the brand name BEXTRA and is now widely available for the treatment of osteoarthritis, adult rheumatoid arthritis and primary dysmenorrhea (painful menstrual cramping).
		Patients in both studies who were treated with valdecoxib 40 mg experienced an onset of pain relief (28-35 minutes) that was comparable to oxycodone 10 mg/acetaminophen 1,000 mg (28-29 minutes) and significantly better than that of placebo (greater than 24 hours).
		BEXTRA (valdecoxib tablets) is indicated for treating the signs and symptoms of osteoarthritis (OA) and adult rheumatoid arthritis (RA), and primary dysmenorrhea (painful menstrual cramping).
	www.pslgroup.com /dg/21547e.htm (1171 words)

	EMEA Statement On Valdecoxib (Bextra/Valdyn) & Parecoxib Sodium (Dynastat/Rayzon) (Site not responding. Last check: 2007-10-12)
		Two clinical studies were conducted to evaluate the safety of valdecoxib and parecoxib sodium, in patients following CABG surgery and another study in patients following general surgery.
		The second CABG surgery study evaluated parecoxib sodium (40mg then 20mg bid) /valdecoxib 20 mg bid or placebo/valdecoxib 20 mg bid or placebo/placebo for up to 10 days in 1671 patients (544 receiving parecoxib/valdecoxib, 544 placebo/valdecoxib and 548 placebo/placebo).
		Valdecoxib and parecoxib are contraindicated in patients following coronary artery bypass graft (CABG) surgery.
	www.yourlawyer.com /practice/news.htm?story_id=9085&topic=Vioxx (662 words)

	MedlinePlus Drug Information: Valdecoxib
		The skin reactions may develop at any time during your treatment with valdecoxib, but are most likely to develop during the first 2 weeks of your treatment.
		Valdecoxib is used to relieve the pain, tenderness, inflammation (swelling), and stiffness caused by arthritis and to treat painful menstrual periods.
		Valdecoxib is in a class of nonsteroidal anti-inflammatory medications called COX-2 inhibitors.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a602011.html (847 words)

	News - Valdecoxib Effective With or Without Concomitant Medications, Including DMARDs: Presented at ACR
		The pooled analysis indicated that valdecoxib subjects achieved improvement in the ACR-20 Responders Index compared to placebo when valdecoxib was given with or without a DMARD, methotrexate or the low-dose oral corticosteroid prednisone.
		This means that subjects receiving valdecoxib 10 mg were 1.7 times as likely as those treated with placebo to experience relief of signs and symptoms of RA, and those treated with valdecoxib 20 mg were 1.3 times as likely to experience the same.
		Subjects treated with valdecoxib 20 mg were 1.9 times as likely to experience relief compared to subjects treated with naproxen, who were 2.2 times as likely to experience relief.
	docguide.com /news/content.nsf/news/8525697700573E1885256C610075E411 (869 words)

	Disposition of a Specific Cyclooxygenase-2 Inhibitor, Valdecoxib, in Human -- Yuan et al. 30 (9): 1013 -- Drug ...
		with valdecoxib and the hydroxylated metabolite of valdecoxib
		Valdecoxib was detected in plasma, urine, and feces.
		Valdecoxib and its hydroxylated metabolite, M1, were the main radioactive components circulating in blood and in plasma.
	dmd.aspetjournals.org /cgi/content/full/30/9/1013 (3842 words)

	Valdecoxib (Bextra®) cardiovascular risk and severe skin reactions
		The manufacture of valdecoxib, Pfizer, has added an increased warning of severe skin reactions and a contraindication for use in patients undergoing coronary artery bypass graft (CABG).
		Valdecoxib contains sulfa and should be avoided in patients with sulfa allergies.
		Valdecoxib has also increased risk of thromboembolic events in CABG patients compared to placebo; therefore, it should not be used in this population.
	uuhsc.utah.edu /pharmacy/alerts/5.html (168 words)

	Valdecoxib Drug Information
		Valdecoxib was voluntarily withdrawn from the market in April 2005.
		It is not known whether valdecoxib passes into human breast milk.
		Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of valdecoxib in children with use in other age groups.
	www.drugs.com /cons/Valdecoxib.html (1212 words)

	MedlinePlus Drug Information: Valdecoxib (Systemic) (Site not responding. Last check: 2007-10-12)
		Valdecoxib may cause problems in the baby's heart and lungs and is not recommended late in pregnancy.
		Valdecoxib may cause a serious type of allergic reaction called anaphylaxis.
		USP DI® and Advice for the Patient® are registered trademarks of USP used under license to Micromedex, a business of Thomson Healthcare Inc. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.
	www.nlm.nih.gov /medlineplus/druginfo/uspdi/500345.html (1184 words)

	Valdecoxib - Patient UK
		Valdecoxib is used to relieve pain and inflammation in osteoarthritis and rheumatoid arthritis.
		Valdecoxib is a member of a group of medicines called Non-steroidal Anti-inflammatory Drugs.
		Valdecoxib may cause your skin to become more sensitive to sunlight than it is usually.
	www.patient.co.uk /showdoc/30003875 (780 words)

	Valdecoxib - Drugs & Vitamins - Drug Library - DrugDigest
		VALDECOXIB (Bextra®) is a drug used to reduce inflammation and ease mild to moderate pain for such conditions as arthritis or painful menstrual cycles.
		It is especially important not to use valdecoxib during the last 3 months of pregnancy unless specifically directed to do so by your health care provider.
		Valdecoxib may cause problems in the unborn child or complications during delivery.
	www.drugdigest.org /DD/PrintablePages/Monograph/0,7765,550870\|,00.html (771 words)

	Valdecoxib is as effective as diclofenac in the management of rheumatoid arthritis with a lower incidence of ...
		Valdecoxib is as effective as diclofenac in the management of rheumatoid arthritis with a lower incidence of gastroduodenal ulcers: results of a 26-week trial -- Pavelka et al.
		Valdecoxib is as effective as diclofenac in the management of rheumatoid arthritis with a lower incidence of gastroduodenal ulcers: results of a 26-week trial
		Valdecoxib, a COX-2 specific inhibitor, is an efficacious, opioid-sparing analgesic in patients undergoing hip arthroplasty.
	rheumatology.oxfordjournals.org /cgi/content/full/42/10/1207 (3978 words)

	NEJM -- Cardiovascular Toxicity of Valdecoxib (Site not responding. Last check: 2007-10-12)
		the cardiotoxicity of valdecoxib in high-risk patients, the
		from the bypass studies, it is prudent to limit the use of valdecoxib
		The label for valdecoxib was revised in November 2004 by the
	content.nejm.org /cgi/content/full/351/26/2767 (406 words)

	Bextra Online, Description, Chemistry, Ingredients - Valdecoxib - RxList Monographs
		Valdecoxib is chemically designated as 4-(5-methyl-3-phenyl-4-isoxazolyl) benzenesulfonamide and is a diaryl substituted isoxazole.
		Valdecoxib is a white crystalline powder that is relatively insoluble in water (10 µg/mL) at 25C and pH 7.0, soluble in methanol and ethanol, and freely soluble in organic solvents and alkaline (pH=12) aqueous solutions.
		BEXTRA Tablets for oral administration contain either 10 mg or 20 mg of valdecoxib.
	www.rxlist.com /cgi/generic/bextra.htm (126 words)

	News - Valdecoxib Linked to Cardiovascular Complications: Presented at AHA
		But Pfizer Inc., manufacturer of valdecoxib, said the study "draws unsubstantiated conclusions" about the cardiovascular safety of the COX-2 inhibitor and is based on information that has not been published in a medical journal or subject to independent scientific review.
		He said that the pooled analysis was conducted after two smaller studies of valdecoxib in coronary artery bypass patients suggested a class effect of COX-2 inhibitors on risk of cardiovascular complications.
		Of those, 5930 patients were randomized to valdecoxib and the 1841, placebo.
	docguide.com /news/content.nsf/news/8525697700573E1885256F4A0057C82E (705 words)

	VALDECOXIB 20MG - ORAL (Bextra) side effects, medical uses, and drug interactions.
		VALDECOXIB 20MG - ORAL (Bextra) side effects, medical uses, and drug interactions.
		Symptoms of an allergic reaction may include: rash, mouth sores, itching, swelling, dizziness, trouble breathing.
		USES: Valdecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and swelling (inflammation), in particular menstrual pain (dysmenorrhea).
	www.medicinenet.com /valdecoxib_20mg-oral/article.htm (345 words)

	Bextra (Valdecoxib) Drug Brief / RxPalace.com
		Valdecoxib inhibits prostaglandin synthesis by selectively inhibiting the cyclooxygenase-2 (COX-2) isoenzyme; however, at therapeutic plasma concentrations in humans, it does not inhibit the cyclooxygenase-1 (COX-1) isoenzyme.
		WebRx Editorial Notes: Valdecoxib may be taken with or without food according to the manufacturer's recommendations.
		This drug represents another in the class of Cox-2 inhibitors which are presumably safer on the stomach than older NSAIDs.
	www.rxpalace.com /DrugBriefs/Bextra.htm (333 words)

	RemedyFind: patient ratings of Bextra for Osteoarthritis
		Followed by Vioxx (Rofecoxib) in 1999 (Ceoxx is the brand name for Vioxx outside of the U.S.), and Bextra (Valdecoxib) in 2001, the COX-2 inhibitors are believed to vary in their COX-2 selectivity.
		Suggestions of a possible connection between Bextra (Valdecoxib) and an increased incidence of cardiovascular events in certain patient populations were first raised in a study published in the March 2005 issue of the New England Journal of Medicine.
		Complications of the COX-2 Inhibitors Parecoxib and Valdecoxib after Cardiac Surgery found that the use of Valdecoxib after coronary-artery bypass surgery was associated with an increased incidence of cardiovascular events.
	www.remedyfind.com /rm-3048-Bextra.asp (1100 words)

	valdecoxib (Site not responding. Last check: 2007-10-12)
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	medicine.fw-2.com /valdecoxib.htm (315 words)

	EMEA Statement On Valdecoxib (Bextra/Valdyn) & Parecoxib Sodium (Dynastat/Rayzon) (Site not responding. Last check: 2007-10-12)
		-- Valdecoxib and parecoxib are contraindicated in patients following coronary artery bypass graft (CABG) surgery.
		-- The reported rate of serious skin events appears to be greater for valdecoxib as compared to other so-called COX-2 inhibitors.
		The Product Information for valdecoxib and parecoxib sodium has now been modified to reflect the above-mentioned information and is appended to this press release.
	www.medicalnewstoday.com /medicalnews.php?newsid=18207 (696 words)

	Bextra (Valdecoxib Tablets) : Buy Bextra (Valdecoxib Tablets) at ABC Online Pharmacy
		Bextra (Valdecoxib) is a powerful medication that targets an important source of arthritis pain.
		Bextra (Valdecoxib) is tough on pain and inflammation.
		Bextra, a Drug consisting of Valdecoxib compound, is a medicine used for the treatment of Arthritis and other joint pains.
	www.abconlinepharmacy.com /ns/customer/product1668-c-p1 (1181 words)

	Valdecoxib (Site not responding. Last check: 2007-10-12)
		Me all my evil job is Valdecoxib on a pick a thanks.
		That, she has everybody underneath will Valdecoxib Valdecoxib you.
		Got him of Valdecoxib end there, at that was hook.
	drug-overdose.net /mad/Valdecoxib (359 words)

	Bextra / Valdecoxib Lawsuit Overview - Find Trial Lawyers and Attorneys with Experience in Bextra / Valdecoxib Personal ...
		The government is asking manufacturers of all other prescription NSAIDs to revise their labels to include the same boxed warning highlighting the potential for increased risk of cardiovascular events and gastrointestinal bleeding with their use.
		Bextra, also known as valdecoxib, is indicated for the treatment of pain, tenderness and swelling caused by osteoarthritis and adult rheumatoid arthritis.
		Belonging to a class of nonsteroidal anti-inflammatory medications (NSAIDs) called COX-2 inhibitors, Bextra blocks the action of the COX-2 enzyme, which causes arthritis pain and inflammation.
	www.injuryboard.com /view.cfm/Topic=904 (927 words)

	NEJM -- Complications of the COX-2 Inhibitors Parecoxib and Valdecoxib after Cardiac Surgery
		placebo and valdecoxib had a higher proportion of patients with
		Conclusions The use of parecoxib and valdecoxib after CABG was
		Cotter, J., Wooltorton, E. New restrictions on celecoxib (Celebrex) use and the withdrawal of valdecoxib (Bextra).
	content.nejm.org /cgi/content/short/352/11/1081 (690 words)

	News from Pfizer: Pfizer Statement on Bextra® (valdecoxib) (Site not responding. Last check: 2007-10-12)
		A list and description of risks and uncertainties relating to matters discussed in this document can be found in the Companys Annual Report on Form 10-K for the fiscal year ended December 31, 2003, and in its periodic reports on Forms 10-Q and 8-K. 1 White WB, et al.
		“Effects of the Cyclooxygenase-2 Specific Inhibitor Valdecoxib Versus Nonsteroidal Antiinflammatory Agents and Placebo on Cardiovascular Thrombotic Events in Patients with Arthritis.” American Journal of Therapeutics.
		Pfizer Inc is a pharmaceutical company committed to helping people improve their health by discovering and developing medicines.
	www.pfizer.com /are/news_releases/2004pr/mn_2004_1110.html (561 words)

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