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Topic: Valganciclovir

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	valganciclovir medical facts from Drugs.com
		Using valganciclovir while you are pregnant may cause harm to the unborn baby.
		Valganciclovir is in the FDA pregnancy category C. This means that it is not known if it will be harmful to an unborn baby.
		Symptoms of a valganciclovir overdose may include seizure (convulsions), kidney failure (urinating more or less than usual, blood in the urine, swelling or numbness in your hands or feet, pain in your lower back or sides), or signs of liver damage (yellowing of the skin or eyes, severe and sudden stomach pain, diarrhea, vomiting).
	www.drugs.com /mtm/valganciclovir.html (1780 words)

	[No title]
		Valganciclovir hydrochloride is a hydrochloride salt of the L-valyl ester of ganciclovir that exists as a mixture of two diastereomers.
		Valganciclovir is a prodrug of ganciclovir; it is converted rapidly to ganciclovir by intestinal and hepatic esterases.
		Valganciclovir is contraindicated in patients with hypersensitivity to valganciclovir or ganciclovir.
	aidsinfo.nih.gov /drugs/htmldrug_tech.asp?int_id=0271 (1225 words)

	Valganciclovir hydrochloride (Valcyte)
		Valganciclovir is a new oral prodrug of ganciclovir labeled for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients.
		Valganciclovir is rapidly metabolized to ganciclovir in the intestinal wall and liver.
		Valganciclovir tablets should not be crushed or split and caution should be taken when handling broken tablets due to the teratogenic, carcinogenic, and mutagenic properties of the drug.
	uuhsc.utah.edu /pharmacy/bulletins/valganciclovir_hydrochloride.html (516 words)

	Valganciclovir - Wikipedia, the free encyclopedia
		Valganciclovir is eliminated as ganciclovir in the urine, with a half-life of about 4 hours in people with normal kidney function.
		Myelosuppression is one of the main side effects that may limit prolonged use of valganciclovir.
		Pescovitz MD et al Valganciclovir results in improved oral absorption of ganciclovir in liver transplant recipients.
	en.wikipedia.org /wiki/Valganciclovir (263 words)

	the Drug Monitor- Valganciclovir / Valcyte - Nasr Anaizi, PhD
		Following oral administration, valganciclovir is rapidly hydrolyzed to ganciclovir by esterases in the intestinal and hepatic cells.
		Valganciclovir tablets can be used to extemporaneously prepare an oral liquid for patients who cannot swallow the tablets.
		Valganciclovir dosage should be adjusted based on the estimated creatinine clearance to prevent the accumulation of ganciclovir and associated toxicities.
	www.thedrugmonitor.com /valganciclovir.html (667 words)

	Data Sheet
		Valganciclovir is an L-valyl ester (prodrug) of ganciclovir, which after oral administration is rapidly converted to ganciclovir by intestinal and hepatic esterases.
		Valganciclovir is a prodrug of ganciclovir, which is well absorbed from the gastrointestinal tract and rapidly metabolised in the intestinal wall and liver to ganciclovir.
		Valganciclovir and ganciclovir were mutagenic in mouse lymphoma cells and clastogenic in mammalian cells.
	www.medsafe.govt.nz /profs/Datasheet/v/Valcytetab.htm (4427 words)

	ICAAC: Valganciclovir An Alternative to Ganciclovir For CMV Suppression in Transplant Patients (Site not responding. Last check: 2007-10-16)
		SAN DIEGO, CA -- October 2, 2002 — Valganciclovir tablets, taken once-daily, are comparable to ganciclovir capsules, taken three times a day, in the prevention of cytomegalovirus (CMV) disease in solid organ transplant recipients, according to research presented at the 42nd Annual Interscience Conference on Antimicrobial Agents and Chemotherapy.
		Valganciclovir is a simpler and equally effective substitute, he said.
		Paya concluded that valganciclovir is comparable to ganciclovir in both efficacy and safety, but has a more convenient dosing regimen — something that may affect compliance — and is better at suppressing virus during the on-treatment period.
	www.pslgroup.com /dg/21f34e.htm (446 words)

	New Treatment Guidelines for Opportunistic Infections Recommend Valganciclovir for AIDS-related CMV Retinitis
		Valganciclovir (Vacyte), a potent oral treatment for AIDS-related CMV retinitis, received positive recommendations in the new treatment guidelines that were issued last month by the CDC and published in the CDC’s Morbidity and Mortality Weekly Report.
		Oral valganciclovir, intravenous ganciclovir, intravenous ganciclovir followed by oral valganciclovir, intravenous foscarnet, intravenous cidofovir, and the ganciclovir intraocular implant coupled with valganciclovir are all effective treatments for CMV retinitis.
		Among patients with peripheral lesions that are not immediately sight-threatening, oral valganciclovir is preferable to the ganciclovir intraocular implant, intravenous ganciclovir, or intravenous foscarnet because of its greater ease of administration and lack of surgical or catheter-associated complications.
	www.hivandhepatitis.com /recent/ois/cmv/020205_c.html (933 words)

	HIV Medicine 2006 \| Valganciclovir
		Valganciclovir is the first CMV drug with good efficacy that can be administered orally.
		Valganciclovir is a prodrug of ganciclovir and therefore has a similar toxicity profile: neutropenia, anemia and thrombocytopenia.
		Valganciclovir is potentially teratogenic and carcinogenic; reliable contraception is required.
	www.hivmedicine.com /textbook/drugs/valgan.htm (300 words)

	MedlinePlus Drug Information: Valganciclovir
		Valganciclovir may lower the number of all types of cells in your blood, causing serious and life-threatening problems.
		Valganciclovir is also used to prevent cytomegalovirus (CMV) disease in people who have received a heart, kidney, or kidney-pancreas transplant and who have a chance of getting CMV disease.
		Valganciclovir is in a class of medications called antivirals.
	www.nlm.nih.gov /medlineplus/druginfo/medmaster/a605021.html (1324 words)

	CPhA: Health Care Professionals: Tools: CPS/CNP Updates: Valcyte TM Pr
		Valganciclovir is an L-valyl ester salt (prodrug) of ganciclovir that exists as a mixture of 2 diastereomers.
		Valganciclovir is well absorbed from the GI tract and rapidly metabolized in the intestinal wall and liver to ganciclovir.
		Valganciclovir is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function.
	www.pharmacists.ca /content/hcp/tools/cps_cnp_updates/valcyte.cfm (6547 words)

	SF AIDS Fdn: BETA Winter 2002-- Valganciclovir - A New Treatment for CMV
		Valganciclovir is the oral prodrug of IV ganciclovir.
		Adverse events were similar for valganciclovir and IV ganciclovir: headache (9% vs 5%, respectively), diarrhea (16% vs 10%), fever (13% vs 11%), nausea (8% vs 14%), and vomiting (11% vs 6%).
		Valganciclovir is the first drug that has been tested against IV ganciclovir for induction therapy for CMV retinitis since the Studies of Ocular Complications of AIDS (SOCA) Research Group tested IV foscarnet vs IV ganciclovir in 1990.
	www.sfaf.org /treatment/beta/b49/b49valganciclovir.html (1620 words)

	Committee Backs Valganciclovir HCl To FDA For AIDS-Related Cytomegalovirus Retinitis
		Valganciclovir is the pro-drug of Cytovene (ganciclovir), also made by Roche, which is currently the most widely prescribed anti-CMV medication worldwide.
		Of the evaluable patients in the efficacy analysis in the Cytovene - IV group, this was seven of 70; in the valganciclovir group, it was 7 of 71.
		In general, valganciclovir's adverse event profile was similar to ganciclovir and included low blood cell counts (granulocytopenia, anemia, thrombocytopenia), diarrhea, nausea, vomiting, fever and fatigue.
	www.docguide.com /dg.nsf/PrintPrint/E1959EFBEDBF67B585256A0100537388 (668 words)

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